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SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
USERS' SCORE
Good
Based on 1 Review
8.5
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Zinc (from 150 mg Zinc Bisglycinate) (TRAACS™)
30 mg
273%
Pumpkin Seed Oil (Cold Pressed)
250 mg
†
Top Medical Research Studies
7
Zinc levels and MS correlation
Relationship between zinc-related nutritional status and the progression of multiple sclerosis.
Highly relevant to MS treatment
We conducted a study to understand how zinc may affect multiple sclerosis (MS). Our research involved 98 participants, divided into two groups: one with MS and another matched control group without the condition. We aimed to examine the levels of zinc in both plasma and red blood cells to see if there’s a connection with MS severity and outbreaks.
The findings were intriguing. We discovered that while the average plasma zinc levels were normal in MS patients, their red blood cell zinc levels were actually higher than those in the control group. Additionally, we noticed that the activity of an important enzyme called superoxide dismutase (SOD) was significantly elevated in MS patients, which correlates positively with these higher zinc levels. This suggests that while the body might be managing zinc rather well, it’s working overtime, possibly to counteract oxidative stress related to MS.
Importantly, we observed a direct correlation between erythrocyte zinc and SOD activity, which was also linked inversely to MS outbreaks—indicating that as SOD increases in activity, the frequency of outbreaks tends to decrease. These insights confirm that there could be a beneficial relationship between zinc levels and the management of MS, but more research is certainly needed to explore this further.
The findings were intriguing. We discovered that while the average plasma zinc levels were normal in MS patients, their red blood cell zinc levels were actually higher than those in the control group. Additionally, we noticed that the activity of an important enzyme called superoxide dismutase (SOD) was significantly elevated in MS patients, which correlates positively with these higher zinc levels. This suggests that while the body might be managing zinc rather well, it’s working overtime, possibly to counteract oxidative stress related to MS.
Importantly, we observed a direct correlation between erythrocyte zinc and SOD activity, which was also linked inversely to MS outbreaks—indicating that as SOD increases in activity, the frequency of outbreaks tends to decrease. These insights confirm that there could be a beneficial relationship between zinc levels and the management of MS, but more research is certainly needed to explore this further.
Read More
9
Zinc supplementation benefits spinal cord health
Dietary zinc status is associated with ZnT3 (SLC30A3), IL-6 gene expressions and spinal cord tissue damage in spinal cord tissue in a cuprizone-induced rat Multiple Sclerosis model.
Study finds zinc effects on MS
We explored the effects of dietary zinc on spinal cord damage and the expression of certain genes linked to multiple sclerosis (MS) in a controlled study involving rat models. The study comprised 46 adult male Wistar rats, divided into five groups, including a control group and others subjected to cuprizone, which is known to induce MS-like symptoms.
Over eight weeks, the rats received different treatments, including a zinc-deficient diet for one group and zinc sulfate supplementation for another group. We observed significant increases in certain markers of spinal cord damage, including malondialdehyde (MDA) and IL-6 levels, particularly in the groups suffering from MS (induced by cuprizone treatment).
Importantly, zinc supplementation was found to reverse these negative effects, restoring certain parameters to control values. This suggests that zinc could potentially be a helpful addition to MS treatment regimens, offering hope for those affected by this challenging condition.
Over eight weeks, the rats received different treatments, including a zinc-deficient diet for one group and zinc sulfate supplementation for another group. We observed significant increases in certain markers of spinal cord damage, including malondialdehyde (MDA) and IL-6 levels, particularly in the groups suffering from MS (induced by cuprizone treatment).
Importantly, zinc supplementation was found to reverse these negative effects, restoring certain parameters to control values. This suggests that zinc could potentially be a helpful addition to MS treatment regimens, offering hope for those affected by this challenging condition.
Read More
7
Zinc affects T cell function in MS
Ionic mitigation of CD4 T cell metabolic fitness, Th1 central nervous system autoimmunity and Th2 asthmatic airway inflammation by therapeutic zinc.
