Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.8
USERS' SCORE
Good
Based on 8 Reviews
8
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Zinc (from 150 mg Zinc Bisglycinate) (TRAACS™)
30 mg
273%
Pumpkin Seed Oil (Cold Pressed)
250 mg
†
Top Medical Research Studies
8
We explored how zinc affects blood clotting, particularly through a substance called Zn@SiO nanocomposite. This material shows promise as a hemostatic agent, which means it helps stop bleeding by promoting the formation of stable blood clots.
During our analysis, we examined various aspects of how this nanocomposite interacts with blood. It activates specific factors in the coagulation cascade—the process our bodies use to form clots. With the presence of zinc in the material, we observed enhanced activation of these factors, leading to improved clot formation.
Our research involved synthesizing and characterizing the Zn@SiO nanocomposite using several methods, including XRD, FTIR, and HRTEM. We also tested its effects on red blood cell aggregation, platelet adhesion, and several vital clotting time measures. The results indicate that Zn@SiO has significant hemostatic properties, showing potential for use in surgeries and trauma care.
This study highlights the exciting role of zinc in optimizing hemostasis, making it a candidate worth considering for medical applications related to bleeding management.
During our analysis, we examined various aspects of how this nanocomposite interacts with blood. It activates specific factors in the coagulation cascade—the process our bodies use to form clots. With the presence of zinc in the material, we observed enhanced activation of these factors, leading to improved clot formation.
Our research involved synthesizing and characterizing the Zn@SiO nanocomposite using several methods, including XRD, FTIR, and HRTEM. We also tested its effects on red blood cell aggregation, platelet adhesion, and several vital clotting time measures. The results indicate that Zn@SiO has significant hemostatic properties, showing potential for use in surgeries and trauma care.
This study highlights the exciting role of zinc in optimizing hemostasis, making it a candidate worth considering for medical applications related to bleeding management.
Read More
8
We observed a significant advance in our understanding of how zinc therapy can affect blood clotting, particularly with a compound called rutin. This study explored how zinc ions can be combined with rutin to enhance its aqueous solubility and therapeutic potential.
Rutin, a natural flavonoid found in various plants and foods, has been known for its ability to inhibit a protein called protein disulfide isomerase (PDI), which plays a role in blood clotting. However, we encountered challenges with rutin’s low solubility in water, which limits its effectiveness in therapeutic settings.
In this study, we found that when we chelated zinc ions with rutin, the resulting rutin:Zn complex showed a remarkable fourfold increase in solubility. More excitingly, this complex also exhibited a stronger inhibition of PDI activity compared to rutin alone.
In further testing with a murine model designed to induce arterial thrombosis, the rutin:Zn complex demonstrated a notable ability to slow down arterial occlusion without increasing bleeding risks. This suggests that zinc not only aids in solubility but also enhances the anti-thrombotic properties of rutin.
Overall, our findings indicate that combining zinc with certain flavonoids could be a promising strategy for elevating their benefits in combating blood clots.
Rutin, a natural flavonoid found in various plants and foods, has been known for its ability to inhibit a protein called protein disulfide isomerase (PDI), which plays a role in blood clotting. However, we encountered challenges with rutin’s low solubility in water, which limits its effectiveness in therapeutic settings.
In this study, we found that when we chelated zinc ions with rutin, the resulting rutin:Zn complex showed a remarkable fourfold increase in solubility. More excitingly, this complex also exhibited a stronger inhibition of PDI activity compared to rutin alone.
In further testing with a murine model designed to induce arterial thrombosis, the rutin:Zn complex demonstrated a notable ability to slow down arterial occlusion without increasing bleeding risks. This suggests that zinc not only aids in solubility but also enhances the anti-thrombotic properties of rutin.
Overall, our findings indicate that combining zinc with certain flavonoids could be a promising strategy for elevating their benefits in combating blood clots.
