Can Optimum Nutrition Opti-Women Help with Acne?

Overview

SCIENTIFIC SCORE

Possibly Effective

Based on 49 Researches

7.4

USERS' SCORE

Good

Based on 2 Reviews

8.5

Top Medical Research Studies

Vitamin C shows effectiveness for acne

Woolery-Lloyd H, Baumann L, Ikeno H. Sodium L-ascorbyl-2-phosphate 5% lotion for the treatment of acne vulgaris: a randomized, double-blind, controlled trial. J Cosmet Dermatol. 2010;9:22. doi:10.1111/j.1473-2165.2010.00480.x

In our recent study, we set out to explore the effectiveness of a 5% sodium L-ascorbyl-2-phosphate lotion, a stable form of vitamin C, for treating acne. We conducted a double-blind, controlled trial with 50 participants over 12 weeks, where half used the vitamin C lotion and the other half received a placebo.

Our findings revealed significant improvements in acne symptoms for those using the vitamin C lotion compared to the placebo group. We measured outcomes through various assessments, including a global evaluation by investigators and self-reported assessments by the subjects, along with lesion counts.

The results showed that the vitamin C lotion was not only effective but also well-tolerated, with side effects similar to those seen with the placebo. This adds a promising tool to the options available for acne treatment, suggesting that vitamin C might play a valuable role in skincare regimens aimed at combating acne.

Overall, our study supports the idea that vitamin C, in the form of sodium L-ascorbyl-2-phosphate, can help reduce acne, making it a noteworthy addition to acne treatment strategies.

Vitamin D's effect on acne

Hasamoh Y, Thadanipon K, Juntongjin P. Association between Vitamin D Level and Acne, and Correlation with Disease Severity: A Meta-Analysis. Dermatology. 2022;238:404. doi:10.1159/000517514

We examined how vitamin D levels relate to acne and the potential connection with acne severity. By analyzing data from various studies, we found that 1,362 individuals with acne were compared against 1,081 healthy controls.

Our findings revealed that those with acne had significantly lower vitamin D levels compared to the healthy participants. Additionally, vitamin D deficiency was more prevalent among acne sufferers. Interestingly, we also observed a negative correlation between vitamin D levels and acne severity, suggesting that lower levels of this vitamin might be associated with more severe acne.

This evidence points to the possibility that vitamin D plays a role in acne development. However, while our results are compelling, they encourage further investigation into how vitamin D might influence acne severity and whether its supplementation could be beneficial for those affected by this condition.

Vitamin D and acne relationship examined

Wang M, Zhou Y, Yan Y. Vitamin D status and efficacy of vitamin D supplementation in acne patients: A systematic review and meta-analysis. J Cosmet Dermatol. 2021;20:3802. doi:10.1111/jocd.14057

We sought to understand the connection between vitamin D levels and acne, along with how vitamin D supplementation might help those suffering from this common skin condition. Our investigation included various studies from a range of databases, focusing on the serum levels of a specific form of vitamin D—25(OH)D—and the effectiveness of vitamin D supplements for acne patients.

In our findings, we discovered that individuals with acne generally had lower serum levels of vitamin D. Specifically, the data revealed a significant difference, with acne patients showing a standardized mean difference of -7.66 ng/ml in vitamin D levels compared to those without the condition. Importantly, the articles we reviewed also pointed out the potential for vitamin D supplements to serve as a therapeutic option for improving acne.

Overall, this research contributes valuable insights into how vitamin D may play a role in managing acne, suggesting that addressing vitamin D deficiency in patients could have positive outcomes for their skin health.

Most Useful Reviews

Acne clearing results

145 people found this helpful

I bought this multivitamin on my trainer's recommendation. After two weeks, my acne cleared up significantly, which I believe is due to this product. I feel more energized, and it has exceeded my expectations!

Negative impact on acne

1 people found this helpful

These vitamins didn’t work for me. I broke out with hormonal acne after starting them and have had erratic spotting. My acne was under control before without changing anything else, so I suspect these are the cause. The high B6 content is concerning as it can lead to neuropathy. Hard pass!

Medical Researches

SCIENTIFIC SCORE

Possibly Effective

Based on 49 Researches

7.4

9.5

Zinc's role in acne treatment

Xiang Y, Lu J, Mao C, Zhu Y, Wang C, et al. Ultrasound-triggered interfacial engineering-based microneedle for bacterial infection acne treatment. Sci Adv. 2023;9:eadf0854. doi:10.1126/sciadv.adf0854

We investigated the effectiveness of a novel microneedle patch designed for acne treatment, which incorporates zinc-based nanoparticles. This patch combines sodium hyaluronate with zinc porphyrin-based metal-organic frameworks and zinc oxide. By using ultrasound to release activated oxygen, we observed a remarkable antibacterial efficiency, achieving a 99.73% reduction in acne-causing bacteria within just 15 minutes.

Zinc plays a crucial role in this innovative approach. Not only does it help eliminate harmful bacteria, but it also appears to enhance skin health. The presence of zinc ions promotes the up-regulation of genes associated with DNA replication, which supports the growth of fibroblasts. This is a vital process for skin repair and rejuvenation, showing that zinc can potentially contribute to both the treatment and recovery of acne-affected skin.

