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SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.3
USERS' SCORE
Good
Based on 2 Reviews
8.3
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Zinc (from 150 mg Zinc Bisglycinate) (TRAACS™)
30 mg
273%
Pumpkin Seed Oil (Cold Pressed)
250 mg
†
Top Medical Research Studies
9
ZnO NPs protect heart health
In vivo cardioprotective effect of zinc oxide nanoparticles against doxorubicin-induced myocardial infarction by enhancing the antioxidant system and nitric oxide production.
Direct focus on cardioprotection
We aimed to explore how zinc oxide nanoparticles (ZnO NPs) could protect the heart from damage caused by doxorubicin, a drug that can lead to serious heart issues, including myocardial infarction (MI). Our study involved rats that were injected with doxorubicin to induce MI and then treated with ZnO NPs at two different doses.
Throughout the research, we observed significant improvements in heart health among the rats that received these nanoparticles. Specifically, their heart function showed recovery, with important biochemical markers reflecting less damage. The lower dose of ZnO NPs was especially effective, aiding the antioxidant system and boosting nitric oxide production, which is vital for heart function.
Our findings suggest that ZnO NPs could be a promising way to counteract the cardiotoxic effects of doxorubicin. This insight opens new avenues for treatment strategies aimed at patients who need chemotherapy without risking their heart health.
Throughout the research, we observed significant improvements in heart health among the rats that received these nanoparticles. Specifically, their heart function showed recovery, with important biochemical markers reflecting less damage. The lower dose of ZnO NPs was especially effective, aiding the antioxidant system and boosting nitric oxide production, which is vital for heart function.
Our findings suggest that ZnO NPs could be a promising way to counteract the cardiotoxic effects of doxorubicin. This insight opens new avenues for treatment strategies aimed at patients who need chemotherapy without risking their heart health.
Read More
8
Zinc treatment aids heart recovery
PIAS3 acts as a zinc sensor under zinc deficiency and plays an important role in myocardial ischemia/reperfusion injury.
Significant findings on zinc's role
We explored the impact of zinc on heart attack recovery, particularly focusing on how zinc deficiency affects heart cells during ischemia/reperfusion (I/R) injury. The study highlighted that when zinc levels drop, a protein known as PIAS3 is quickly degraded. This degradation helps activate another protein called STAT3, which plays a key role in encouraging the expression of zinc transporter genes. These transporters are vital in regulating zinc levels within heart cells.
The importance of the RING finger domain of PIAS3 emerged as crucial. It turns out that this domain is necessary for both degrading PIAS3 and inhibiting STAT3 activation. We found that when PIAS3 was knocked down, cardiac zinc levels increased, leading to less myocardial infarction in mice undergoing I/R. In contrast, overexpressing the regular PIAS3 protein lowered zinc levels and worsened heart damage.
Through these findings, we gained insight into a fascinating mechanism—when zinc is lacking, the body quickly eliminates this regulatory protein, thereby helping to restore balance and protect the heart from injury during the critical ischemia/reperfusion phase.
The importance of the RING finger domain of PIAS3 emerged as crucial. It turns out that this domain is necessary for both degrading PIAS3 and inhibiting STAT3 activation. We found that when PIAS3 was knocked down, cardiac zinc levels increased, leading to less myocardial infarction in mice undergoing I/R. In contrast, overexpressing the regular PIAS3 protein lowered zinc levels and worsened heart damage.
Through these findings, we gained insight into a fascinating mechanism—when zinc is lacking, the body quickly eliminates this regulatory protein, thereby helping to restore balance and protect the heart from injury during the critical ischemia/reperfusion phase.
Read More
8
Zinc levels linked to heart failure
Serum zinc concentration in patients with myocardial infarction: a retrospective study.
Direct study on zinc impact
We investigated the connection between serum zinc levels and the risk of heart failure following a myocardial infarction, commonly known as a heart attack. In our study, we focused on 243 patients who were divided based on their zinc levels at the time of their hospital admission. Those with lower zinc levels (below 66 µg/dL) numbered 111, while 132 patients had higher zinc levels.
Throughout an average follow-up of about two years, we observed that 12 of the patients were readmitted due to heart failure. Notably, 10 of these cases were from the low zinc group, highlighting a concerning trend. The results indicated that having lower serum zinc levels significantly increased the likelihood of being readmitted for heart failure, with a hazard ratio of 15.7 when compared to those with higher zinc levels.
This finding suggests a potential risk factor linked to low zinc concentrations following a heart attack. Our analysis indicates that maintaining adequate zinc levels could be crucial for heart health post-myocardial infarction, but further research is necessary to confirm these results and determine the potential benefits of zinc treatment.
