Supplement Facts
Serving Size:  3 Capsules
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine hydrochloride)
10 mg
588%
Magnesium (as magnesium aspartate, magnesium oxide)
435 mg
104%
Zinc (as zinc aspartate, zinc monomethionine, zinc oxide)
28 mg
255%

The product is found useful for the following medical conditions

Cold details

SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8.6
USERS' SCORE
Good
Based on 2 Reviews
8.6
We explored how zinc might help in treating and preventing the common cold. The study focused on zinc's effects, isolating it from other treatments to understand its true impact on cold symptoms. By doing this, the researchers aimed to clarify whether zinc could genuinely shorten the duration of a cold or alleviate its symptoms.

The findings were intriguing but showed that zinc might not yield significant benefits for everyone. While some individuals reported a slight reduction in cold symptoms, the evidence did not strongly support zinc as an effective treatment overall.

This means that, for those seeking relief from a nasty cold, zinc alone might not be the go-to solution we hoped it would be. It’s essential to consider this information when deciding on a cold treatment plan and to approach zinc with realistic expectations.
9
Reduces cold sores
Most Useful Review
1 people found this helpful
ZMA is incredible! I've always struggled with sleep, but since taking it, I fall asleep easily and stay asleep. Although I have vivid dreams, I find it hard to remember them. The improvement in my sleep quality has aided my recovery. Though I take other supplements for recovery, the unexpected immune boost from Zinc has been remarkable. Previously suffering from frequent cold sores, I haven't had any breakouts since starting ZMA.

Autoimmune Disorder details

SCIENTIFIC SCORE
Moderately Effective
Based on 21 Researches
8.1
USERS' SCORE
Good
Based on 5 Reviews
8.5
We analyzed how magnesium supplementation affects the biology of rheumatoid arthritis (RA) in mice. By feeding one group a diet rich in magnesium and another a standard diet over 15 days, we examined changes in their tissue responses.

Our findings revealed that increased magnesium intake may alter gene expression linked to oxidative stress and cellular aging, processes that are significant in RA development. This suggests that magnesium could be beneficial for managing RA and potentially other autoimmune disorders by reducing disease severity and joint damage.
9
Deep sleep
Most Useful Review
2 people found this helpful
A fantastic supplement; we sleep so soundly! This isn't my first order. We're very pleased with its effects. The recommended dosage for women is two capsules a day before bedtime. Both my mother, aged 70, and I, at 49, experience improved quality of sleep with deeper, more vivid dreams, reminiscent of childhood.

Constipation details

SCIENTIFIC SCORE
Questionable
Based on 25 Researches
6.9
USERS' SCORE
Good
Based on 5 Reviews
8.5
We explored the effectiveness of magnesium oxide (MgO) as a treatment for chronic constipation using a robust randomized, placebo-controlled trial. Over 28 days, participants received MgO, senna, or a placebo.

Both MgO and senna significantly improved bowel movement frequency and quality of life compared to placebo. About 68.3% of those using MgO reported symptom improvement, showcasing its potential as an effective osmotic agent alongside a stimulant laxative.

Importantly, there were no severe treatment-related side effects reported during the trial.
10
Solves constipation
Most Useful Review
I utilized this under a doctor's guidance alongside a dietary programme to prevent waste from building up in the colon and intestines. I noticed its effects immediately after use; it resolved my constipation issue. A very useful and effective product.

Leg Cramps details

SCIENTIFIC SCORE
Likely Ineffective
Based on 17 Researches
4.8
USERS' SCORE
Good
Based on 5 Reviews
8.5
We conducted a study to evaluate how effective magnesium oxide monohydrate (MOMH) is in treating nocturnal leg cramps (NLC). This was a randomized, double-blind, placebo-controlled trial involving multiple centers in Ukraine, where participants took either MOMH or a placebo nightly for 60 days.

Our focus was on measuring the frequency and duration of cramps, the pain they caused, and how they affected sleep quality and overall life satisfaction. We used thorough statistical methods to compare the results between the two groups.

The findings indicated that MOMH is both effective and safe for individuals dealing with NLC. Participants reported improvements in their symptoms, demonstrating that this magnesium supplement can play a helpful role in managing nocturnal leg cramps.
10
No more cramps
Most Useful Review
1 people found this helpful
It works! I bought these vitamins for my husband, who had calf cramps at night. After a few days of taking them, everything cleared up. They also positively affect the nervous system and should be taken at night. The vitamins are of excellent quality, with no taste or aftertaste, and come in a standard-size capsule. I recommend them for anyone wanting to eliminate night cramps or restore their nervous system.

