5/13/2025
Last update
5/13/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.5
USERS' SCORE
Good
Based on 3 Reviews
8.1
Top Medical Research Studies
8
We explored the connection between vitamin D levels and upper respiratory tract infections (URTIs) among military recruits during their training. This observation spanned across different seasons and included over 1,600 recruits. Our aim was to understand how achieving sufficient vitamin D levels could potentially impact the frequency and severity of colds among physically active individuals.
In an additional phase of the research, we conducted a randomized controlled trial with 250 male recruits. They received either a placebo, simulated sunlight exposure, or oral vitamin D3 supplements during winter. This comparison allowed us to see if these methods effectively increased vitamin D levels to a sufficient status of 25(OH)D at 50 nmol/L or higher.
Notably, our findings showed that only 21% of recruits had adequate vitamin D during winter, yet those who did were 40% less likely to suffer from URTIs. Furthermore, both vitamin D supplementation strategies similarly helped nearly all participants achieve sufficient levels. Vitamin D supplementation notably reduced the severity of URTI symptoms by 15% and the number of days with URTIs by 36% compared to placebo.
While the supplementation strategies did not significantly alter other immune factors, such as salivary secretory immunoglobulin A, the overall reduction in respiratory infections indicates a beneficial effect of maintaining vitamin D sufficiency during military training.
In an additional phase of the research, we conducted a randomized controlled trial with 250 male recruits. They received either a placebo, simulated sunlight exposure, or oral vitamin D3 supplements during winter. This comparison allowed us to see if these methods effectively increased vitamin D levels to a sufficient status of 25(OH)D at 50 nmol/L or higher.
Notably, our findings showed that only 21% of recruits had adequate vitamin D during winter, yet those who did were 40% less likely to suffer from URTIs. Furthermore, both vitamin D supplementation strategies similarly helped nearly all participants achieve sufficient levels. Vitamin D supplementation notably reduced the severity of URTI symptoms by 15% and the number of days with URTIs by 36% compared to placebo.
While the supplementation strategies did not significantly alter other immune factors, such as salivary secretory immunoglobulin A, the overall reduction in respiratory infections indicates a beneficial effect of maintaining vitamin D sufficiency during military training.
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8
We explored how zinc might help in treating and preventing the common cold. The study focused on zinc's effects, isolating it from other treatments to understand its true impact on cold symptoms. By doing this, the researchers aimed to clarify whether zinc could genuinely shorten the duration of a cold or alleviate its symptoms.
The findings were intriguing but showed that zinc might not yield significant benefits for everyone. While some individuals reported a slight reduction in cold symptoms, the evidence did not strongly support zinc as an effective treatment overall.
This means that, for those seeking relief from a nasty cold, zinc alone might not be the go-to solution we hoped it would be. It’s essential to consider this information when deciding on a cold treatment plan and to approach zinc with realistic expectations.
The findings were intriguing but showed that zinc might not yield significant benefits for everyone. While some individuals reported a slight reduction in cold symptoms, the evidence did not strongly support zinc as an effective treatment overall.
This means that, for those seeking relief from a nasty cold, zinc alone might not be the go-to solution we hoped it would be. It’s essential to consider this information when deciding on a cold treatment plan and to approach zinc with realistic expectations.
Read More
8
We investigated how dihydroporphyrin iron (DH-Fe) acts as a plant growth regulator, particularly in enhancing cold tolerance. Our research focused on plants that are usually sensitive to low temperatures, finding that DH-Fe plays a vital role in helping these plants cope with cold stress by using different concentrations of this treatment.
Through our study, we applied varying levels of DH-Fe to see how it impacts carbon and nitrogen metabolism, as well as oxidative stress responses, when plants were exposed to low temperatures. Notably, we observed that DH-Fe significantly reduces oxidative stress and other harmful effects associated with cold exposure. For instance, it reduced certain sugars while simultaneously boosting the activity of enzymes crucial for sugar breakdown and nitrogen assimilation.