Read More
9.5
We explored the effects of a newly discovered fibrinolytic enzyme from the marine fungus Penicillium steckii KU1, particularly its interaction with zinc in the context of blood clot dissolution. This enzyme, which has a molecular weight of 12.6 kDa, is a plasmin-like protein that becomes more active in the presence of zinc. While it effectively dissolves blood clots, achieving complete dissolution in just 30 minutes with a specific concentration, we also observed that its activity is significantly inhibited by certain agents like EDTA.
Interestingly, the enzyme demonstrated a low level of hemolysis at just 2.60%, indicating that it could be a safer alternative for thrombolytic therapy. However, it's important to note that while zinc enhances the enzymatic activity, the isolated effects of zinc on blood clot breakdown remain somewhat unclear due to the enzyme's overall presence.
This research highlights the potential of the marine-derived enzyme and the role of zinc, suggesting that further studies could provide deeper insights into improving thrombolytic treatments. These findings could be significant for enhancing the safety and effectiveness of therapies designed for clot management.
Interestingly, the enzyme demonstrated a low level of hemolysis at just 2.60%, indicating that it could be a safer alternative for thrombolytic therapy. However, it's important to note that while zinc enhances the enzymatic activity, the isolated effects of zinc on blood clot breakdown remain somewhat unclear due to the enzyme's overall presence.
This research highlights the potential of the marine-derived enzyme and the role of zinc, suggesting that further studies could provide deeper insights into improving thrombolytic treatments. These findings could be significant for enhancing the safety and effectiveness of therapies designed for clot management.
Read More
Most Useful Reviews
9
Resolved deficiency
3 people found this helpful
I constantly have zinc deficiency in my blood tests, but since my nutritionist prescribed this supplement, the deficiency has improved without side effects like digestive discomfort. I’ve tried other brands unsuccessfully and always keep this one in stock.
Read More
9
Effective zinc increase
1 people found this helpful
Excellent! This supplement has significantly raised my zinc levels in the blood! Highly recommend!
Read More
6
Pain relief noticed
3 people found this helpful
After a recent blood test revealed low zinc levels, I switched to a 30 mg zinc product. It's been a week, and I'm already feeling my body aches alleviating. The supplement is small and easy to consume. Additionally, it contains pumpkin seed oil, which I hope will benefit my lungs, mucous membranes, and digestive health.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.8
- All Researches
9.5
We explored the effects of a newly discovered fibrinolytic enzyme from the marine fungus Penicillium steckii KU1, particularly its interaction with zinc in the context of blood clot dissolution. This enzyme, which has a molecular weight of 12.6 kDa, is a plasmin-like protein that becomes more active in the presence of zinc. While it effectively dissolves blood clots, achieving complete dissolution in just 30 minutes with a specific concentration, we also observed that its activity is significantly inhibited by certain agents like EDTA.
Interestingly, the enzyme demonstrated a low level of hemolysis at just 2.60%, indicating that it could be a safer alternative for thrombolytic therapy. However, it's important to note that while zinc enhances the enzymatic activity, the isolated effects of zinc on blood clot breakdown remain somewhat unclear due to the enzyme's overall presence.
This research highlights the potential of the marine-derived enzyme and the role of zinc, suggesting that further studies could provide deeper insights into improving thrombolytic treatments. These findings could be significant for enhancing the safety and effectiveness of therapies designed for clot management.
Interestingly, the enzyme demonstrated a low level of hemolysis at just 2.60%, indicating that it could be a safer alternative for thrombolytic therapy. However, it's important to note that while zinc enhances the enzymatic activity, the isolated effects of zinc on blood clot breakdown remain somewhat unclear due to the enzyme's overall presence.
This research highlights the potential of the marine-derived enzyme and the role of zinc, suggesting that further studies could provide deeper insights into improving thrombolytic treatments. These findings could be significant for enhancing the safety and effectiveness of therapies designed for clot management.
Read More
9.5
We investigated how a new hemostatic agent, HEMO-IONIC®, which is enriched with zinc and made from calcium alginate, influences blood clotting and tissue repair. Our focus was on how this innovative compress can help control bleeding while also promoting healing after surgery.