Acne details

SCIENTIFIC SCORE
Possibly Effective
Based on 22 Researches
7.8
USERS' SCORE
Good
Based on 2 Reviews
8.4
We explored how zinc affects acne through a systematic review and meta-analysis that looked at two main questions. First, we wanted to know if there are differences in zinc levels between people with acne and those without. Second, we examined how effective zinc treatments are for managing acne.

Our findings showed that individuals with acne had noticeably lower serum zinc levels compared to those in the control group. Furthermore, when we looked at treatments, those who received zinc showed a significant reduction in their inflammatory papule count—a common symptom of acne. Importantly, we noted that side effects from zinc supplementation were similar to those seen in other treatments, suggesting that zinc is safe to use.

Overall, acne patients appear to benefit from improved zinc levels, especially when zinc is used either on its own or alongside other acne treatments. This gives hope for those looking for effective ways to tackle acne issues!
9
Acne disappeared
Most Useful Review
3 people found this helpful
We will order more! My son, who is involved in professional sports, tried this product and it genuinely works. It helped him recover, and his acne has vanished. Overall, we are very pleased!

Cold Sores details

SCIENTIFIC SCORE
Moderately Effective
Based on 9 Researches
8.2
USERS' SCORE
Good
Based on 3 Reviews
8.4
We conducted a double-blind, placebo-controlled clinical trial to explore the effectiveness of a zinc oxide/glycine cream in treating cold sores caused by facial and circumoral herpes. By dividing 46 participants into two groups, one receiving the zinc treatment and the other a placebo, we aimed to measure how this formulation affected the duration and severity of cold sore symptoms.

Our results were quite promising! Participants who began using the zinc oxide/glycine cream within the first 24 hours of noticing symptoms experienced cold sore lesions that lasted only an average of 5 days, compared to 6.5 days for those on the placebo. Additionally, we noticed a significant reduction in the overall severity of their symptoms, including blistering, soreness, itching, and tingling.

As for side effects, subjects treated with the zinc cream experienced only minor and reversible issues typical of ionic zinc salt solutions. This indicates that the zinc oxide/glycine cream is not only effective but also safe for treating cold sores, presenting a valuable option for many people seeking relief from this common condition.
8
No colds noticed
Most Useful Review
2 people found this helpful
It's a nutrient that can only be obtained through external consumption, but the benefits may not be immediately apparent. I used to consume black garlic, which is rich in zinc, before trying this product. Unlike that, I haven't experienced any cold since taking it, though the tonic effects are not as obvious. Although the recommendation is for 2 tablets, I prefer to take just 1.

Low Libido details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 7 Reviews
8.4
9
Libido confirmed
Most Useful Review
13 people found this helpful
The ZMA is relatively inexpensive and has been effective in increasing my libido, which is a verified improvement.

Pelvic Pain details

SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.3
USERS' SCORE
Good
Based on 6 Reviews
8.4
We evaluated how magnesium pidolate impacts primary dysmenorrhea in 30 young women. Over six menstrual cycles, we tracked their pain levels using a visual scale. Initially, no treatment was given, and subsequently, magnesium was administered just before menstruation.

The first day of menstrual pain showed a notable decrease with magnesium treatment, especially from the first to the sixth cycle. While there were some improvements on days two and three, those weren't statistically significant. Importantly, no side effects were reported, suggesting magnesium can be a reliable option for managing menstrual pain.
9
Strength and recovery
Most Useful Review
1 people found this helpful
Great complex 💪. I was advised to increase testosterone levels. After a week, I feel more energetic and motivated. It helps with my recovery after my sciatica flare-ups, as cramps and pain have gone. I believe magnesium and B6 are responsible for this. I also expect zinc to help with muscle growth and beard development through increased testosterone 💪🧔🏼.

Back Pain details

SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.8
USERS' SCORE
Good
Based on 2 Reviews
8.4
We explored the effectiveness of magnesium sulfate (MS) in relieving low back pain (LBP) for patients who underwent iliac venous stenting. This study involved 97 patients, divided into two groups: one received MS infusion during their surgery, while the other did not.

Patients who received MS experienced significantly lower pain levels at all follow-up intervals. We found that, at 24 hours after surgery, those in the magnesium group consumed much less tramadol—a common pain medication—compared to the control group. Additionally, the need for extra pain relief was lower among those who received magnesium.

Importantly, the side effects like nausea and vomiting were similar in both groups, indicating that magnesium can be a safe option for pain management after this type of surgery. Overall, the findings suggest that magnesium sulfate not only alleviates pain but also reduces reliance on opioids, making it a valuable treatment for postoperative care.
9
Chronic pain diminished
Most Useful Review
1 people found this helpful
For the past year, using a specific recipe has significantly crushed my fibromyalgia and plantar fasciitis. Taking three capsules each night has led to a complete disappearance of chronic pain. If I substitute any ingredient, the pain returns. This concoction has been transformational for me.