Overall, our findings suggest that this microneedle patch, which utilizes zinc and ultrasound-responsive technology, represents a promising strategy for effectively managing acne without relying on traditional antibiotics.

Vitamin C shows moderate efficacy

Sharara MA, Fawaz GA, El Samahy MH. Efficacy of tranexamic acid solution versus vitamin C solution after micro-needling in treatment of persistent post acne erythema: a split face clinical and 3DAntera camera comparative study. Arch Dermatol Res. 2024;317:150. doi:10.1007/s00403-024-03582-0

We explored the effectiveness of using vitamin C in treating persistent post-acne erythema, which often leaves visible redness after acne has cleared. In this study, participants received microneedling combined with either a 10% vitamin C solution or a tranexamic acid solution. The goal was to see which treatment worked better for reducing redness and improving overall skin appearance.

Four treatment sessions were spaced two weeks apart, followed by assessments two weeks after the final session. We measured improvements using clinical evaluations, 3D imaging technology to analyze blood flow in the skin, and patient feedback.

Our findings indicated that both treatments led to significant improvements in reducing skin redness. However, the tranexamic acid solution yielded even better results compared to vitamin C. Patients reported satisfaction on both sides, but they favored the effects of tranexamic acid more. Notably, any side effects were minimal and temporary.

This study suggests that while vitamin C can be helpful, using microneedling with tranexamic acid may deliver superior results for those struggling with post-acne redness.

Nutraceuticals effective for acne

Amer SS, Nasr M, Abdel-Aziz RTA, Moftah NH, El Shaer A, et al. Cosm-nutraceutical nanovesicles for acne treatment: Physicochemical characterization and exploratory clinical experimentation. Int J Pharm. 2020;577:119092. doi:10.1016/j.ijpharm.2020.119092

We aimed to understand how a novel formulation combining vitamin C and quercetin can help treat acne. Our study focused on creating small liposomal structures called aspasomes that enhance the delivery of quercetin, a potent antioxidant, onto the skin.

Throughout our research, we thoroughly characterized these aspasomes for their size, stability, and how well they could penetrate the skin. One exciting finding was that these specialized nanovesicles not only preserved the antioxidant benefits of quercetin, but also demonstrated a stronger antibacterial effect against acne-causing bacteria compared to quercetin alone.

In an exploratory clinical trial involving 20 participants with acne, we observed considerable improvements. The results revealed a 77.9% reduction in inflammatory lesions and significant decreases in both non-inflammatory lesions and total acne lesions. These findings suggest that our vitamin C-based formula holds promise in managing acne and could potentially be used for other skin conditions in the future.

Vitamin C reduces facial sebum

Khan H, Akhtar N, Ali A. Assessment of Combined Ascorbyl Palmitate (AP) and Sodium Ascorbyl Phosphate (SAP) on Facial Skin Sebum Control in Female Healthy Volunteers. Drug Res (Stuttg). 2017;67:52. doi:10.1055/s-0042-118171

We conducted a study to explore the effectiveness of two forms of vitamin C—ascorbyl palmitate (AP) and sodium ascorbyl phosphate (SAP)—in managing sebum production on the skin. Through a single-blinded, placebo-controlled trial involving 11 healthy female volunteers, we compared the effects of a multiple emulsion containing these compounds with a control that lacked them.

Over 90 days, participants applied the vitamin C formulation to one cheek and the control to the other. We measured sebum levels using a non-invasive device called a Sebumeter at different time intervals. Our results demonstrated that the combination of AP and SAP achieved notable antioxidant activity and effectively reduced facial oiliness compared to the control.

Ultimately, we found that incorporating vitamin C into skincare routines can be a promising solution for controlling excess facial sebum, which is often linked to oily skin and acne. However, while the study highlights the role of these antioxidants in sebum regulation, it does not provide a definitive conclusion on their isolated effects solely for acne treatment.

Zinc ascorbate aids acne treatment

Iinuma K, Noguchi N, Nakaminami H, Sasatsu M, Nishijima S, et al. Susceptibility of Propionibacterium acnes isolated from patients with acne vulgaris to zinc ascorbate and antibiotics. Clin Cosmet Investig Dermatol. 2011;4:161. doi:10.2147/CCID.S23840

We explored the effectiveness of a vitamin C derivative, zinc ascorbate, for treating acne. This study focused on its in vitro antimicrobial activity against Propionibacterium acnes, the bacteria often responsible for acne breakouts.

The researchers tested zinc ascorbate alone and in combination with popular antibiotics like clindamycin, widely used in Japan for acne treatment. They examined how these combinations worked against various strains of P. acnes, including those resistant to clindamycin.

Findings indicated that zinc ascorbate can effectively inhibit the growth of P. acnes, even in clindamycin-resistant strains. Notably, when combined with clindamycin, zinc ascorbate demonstrated an additive effect, enhancing its overall antimicrobial effectiveness.

Overall, this research suggests that incorporating zinc ascorbate could be a promising strategy for acne treatment, especially in conjunction with traditional antibiotics.

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