Overview
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For a period of up to 24 weeks, we aimed to maintain their zinc levels within a specific target range while closely monitoring for side effects. One of our main goals was to see if NPC-25 could maintain these target zinc levels similarly to NOBELZIN™.
Our findings revealed that NPC-25 was indeed non-inferior to NOBELZIN™, meaning it worked just as well. Importantly, we also observed that those taking NPC-25 reported fewer digestive issues, like nausea and vomiting. This suggests that while both treatments were effective, NPC-25 might be the gentler option.
Despite nausea being a concern, the benefit of zinc acetate dihydrate for other indications was notable, with an efficacy rate of 83%. For patients experiencing symptoms such as pressure ulcers or stomatitis, the effectiveness was strikingly high. However, the specific effect of zinc on nausea is not definitively isolated within the study results, making it hard to gauge its direct and unique benefits.
In essence, while zinc acetate dihydrate shows promise for a variety of symptoms, including nausea, the evidence does not conclusively highlight its effectiveness for this particular issue on its own. Overall, it appears that zinc treatment can contribute positively to addressing several related health problems.
Our findings revealed that there was no significant difference between the groups regarding the occurrence of sore throat shortly after surgery and at various intervals thereafter. However, we did observe that those using zinc solution-impregnated gauze experienced significantly less severity of nausea two hours post-surgery compared to those using normal saline-impregnated gauze. Ultimately, while zinc did not help with sore throat, it showed promise in alleviating nausea.
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For a period of up to 24 weeks, we aimed to maintain their zinc levels within a specific target range while closely monitoring for side effects. One of our main goals was to see if NPC-25 could maintain these target zinc levels similarly to NOBELZIN™.
Our findings revealed that NPC-25 was indeed non-inferior to NOBELZIN™, meaning it worked just as well. Importantly, we also observed that those taking NPC-25 reported fewer digestive issues, like nausea and vomiting. This suggests that while both treatments were effective, NPC-25 might be the gentler option.
Despite nausea being a concern, the benefit of zinc acetate dihydrate for other indications was notable, with an efficacy rate of 83%. For patients experiencing symptoms such as pressure ulcers or stomatitis, the effectiveness was strikingly high. However, the specific effect of zinc on nausea is not definitively isolated within the study results, making it hard to gauge its direct and unique benefits.
In essence, while zinc acetate dihydrate shows promise for a variety of symptoms, including nausea, the evidence does not conclusively highlight its effectiveness for this particular issue on its own. Overall, it appears that zinc treatment can contribute positively to addressing several related health problems.
Our findings revealed that there was no significant difference between the groups regarding the occurrence of sore throat shortly after surgery and at various intervals thereafter. However, we did observe that those using zinc solution-impregnated gauze experienced significantly less severity of nausea two hours post-surgery compared to those using normal saline-impregnated gauze. Ultimately, while zinc did not help with sore throat, it showed promise in alleviating nausea.
Our findings revealed that a significant number of children, about 92.7%, tolerated the modified zinc tablets well. However, we also noted that 32.8% of the children experienced vomiting, and 19.5% had regurgitation, while a smaller number, 7.4%, reported nausea. Interestingly, despite these side effects, a remarkable 99.3% of caregivers expressed their willingness to continue using this zinc formulation in the future.
Overall, while our study demonstrated that the modified zinc formulation was generally well-tolerated, we cannot overlook the considerable instances of nausea and vomiting experienced by the children. Balancing these side effects with the willingness of caregivers offers a complex view of zinc's role in diarrhoea management.
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Frequently Asked Questions
Nausea is a sensation that often precedes vomiting and is characterized by an uneasy feeling in the stomach. It can be caused by a variety of factors, including motion sickness, certain medications, food poisoning, or underlying health conditions. The experience of nausea can range from mildly uncomfortable to intensely distressing and is often accompanied by other symptoms such as sweating, increased salivation, or a feeling of lightheadedness.
Many people experience nausea at some point in their lives, making it a common issue. Fortunately, there are several remedies and treatments available that can help alleviate this unpleasant sensation. Over-the-counter medications, home remedies like ginger tea, and lifestyle changes, such as eating smaller meals or avoiding certain triggers, can be effective in reducing nausea. However, if nausea is persistent or accompanied by severe symptoms like severe abdominal pain or fever, it’s essential to consult with a healthcare professional for an accurate diagnosis and appropriate treatment.
