Last update
5/13/2025

Overview

SCIENTIFIC SCORE
Questionable
Based on 11 Researches
6.3
USERS' SCORE
Good
Based on 3 Reviews
8.5

Top Medical Research Studies

9
FCH reduces nausea in IDA treatment
We evaluated how switching to ferric citrate hydrate (FCH) impacts nausea in women with iron deficiency anemia (IDA) who struggled with oral iron. In a multicenter study of 30 patients, those on FCH experienced significant improvements. Nausea scores dropped from 5.7 to 1.7, and the overall incidence of nausea decreased notably. Also, 80% reported better experiences compared to previous treatments.

Overall, our findings suggest that FCH not only enhances medication adherence but also effectively reduces nausea and improves quality of life in these patients.
Read More
9
Iron treatment eases nausea in pregnancy
We conducted a study to examine the effectiveness of a specific iron supplement, emulsified microsomal ferric pyrophosphate (EMFP), in treating iron deficiency anemia among pregnant women. Our focus was not only on improving hemoglobin levels but also on alleviating related symptoms, including nausea.

Within 30 days of starting treatment with EMFP, we observed significant increases in hemoglobin levels, alongside marked improvements in serum ferritin and iron levels. As nausea is a common complaint among pregnant women, we noted a decrease in various symptoms, including nausea, breathlessness, and dizziness, which contributed to a better quality of life for the participants.

Notably, treatment compliance was remarkably high at 99.5%, indicating that the participants were committed to managing their anemia effectively. Importantly, we did not encounter any severe side effects related to the treatment, suggesting a favorable safety profile.

Overall, our findings support the idea that iron treatment can help alleviate nausea and other discomforts related to iron deficiency anemia in pregnancy, positively impacting both mother and baby.
Read More
8
Vitamin D and nausea in gastroparesis
We delved into an intriguing question: how do low vitamin D levels affect nausea in people experiencing gastroparesis, a condition that slows gastric emptying? By measuring the vitamin D levels of patients from the Gastroparesis Clinical Consortium Registry, we aimed to uncover the relationships between vitamin D, nausea, and gastric function.

Our findings revealed that over half of the patients had low vitamin D levels, specifically 56.1% of the 513 individuals studied. We observed a clear association between these low levels of vitamin D and increased experiences of nausea and vomiting. This was particularly notable in patients with delayed gastric emptying, where those with low vitamin D levels reported significantly more nausea.

While the study showed a correlation, it did not address whether supplementing with vitamin D could directly alleviate these symptoms. Instead, we found that lower vitamin D levels also related to a greater retention of food in the stomach after meals, which hints at a connection to gastric neuromuscular dysfunction. Overall, our study emphasized a noteworthy link between vitamin D and nausea but stopped short of confirming any direct treatment benefits.
Read More

Most Useful Reviews

10
No nausea experienced
15 people found this helpful
I've only been taking these for a few days, but I'm glad to report NO NAUSEA. This is significant because other multivitamins have made me sick within an hour of taking them. This one is different, and I'm very pleased! However, the pills are large, so it may not suit those who struggle with that, especially since two are required daily. The Vitamin B content has also caused my urine to turn neon yellow, which is normal, so don't be alarmed if that happens to you.
Read More
10
Nausea eliminated
2 people found this helpful
No more nausea! The main reasons I purchased these were the fantastic reviews, specifically about how people did not feel sick after taking them. I had quit taking vitamins due to nausea from the Target Up & Up brand, which made me sick regardless of other medications I tried. I can confidently say the reviews are accurate! No nausea (thank you!!) and these vitamins positively affect my daily energy levels. Unlike previous vitamins, I can feel a noticeable difference in how I feel. I only take one a day currently but might increase to two next week.
Read More
6
Nausea improved
8 people found this helpful
Widest Variety of Nutrients. These are excellent multivitamins for women, particularly with ingredients like Horse Chestnut. I have tried other brands but always return to this one for its consistent quality and diverse nutrition. I used to experience nausea when taking them on an empty stomach, but this has gradually improved. I suggest taking them with food if you are sensitive. These large pills are easy to swallow, and I believe they work, as my doctor has noted improvements in my Vitamin D and iron levels since I started taking them regularly.
Read More

Medical Researches

SCIENTIFIC SCORE
Questionable
Based on 11 Researches
6.3
  • All Researches
9
Iron treatment eases nausea in pregnancy
We conducted a study to examine the effectiveness of a specific iron supplement, emulsified microsomal ferric pyrophosphate (EMFP), in treating iron deficiency anemia among pregnant women. Our focus was not only on improving hemoglobin levels but also on alleviating related symptoms, including nausea.