Zinc treatment shows promise for MS
We explored how zinc, specifically zinc aspartate (UNIZINK), influences the immune system in the context of multiple sclerosis (MS). This study looked at zinc's effects on CD4 T cells, which play a significant role in autoimmune responses like those found in MS. Through transcriptomic analysis, we found that high doses of zinc negatively affect gene networks associated with cell cycle and energy metabolism in these T cells.
Particularly, in the presence of zinc, we observed reduced expression of vital genes involved in processes like glycolysis and oxidative phosphorylation, leading to decreased metabolic fitness and viability of the T cells. This inability to properly function might help explain why high zinc levels could prevent the differentiation of T cells into harmful Th1 cells, which are linked to MS inflammation in the central nervous system.
Moreover, the research showed that zinc treatment significantly reduced Th1 autoimmune inflammation in vivo and also impacted Th2-driven airway inflammation, suggesting a broader immunomodulatory role. Overall, while zinc treatment appears to offer some promise in reducing autoimmune responses associated with multiple sclerosis, more research is definitely needed to fully understand its capacity and effectiveness in clinical applications.
Particularly, in the presence of zinc, we observed reduced expression of vital genes involved in processes like glycolysis and oxidative phosphorylation, leading to decreased metabolic fitness and viability of the T cells. This inability to properly function might help explain why high zinc levels could prevent the differentiation of T cells into harmful Th1 cells, which are linked to MS inflammation in the central nervous system.
Moreover, the research showed that zinc treatment significantly reduced Th1 autoimmune inflammation in vivo and also impacted Th2-driven airway inflammation, suggesting a broader immunomodulatory role. Overall, while zinc treatment appears to offer some promise in reducing autoimmune responses associated with multiple sclerosis, more research is definitely needed to fully understand its capacity and effectiveness in clinical applications.
Read More
Most Useful Reviews
8.8
Positive effects noted
I use this medication as part of my treatment for multiple sclerosis, as prescribed by my doctor. It has a significant impact on my hair and nails, and I find myself craving fewer sweets.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
9
Zinc supplementation benefits spinal cord health
Dietary zinc status is associated with ZnT3 (SLC30A3), IL-6 gene expressions and spinal cord tissue damage in spinal cord tissue in a cuprizone-induced rat Multiple Sclerosis model.
Study finds zinc effects on MS
We explored the effects of dietary zinc on spinal cord damage and the expression of certain genes linked to multiple sclerosis (MS) in a controlled study involving rat models. The study comprised 46 adult male Wistar rats, divided into five groups, including a control group and others subjected to cuprizone, which is known to induce MS-like symptoms.
Over eight weeks, the rats received different treatments, including a zinc-deficient diet for one group and zinc sulfate supplementation for another group. We observed significant increases in certain markers of spinal cord damage, including malondialdehyde (MDA) and IL-6 levels, particularly in the groups suffering from MS (induced by cuprizone treatment).
Importantly, zinc supplementation was found to reverse these negative effects, restoring certain parameters to control values. This suggests that zinc could potentially be a helpful addition to MS treatment regimens, offering hope for those affected by this challenging condition.
Over eight weeks, the rats received different treatments, including a zinc-deficient diet for one group and zinc sulfate supplementation for another group. We observed significant increases in certain markers of spinal cord damage, including malondialdehyde (MDA) and IL-6 levels, particularly in the groups suffering from MS (induced by cuprizone treatment).
Importantly, zinc supplementation was found to reverse these negative effects, restoring certain parameters to control values. This suggests that zinc could potentially be a helpful addition to MS treatment regimens, offering hope for those affected by this challenging condition.
Read More
7
Zinc levels and MS correlation
Relationship between zinc-related nutritional status and the progression of multiple sclerosis.
