Last update
3/27/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 29 Reviews
8.1
Supplement Facts
Serving Size: 2 Tablets
Amount Per Serving
%DV
Calories
10
Total Carbohydrate
2 g
1%**
Vitamin C (as Ascorbic Acid)
60 mg
67%
Manganese (as Manganese Sulfate)
2 mg
87%
Sodium
35 mg
2%
Glucosamine HCl
1,500 mg (1.5 g)
***
Joint Shield™ 5-Loxin Advanced® Boswellia serrata Extract (resin)
100 mg
***
Chondroitin/MSM ComplexChondroitin Sulfate, Methylsulfonylmethane (MSM), Collagen (Hydrolyzed Gelatin), Boswellia serrata (resin), Boron (as Bororganic Glycine), Hyaluronic Acid
1,103 mg (1.1 g)
***
Top Medical Research Studies
8
Glucosamine and exercise enhance arthritis treatment
We sought to determine whether a combination of a nutrition supplement, including glucosamine and chondroitin, along with supervised exercise, is more effective for knee osteoarthritis than exercise alone.
In a six-month double-blinded trial involving 65 participants, those who took the supplement experienced significant improvements in pain and stiffness earlier compared to those receiving a placebo.
This suggests that using glucosamine chondroitin supplementation along with exercise could be a more efficient treatment strategy for arthritis in the knee.
In a six-month double-blinded trial involving 65 participants, those who took the supplement experienced significant improvements in pain and stiffness earlier compared to those receiving a placebo.
This suggests that using glucosamine chondroitin supplementation along with exercise could be a more efficient treatment strategy for arthritis in the knee.
Read More
Most Useful Reviews
9
Significant pain reduction
6 people found this helpful
I purchased this for my mother after she began having arthritis. After a week of use, she reported less twisting of her joints at night and a significant decrease in pain. She also occasionally takes collagen. I recommend this complex for anyone with joint diseases or as a preventative measure.
Read More
9
Improved joint condition
5 people found this helpful
I bought this nutritional supplement for my mother to maintain her joint health due to arthritis. I was pleased to find a 120 capsule option that was quite affordable, especially with a discount. It was delivered quickly within 8 days. Since she started taking it, she has experienced less aching in her joints during bad weather, and her overall condition has improved remarkably. I will certainly order this supplement again.
Read More
10
Zero pain relief
3 people found this helpful
Works!!! I am impressed by how well this product works. I suffer from osteoarthritis in both thumbs, which has worsened recently. After starting this product, I am happy to report that I experience zero pain. 99% of the pain is gone now.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
- All Researches
8
Glucosamine and exercise enhance arthritis treatment
We sought to determine whether a combination of a nutrition supplement, including glucosamine and chondroitin, along with supervised exercise, is more effective for knee osteoarthritis than exercise alone.
In a six-month double-blinded trial involving 65 participants, those who took the supplement experienced significant improvements in pain and stiffness earlier compared to those receiving a placebo.
This suggests that using glucosamine chondroitin supplementation along with exercise could be a more efficient treatment strategy for arthritis in the knee.
In a six-month double-blinded trial involving 65 participants, those who took the supplement experienced significant improvements in pain and stiffness earlier compared to those receiving a placebo.
This suggests that using glucosamine chondroitin supplementation along with exercise could be a more efficient treatment strategy for arthritis in the knee.
Read More
User Reviews
USERS' SCORE
Good
Based on 29 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Significant pain reduction
6 people found this helpful
I purchased this for my mother after she began having arthritis. After a week of use, she reported less twisting of her joints at night and a significant decrease in pain. She also occasionally takes collagen. I recommend this complex for anyone with joint diseases or as a preventative measure.
Read More
9
Improved joint condition
5 people found this helpful
I bought this nutritional supplement for my mother to maintain her joint health due to arthritis. I was pleased to find a 120 capsule option that was quite affordable, especially with a discount. It was delivered quickly within 8 days. Since she started taking it, she has experienced less aching in her joints during bad weather, and her overall condition has improved remarkably. I will certainly order this supplement again.
Read More
10
Zero pain relief
3 people found this helpful
Works!!! I am impressed by how well this product works. I suffer from osteoarthritis in both thumbs, which has worsened recently. After starting this product, I am happy to report that I experience zero pain. 99% of the pain is gone now.