Among the various findings, we noted that a concentration of 20 μg·L of DH-Fe was particularly effective, improving the overall health and resilience of the plants against low temperatures. This suggests that by applying the right amount of iron, we can potentially mitigate the negative effects of cold weather on sensitive plant species, providing a fresh perspective on how to enhance cold tolerance through nutrient management.
Overall, our findings shine a light on how incorporating iron into agricultural practices might be a practical strategy for improving plant resilience to cold stress.
Through our study, we applied varying levels of DH-Fe to see how it impacts carbon and nitrogen metabolism, as well as oxidative stress responses, when plants were exposed to low temperatures. Notably, we observed that DH-Fe significantly reduces oxidative stress and other harmful effects associated with cold exposure. For instance, it reduced certain sugars while simultaneously boosting the activity of enzymes crucial for sugar breakdown and nitrogen assimilation.
Among the various findings, we noted that a concentration of 20 μg·L of DH-Fe was particularly effective, improving the overall health and resilience of the plants against low temperatures. This suggests that by applying the right amount of iron, we can potentially mitigate the negative effects of cold weather on sensitive plant species, providing a fresh perspective on how to enhance cold tolerance through nutrient management.
Overall, our findings shine a light on how incorporating iron into agricultural practices might be a practical strategy for improving plant resilience to cold stress.
Read More
Most Useful Reviews
7.5
Helps keep colds away
8 people found this helpful
Rating a multivitamin is challenging since it’s preventive rather than reactive. I believe this has helped keep colds at bay during winter while around sick people, hence the four stars. I haven’t noticed much difference in energy levels or overall vitality, but it’s caused no adverse effects, aside from bright urine that normalises during the day.
Read More
6
Energizing effects noted
6 people found this helpful
Despite dealing with allergies this week, I started using this product on day three, and I've felt more awake and stronger, though still fatigued while taking allergy meds for my cold. I’ve many types of gym supplements throughout the years, but I genuinely feel the difference with these. I can also do my workouts more effectively. They help me feel healthier even when I'm unwell!
Read More
6
Improves cold symptoms
2 people found this helpful
I initially wanted to avoid taking multiple vitamins, so I chose this multivitamin based on positive reviews. While I haven't noticed dramatic differences other than bright urine, I've realised that when sick with a cold, taking it makes me feel slightly better—more energetic and less stuffy. When taken consistently, my energy levels seem to improve as well.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.5
- All Researches
9
We explored the effects of ascorbic acid, commonly known as vitamin C, on cold tolerance in tomato seedlings. In our study, we discovered that applying vitamin C significantly boosts the seedlings' ability to handle cold stress.
By enhancing the antioxidant defense system, vitamin C treatment increased the enzyme activity in the seedlings' leaves. Additionally, it raised levels of important compounds such as proline, sugar, and abscisic acid, all of which play crucial roles in plant stress responses.
Our observations showed that vitamin C also protects the photosynthesis system of tomato seedlings. This implies that it helps maintain chlorophyll function, which is critical for the plant's overall health, especially under cold conditions.
Moreover, we found that vitamin C treatments led to increased expression of genes linked to antioxidant enzymes and cold response mechanisms. Overall, our findings suggest that exogenous vitamin C is a beneficial approach to improve cold tolerance in tomatoes and may provide helpful insights for farmers looking to cultivate hardier varieties during colder months.
By enhancing the antioxidant defense system, vitamin C treatment increased the enzyme activity in the seedlings' leaves. Additionally, it raised levels of important compounds such as proline, sugar, and abscisic acid, all of which play crucial roles in plant stress responses.
Our observations showed that vitamin C also protects the photosynthesis system of tomato seedlings. This implies that it helps maintain chlorophyll function, which is critical for the plant's overall health, especially under cold conditions.
Moreover, we found that vitamin C treatments led to increased expression of genes linked to antioxidant enzymes and cold response mechanisms. Overall, our findings suggest that exogenous vitamin C is a beneficial approach to improve cold tolerance in tomatoes and may provide helpful insights for farmers looking to cultivate hardier varieties during colder months.
Read More
9
We explored the impact of zinc-amino acids chelate on cold stress resistance in machine-transplanted early rice. Our investigation included other cold-resistant agents like uniconazole and abscisic acid, but we found zinc to be particularly effective. When applied during the regreening stage, zinc notably enhanced rice growth by promoting tillering and increasing the leaf area, which led to better yields.