Throughout an average follow-up of about two years, we observed that 12 of the patients were readmitted due to heart failure. Notably, 10 of these cases were from the low zinc group, highlighting a concerning trend. The results indicated that having lower serum zinc levels significantly increased the likelihood of being readmitted for heart failure, with a hazard ratio of 15.7 when compared to those with higher zinc levels.
This finding suggests a potential risk factor linked to low zinc concentrations following a heart attack. Our analysis indicates that maintaining adequate zinc levels could be crucial for heart health post-myocardial infarction, but further research is necessary to confirm these results and determine the potential benefits of zinc treatment.
Read More
Most Useful Reviews
7.5
Boosts immunity
Zinc is a very beneficial drug for heart health. It should be consumed regularly and is well absorbed by the body. The large packaging is a plus. It’s essential to have a test to assess zinc deficiency before starting the drug. It is also great for boosting immunity during winter.
Read More
6.8
Nausea risk
It effectively boosts my immunity during illness, but it's crucial to take it with a substantial meal to avoid nausea.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.3
9
ZnO NPs protect heart health
In vivo cardioprotective effect of zinc oxide nanoparticles against doxorubicin-induced myocardial infarction by enhancing the antioxidant system and nitric oxide production.
Direct focus on cardioprotection
We aimed to explore how zinc oxide nanoparticles (ZnO NPs) could protect the heart from damage caused by doxorubicin, a drug that can lead to serious heart issues, including myocardial infarction (MI). Our study involved rats that were injected with doxorubicin to induce MI and then treated with ZnO NPs at two different doses.
Throughout the research, we observed significant improvements in heart health among the rats that received these nanoparticles. Specifically, their heart function showed recovery, with important biochemical markers reflecting less damage. The lower dose of ZnO NPs was especially effective, aiding the antioxidant system and boosting nitric oxide production, which is vital for heart function.
Our findings suggest that ZnO NPs could be a promising way to counteract the cardiotoxic effects of doxorubicin. This insight opens new avenues for treatment strategies aimed at patients who need chemotherapy without risking their heart health.
Throughout the research, we observed significant improvements in heart health among the rats that received these nanoparticles. Specifically, their heart function showed recovery, with important biochemical markers reflecting less damage. The lower dose of ZnO NPs was especially effective, aiding the antioxidant system and boosting nitric oxide production, which is vital for heart function.
Our findings suggest that ZnO NPs could be a promising way to counteract the cardiotoxic effects of doxorubicin. This insight opens new avenues for treatment strategies aimed at patients who need chemotherapy without risking their heart health.
Read More
9
Zinc benefits heart attack recovery
Zn SiO Bioceramic Attenuates Cardiac Remodeling after Myocardial Infarction.
Combined effects of zinc and silicon
We investigated how zinc contributes to recovery after a heart attack, specifically focusing on its role in promoting heart health. The study centered on a new bioceramic material made from zinc and silicon oxide, which releases bioactive elements that work together to support heart cell function and reduce damage.
Our findings revealed that both zinc and silicon oxide enhance blood vessel growth and protect heart cells from harm during a heart attack. We observed that administering this material, either through injections or as a hydrogel, improved heart function and reduced scar tissue formation in a murine model of myocardial infarction.
This research marks a significant step in demonstrating the combined benefits of zinc and silicon oxide in heart protection. While zinc alone is part of the treatment, it’s essential to note that this study showcases their combined effects rather than evaluating zinc in isolation.
Our findings revealed that both zinc and silicon oxide enhance blood vessel growth and protect heart cells from harm during a heart attack. We observed that administering this material, either through injections or as a hydrogel, improved heart function and reduced scar tissue formation in a murine model of myocardial infarction.
This research marks a significant step in demonstrating the combined benefits of zinc and silicon oxide in heart protection. While zinc alone is part of the treatment, it’s essential to note that this study showcases their combined effects rather than evaluating zinc in isolation.
Read More
8
Zinc-ANP interaction protects heart
ANP Increases Zn Accumulation During Reperfusion in Ex Vivo and In Vivo Hearts.
Moderately relevant zinc-heart study
The research examined how zinc interacts with atrial natriuretic peptide (ANP) to offer protection during heart attacks, specifically in situations involving ischemia and reperfusion. Through studies conducted in both isolated rat hearts and mouse models, we investigated whether ANP could modify zinc levels to help protect heart tissue from damage.
Our findings revealed that ANP levels increased during reperfusion, which is when blood flow returns to the heart after being temporarily stopped. Alongside this, we observed a rise in zinc accumulation in the heart during this process. Notably, zinc seemed to play a supportive role, helping to safeguard mitochondrial function and reducing the extent of heart damage.
However, when we introduced a zinc chelator, it negated some of these protective effects, emphasizing the importance of zinc in this protective mechanism. While we saw improved heart function with ANP pretreatment, combining it with the zinc chelator actually worsened the cardiac function, suggesting that both ANP and zinc work best when together.