Within 30 days of starting treatment with EMFP, we observed significant increases in hemoglobin levels, alongside marked improvements in serum ferritin and iron levels. As nausea is a common complaint among pregnant women, we noted a decrease in various symptoms, including nausea, breathlessness, and dizziness, which contributed to a better quality of life for the participants.

Notably, treatment compliance was remarkably high at 99.5%, indicating that the participants were committed to managing their anemia effectively. Importantly, we did not encounter any severe side effects related to the treatment, suggesting a favorable safety profile.

Overall, our findings support the idea that iron treatment can help alleviate nausea and other discomforts related to iron deficiency anemia in pregnancy, positively impacting both mother and baby.
Read More
9
FCH reduces nausea in IDA treatment
We evaluated how switching to ferric citrate hydrate (FCH) impacts nausea in women with iron deficiency anemia (IDA) who struggled with oral iron. In a multicenter study of 30 patients, those on FCH experienced significant improvements. Nausea scores dropped from 5.7 to 1.7, and the overall incidence of nausea decreased notably. Also, 80% reported better experiences compared to previous treatments.

Overall, our findings suggest that FCH not only enhances medication adherence but also effectively reduces nausea and improves quality of life in these patients.
Read More
8
Vitamin D and nausea in gastroparesis
We delved into an intriguing question: how do low vitamin D levels affect nausea in people experiencing gastroparesis, a condition that slows gastric emptying? By measuring the vitamin D levels of patients from the Gastroparesis Clinical Consortium Registry, we aimed to uncover the relationships between vitamin D, nausea, and gastric function.

Our findings revealed that over half of the patients had low vitamin D levels, specifically 56.1% of the 513 individuals studied. We observed a clear association between these low levels of vitamin D and increased experiences of nausea and vomiting. This was particularly notable in patients with delayed gastric emptying, where those with low vitamin D levels reported significantly more nausea.

While the study showed a correlation, it did not address whether supplementing with vitamin D could directly alleviate these symptoms. Instead, we found that lower vitamin D levels also related to a greater retention of food in the stomach after meals, which hints at a connection to gastric neuromuscular dysfunction. Overall, our study emphasized a noteworthy link between vitamin D and nausea but stopped short of confirming any direct treatment benefits.
Read More
7
Zinc treatment reduces nausea risk
We conducted a study to evaluate how effective NPC-25, a new form of zinc, is compared to a well-known treatment, NOBELZINā„¢, for patients with low zinc levels. Participants in this trial had their zinc levels checked and were grouped to receive either NPC-25 or NOBELZINā„¢.

For a period of up to 24 weeks, we aimed to maintain their zinc levels within a specific target range while closely monitoring for side effects. One of our main goals was to see if NPC-25 could maintain these target zinc levels similarly to NOBELZINā„¢.

Our findings revealed that NPC-25 was indeed non-inferior to NOBELZINā„¢, meaning it worked just as well. Importantly, we also observed that those taking NPC-25 reported fewer digestive issues, like nausea and vomiting. This suggests that while both treatments were effective, NPC-25 might be the gentler option.
Read More
7
Zinc treatment in hypozincemia study
We explored the impact of zinc acetate dihydrate on several symptoms, including nausea, through a comprehensive study that assessed its safety and effectiveness for treating hypozincemia over a 52-week period. From the data collected, we observed an overall adverse reaction rate of 9.4%, with nausea reported in 1.4% of patients.

Despite nausea being a concern, the benefit of zinc acetate dihydrate for other indications was notable, with an efficacy rate of 83%. For patients experiencing symptoms such as pressure ulcers or stomatitis, the effectiveness was strikingly high. However, the specific effect of zinc on nausea is not definitively isolated within the study results, making it hard to gauge its direct and unique benefits.

In essence, while zinc acetate dihydrate shows promise for a variety of symptoms, including nausea, the evidence does not conclusively highlight its effectiveness for this particular issue on its own. Overall, it appears that zinc treatment can contribute positively to addressing several related health problems.
Read More