We noted that zinc-amino acids chelate improved antioxidant enzyme activities, which are crucial for helping rice withstand cold temperatures. The yield of rice treated with zinc was approximately 9.22% higher than with uniconazole and 7.14% higher than with abscisic acid.
Additionally, we observed that using 750 g/ha of zinc-amino acids chelate during the transplanting and regreening stages yielded the best results. The timing of the application played a critical role, as spraying during these specific phases maximized both yield and cold resistance.
Overall, zinc treatments stand out as a promising option for improving cold stress resilience in early rice, making it a key consideration for farmers dealing with cold climate conditions.
We noted that zinc-amino acids chelate improved antioxidant enzyme activities, which are crucial for helping rice withstand cold temperatures. The yield of rice treated with zinc was approximately 9.22% higher than with uniconazole and 7.14% higher than with abscisic acid.
Additionally, we observed that using 750 g/ha of zinc-amino acids chelate during the transplanting and regreening stages yielded the best results. The timing of the application played a critical role, as spraying during these specific phases maximized both yield and cold resistance.
Overall, zinc treatments stand out as a promising option for improving cold stress resilience in early rice, making it a key consideration for farmers dealing with cold climate conditions.
Read More
9
We explored the effects of adding nano-scale zero-valent iron modified biochar (nZVI@BC) to two different anaerobic ammonia oxidation (anammox) systems. Our goal was to determine whether this iron-enhanced biochar could improve the cold resistance of low-nitrogen anammox processes during cold conditions.
The results were striking. At lower temperatures, the system with nZVI@BC maintained a robust nitrogen removal efficiency of around 80%. In comparison, the system with regular biochar saw its efficiency drop to about 69.49%, showing that iron truly makes a difference in cold performance.
We also noted that the biomass enriched with nZVI@BC contained significantly more heme-c, a vital component that contributes to the biological processes in these systems. Plus, the addition of nZVI@BC led to more extracellular polymeric substances and better granulation of the biomass, as well as an increased number of anammox bacteria, all of which play crucial roles in maintaining effective nitrogen removal.
Importantly, specific anammox genes proved essential in keeping nitrogen removal performance high, even at chilly temperatures of 15°C. Overall, our findings suggest that incorporating iron-modified biochar may be a game-changer for treating low-nitrogen wastewater in cold environments.
The results were striking. At lower temperatures, the system with nZVI@BC maintained a robust nitrogen removal efficiency of around 80%. In comparison, the system with regular biochar saw its efficiency drop to about 69.49%, showing that iron truly makes a difference in cold performance.
We also noted that the biomass enriched with nZVI@BC contained significantly more heme-c, a vital component that contributes to the biological processes in these systems. Plus, the addition of nZVI@BC led to more extracellular polymeric substances and better granulation of the biomass, as well as an increased number of anammox bacteria, all of which play crucial roles in maintaining effective nitrogen removal.
Importantly, specific anammox genes proved essential in keeping nitrogen removal performance high, even at chilly temperatures of 15°C. Overall, our findings suggest that incorporating iron-modified biochar may be a game-changer for treating low-nitrogen wastewater in cold environments.
Read More
8
We explored the connection between vitamin D levels and upper respiratory tract infections (URTIs) among military recruits during their training. This observation spanned across different seasons and included over 1,600 recruits. Our aim was to understand how achieving sufficient vitamin D levels could potentially impact the frequency and severity of colds among physically active individuals.
In an additional phase of the research, we conducted a randomized controlled trial with 250 male recruits. They received either a placebo, simulated sunlight exposure, or oral vitamin D3 supplements during winter. This comparison allowed us to see if these methods effectively increased vitamin D levels to a sufficient status of 25(OH)D at 50 nmol/L or higher.
Notably, our findings showed that only 21% of recruits had adequate vitamin D during winter, yet those who did were 40% less likely to suffer from URTIs. Furthermore, both vitamin D supplementation strategies similarly helped nearly all participants achieve sufficient levels. Vitamin D supplementation notably reduced the severity of URTI symptoms by 15% and the number of days with URTIs by 36% compared to placebo.