In our study, we compared the effects of HEMO-IONIC with other common hemostatic products, like Surgicel® and TachoSil®. What we found was impressive: HEMO-IONIC not only effectively helped to achieve hemostasis, but it also supported the health of vascular endothelial cells, which are crucial for tissue repair.
Unlike Surgicel, which showed high cytotoxicity, and TachoSil, which inhibited cell migration, HEMO-IONIC promoted the migration of endothelial cells and increased angiogenesis—the formation of new blood vessels. This means that it not only helps stop bleeding but also enhances the body's natural repair processes by attracting essential healing cells and speeding up the maturation of the extracellular matrix.
Overall, we found that using HEMO-IONIC at the end of surgical procedures has long-term positive effects on every phase of tissue repair, making it a promising alternative to traditional hemostatic agents.
In our study, we compared the effects of HEMO-IONIC with other common hemostatic products, like Surgicel® and TachoSil®. What we found was impressive: HEMO-IONIC not only effectively helped to achieve hemostasis, but it also supported the health of vascular endothelial cells, which are crucial for tissue repair.
Unlike Surgicel, which showed high cytotoxicity, and TachoSil, which inhibited cell migration, HEMO-IONIC promoted the migration of endothelial cells and increased angiogenesis—the formation of new blood vessels. This means that it not only helps stop bleeding but also enhances the body's natural repair processes by attracting essential healing cells and speeding up the maturation of the extracellular matrix.
Overall, we found that using HEMO-IONIC at the end of surgical procedures has long-term positive effects on every phase of tissue repair, making it a promising alternative to traditional hemostatic agents.
Read More
8
We explored how zinc affects blood clotting, particularly through a substance called Zn@SiO nanocomposite. This material shows promise as a hemostatic agent, which means it helps stop bleeding by promoting the formation of stable blood clots.
During our analysis, we examined various aspects of how this nanocomposite interacts with blood. It activates specific factors in the coagulation cascade—the process our bodies use to form clots. With the presence of zinc in the material, we observed enhanced activation of these factors, leading to improved clot formation.
Our research involved synthesizing and characterizing the Zn@SiO nanocomposite using several methods, including XRD, FTIR, and HRTEM. We also tested its effects on red blood cell aggregation, platelet adhesion, and several vital clotting time measures. The results indicate that Zn@SiO has significant hemostatic properties, showing potential for use in surgeries and trauma care.
This study highlights the exciting role of zinc in optimizing hemostasis, making it a candidate worth considering for medical applications related to bleeding management.
During our analysis, we examined various aspects of how this nanocomposite interacts with blood. It activates specific factors in the coagulation cascade—the process our bodies use to form clots. With the presence of zinc in the material, we observed enhanced activation of these factors, leading to improved clot formation.
Our research involved synthesizing and characterizing the Zn@SiO nanocomposite using several methods, including XRD, FTIR, and HRTEM. We also tested its effects on red blood cell aggregation, platelet adhesion, and several vital clotting time measures. The results indicate that Zn@SiO has significant hemostatic properties, showing potential for use in surgeries and trauma care.
This study highlights the exciting role of zinc in optimizing hemostasis, making it a candidate worth considering for medical applications related to bleeding management.
Read More
8
We examined how zinc (Zn) impacts blood clotting, particularly focusing on its interaction with prostacyclin (PGI) signaling in platelets. The study revealed that about 17.3% of people worldwide experience some level of zinc deficiency, which can lead to impaired blood clotting and increased bleeding.
By conducting a series of experiments involving platelet aggregation and thrombus formation, we found that zinc chelators, which bind and remove zinc, enhanced the signaling pathway of PGI. This signaling is crucial because it helps platelets avoid becoming overly activated, thus reducing clot formation.
