Infographics 
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.3
USERS' SCORE
Good
Based on 2 Reviews
8.7
Top Medical Research Studies
8
We explored the effects of eicosapentaenoic acid (EPA), a key component of omega-3 fatty acids, on patients with rheumatoid arthritis (RA). This analysis gathered data from eighteen randomized controlled trials involving over a thousand RA patients, ensuring a comprehensive look at its impact.
Our findings revealed that EPA supplementation significantly increased levels of both eicosapentaenoic acid and docosahexaenoic acid (DHA). Additionally, we noted a reduction in the omega-6 to omega-3 fatty acid ratio, which is beneficial for overall health.
Moreover, we observed that EPA led to a decrease in triglyceride levels and tender joint counts among RA patients. However, while there were slight decreases in markers of inflammation, such as erythrocyte sedimentation rate and C-reactive protein, these changes were not statistically significant.
Overall, our analysis supports the idea that EPA has positive effects on lipid profiles and joint tenderness for those with RA, although not all inflammatory markers showed significant improvement.
Our findings revealed that EPA supplementation significantly increased levels of both eicosapentaenoic acid and docosahexaenoic acid (DHA). Additionally, we noted a reduction in the omega-6 to omega-3 fatty acid ratio, which is beneficial for overall health.
Moreover, we observed that EPA led to a decrease in triglyceride levels and tender joint counts among RA patients. However, while there were slight decreases in markers of inflammation, such as erythrocyte sedimentation rate and C-reactive protein, these changes were not statistically significant.
Overall, our analysis supports the idea that EPA has positive effects on lipid profiles and joint tenderness for those with RA, although not all inflammatory markers showed significant improvement.
Read More
9
We conducted a study to examine the effects of eicosapentaenoic acid (EPA) combined with l-serine on individuals suffering from chronic low-back and knee pain. This was a randomized, double-blind, placebo-controlled trial, ensuring rigorous evaluation of the treatment's impact.
Over the course of 12 weeks, we assessed participants using well-structured questionnaires to measure their pain levels and overall experience. Our group comprised 120 adults who, despite enduring persistent pain for more than three months, showed promising results from the active treatment.
It appears that EPA, known for its anti-inflammatory properties, alongside l-serine, which supports nerve function, provided noticeable relief from pain. By the end of the study, many participants experienced significant improvements in their pain scores, suggesting that this combination could be a valuable option for those managing arthritis-related discomfort.
It's encouraging to see how l-serine and EPA can help enhance the quality of life for individuals struggling with painful conditions, reinforcing their importance as potential treatments for arthritis-related pain.
Over the course of 12 weeks, we assessed participants using well-structured questionnaires to measure their pain levels and overall experience. Our group comprised 120 adults who, despite enduring persistent pain for more than three months, showed promising results from the active treatment.
It appears that EPA, known for its anti-inflammatory properties, alongside l-serine, which supports nerve function, provided noticeable relief from pain. By the end of the study, many participants experienced significant improvements in their pain scores, suggesting that this combination could be a valuable option for those managing arthritis-related discomfort.
It's encouraging to see how l-serine and EPA can help enhance the quality of life for individuals struggling with painful conditions, reinforcing their importance as potential treatments for arthritis-related pain.
Read More
8
Dietary compliance and EPA impact
We observed participants in the ADIRA trial, which aimed to see how different diets could affect rheumatoid arthritis. The study divided fifty patients into two groups: one followed an anti-inflammatory diet rich in whole grains, fruits, vegetables, and seafood, while the other consumed a control diet heavy in meat and high-fat dairy products for ten weeks. After this period, participants switched diets, allowing researchers to monitor their compliance with the prescribed eating patterns.
Our focus was on how well participants adhered to their diets, particularly regarding important dietary components like eicosapentaenoic acid (EPA), a fatty acid found in seafood known for its potential anti-inflammatory benefits. By analyzing blood samples for dietary biomarkers, we could assess their intake of whole grains, cooking oils, seafood, and fats and how these relate to the expected positive effects on arthritis.
The findings suggested that participants generally complied well with the diet emphasizing whole grains, cooking fats, seafood, and overall dietary fat quality, which is where EPA features prominently. However, we noted some uncertainty about compliance regarding fruit and vegetable intake, making it unclear if these elements were adequately incorporated into their diets.
Overall, while our study highlighted the compliance to an anti-inflammatory diet's key components, the specific impact of eicosapentaenoic acid on arthritis symptoms requires further investigation to draw solid conclusions about its effectiveness.
Our focus was on how well participants adhered to their diets, particularly regarding important dietary components like eicosapentaenoic acid (EPA), a fatty acid found in seafood known for its potential anti-inflammatory benefits. By analyzing blood samples for dietary biomarkers, we could assess their intake of whole grains, cooking oils, seafood, and fats and how these relate to the expected positive effects on arthritis.