While the supplementation strategies did not significantly alter other immune factors, such as salivary secretory immunoglobulin A, the overall reduction in respiratory infections indicates a beneficial effect of maintaining vitamin D sufficiency during military training.
In an additional phase of the research, we conducted a randomized controlled trial with 250 male recruits. They received either a placebo, simulated sunlight exposure, or oral vitamin D3 supplements during winter. This comparison allowed us to see if these methods effectively increased vitamin D levels to a sufficient status of 25(OH)D at 50 nmol/L or higher.
Notably, our findings showed that only 21% of recruits had adequate vitamin D during winter, yet those who did were 40% less likely to suffer from URTIs. Furthermore, both vitamin D supplementation strategies similarly helped nearly all participants achieve sufficient levels. Vitamin D supplementation notably reduced the severity of URTI symptoms by 15% and the number of days with URTIs by 36% compared to placebo.
While the supplementation strategies did not significantly alter other immune factors, such as salivary secretory immunoglobulin A, the overall reduction in respiratory infections indicates a beneficial effect of maintaining vitamin D sufficiency during military training.
Read More
8
We explored the impact of regular gargling with an antimicrobial mouthwash that contains both cetylpyridinium chloride and zinc on upper respiratory symptoms. A total of 150 participants were split into two groups; one group just brushed their teeth, while the other group brushed and gargled with the mouthwash twice a day over three months.
Our findings revealed that those using the mouthwash experienced a 21.5% reduction in the frequency and an 11% decrease in the severity of respiratory symptoms. This strongly suggests that incorporating zinc, alongside cetylpyridinium chloride, can provide benefits for those suffering from cold-related symptoms.
However, it’s important to note that this study’s design involved multiple components, and we can’t isolate zinc’s effectiveness from the impact of the other ingredients. Still, the results encourage us to view mouthwash with these ingredients as a helpful addition to our daily hygiene routines, especially during cold and flu season.
Ultimately, this research indicates that gargling with a mouthwash containing zinc and cetylpyridinium chloride can indeed help alleviate some unpleasant cold symptoms, but we should be mindful of the combination's effects when interpreting these outcomes.
Our findings revealed that those using the mouthwash experienced a 21.5% reduction in the frequency and an 11% decrease in the severity of respiratory symptoms. This strongly suggests that incorporating zinc, alongside cetylpyridinium chloride, can provide benefits for those suffering from cold-related symptoms.
However, it’s important to note that this study’s design involved multiple components, and we can’t isolate zinc’s effectiveness from the impact of the other ingredients. Still, the results encourage us to view mouthwash with these ingredients as a helpful addition to our daily hygiene routines, especially during cold and flu season.
Ultimately, this research indicates that gargling with a mouthwash containing zinc and cetylpyridinium chloride can indeed help alleviate some unpleasant cold symptoms, but we should be mindful of the combination's effects when interpreting these outcomes.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Helps keep colds away
8 people found this helpful
Rating a multivitamin is challenging since it’s preventive rather than reactive. I believe this has helped keep colds at bay during winter while around sick people, hence the four stars. I haven’t noticed much difference in energy levels or overall vitality, but it’s caused no adverse effects, aside from bright urine that normalises during the day.
Read More
6
Energizing effects noted
6 people found this helpful
Despite dealing with allergies this week, I started using this product on day three, and I've felt more awake and stronger, though still fatigued while taking allergy meds for my cold. I’ve many types of gym supplements throughout the years, but I genuinely feel the difference with these. I can also do my workouts more effectively. They help me feel healthier even when I'm unwell!
