' 
![]()
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8.2
USERS' SCORE
Good
Based on 1 Reviews
8.6
Top Medical Research Studies
9
Microneedling depth impacts scars
Evaluation of microneedling depth of penetration in management of atrophic acne scars: a split-face comparative study.
Moderate relevance to collagen treatment
In our exploration of treating atrophic acne scars, we focused on the effects of different microneedling depths using Dermapen. We designed a split-face study involving 14 individuals, where each side of their face received a different treatment depth over six sessions, spaced two weeks apart.
On one side, the needles penetrated 2.5 mm into the skin, while the other side used 1.5 mm. We observed a noticeable difference in the improvement of scars, with the deeper 2.5 mm treatment showing significantly better results both clinically and at a cellular level.
The findings suggest that deeper microneedling might foster better collagen induction, which is crucial for skin repair. Both treatments improved collagen and elastin fibers, but the more profound impact from the deeper needles highlights how penetration depth might be a key factor in achieving effective results in scar management.
On one side, the needles penetrated 2.5 mm into the skin, while the other side used 1.5 mm. We observed a noticeable difference in the improvement of scars, with the deeper 2.5 mm treatment showing significantly better results both clinically and at a cellular level.
The findings suggest that deeper microneedling might foster better collagen induction, which is crucial for skin repair. Both treatments improved collagen and elastin fibers, but the more profound impact from the deeper needles highlights how penetration depth might be a key factor in achieving effective results in scar management.
Read More
8
Collagen treatment shows potential
Comment on "A Split-Face Study to Evaluate Efficacy of Autologous Injectable Platelet-Rich Fibrin With Microneedling Against Microneedling With Normal Saline (Placebo Control) in Atrophic Acne Scars".
Relevant to collagen's impact
This study investigated how effective autologous injectable platelet-rich fibrin (PRF) is when combined with microneedling in treating atrophic acne scars. We observed that this approach was compared to microneedling with a normal saline placebo, aiming to assess the specific impact of collagen stimulation on these scars.
The methodology involved a split-face design, allowing for a direct comparison on each patient's skin. In this way, we could monitor the results and determine whether the collagen boost from PRF made a significant difference in healing acne scars.
While we noted some positive results, the overall effectiveness of collagen treatment was intertwined with the microneedling technique used. This means that while collagen plays a vital role in skin repair, the exact benefits from PRF alone were challenging to isolate due to the dual treatment approach. Consequently, we are left with a nuanced understanding—collagen treatments have potential, yet more research is necessary to fully capture their independent effects.
The methodology involved a split-face design, allowing for a direct comparison on each patient's skin. In this way, we could monitor the results and determine whether the collagen boost from PRF made a significant difference in healing acne scars.
While we noted some positive results, the overall effectiveness of collagen treatment was intertwined with the microneedling technique used. This means that while collagen plays a vital role in skin repair, the exact benefits from PRF alone were challenging to isolate due to the dual treatment approach. Consequently, we are left with a nuanced understanding—collagen treatments have potential, yet more research is necessary to fully capture their independent effects.
Read More
8
Hybrid fillers for acne scars
Minimally Invasive Post-Acne Scars Treatment with the Hybrid Filler HArmonyCa™.
Collagen's role remains unclear
We examined the use of a hybrid filler called HArmonyCa™, which combines hyaluronic acid (HA) and calcium hydroxyapatite (CaHa), as a promising solution for treating post-acne scarring. This approach not only aims to restore volume but also stimulates collagen production—critical for improving skin texture and elasticity.
In our analysis, HArmonyCa™ was used alongside other treatments, including Volite™ injections, CO2 laser resurfacing, and chemical peels. The outcome was noteworthy; patients reported significant improvements in the appearance of their skin. Changes included a smoother texture and less shadowing, leading to heightened satisfaction with the results.
While the findings are encouraging, it's important to remember that further studies are necessary to fully understand the efficacy of collagen in acne treatment specifically. Our journey into this innovative treatment has provided valuable insights, but we must continue exploring to establish its long-term benefits clearly.
In our analysis, HArmonyCa™ was used alongside other treatments, including Volite™ injections, CO2 laser resurfacing, and chemical peels. The outcome was noteworthy; patients reported significant improvements in the appearance of their skin. Changes included a smoother texture and less shadowing, leading to heightened satisfaction with the results.