Our investigation deepened our understanding of zinc by revealing that it works through the PI3K signaling pathway, effectively reducing a specific zinc transporter expression that contributes to heart injury. In summary, this study highlighted the complex interaction between ANP and zinc and proposed that this combination could be crucial in developing strategies against heart attack damage.
Our findings revealed that ANP levels increased during reperfusion, which is when blood flow returns to the heart after being temporarily stopped. Alongside this, we observed a rise in zinc accumulation in the heart during this process. Notably, zinc seemed to play a supportive role, helping to safeguard mitochondrial function and reducing the extent of heart damage.
However, when we introduced a zinc chelator, it negated some of these protective effects, emphasizing the importance of zinc in this protective mechanism. While we saw improved heart function with ANP pretreatment, combining it with the zinc chelator actually worsened the cardiac function, suggesting that both ANP and zinc work best when together.
Our investigation deepened our understanding of zinc by revealing that it works through the PI3K signaling pathway, effectively reducing a specific zinc transporter expression that contributes to heart injury. In summary, this study highlighted the complex interaction between ANP and zinc and proposed that this combination could be crucial in developing strategies against heart attack damage.
Read More
8
Zinc intake linked to heart attack
Nonlinear associations between dietary zinc intake and cardiovascular disease risk, a National cross-sectional study based on the NHANES 2005-2018.
Moderate relevance to cardiovascular health
We aimed to understand how dietary zinc intake influences the risk of heart attacks, along with other cardiovascular diseases (CVDs). Utilizing data from a National Health and Nutrition Examination Survey spanning 2005 to 2018, we looked at various ranges of zinc consumption among participants.
Our findings showed promising results: higher zinc intake was associated with a reduced risk of heart attacks. Specifically, those in the second, third, and fourth quartiles of zinc intake had significantly lower odds of experiencing a heart attack compared to those consuming less zinc.
However, it's important to note that while we saw a strong link between zinc consumption and reduced heart attack risk, the same was not observed for conditions like coronary heart disease or angina. This suggests that zinc may play a specific role in heart attack prevention, but more research is needed to clarify its benefits on other cardiovascular issues.
Our findings showed promising results: higher zinc intake was associated with a reduced risk of heart attacks. Specifically, those in the second, third, and fourth quartiles of zinc intake had significantly lower odds of experiencing a heart attack compared to those consuming less zinc.
However, it's important to note that while we saw a strong link between zinc consumption and reduced heart attack risk, the same was not observed for conditions like coronary heart disease or angina. This suggests that zinc may play a specific role in heart attack prevention, but more research is needed to clarify its benefits on other cardiovascular issues.
Read More
8
Zinc treatment aids heart recovery
PIAS3 acts as a zinc sensor under zinc deficiency and plays an important role in myocardial ischemia/reperfusion injury.
Significant findings on zinc's role
We explored the impact of zinc on heart attack recovery, particularly focusing on how zinc deficiency affects heart cells during ischemia/reperfusion (I/R) injury. The study highlighted that when zinc levels drop, a protein known as PIAS3 is quickly degraded. This degradation helps activate another protein called STAT3, which plays a key role in encouraging the expression of zinc transporter genes. These transporters are vital in regulating zinc levels within heart cells.
The importance of the RING finger domain of PIAS3 emerged as crucial. It turns out that this domain is necessary for both degrading PIAS3 and inhibiting STAT3 activation. We found that when PIAS3 was knocked down, cardiac zinc levels increased, leading to less myocardial infarction in mice undergoing I/R. In contrast, overexpressing the regular PIAS3 protein lowered zinc levels and worsened heart damage.
Through these findings, we gained insight into a fascinating mechanism—when zinc is lacking, the body quickly eliminates this regulatory protein, thereby helping to restore balance and protect the heart from injury during the critical ischemia/reperfusion phase.
The importance of the RING finger domain of PIAS3 emerged as crucial. It turns out that this domain is necessary for both degrading PIAS3 and inhibiting STAT3 activation. We found that when PIAS3 was knocked down, cardiac zinc levels increased, leading to less myocardial infarction in mice undergoing I/R. In contrast, overexpressing the regular PIAS3 protein lowered zinc levels and worsened heart damage.
Through these findings, we gained insight into a fascinating mechanism—when zinc is lacking, the body quickly eliminates this regulatory protein, thereby helping to restore balance and protect the heart from injury during the critical ischemia/reperfusion phase.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.3
7.5
Boosts immunity
Zinc is a very beneficial drug for heart health. It should be consumed regularly and is well absorbed by the body. The large packaging is a plus. It’s essential to have a test to assess zinc deficiency before starting the drug. It is also great for boosting immunity during winter.
6.8
Nausea risk
It effectively boosts my immunity during illness, but it's crucial to take it with a substantial meal to avoid nausea.