Read More
6
Improves cold symptoms
2 people found this helpful
I initially wanted to avoid taking multiple vitamins, so I chose this multivitamin based on positive reviews. While I haven't noticed dramatic differences other than bright urine, I've realised that when sick with a cold, taking it makes me feel slightly better—more energetic and less stuffy. When taken consistently, my energy levels seem to improve as well.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Hemilä H, Chalker E. Vitamin C for the common cold and pneumonia. Pol Arch Intern Med. 2025;135. 10.20452/pamw.16926
- Wang X, Ran C, Fu Y, Han L, Yang X, et al. Application of Exogenous Ascorbic Acid Enhances Cold Tolerance in Tomato Seedlings through Molecular and Physiological Responses. Int J Mol Sci. 2024;25. 10.3390/ijms251810093
- Marusca LM, Reddy G, Blaj M, Prathipati R, Rosca O, et al. The Effects of Vitamin D Supplementation on Respiratory Infections in Children under 6 Years Old: A Systematic Review. Diseases. 2023;11. 10.3390/diseases11030104
- Carboo JA, Dolman-Macleod RC, Malan L, Lombard MJ. High-dose oral vitamin D supplementation for prevention of infections in children aged 0 to 59 months: a systematic review and meta-analysis. Nutr Rev. 2024;82:579. 10.1093/nutrit/nuad082
- Kisla Ekinci RM, Taskin Karacay IE, Celik U. Serum vitamin B12 and D levels in children with Primary Raynaud Phenomenon: a retrospective cohort study. Eur J Clin Nutr. 2022;76:1615. 10.1038/s41430-022-01151-0
- Harrison SE, Oliver SJ, Kashi DS, Carswell AT, Edwards JP, et al. Influence of Vitamin D Supplementation by Simulated Sunlight or Oral D3 on Respiratory Infection during Military Training. Med Sci Sports Exerc. 2021;53:1505. 10.1249/MSS.0000000000002604
- Shimizu Y, Ito Y, Uotsu N, Yui K. Intake of 25-Hydroxyvitamin D May Reduce the Severity of Upper Respiratory Tract Infection: Post hoc Analysis of a Randomized, Double-Blind, Placebo-Controlled, Parallel Group Comparison Study. Nutrients. 2020;12. 10.3390/nu12123769
- Muniz FWMG, Casarin M, Pola NM, Rösing CK, Silveira TMD, et al. Efficacy of regular gargling with a cetylpyridinium chloride plus zinc containing mouthwash can reduce upper respiratory symptoms. PLoS One. 2025;20:e0316807. 10.1371/journal.pone.0316807
- Wieland LS. Zinc for prevention and treatment of the common cold: Summary of a Cochrane review. Explore (NY). 2025;21:103111. 10.1016/j.explore.2025.103111
- Yuan S, Qin S, Shi Q, Chen P, Tu N, et al. Effects of different cold-resistant agents and application methods on yield and cold-resistance of machine-transplanted early rice. Front Plant Sci. 2024;15:1422374. 10.3389/fpls.2024.1422374
- Jian SF, Huang YF, Chen DL, Zhong C. Dihydroporphyrin iron (III) enhances low temperature tolerance by increasing carbon and nitrogen metabolism in . Front Plant Sci. 2024;15:1522481. 10.3389/fpls.2024.1522481
- Wen D, Yang N, Zhang W, Wang X, Zhang J, et al. GATA3-COMT1-Melatonin as Upstream Signaling of ABA Participated in Se-Enhanced Cold Tolerance by Regulate Iron Uptake and Distribution in Cucumis sativus L. J Pineal Res. 2025;77:e70028. 10.1111/jpi.70028
- Zhang Y, Zhang Z, Sun Z, Zhao Y, Cui Y, et al. Effects of Cold Deformation and Heat Treatments on the Microstructure and Properties of Fe-15Cr-25Ni Superalloy Cold-Drawn Bars. Nanomaterials (Basel). 2024;14. 10.3390/nano14231949
- Chen W, Zhang L, Liu Z, Liu W, Lu B, et al. Mechanism of nano-scale zero-valent iron modified biochar for enhancing low-nitrogen anammox process resistance to low temperatures. J Environ Sci (China). 2025;152:442. 10.1016/j.jes.2024.05.049
- Suo W, Li L, Zheng Y, Pan S, Niu Y, et al. Effect of seed priming with zinc, iron and selenium on the low temperature tolerance of Nicotiana tabacum L. during seed germination. Biochem Biophys Res Commun. 2024;735:150806. 10.1016/j.bbrc.2024.150806
