Can Optimum Nutrition Opti-Women Help with Migraine?

Last update

5/13/2025

Reviewed By

🩺 Dr. Talia Klein

Overview

SCIENTIFIC SCORE

Possibly Effective

Based on 35 Researches

7.4

USERS' SCORE

Good

Based on 3 Reviews

Top Medical Research Studies

Vitamin D helps reduce migraines

Hu C, Fan Y, Wu S, Zou Y, Qu X. Vitamin D supplementation for the treatment of migraine: A meta-analysis of randomized controlled studies. Am J Emerg Med. 2021;50:784. doi:10.1016/j.ajem.2021.07.062

We explored the potential benefits of vitamin D supplementation for treating migraines. Our analysis focused on several randomized controlled trials (RCTs) to examine how effective vitamin D could be in alleviating migraine symptoms.

Through our review, we included six RCTs involving 301 patients. The results were quite promising. Vitamin D supplementation significantly reduced the number of headache attacks per month and the number of headache days experienced by patients. Additionally, it improved the MIDAS score, which measures the impact of migraines on daily life.

However, it's important to note that vitamin D did not show a significant effect on how long migraine attacks lasted or the severity of the headaches. Overall, our findings suggest that while vitamin D might be beneficial for reducing certain migraine-related symptoms, it isn’t a miracle cure for everyone.

Vitamin D reduces migraine symptoms

Zhang YF, Xu ZQ, Zhou HJ, Liu YZ, Jiang XJ. The Efficacy of Vitamin D Supplementation for Migraine: A Meta-Analysis of Randomized Controlled Studies. Clin Neuropharmacol. 2021;44:5. doi:10.1097/WNF.0000000000000419

We explored how vitamin D may impact migraines through a systematic review and meta-analysis of randomized controlled trials.

Analyzing data from five trials, we found that vitamin D significantly reduced the number of headache days, frequency of attacks, severity of headaches, and overall migraine-related disability compared to placebo.

This suggests that vitamin D treatment can effectively help alleviate migraine symptoms for many individuals.

Zinc reduces migraine symptoms

Mazaheri M, Aghdam AM, Heidari M, Zarrin R. Assessing the Effect of Zinc Supplementation on the Frequency of Migraine Attack, Duration, Severity, Lipid Profile and hs-CRP in Adult Women. Clin Nutr Res. 2021;10:127. doi:10.7762/cnr.2021.10.2.127

This study was designed as a randomized double-blind, placebo-controlled trial to examine how zinc gluconate supplementation might alleviate migraine symptoms in adult women. We followed 60 women, averaging about 35 years old, who either received 15 mg of zinc per day or a placebo for a duration of 12 weeks.

Over the trial, we observed significant improvements in those taking zinc. The frequency of migraine attacks, as well as the duration and severity of the headaches, drastically decreased for participants receiving zinc. We used various assessments, such as a numerical rating scale and the Migraine Disability Assessment test, to evaluate these changes.

Additionally, zinc supplementation showed a notable reduction in levels of low-density lipoprotein (LDL) cholesterol and high-sensitivity C-reactive protein (hs-CRP), both of which are associated with inflammation. However, no significant changes in triglycerides or high-density lipoprotein (HDL) levels were seen. After taking initial values into account, the changes in lipid levels and hs-CRP weren’t significant.

Overall, we found that zinc supplementation can beneficially impact migraine symptoms, reducing their severity and frequency among women. This offers a promising direction for migraine management without the side effects often associated with traditional medications.

Most Useful Reviews

Migraine relief

6 people found this helpful

Great multivitamin for chronic migraine sufferers! I have retinal migraines, where my vision becomes limited followed by severe migraines. When I take this product consistently, I do not experience migraines. This product contains magnesium and B-vitamins, which may be why I avoid migraines. Since stopping this supplement, I've continually suffered from migraines, unlike with Opti-Women, which provided beneficial effects both mentally and physically. I regret discontinuing it. My periods remain irregular, but I believe this product truly helps.