Interestingly, we observed that the presence of these zinc chelators resulted in either the breakdown of preformed clots in whole blood or the reversal of platelet spreading in isolated platelets. Moreover, our findings indicated that blocking adenylyl cyclase—an enzyme involved in PGI signaling—prevented the effects of zinc chelation, solidifying the idea that zinc plays a regulatory role in this process.
Ultimately, our research suggests that reducing zinc levels can amplify the effectiveness of PGI in controlling platelet activity and preventing excessive clotting. This could have important implications for individuals suffering from bleeding disorders or those at risk of blood clot-related complications.
By conducting a series of experiments involving platelet aggregation and thrombus formation, we found that zinc chelators, which bind and remove zinc, enhanced the signaling pathway of PGI. This signaling is crucial because it helps platelets avoid becoming overly activated, thus reducing clot formation.
Interestingly, we observed that the presence of these zinc chelators resulted in either the breakdown of preformed clots in whole blood or the reversal of platelet spreading in isolated platelets. Moreover, our findings indicated that blocking adenylyl cyclase—an enzyme involved in PGI signaling—prevented the effects of zinc chelation, solidifying the idea that zinc plays a regulatory role in this process.
Ultimately, our research suggests that reducing zinc levels can amplify the effectiveness of PGI in controlling platelet activity and preventing excessive clotting. This could have important implications for individuals suffering from bleeding disorders or those at risk of blood clot-related complications.
Read More
8
We observed a significant advance in our understanding of how zinc therapy can affect blood clotting, particularly with a compound called rutin. This study explored how zinc ions can be combined with rutin to enhance its aqueous solubility and therapeutic potential.
Rutin, a natural flavonoid found in various plants and foods, has been known for its ability to inhibit a protein called protein disulfide isomerase (PDI), which plays a role in blood clotting. However, we encountered challenges with rutin’s low solubility in water, which limits its effectiveness in therapeutic settings.
In this study, we found that when we chelated zinc ions with rutin, the resulting rutin:Zn complex showed a remarkable fourfold increase in solubility. More excitingly, this complex also exhibited a stronger inhibition of PDI activity compared to rutin alone.
In further testing with a murine model designed to induce arterial thrombosis, the rutin:Zn complex demonstrated a notable ability to slow down arterial occlusion without increasing bleeding risks. This suggests that zinc not only aids in solubility but also enhances the anti-thrombotic properties of rutin.
Overall, our findings indicate that combining zinc with certain flavonoids could be a promising strategy for elevating their benefits in combating blood clots.
Rutin, a natural flavonoid found in various plants and foods, has been known for its ability to inhibit a protein called protein disulfide isomerase (PDI), which plays a role in blood clotting. However, we encountered challenges with rutin’s low solubility in water, which limits its effectiveness in therapeutic settings.
In this study, we found that when we chelated zinc ions with rutin, the resulting rutin:Zn complex showed a remarkable fourfold increase in solubility. More excitingly, this complex also exhibited a stronger inhibition of PDI activity compared to rutin alone.
In further testing with a murine model designed to induce arterial thrombosis, the rutin:Zn complex demonstrated a notable ability to slow down arterial occlusion without increasing bleeding risks. This suggests that zinc not only aids in solubility but also enhances the anti-thrombotic properties of rutin.
Overall, our findings indicate that combining zinc with certain flavonoids could be a promising strategy for elevating their benefits in combating blood clots.
Read More
User Reviews
USERS' SCORE
Good
Based on 8 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Resolved deficiency
3 people found this helpful
I constantly have zinc deficiency in my blood tests, but since my nutritionist prescribed this supplement, the deficiency has improved without side effects like digestive discomfort. I’ve tried other brands unsuccessfully and always keep this one in stock.
Read More
9
Effective zinc increase
1 people found this helpful
Excellent! This supplement has significantly raised my zinc levels in the blood! Highly recommend!
Read More
6
Pain relief noticed
3 people found this helpful
After a recent blood test revealed low zinc levels, I switched to a 30 mg zinc product. It's been a week, and I'm already feeling my body aches alleviating. The supplement is small and easy to consume. Additionally, it contains pumpkin seed oil, which I hope will benefit my lungs, mucous membranes, and digestive health.