Irritable Bowel Syndrome details

SCIENTIFIC SCORE
Possibly Effective
Based on 5 Researches
7.3
USERS' SCORE
Good
Based on 2 Reviews
8.3
We set out to understand how magnesium sulphate influences the symptoms of irritable bowel syndrome (IBS). In a study involving 20 IBS patients, magnesium sulphate was administered orally, resulting in a quick boost in colonic motor activity. Most participants experienced this increase within just two to six minutes.

Specifically, the percentage of colonic activity rose from 16.2% to 23.7%, signaling a notable change. Those who often felt abdominal pain after eating showed even more pronounced reactions, with their activity jumping from 16.1% to 29.8%. However, it’s important to note that three of these patients still experienced their usual pain after taking magnesium, suggesting that while magnesium can enhance motility, it doesn’t eliminate the pain for everyone.

Ultimately, these findings lend support to the idea that some cases of abdominal pain related to food may stem from heightened intestinal responses to cholecystokinin, a hormone released by the intestine. So while magnesium shows promise for intriguing changes in colonic movement in IBS patients, its effectiveness in alleviating pain remains mixed.
9
Easier bathroom visits
Most Useful Review
Excellent, it assisted me with sleeping and made going to the bathroom easier, as I suffer from irritable bowel syndrome.

Knee Pain details

SCIENTIFIC SCORE
Moderately Effective
Based on 17 Researches
8
USERS' SCORE
Good
Based on 2 Reviews
8.3
We explored the impact of magnesium sulfate on managing pain following total knee arthroplasty. In a randomized, double-blind trial with 90 patients, half received a blend of analgesics that included magnesium sulfate, while the other half did not.

Following surgery, the results showed that magnesium sulfate helped prolong pain relief and reduced the need for opioids. Patients receiving it experienced less postoperative pain and moved towards recovery more effectively.

Overall, adding magnesium sulfate appears beneficial for postoperative knee pain management.
9
Eliminated knee noises
Most Useful Review
I requested this for my father, and it has benefited him immensely. His lethargy vanished, and the crackling sound in his knees disappeared after taking it. Thank God!

Anxiety details

SCIENTIFIC SCORE
Possibly Effective
Based on 30 Researches
7.4
USERS' SCORE
Good
Based on 2 Reviews
8.2
We explored the connection between zinc intake and anxiety in adults through a systematic review of nine original studies. Two of these studies looked at how zinc consumption impacts anxiety, while the other seven focused on the relationship between serum zinc levels and anxiety symptoms. Our analysis included studies published in English within peer-reviewed journals, ensuring a solid foundation for understanding this potential link.

What we discovered was quite illuminating. The data indicated that individuals experiencing anxiety often had lower levels of zinc in their serum compared to those who did not suffer from anxiety. Additionally, we observed an inverse association between zinc intake and anxiety levels. This suggests that higher consumption of zinc may contribute to reduced anxiety symptoms.

In conclusion, the evidence points towards zinc playing a positive role in treating anxiety, although we acknowledge some limitations in the available studies. This means zinc supplementation could be a beneficial strategy for those looking to manage their anxiety, but more research is needed to confirm these findings and understand the underlying mechanisms better.
7.5
Better sleep
Most Useful Review
1 people found this helpful
This supplement was suggested by a friend familiar with weight lifting and sleeping issues. While I can't definitively say how the supplements affect me, they have noticeably improved how quickly I return to sleep after waking up at night. I often struggled with anxiety keeping me awake, but now I can fall back asleep more easily and experience less nighttime anxiety. I’ll continue taking it.

Insomnia details

SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.5
USERS' SCORE
Good
Based on 13 Reviews
8.2
We conducted a double-blind, placebo-controlled clinical trial to investigate the effects of magnesium supplementation on insomnia in elderly individuals. Our study involved 46 participants who were assigned either to receive 500 mg of magnesium daily or a placebo for a duration of 8 weeks.

Throughout the study, we employed various questionnaires, including the Insomnia Severity Index (ISI), to evaluate the participants' sleep quality both before and after the treatment period. We also monitored the intake of other nutrients and performed blood tests to assess hormone levels related to sleep.

The results showed that magnesium supplementation led to significant improvements in areas such as sleep efficiency, sleep onset timing, and overall insomnia severity. We observed increases in serum levels of melatonin and changes in cortisol and renin levels, indicating a physiological response that could enhance sleep quality.

Overall, it seems that supplementing with magnesium has the potential to improve sleep for older adults struggling with insomnia. This finding could pave the way for new, accessible treatment options for those affected by sleep disorders.
9
Wonderful sleep aid
Most Useful Review
4 people found this helpful
I’m not a gym enthusiast but gave ZMA a try for its sleep aid properties. I occasionally suffer from insomnia, and it has worked wonders for me. An hour after taking it, I feel calm and then I’m quickly off to sleep. While I can’t verify its claims about testosterone, it’s indisputably a great sleep aid!