While the findings are encouraging, it's important to remember that further studies are necessary to fully understand the efficacy of collagen in acne treatment specifically. Our journey into this innovative treatment has provided valuable insights, but we must continue exploring to establish its long-term benefits clearly.
Read More
Most Useful Reviews
10
Completely gone
This collagen has been a game-changer! After a couple of weeks of daily use, my horrible acne has completely gone. Additionally, it's a fantastic source of protein with a superb protein to calorie ratio! I highly recommend it to everyone.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8.2
9
Microneedling depth impacts scars
Evaluation of microneedling depth of penetration in management of atrophic acne scars: a split-face comparative study.
Moderate relevance to collagen treatment
In our exploration of treating atrophic acne scars, we focused on the effects of different microneedling depths using Dermapen. We designed a split-face study involving 14 individuals, where each side of their face received a different treatment depth over six sessions, spaced two weeks apart.
On one side, the needles penetrated 2.5 mm into the skin, while the other side used 1.5 mm. We observed a noticeable difference in the improvement of scars, with the deeper 2.5 mm treatment showing significantly better results both clinically and at a cellular level.
The findings suggest that deeper microneedling might foster better collagen induction, which is crucial for skin repair. Both treatments improved collagen and elastin fibers, but the more profound impact from the deeper needles highlights how penetration depth might be a key factor in achieving effective results in scar management.
On one side, the needles penetrated 2.5 mm into the skin, while the other side used 1.5 mm. We observed a noticeable difference in the improvement of scars, with the deeper 2.5 mm treatment showing significantly better results both clinically and at a cellular level.
The findings suggest that deeper microneedling might foster better collagen induction, which is crucial for skin repair. Both treatments improved collagen and elastin fibers, but the more profound impact from the deeper needles highlights how penetration depth might be a key factor in achieving effective results in scar management.
Read More
9
Effective collagen treatments for scars
Efficacy of Polycaprolactone Threads in Treating Atrophic Acne Scars: A Split-face Comparative Study.
Moderate connection to collagen impact
We set out to explore the effectiveness of collagen treatment for atrophic acne scars using two different approaches: polycaprolactone (PCL) threads and microneedling combined with platelet-rich plasma (PRP). In our research, 24 patients participated in a split-face study where one side of the face was treated with PCL threads, and the other side underwent microneedling with PRP. Each participant received four sessions of microneedling on one side, while the other side was treated with just one session of threads.
After monitoring the patients for six months, we observed a significant improvement in skin texture and scar appearance. Specifically, 95.8% of patients noted progress on the side treated with threads compared to 83.3% on the microneedling side. Additionally, satisfaction ratings were notably higher among those who received the thread treatment.
Both procedures were associated with mild side effects, like transient swelling and redness, which cleared up quickly. Our findings suggest that PCL threads could be a promising collagen-boosting alternative for treating acne scars, providing effective results with minimal discomfort.
After monitoring the patients for six months, we observed a significant improvement in skin texture and scar appearance. Specifically, 95.8% of patients noted progress on the side treated with threads compared to 83.3% on the microneedling side. Additionally, satisfaction ratings were notably higher among those who received the thread treatment.
Both procedures were associated with mild side effects, like transient swelling and redness, which cleared up quickly. Our findings suggest that PCL threads could be a promising collagen-boosting alternative for treating acne scars, providing effective results with minimal discomfort.
Read More
8
Investigation of collagen in acne
The combination of RL-QN15 and OH-CATH30 promotes the repair of acne via the TLR2/NF-κB pathway.
Collagen's role not isolated
We examined the potential of two peptides, RL-QN15 and OH-CATH30, to address acne treatment challenges. By applying these peptides topically to mice, we aimed to see if they could suppress the proliferation of P. acnes, the bacteria linked to acne, and reduce inflammation associated with skin damage.
Our findings showed that the combination of these peptides led to a significant decrease in the expression of various pro-inflammatory cytokines, such as IL-1β and TNF-α. This reduction plays a vital role in lessening the redness and swelling often seen in acne. Additionally, we noticed that the combined treatment seemed to promote collagen deposition in the skin, which is essential for healing.
Mechanistically, the treatment worked by inhibiting the activation of the TLR2/NF-κB signaling pathway, which is known to regulate inflammation. While there was improvement in collagen deposition, we did not isolate its specific impact on the overall healing of acne, making it difficult to attribute the observed benefits solely to collagen.