User Reviews

USERS' SCORE
Good
Based on 3 Reviews
8.5
  • All Reviews
  • Positive Reviews
  • Negative Reviews
10
No nausea experienced
15 people found this helpful
I've only been taking these for a few days, but I'm glad to report NO NAUSEA. This is significant because other multivitamins have made me sick within an hour of taking them. This one is different, and I'm very pleased! However, the pills are large, so it may not suit those who struggle with that, especially since two are required daily. The Vitamin B content has also caused my urine to turn neon yellow, which is normal, so don't be alarmed if that happens to you.
Read More
10
Nausea eliminated
2 people found this helpful
No more nausea! The main reasons I purchased these were the fantastic reviews, specifically about how people did not feel sick after taking them. I had quit taking vitamins due to nausea from the Target Up & Up brand, which made me sick regardless of other medications I tried. I can confidently say the reviews are accurate! No nausea (thank you!!) and these vitamins positively affect my daily energy levels. Unlike previous vitamins, I can feel a noticeable difference in how I feel. I only take one a day currently but might increase to two next week.
Read More
6
Nausea improved
8 people found this helpful
Widest Variety of Nutrients. These are excellent multivitamins for women, particularly with ingredients like Horse Chestnut. I have tried other brands but always return to this one for its consistent quality and diverse nutrition. I used to experience nausea when taking them on an empty stomach, but this has gradually improved. I suggest taking them with food if you are sensitive. These large pills are easy to swallow, and I believe they work, as my doctor has noted improvements in my Vitamin D and iron levels since I started taking them regularly.
Read More

Frequently Asked Questions

No FAQs are available for this product and symptom.

References

  1. Foessleitner P, Rager L, Mikula F, Hager M, Granser S, et al. The Role of hCG and Histamine in Emesis Gravidarum and Use of a Chewing Gum Containing Vitamin C as a Treatment Option: A Double-Blinded, Randomized, Controlled Trial. J Clin Med. 2024;13. 10.3390/jcm13175099
  2. Koch KL, Parkman HP, Yates KP, Van Natta ML, Grover M, et al. Low Vitamin D Levels in Patients with Symptoms of Gastroparesis: Relationships with Nausea and Vomiting, Gastric Emptying and Gastric Myoelectrical Activity. Dig Dis Sci. 2024;69:2904. 10.1007/s10620-024-08520-8
  3. Jarosz AC, Noori D, Zeitoun T, Garcia-Bailo B, El-Sohemy A. Variation in the vitamin D receptor gene, plasma 25-hydroxyvitamin D, and risk of premenstrual symptoms. Genes Nutr. 2021;16:15. 10.1186/s12263-021-00696-2
  4. Asaoka D, Ishihara T, Ezoe S, Hamada I, Kitamura M, et al. Randomized, multicenter, active-controlled open-label study of NPC-25, zinc histidine hydrate, (non-inferiority to NOBELZINā„¢, zinc acetate dihydrate) for patients with hypozincemia. J Trace Elem Med Biol. 2025;87:127558. 10.1016/j.jtemb.2024.127558
  5. Ezoe S, Ishihara T, Hosogai T, Kokubo T. Post-marketing surveillance of zinc acetate dihydrate for hypozincemia in Japan. Pharmazie. 2024;79:29. 10.1691/ph.2024.3630
  6. Parvizi A, Haddadi S, Akbari M, Akbarpour M, Taghipour Rudsari F, et al. Comparing the Effect of Zinc-impregnated Pharyngeal Packs with Conventional Methods on the Level of Sore Throat Among Patients Undergoing Septorhinoplasty. Anesth Pain Med. 2022;12:e127262. 10.5812/aapm-127262
  7. Nuzhat S, Ahmed T, Alam J, Billal SM, Khan AI, et al. New formulation zinc sulphate acceptability and adherence in children with acute diarrhoea: A prospective, open-label, interventional study in Bangladesh. J Paediatr Child Health. 2022;58:1215. 10.1111/jpc.15953
  8. Srivastav A, Kshirsagar S, Adhav T, Ganu G, Shah A. Efficacy and Safety of Microsomal Ferric Pyrophosphate Supplement for Iron Deficiency Anemia in Pregnancy. Cureus. 2024;16:e57108. 10.7759/cureus.57108
  9. Schulte J, Peterson K, Thomsen T, Lentz S, Hall M, et al. Daily versus three times weekly dosing for treatment of iron deficiency nonanemia in NCAA Division 1 female athletes. PM R. 2024;16:316. 10.1002/pmrj.13172
  10. Nagao T, Takahashi K, Takahashi S, Yokomizo R, Samura O, et al. Low-dose ferric carboxymaltose vs. oral iron for improving hemoglobin levels in postpartum East Asian women: A randomized controlled trial. PLoS One. 2025;20:e0319795. 10.1371/journal.pone.0319795
  11. Wada-Hiraike O, Maruyama A, Mitobe Y, Iriyama T, Mori-Uchino M, et al. A Multicenter Single-Arm Study of Switching to Ferric Citrate Hydrate for Iron Deficiency Anemia in Patients Intolerant to Oral Iron: RIO-SWITCH. Adv Ther. 2025. 10.1007/s12325-025-03123-9
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