Common Cold details

SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.3
USERS' SCORE
Good
Based on 3 Reviews
8.1
We explored how zinc lozenges affect the duration of the common cold through a detailed analysis of multiple trials. In particular, we focused on the Mossad (1996) trial involving zinc gluconate lozenges, which revealed an average reduction of cold duration by about 4.0 days. While that sounds promising, our findings through a quantile treatment effect (QTE) analysis tell a more nuanced story.

Interestingly, the QTE analysis showed that for individuals suffering from lengthy colds lasting 15 to 17 days, the zinc lozenges could shorten their illness by as much as 8 days. On the flip side, those with shorter, 2-day colds only experienced a 1-day reduction in sickness. This suggests that while zinc may help, its effectiveness varies significantly depending on the initial duration of the cold, making the overall average effect less informative than we might think.

Our examination extended to three trials that used zinc acetate lozenges, yielding a similar average reduction of around 2.7 days. However, again, those averages concealed varying effects for short and long colds, highlighting the importance of looking beyond simple averages in treatment studies.

Overall, we observed that zinc lozenges can indeed help with cold duration, but the extent of that help is very much dependent on how long a person has been suffering. This approach to understanding treatment effects through QTE analysis could have important implications not just for cold treatment but also for analyzing other health outcomes.
9
Excellent for immunity
Most Useful Review
I absolutely love it. It serves as an excellent sleep aid and significantly boosts my immune system. I haven’t caught a common cold for a year while taking it, although there is a slight acidic smell upon opening the bottle.

Chronic Fatigue Syndrome details

SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7.1
USERS' SCORE
Good
Based on 8 Reviews
8
We explored the relationship between serum zinc levels and chronic fatigue syndrome (CFS) in a study that compared patients with CFS to normal volunteers. By using an atomic absorption method, we measured serum zinc concentrations and found that those suffering from CFS had significantly lower levels of zinc compared to healthy individuals.

Interestingly, we observed a trend indicating that lower zinc levels correlated with greater CFS severity. Patients also reported a negative correlation between their zinc levels and their subjective experiences of infection. This suggests that zinc plays a role in the immune dysfunction commonly seen in CFS.

Furthermore, we noted that lower serum zinc was associated with higher levels of inflammatory markers and certain defects in the early activation of T cells. Since zinc acts as a potent antioxidant, our findings indicate that CFS is linked to increased oxidative stress in these patients. Given this, it may be beneficial for some CFS patients to consider zinc supplements as part of their treatment approach.
9
Relieves fatigue effectively
Most Useful Review
This product effectively alleviates fatigue. I consume it when I exercise rigorously, and I notice I feel less exhausted the next day. Additionally, it provides excellent sleep quality, making it a good choice for a restorative night's rest.

Sleep Apnea details

SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Moderately Good
Based on 66 Reviews
7.6
We explored how zinc affects heart function in the context of obstructive sleep apnea (OSA), specifically focusing on cases of intermittent hypoxia (IH). In a detailed study using male rats, researchers set up different groups: a control group and one that underwent 10 weeks of exercise training. Half of the rats in both groups were exposed to IH conditions to simulate the effects of sleep apnea.

The results were eye-opening. Rats that experienced IH showed notable impairment in their heart's left ventricular function, characterized by reduced ejection fraction and increased inflammation. However, when treated with zinc, these negative effects were significantly countered. Notably, those who exercised and received zinc treatment displayed improved heart function and antioxidant capabilities compared to their counterparts that did not receive zinc.

On the flip side, exercise alone did not provide the same protective benefits when zinc was absent. The findings suggest that zinc is essential not only for the heart's protection against the damaging effects of IH but also enhances the benefits of physical exercise. This research indicates the importance of zinc in potentially managing heart health in individuals suffering from sleep apnea.
7.5
Improved sleep quality
Most Useful Review
29 people found this helpful
Gorgeous combination of zinc, magnesium, and vitamin B6! Optimum Nutrition's ZMA is essential for maximum recovery post-training. Zinc regulates cell growth and tissue repair, while magnesium maintains water-salt balance, generates energy, and normalises neuromuscular function. Exercising increases the need for these minerals, making ZMA a perfect supplement. Avoid taking ZMA with dairy or calcium supplements as it may reduce the anabolic effect and increase kidney stone risk. The effects are noticeably superior to other brands; I sleep like a baby on days I take it. My morning fatigue vanished with ZMA. I take 2 capsules before bedtime. Wishing you good health and a successful shopping experience on iHerb!
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