Read More
7.5
Immediate wellness effect
1 people found this helpful
My favourite zinc! I have a proven deficiency, and while using the Nordic Natural brand, my levels only improved slightly. However, when I switched to Life Extension lozenges, I felt an immediate uplift, although it upset my stomach. Now, I’ve tried the Now brand and it's perfect! I experience instant wellness and no digestive issues, likely due to the gentle glycine and beneficial pumpkin seed oil.
Read More
7.5
Positive zinc effect
27 people found this helpful
Many adolescents and adults suffer from problematic skin, such as oiliness and acne. I've struggled with oily skin since my teens, making it impossible to leave home without cosmetics that often wear off quickly. After trying various remedies, I discovered zinc deficiency could be the issue and ordered zinc from iherb.com. Within three days of use, I noticed my scalp and face were less greasy, a couple of PMS-related spots disappeared, and my menstrual cramps were less severe. The tablets are easy to swallow, and I’ve experienced no adverse effects. I’m optimistic about the benefits of this treatment.
Read More
Frequently Asked Questions
7.5
Positive zinc effect
27 people found this helpful
Many adolescents and adults suffer from problematic skin, such as oiliness and acne. I've struggled with oily skin since my teens, making it impossible to leave home without cosmetics that often wear off quickly. After trying various remedies, I discovered zinc deficiency could be the issue and ordered zinc from iherb.com. Within three days of use, I noticed my scalp and face were less greasy, a couple of PMS-related spots disappeared, and my menstrual cramps were less severe. The tablets are easy to swallow, and I’ve experienced no adverse effects. I’m optimistic about the benefits of this treatment.
6
Pain relief noticed
3 people found this helpful
After a recent blood test revealed low zinc levels, I switched to a 30 mg zinc product. It's been a week, and I'm already feeling my body aches alleviating. The supplement is small and easy to consume. Additionally, it contains pumpkin seed oil, which I hope will benefit my lungs, mucous membranes, and digestive health.
7.5
Immediate wellness effect
1 people found this helpful
My favourite zinc! I have a proven deficiency, and while using the Nordic Natural brand, my levels only improved slightly. However, when I switched to Life Extension lozenges, I felt an immediate uplift, although it upset my stomach. Now, I’ve tried the Now brand and it's perfect! I experience instant wellness and no digestive issues, likely due to the gentle glycine and beneficial pumpkin seed oil.
9
Effective zinc increase
1 people found this helpful
Excellent! This supplement has significantly raised my zinc levels in the blood! Highly recommend!
6
Mental clarity improved
5 people found this helpful
This product has become essential for me after discovering I had a zinc deficiency from blood tests. I used to feel fatigued and mentally groggy, but since I began taking zinc, my mental alertness has significantly improved. I continue to repurchase this product as it's easy to use.
7.5
Immunity booster
2 people found this helpful
I’ve never regretted ordering this zinc supplement! It's remarkable for boosting immunity; whenever I feel unwell, zinc alleviates my symptoms promptly. It effectively contributes to normalising blood sugar levels. It’s crucial to take zinc separately from other vitamins for optimal absorption. If this review has helped, please click "Yes".
9.5
We explored the effects of a newly discovered fibrinolytic enzyme from the marine fungus Penicillium steckii KU1, particularly its interaction with zinc in the context of blood clot dissolution. This enzyme, which has a molecular weight of 12.6 kDa, is a plasmin-like protein that becomes more active in the presence of zinc. While it effectively dissolves blood clots, achieving complete dissolution in just 30 minutes with a specific concentration, we also observed that its activity is significantly inhibited by certain agents like EDTA.
Interestingly, the enzyme demonstrated a low level of hemolysis at just 2.60%, indicating that it could be a safer alternative for thrombolytic therapy. However, it's important to note that while zinc enhances the enzymatic activity, the isolated effects of zinc on blood clot breakdown remain somewhat unclear due to the enzyme's overall presence.