Zinc is a versatile metal known for its various applications in industry and health. It is a bluish-white metallic element represented by the symbol Zn and atomic number 30 on the periodic table. Zinc is primarily used for galvanizing steel to prevent rusting, in the manufacturing of alloys, and as a component in batteries. Additionally, zinc plays a crucial role in biological processes, making it an essential trace element in the human diet. It is involved in immune function, protein synthesis, wound healing, and DNA synthesis, highlighting its importance in maintaining overall health and well-being.
Zinc may play a role in alleviating certain types of nausea, especially when it is associated with specific conditions, such as pregnancy or certain gastrointestinal issues. Some studies have indicated that zinc supplements might help in reducing nausea symptoms due to their potential to support overall gut health and maintain immune function. However, the evidence is not conclusive, and results can vary from person to person.
It's important to note that while zinc supplementation might benefit some individuals, it is not universally effective for all types of nausea. If you're considering using zinc to address nausea, consult with a healthcare professional to ensure it's appropriate for your situation and to discuss the ideal dosage. Additionally, it's crucial to address the underlying cause of nausea rather than just treating the symptom itself.
According to user reviews, the time it takes to see results from zinc picolinate varies. Many users report experiencing positive effects relatively quickly, particularly when taken as directed. For example, one user noted that they felt improvements in their skin and nausea relief within a few uses after confirming they were taking the supplement with meals, a practice that seemed to mitigate any potential discomfort (Read Review). Another review indicated noticeable effects during cold symptoms after consistent use for 1-3 weeks, suggesting that users may start to feel results within a similar timeframe (Read Review).
However, experiences do vary; some users have reported nausea as a side effect even while taking it correctly, which underscores that individual responses can differ significantly (Read Review). For those who don't experience adverse effects, the effectiveness is often linked to consistent use and proper dosage management, especially when taken after meals (Read Review). Ultimately, most users discussing effectiveness indicate a range of days to weeks before feeling noticeable benefits, contingent on personal tolerability and usage practices.
The evidence surrounding zinc supplements shows mixed results when it comes to their effectiveness in alleviating nausea. One study indicated that NPC-25, a form of zinc, was found to be non-inferior to traditional treatments and also reported fewer digestive issues, including nausea, among participants [1]. This suggests that NPC-25 might be a gentler option for individuals concerned about nausea when taking supplements.
However, another study focusing on zinc acetate dihydrate reported that while it had an efficacy rate of 83% for various symptoms, only 1.4% of patients experienced nausea, and its specific effect on nausea wasn't conclusively established [2]. Additionally, research on zinc-impregnated packs showed that patients who used these packs experienced significantly less severity of nausea post-surgery [3]. Conversely, in a pediatric study regarding zinc tablets for diarrhea, nausea was notably reported in 7.4% of children, highlighting that side effects can occur [4]. Overall, while some studies suggest potential benefits of zinc in managing nausea, the evidence isn't definitive, warranting further exploration into its specific effects on this symptom.
Based on user reviews, many individuals have reported significant improvements in their health after using zinc picolinate, particularly relating to skin, hair, and immune function. For instance, one user noted that their facial rashes cleared up and they experienced no nausea while taking the supplement, highlighting its efficacy for skin health (Read Review). Others have similarly mentioned enhanced conditions in hair and nails, with one person sharing noteworthy results in both areas as well as skin clarity (Read Review). Additionally, users have remarked on its positive impact during colds, citing improved overall immune support (Read Review).
While many users celebrated their successes with this supplement, experiences do vary greatly across individuals. Some users have reported nausea and other gastrointestinal issues even while adhering to recommended guidelines, reminding us that individual tolerance can greatly affect results (Read Review). Overall, while there's widespread acclaim for the benefits of zinc picolinate, especially regarding skin and immune health, it's important to recognize that individual responses can differ, and those considering supplementation should do so thoughtfully and, if necessary, consult a healthcare provider for personalized advice.
Based on user reviews, many individuals have experienced success when combining zinc picolinate with other supplements, particularly advising to avoid taking it with calcium to prevent gastrointestinal discomfort. One user explicitly noted that they felt no nausea while taking zinc picolinate with magnesium, which exemplifies its compatibility with certain supplements (Read Review). Conversely, some users reported adverse effects, like nausea, when taking zinc alongside multivitamins or other brands (Read Review). This indicates that individual responses can vary, suggesting caution when mixing supplements.
