Calcium's role in bone pain unclearIn-depth clinical characterization of intravenous iron infusion-induced hypophosphatemic osteomalacia and its resolution.
Calcium's effect isn't isolated
We explored the impact of calcium treatment on bone pain in patients who developed osteomalacia, a condition linked to intravenous iron infusions. Our focus was on a group of 13 patients diagnosed with this condition, who experienced low phosphate levels due to excess fibroblast growth factor 23 (iFGF23) after receiving ferric carboxymaltose (FCM) infusions.
After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.
Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.
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Riluzole effectively reduces bone painThe TREK-1 potassium channel is involved in both the analgesic and anti-proliferative effects of riluzole in bone cancer pain.
Highly relevant treatment insights.
We explored whether riluzole could help ease bone pain caused by prostate cancer. Using a mouse model that mimicked human bone cancer pain, we treated some mice with riluzole while others were not.
Our findings indicated that riluzole significantly reduced pain sensitivity without hindering cancer progression or bone health. This treatment seems effective in offering relief from unpleasant pain sensations associated with bone metastases.
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Potassium aids bone pain reliefTubulointerstitial nephritis-induced hypophosphatemic osteomalacia in Sjögren's syndrome: a case report and review of the literature.
Study reveals potassium's importance
We explored a unique case where a 39-year-old man presented with severe bone pain due to Sjögren's syndrome-related renal issues. He also exhibited symptoms like polydipsia and hypophosphatemic osteomalacia. After one month of potassium, phosphate, vitamin D, and sodium bicarbonate supplements, we observed significant relief in his bone pain, alongside normalized potassium and phosphorus levels. This indicates that potassium intake can play a crucial role in alleviating bone pain linked to kidney dysfunction in autoimmune conditions, such as Sjögren's syndrome.
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Potassium aids bone pain reliefNephrogenic hypophosphatemic osteomalacia during adefovir monotherapy for chronic hepatitis B monoinfection.
Significant improvement in bone pain.
We examined the effects of low-dose adefovir therapy on bone pain in patients showing signs of nephrogenic hypophosphatemic osteomalacia. Over two years, five patients developed reduced phosphate levels and renal issues, leading to bone pain. After stopping the treatment and providing phosphate and potassium supplements, we noticed significant decreases in bone pain and improved mobility in some patients. This indicates that potassium treatment, alongside phosphate supplementation, can positively affect bone pain related to kidney issues stemming from adefovir.
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We explored a unique case of a 22-year-old woman with Sjögren’s syndrome who experienced unexpected symptoms, including severe bone pain and hypokalemic paralysis.
After thorough diagnostics, including serological tests and assessments, she was diagnosed with distal renal tubular acidosis linked to her condition.
An intensive treatment plan focused on stabilizing her potassium levels effectively relieved her symptoms within just two weeks.
This case highlights the importance of recognizing Sjögren's syndrome early, especially in younger patients, and the need for a comprehensive approach to treatment.
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