This research highlights the potential of the marine-derived enzyme and the role of zinc, suggesting that further studies could provide deeper insights into improving thrombolytic treatments. These findings could be significant for enhancing the safety and effectiveness of therapies designed for clot management.
Interestingly, the enzyme demonstrated a low level of hemolysis at just 2.60%, indicating that it could be a safer alternative for thrombolytic therapy. However, it's important to note that while zinc enhances the enzymatic activity, the isolated effects of zinc on blood clot breakdown remain somewhat unclear due to the enzyme's overall presence.
This research highlights the potential of the marine-derived enzyme and the role of zinc, suggesting that further studies could provide deeper insights into improving thrombolytic treatments. These findings could be significant for enhancing the safety and effectiveness of therapies designed for clot management.
8
We explored how zinc affects blood clotting, particularly through a substance called Zn@SiO nanocomposite. This material shows promise as a hemostatic agent, which means it helps stop bleeding by promoting the formation of stable blood clots.
During our analysis, we examined various aspects of how this nanocomposite interacts with blood. It activates specific factors in the coagulation cascade—the process our bodies use to form clots. With the presence of zinc in the material, we observed enhanced activation of these factors, leading to improved clot formation.
Our research involved synthesizing and characterizing the Zn@SiO nanocomposite using several methods, including XRD, FTIR, and HRTEM. We also tested its effects on red blood cell aggregation, platelet adhesion, and several vital clotting time measures. The results indicate that Zn@SiO has significant hemostatic properties, showing potential for use in surgeries and trauma care.
This study highlights the exciting role of zinc in optimizing hemostasis, making it a candidate worth considering for medical applications related to bleeding management.
During our analysis, we examined various aspects of how this nanocomposite interacts with blood. It activates specific factors in the coagulation cascade—the process our bodies use to form clots. With the presence of zinc in the material, we observed enhanced activation of these factors, leading to improved clot formation.
Our research involved synthesizing and characterizing the Zn@SiO nanocomposite using several methods, including XRD, FTIR, and HRTEM. We also tested its effects on red blood cell aggregation, platelet adhesion, and several vital clotting time measures. The results indicate that Zn@SiO has significant hemostatic properties, showing potential for use in surgeries and trauma care.
This study highlights the exciting role of zinc in optimizing hemostasis, making it a candidate worth considering for medical applications related to bleeding management.
8
We examined how zinc (Zn) impacts blood clotting, particularly focusing on its interaction with prostacyclin (PGI) signaling in platelets. The study revealed that about 17.3% of people worldwide experience some level of zinc deficiency, which can lead to impaired blood clotting and increased bleeding.
By conducting a series of experiments involving platelet aggregation and thrombus formation, we found that zinc chelators, which bind and remove zinc, enhanced the signaling pathway of PGI. This signaling is crucial because it helps platelets avoid becoming overly activated, thus reducing clot formation.
Interestingly, we observed that the presence of these zinc chelators resulted in either the breakdown of preformed clots in whole blood or the reversal of platelet spreading in isolated platelets. Moreover, our findings indicated that blocking adenylyl cyclase—an enzyme involved in PGI signaling—prevented the effects of zinc chelation, solidifying the idea that zinc plays a regulatory role in this process.
Ultimately, our research suggests that reducing zinc levels can amplify the effectiveness of PGI in controlling platelet activity and preventing excessive clotting. This could have important implications for individuals suffering from bleeding disorders or those at risk of blood clot-related complications.
By conducting a series of experiments involving platelet aggregation and thrombus formation, we found that zinc chelators, which bind and remove zinc, enhanced the signaling pathway of PGI. This signaling is crucial because it helps platelets avoid becoming overly activated, thus reducing clot formation.