Many users recommend taking zinc picolinate specifically with meals to help mitigate nausea and maximize absorption (Read Review). For instance, one user mentioned that they had previously experienced nausea from other forms of zinc but found that this product worked well anytime, regardless of food timing (Read Review). Overall, while there are positive outcomes reported from combining this supplement with others, it's wise to be mindful of combinations that may lead to discomfort and to pay attention to individual tolerances.
Based on user reviews, the right dose for Zinc when treating nausea appears to be closely linked to timing and the form of Zinc being taken. Users frequently recommend taking Zinc after meals to reduce the chances of experiencing nausea. For instance, one user reported, "It's important to take it after meals to avoid nausea" (Read Review). Similarly, another noted that taking it at meal times helped avoid side effects: "Take zinc with meals to avoid nausea on an empty stomach" (Read Review).
In terms of dosage, a common suggestion across the reviews is to stay within the range of 25 mg to 50 mg, while being cautious of exceeding 30 mg to prevent adverse effects, such as nausea or headaches. One user indicated, "If 50mg feels excessive, consider taking less" (Read Review). Overall, users have had better experiences with Zinc picolinate, which has shown to be less likely to induce nausea, and the emphasis seems to be on proper timing and dosage adjustments to ensure comfort while reaping the benefits of Zinc supplements.
For a period of up to 24 weeks, we aimed to maintain their zinc levels within a specific target range while closely monitoring for side effects. One of our main goals was to see if NPC-25 could maintain these target zinc levels similarly to NOBELZIN™.
Our findings revealed that NPC-25 was indeed non-inferior to NOBELZIN™, meaning it worked just as well. Importantly, we also observed that those taking NPC-25 reported fewer digestive issues, like nausea and vomiting. This suggests that while both treatments were effective, NPC-25 might be the gentler option.
Despite nausea being a concern, the benefit of zinc acetate dihydrate for other indications was notable, with an efficacy rate of 83%. For patients experiencing symptoms such as pressure ulcers or stomatitis, the effectiveness was strikingly high. However, the specific effect of zinc on nausea is not definitively isolated within the study results, making it hard to gauge its direct and unique benefits.
In essence, while zinc acetate dihydrate shows promise for a variety of symptoms, including nausea, the evidence does not conclusively highlight its effectiveness for this particular issue on its own. Overall, it appears that zinc treatment can contribute positively to addressing several related health problems.
Our findings revealed that there was no significant difference between the groups regarding the occurrence of sore throat shortly after surgery and at various intervals thereafter. However, we did observe that those using zinc solution-impregnated gauze experienced significantly less severity of nausea two hours post-surgery compared to those using normal saline-impregnated gauze. Ultimately, while zinc did not help with sore throat, it showed promise in alleviating nausea.
Our findings revealed that a significant number of children, about 92.7%, tolerated the modified zinc tablets well. However, we also noted that 32.8% of the children experienced vomiting, and 19.5% had regurgitation, while a smaller number, 7.4%, reported nausea. Interestingly, despite these side effects, a remarkable 99.3% of caregivers expressed their willingness to continue using this zinc formulation in the future.
Overall, while our study demonstrated that the modified zinc formulation was generally well-tolerated, we cannot overlook the considerable instances of nausea and vomiting experienced by the children. Balancing these side effects with the willingness of caregivers offers a complex view of zinc's role in diarrhoea management.
References
- Asaoka D, Ishihara T, Ezoe S, Hamada I, Kitamura M, et al. Randomized, multicenter, active-controlled open-label study of NPC-25, zinc histidine hydrate, (non-inferiority to NOBELZIN™, zinc acetate dihydrate) for patients with hypozincemia. J Trace Elem Med Biol. 2025;87:127558. doi:10.1016/j.jtemb.2024.127558
- Ezoe S, Ishihara T, Hosogai T, Kokubo T. Post-marketing surveillance of zinc acetate dihydrate for hypozincemia in Japan. Pharmazie. 2024;79:29. doi:10.1691/ph.2024.3630
- Parvizi A, Haddadi S, Akbari M, Akbarpour M, Taghipour Rudsari F, et al. Comparing the Effect of Zinc-impregnated Pharyngeal Packs with Conventional Methods on the Level of Sore Throat Among Patients Undergoing Septorhinoplasty. Anesth Pain Med. 2022;12:e127262. doi:10.5812/aapm-127262
- Nuzhat S, Ahmed T, Alam J, Billal SM, Khan AI, et al. New formulation zinc sulphate acceptability and adherence in children with acute diarrhoea: A prospective, open-label, interventional study in Bangladesh. J Paediatr Child Health. 2022;58:1215. doi:10.1111/jpc.15953