Read More
8.5
Reduced pain frequency
2 people found this helpful
I have been taking Osteo Bi-Flex with type 2 collagen for six months due to my arthritis. These products have significantly reduced the constant pain I experienced in my hands and knees. Although I know the disease cannot be completely cured, I feel supported in managing my joint health and the pain occurs much less frequently now.
Read More
10
Increased mobility noted
1 people found this helpful
I suffer from widespread arthritis, and my knees were severely affected, causing debilitating pain. After trying Osteo Bi-Flex, I noticed improvements within weeks; I could walk better and experienced much less pain when getting up or sitting. I couldn't believe how rejuvenated I felt, able to enjoy long walks again with reduced reliance on a cane. The cost is manageable, especially on a fixed income—this is truly an excellent product.
Read More
Frequently Asked Questions
10
Pain relief achieved
1 people found this helpful
I introduced this to my 66-year-old father, who was suffering from knee pain due to arthritis. Within a week of treatment, his symptoms disappeared, and he no longer needed anti-inflammatory or analgesic drugs. He now takes this medication consistently and the results are verified. The price is excellent compared to alternatives.
9
Effective for arthritis
I have arthritis in my knee, and it works extremely well. I've been using it for three months and have no intention of stopping.
8.5
Reduced pain frequency
2 people found this helpful
I have been taking Osteo Bi-Flex with type 2 collagen for six months due to my arthritis. These products have significantly reduced the constant pain I experienced in my hands and knees. Although I know the disease cannot be completely cured, I feel supported in managing my joint health and the pain occurs much less frequently now.
0
Relief from pain
3 people found this helpful
I've used this product for three years, having first obtained a sample. As a fitness enthusiast, I experienced joint issues and was diagnosed with arthrosis. My rheumatologist advised an increased dosage due to my physical activities. This supplement has provided significant support for my arthritis and arthrosis in my knees and hips.
9
Significant pain reduction
6 people found this helpful
I purchased this for my mother after she began having arthritis. After a week of use, she reported less twisting of her joints at night and a significant decrease in pain. She also occasionally takes collagen. I recommend this complex for anyone with joint diseases or as a preventative measure.
9
Improved joint condition
5 people found this helpful
I bought this nutritional supplement for my mother to maintain her joint health due to arthritis. I was pleased to find a 120 capsule option that was quite affordable, especially with a discount. It was delivered quickly within 8 days. Since she started taking it, she has experienced less aching in her joints during bad weather, and her overall condition has improved remarkably. I will certainly order this supplement again.
7.5
Improved joint health
Good product I ordered for my father, who suffers from arthritis and inflammation in his leg joints. During the course of taking it, he noticed an improvement, especially when combining it with omega and Vitamin D3. I believe that for anyone with joint problems, a course twice a year could be beneficial.
10
Increased mobility noted
1 people found this helpful
I suffer from widespread arthritis, and my knees were severely affected, causing debilitating pain. After trying Osteo Bi-Flex, I noticed improvements within weeks; I could walk better and experienced much less pain when getting up or sitting. I couldn't believe how rejuvenated I felt, able to enjoy long walks again with reduced reliance on a cane. The cost is manageable, especially on a fixed income—this is truly an excellent product.
8
Glucosamine and exercise enhance arthritis treatment
We sought to determine whether a combination of a nutrition supplement, including glucosamine and chondroitin, along with supervised exercise, is more effective for knee osteoarthritis than exercise alone.
In a six-month double-blinded trial involving 65 participants, those who took the supplement experienced significant improvements in pain and stiffness earlier compared to those receiving a placebo.
This suggests that using glucosamine chondroitin supplementation along with exercise could be a more efficient treatment strategy for arthritis in the knee.
In a six-month double-blinded trial involving 65 participants, those who took the supplement experienced significant improvements in pain and stiffness earlier compared to those receiving a placebo.
This suggests that using glucosamine chondroitin supplementation along with exercise could be a more efficient treatment strategy for arthritis in the knee.
References
- Liu W, Yu Y, Zhang Z, Li Z, Wu Y, et al. Nutrition supplementation combined with exercise versus exercise alone in treating knee osteoarthritis: a double-blinded, randomised, placebo-controlled trial. Age Ageing. 2025;54. 10.1093/ageing/afaf010
