I have a weird reaction to most fish oil supplements. Usually whenever I take those large pills, my skin breaks out with deep cystic Acne, although that seems counterintuitive due to fish oil's anti-inflammatory effects. I have had this reaction to fish oil pills my entire life. This brand is the only fish oil brand that actually helps my skin and doesn't cause breakouts. It's also very easy to swallow. I recently ran out of my last bottle of MegaRed, so I tried another brand that my doctor gave me. Within a few days, I developed 3 cystic Acne lesions on my face (one on my temple, cheek, and neck). I have not have any problems with Acne in a few years until now. I immediately ceased taking those supplements and ordered another bottle of this one. Bonus: these are much easier to swallow. Highly recommend. For the record, I am a 48 year old woman