Interestingly, we observed that the presence of these zinc chelators resulted in either the breakdown of preformed clots in whole blood or the reversal of platelet spreading in isolated platelets. Moreover, our findings indicated that blocking adenylyl cyclase—an enzyme involved in PGI signaling—prevented the effects of zinc chelation, solidifying the idea that zinc plays a regulatory role in this process.
Ultimately, our research suggests that reducing zinc levels can amplify the effectiveness of PGI in controlling platelet activity and preventing excessive clotting. This could have important implications for individuals suffering from bleeding disorders or those at risk of blood clot-related complications.
4
We explored how zinc and iron ions influence the body’s ability to break down blood clots using a drug called tissue plasminogen activator (tPA). This study is particularly important due to the limited options available for treating acute ischemic strokes, where rapid clot removal is crucial.
Our research included laboratory tests and in vivo experiments to observe the effects of these metal ions on tPA-induced thrombolysis. We found that while zinc and iron appeared to inhibit this process, adding a metal ion chelator, EDTA, along with tPA significantly improved the efficiency of clot dissolution.
Interestingly, using zinc or iron by themselves did not show strong thrombolytic effects, but when combined with EDTA, the rate of reperfusion, which is the restoration of blood flow, drastically increased compared to using tPA alone. This suggests that ion chelation might not only make tPA more effective but could also potentially reduce side effects by lowering the dosage needed for treatment.
We did not find a strong independent benefit of zinc alone on its own for thrombolysis, but its role in combination with other agents like EDTA opens up new avenues for safer and more effective treatments for stroke patients.
Our research included laboratory tests and in vivo experiments to observe the effects of these metal ions on tPA-induced thrombolysis. We found that while zinc and iron appeared to inhibit this process, adding a metal ion chelator, EDTA, along with tPA significantly improved the efficiency of clot dissolution.
Interestingly, using zinc or iron by themselves did not show strong thrombolytic effects, but when combined with EDTA, the rate of reperfusion, which is the restoration of blood flow, drastically increased compared to using tPA alone. This suggests that ion chelation might not only make tPA more effective but could also potentially reduce side effects by lowering the dosage needed for treatment.
We did not find a strong independent benefit of zinc alone on its own for thrombolysis, but its role in combination with other agents like EDTA opens up new avenues for safer and more effective treatments for stroke patients.
References
- Kunhiraman S, Haridas M, Basheer SM, Chellappan S, Abdulhameed S. Least hemolytic, 12.6 kDa, plasmin-like fibrinolytic protease from marine Penicillium steckii KU1. Int J Biol Macromol. 2024;283:137854. 10.1016/j.ijbiomac.2024.137854
- M S M, Samal DB, Amirtraj J V, Subramanian S, Venkatasubbu GD. Enhanced coagulation cascade activation and styptic effects of Zn@SiO nanocomposite. Colloids Surf B Biointerfaces. 2024;239:113927. 10.1016/j.colsurfb.2024.113927
- Coupland CA, Naylor-Adamson L, Booth Z, Price TW, Gil HM, et al. Platelet zinc status regulates prostaglandin-induced signaling, altering thrombus formation. J Thromb Haemost. 2023;21:2545. 10.1016/j.jtha.2023.05.008
- Liao X, Ji P, Chi K, Chen X, Zhou Y, et al. Enhanced inhibition of protein disulfide isomerase and anti-thrombotic activity of a rutin derivative: rutin:Zn complex. RSC Adv. 2023;13:11464. 10.1039/d3ra01135f
- Ponsen AC, Proust R, Soave S, Mercier-Nomé F, Garcin I, et al. A new hemostatic agent composed of Zn-enriched Ca alginate activates vascular endothelial cells and promotes tissue repair . Bioact Mater. 2022;18:368. 10.1016/j.bioactmat.2022.01.049
- Yu X, Wang Z, Li YV. Metal ion chelation enhances tissue plasminogen activator (tPA)-induced thrombolysis: an in vitro and in vivo study. J Thromb Thrombolysis. 2022;53:291. 10.1007/s11239-021-02600-6