Highly relevant to MS treatment
We conducted a study to understand how zinc may affect multiple sclerosis (MS). Our research involved 98 participants, divided into two groups: one with MS and another matched control group without the condition. We aimed to examine the levels of zinc in both plasma and red blood cells to see if there’s a connection with MS severity and outbreaks.
The findings were intriguing. We discovered that while the average plasma zinc levels were normal in MS patients, their red blood cell zinc levels were actually higher than those in the control group. Additionally, we noticed that the activity of an important enzyme called superoxide dismutase (SOD) was significantly elevated in MS patients, which correlates positively with these higher zinc levels. This suggests that while the body might be managing zinc rather well, it’s working overtime, possibly to counteract oxidative stress related to MS.
Importantly, we observed a direct correlation between erythrocyte zinc and SOD activity, which was also linked inversely to MS outbreaks—indicating that as SOD increases in activity, the frequency of outbreaks tends to decrease. These insights confirm that there could be a beneficial relationship between zinc levels and the management of MS, but more research is certainly needed to explore this further.
The findings were intriguing. We discovered that while the average plasma zinc levels were normal in MS patients, their red blood cell zinc levels were actually higher than those in the control group. Additionally, we noticed that the activity of an important enzyme called superoxide dismutase (SOD) was significantly elevated in MS patients, which correlates positively with these higher zinc levels. This suggests that while the body might be managing zinc rather well, it’s working overtime, possibly to counteract oxidative stress related to MS.
Importantly, we observed a direct correlation between erythrocyte zinc and SOD activity, which was also linked inversely to MS outbreaks—indicating that as SOD increases in activity, the frequency of outbreaks tends to decrease. These insights confirm that there could be a beneficial relationship between zinc levels and the management of MS, but more research is certainly needed to explore this further.
Read More
7
Zinc affects T cell function in MS
Ionic mitigation of CD4 T cell metabolic fitness, Th1 central nervous system autoimmunity and Th2 asthmatic airway inflammation by therapeutic zinc.
Zinc treatment shows promise for MS
We explored how zinc, specifically zinc aspartate (UNIZINK), influences the immune system in the context of multiple sclerosis (MS). This study looked at zinc's effects on CD4 T cells, which play a significant role in autoimmune responses like those found in MS. Through transcriptomic analysis, we found that high doses of zinc negatively affect gene networks associated with cell cycle and energy metabolism in these T cells.
Particularly, in the presence of zinc, we observed reduced expression of vital genes involved in processes like glycolysis and oxidative phosphorylation, leading to decreased metabolic fitness and viability of the T cells. This inability to properly function might help explain why high zinc levels could prevent the differentiation of T cells into harmful Th1 cells, which are linked to MS inflammation in the central nervous system.
Moreover, the research showed that zinc treatment significantly reduced Th1 autoimmune inflammation in vivo and also impacted Th2-driven airway inflammation, suggesting a broader immunomodulatory role. Overall, while zinc treatment appears to offer some promise in reducing autoimmune responses associated with multiple sclerosis, more research is definitely needed to fully understand its capacity and effectiveness in clinical applications.
Particularly, in the presence of zinc, we observed reduced expression of vital genes involved in processes like glycolysis and oxidative phosphorylation, leading to decreased metabolic fitness and viability of the T cells. This inability to properly function might help explain why high zinc levels could prevent the differentiation of T cells into harmful Th1 cells, which are linked to MS inflammation in the central nervous system.
Moreover, the research showed that zinc treatment significantly reduced Th1 autoimmune inflammation in vivo and also impacted Th2-driven airway inflammation, suggesting a broader immunomodulatory role. Overall, while zinc treatment appears to offer some promise in reducing autoimmune responses associated with multiple sclerosis, more research is definitely needed to fully understand its capacity and effectiveness in clinical applications.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
8.8
Positive effects noted
I use this medication as part of my treatment for multiple sclerosis, as prescribed by my doctor. It has a significant impact on my hair and nails, and I find myself craving fewer sweets.