Overall, our study demonstrates promising results from using RL-QN15 and OH-CATH30 in acne management and highlights the important role of the TLR2/NF-κB pathway as a target for future treatments.
Our findings showed that the combination of these peptides led to a significant decrease in the expression of various pro-inflammatory cytokines, such as IL-1β and TNF-α. This reduction plays a vital role in lessening the redness and swelling often seen in acne. Additionally, we noticed that the combined treatment seemed to promote collagen deposition in the skin, which is essential for healing.
Mechanistically, the treatment worked by inhibiting the activation of the TLR2/NF-κB signaling pathway, which is known to regulate inflammation. While there was improvement in collagen deposition, we did not isolate its specific impact on the overall healing of acne, making it difficult to attribute the observed benefits solely to collagen.
Overall, our study demonstrates promising results from using RL-QN15 and OH-CATH30 in acne management and highlights the important role of the TLR2/NF-κB pathway as a target for future treatments.
Read More
8
Hybrid fillers for acne scars
Minimally Invasive Post-Acne Scars Treatment with the Hybrid Filler HArmonyCa™.
Collagen's role remains unclear
We examined the use of a hybrid filler called HArmonyCa™, which combines hyaluronic acid (HA) and calcium hydroxyapatite (CaHa), as a promising solution for treating post-acne scarring. This approach not only aims to restore volume but also stimulates collagen production—critical for improving skin texture and elasticity.
In our analysis, HArmonyCa™ was used alongside other treatments, including Volite™ injections, CO2 laser resurfacing, and chemical peels. The outcome was noteworthy; patients reported significant improvements in the appearance of their skin. Changes included a smoother texture and less shadowing, leading to heightened satisfaction with the results.
While the findings are encouraging, it's important to remember that further studies are necessary to fully understand the efficacy of collagen in acne treatment specifically. Our journey into this innovative treatment has provided valuable insights, but we must continue exploring to establish its long-term benefits clearly.
In our analysis, HArmonyCa™ was used alongside other treatments, including Volite™ injections, CO2 laser resurfacing, and chemical peels. The outcome was noteworthy; patients reported significant improvements in the appearance of their skin. Changes included a smoother texture and less shadowing, leading to heightened satisfaction with the results.
While the findings are encouraging, it's important to remember that further studies are necessary to fully understand the efficacy of collagen in acne treatment specifically. Our journey into this innovative treatment has provided valuable insights, but we must continue exploring to establish its long-term benefits clearly.
Read More
8
Collagen treatment shows potential
Comment on "A Split-Face Study to Evaluate Efficacy of Autologous Injectable Platelet-Rich Fibrin With Microneedling Against Microneedling With Normal Saline (Placebo Control) in Atrophic Acne Scars".
Relevant to collagen's impact
This study investigated how effective autologous injectable platelet-rich fibrin (PRF) is when combined with microneedling in treating atrophic acne scars. We observed that this approach was compared to microneedling with a normal saline placebo, aiming to assess the specific impact of collagen stimulation on these scars.
The methodology involved a split-face design, allowing for a direct comparison on each patient's skin. In this way, we could monitor the results and determine whether the collagen boost from PRF made a significant difference in healing acne scars.
While we noted some positive results, the overall effectiveness of collagen treatment was intertwined with the microneedling technique used. This means that while collagen plays a vital role in skin repair, the exact benefits from PRF alone were challenging to isolate due to the dual treatment approach. Consequently, we are left with a nuanced understanding—collagen treatments have potential, yet more research is necessary to fully capture their independent effects.
The methodology involved a split-face design, allowing for a direct comparison on each patient's skin. In this way, we could monitor the results and determine whether the collagen boost from PRF made a significant difference in healing acne scars.
While we noted some positive results, the overall effectiveness of collagen treatment was intertwined with the microneedling technique used. This means that while collagen plays a vital role in skin repair, the exact benefits from PRF alone were challenging to isolate due to the dual treatment approach. Consequently, we are left with a nuanced understanding—collagen treatments have potential, yet more research is necessary to fully capture their independent effects.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Reviews
8.6
10
Completely gone
This collagen has been a game-changer! After a couple of weeks of daily use, my horrible acne has completely gone. Additionally, it's a fantastic source of protein with a superb protein to calorie ratio! I highly recommend it to everyone.