7.5

Increased energy

5 people found this helpful

Best multivitamin for active women or those with physically demanding jobs! This is my third bottle, and I can't say enough good things about it! After trying many other brands that had large pills, gave me migraines, tasted horrible, and didn't aid my health, I feel I've hit the jackpot. I work in a warehouse, standing 10 hours a day, and workout on my days off. This multi provides the energy and essential vitamins my body needs to stay strong and healthy every day. Combined with source naturals when feeling unwell, I haven't felt better in years.

Increased migraines

2 people found this helpful

It gives me the worst migraines. I started taking two a day as recommended and noticed an increase in migraines compared to before. I didn’t change any other part of my diet. I suggest caution if you're sensitive.

Medical Researches

SCIENTIFIC SCORE

Possibly Effective

Based on 35 Researches

7.4

9.5

Zinc may alleviate migraines

Dhillon KS, Singh J, Lyall JS. A new horizon into the pathobiology, etiology and treatment of migraine. Med Hypotheses. 2011;77:147. doi:10.1016/j.mehy.2011.03.050

We embarked on an investigation into the potential of zinc as a treatment for migraines. The study involved 30 migraine sufferers who were given 75 mg of zinc sulfate daily for six weeks, along with vitamin B-complex and vitamin A or E during the first ten days.

Remarkably, this combination led to a significant improvement in most participants, suggesting that zinc could play a vital role in alleviating migraine symptoms. Zinc's effectiveness may stem from its essential functions in various biological processes, such as supporting the nervous system and regulating mineral balance in the body.

However, it’s important to note that the research combined zinc with other supplements, which makes it challenging to ascertain zinc's isolated effect on migraines. Future studies may benefit from a more controlled approach—perhaps comparing zinc against a placebo or examining its impact in larger groups.

Overall, this exploration opens new avenues for understanding how zinc and other nutrients can contribute to migraine relief, but further research is needed to fully validate these findings.

Vitamin D may alleviate migraines

Ioannidou E, Tsakiris C, Goulis DG, Christoforidis A, Zafeiriou D. The association of serum vitamin D concentrations in paediatric migraine. Eur J Paediatr Neurol. 2023;47:60. doi:10.1016/j.ejpn.2023.09.007

We aimed to understand how vitamin D impacts migraine headaches in children. Through a thorough review of existing literature, we explored the significant association between serum vitamin D levels and the frequency and duration of migraine episodes in the pediatric population.

Our findings suggest that children with migraines might benefit from vitamin D supplementation. By potentially reducing the number and intensity of migraine episodes, vitamin D could improve the overall quality of life for these young patients.

It's important to note that this connection primarily focuses on children, as most studies have looked at adults. With vitamin D deficiency being a growing public health concern, our research highlights how addressing this deficiency may serve as a helpful strategy in managing pediatric migraines.

Pediatric migraines and vitamin D

Kotb Elmala M, Suliman HA, Al-Shokary AH, Ibrahim AO, Kamal NM, et al. The Impact of Vitamin D Supplementation to Topiramate Therapy on Pediatric Migraine Prophylaxis. J Child Neurol. 2022;37:833. doi:10.1177/08830738221092882

We conducted a study to investigate whether adding vitamin D supplements to topiramate therapy would improve migraine outcomes in children aged 5 to 14. In our double-blinded clinical trial, we randomly assigned participants to receive either topiramate with a daily 5000-IU vitamin D supplement or topiramate with a placebo for four months. By evaluating changes in headache frequency, severity, disability, and overall response to treatment, we aimed to see if vitamin D could provide additional benefits.

Our findings were quite promising. The children receiving the vitamin D supplement had a significant reduction in the number of headaches they experienced each month compared to those on placebo. Additionally, the vitamin D group reported less disability due to migraines and a higher percentage of positive treatment responses. Specifically, about 76% of children in the vitamin D group showed a good response, compared to just over 53% in the placebo group.

Safety was assessed as well, with side effects occurring in 13.3% of the vitamin D group and 20% in the placebo group, indicating that vitamin D was well-tolerated. Overall, we believe that combining vitamin D with topiramate represents a safe and potentially effective approach to managing pediatric migraines.