The findings suggested that participants generally complied well with the diet emphasizing whole grains, cooking fats, seafood, and overall dietary fat quality, which is where EPA features prominently. However, we noted some uncertainty about compliance regarding fruit and vegetable intake, making it unclear if these elements were adequately incorporated into their diets.
Overall, while our study highlighted the compliance to an anti-inflammatory diet's key components, the specific impact of eicosapentaenoic acid on arthritis symptoms requires further investigation to draw solid conclusions about its effectiveness.
Read More
Most Useful Reviews
10
Remarkable pain relief
4 people found this helpful
I struggled with walking and severe pain when going to bed, especially in my lower back and left hip. After starting Pharmepa RESTORE—taking it for seven days—my pain significantly diminished, allowing me to walk and work for longer. I am grateful for Pharmepa RESTORE; it acts quickly to alleviate pain caused by arthritis. Although I still experience some pain when getting up at night, I often forget about the issue throughout the day. Thank you for your help; I wish to continue using these products.
Read More
9
Less joint stiffness
2 people found this helpful
It works great for me. I had severe joint pain after my daughter was born, likely due to psoriatic arthritis. I researched ways to help my condition safely while nursing and found pure EPA helpful. After a few days of taking Pharmepa RESTORE, I experienced a significant improvement: much less joint stiffness and pain. I can walk up the stairs in the morning pain-free! It's also easy to swallow without the fishy aftertaste found in other products.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.3
- All Researches
9
We conducted a study to examine the effects of eicosapentaenoic acid (EPA) combined with l-serine on individuals suffering from chronic low-back and knee pain. This was a randomized, double-blind, placebo-controlled trial, ensuring rigorous evaluation of the treatment's impact.
Over the course of 12 weeks, we assessed participants using well-structured questionnaires to measure their pain levels and overall experience. Our group comprised 120 adults who, despite enduring persistent pain for more than three months, showed promising results from the active treatment.
It appears that EPA, known for its anti-inflammatory properties, alongside l-serine, which supports nerve function, provided noticeable relief from pain. By the end of the study, many participants experienced significant improvements in their pain scores, suggesting that this combination could be a valuable option for those managing arthritis-related discomfort.
It's encouraging to see how l-serine and EPA can help enhance the quality of life for individuals struggling with painful conditions, reinforcing their importance as potential treatments for arthritis-related pain.
Over the course of 12 weeks, we assessed participants using well-structured questionnaires to measure their pain levels and overall experience. Our group comprised 120 adults who, despite enduring persistent pain for more than three months, showed promising results from the active treatment.
It appears that EPA, known for its anti-inflammatory properties, alongside l-serine, which supports nerve function, provided noticeable relief from pain. By the end of the study, many participants experienced significant improvements in their pain scores, suggesting that this combination could be a valuable option for those managing arthritis-related discomfort.
It's encouraging to see how l-serine and EPA can help enhance the quality of life for individuals struggling with painful conditions, reinforcing their importance as potential treatments for arthritis-related pain.
Read More
9
We investigated the impact of eicosapentaenoic acid (EPA) on osteoarthritis (OA) progression through an innovative approach involving gelatin hydrogels. In our study, we divided ten-week-old male mice into six different groups, each receiving various treatments after undergoing surgery that mimicked OA. This design allowed us to effectively compare the benefits of EPA delivered directly and through hydrogels.
Our findings revealed that when EPA was delivered in gelatin hydrogels, it significantly outperformed EPA injection alone in slowing down OA progression. Specifically, we measured several inflammatory markers and found that the group receiving the gelatin hydrogels exhibited lower levels of harmful proteins linked to inflammation and cartilage damage compared to those receiving just the EPA injections.
This suggests that the controlled release of EPA from these hydrogels can be a promising new strategy for treating OA. The potential benefits of gelatin hydrogels in enhancing the effectiveness of EPA treatment present a valuable insight for future therapeutic approaches addressing arthritis.
Our findings revealed that when EPA was delivered in gelatin hydrogels, it significantly outperformed EPA injection alone in slowing down OA progression. Specifically, we measured several inflammatory markers and found that the group receiving the gelatin hydrogels exhibited lower levels of harmful proteins linked to inflammation and cartilage damage compared to those receiving just the EPA injections.
This suggests that the controlled release of EPA from these hydrogels can be a promising new strategy for treating OA. The potential benefits of gelatin hydrogels in enhancing the effectiveness of EPA treatment present a valuable insight for future therapeutic approaches addressing arthritis.
Read More
8
We explored the effects of eicosapentaenoic acid (EPA), a key component of omega-3 fatty acids, on patients with rheumatoid arthritis (RA). This analysis gathered data from eighteen randomized controlled trials involving over a thousand RA patients, ensuring a comprehensive look at its impact.
Our findings revealed that EPA supplementation significantly increased levels of both eicosapentaenoic acid and docosahexaenoic acid (DHA). Additionally, we noted a reduction in the omega-6 to omega-3 fatty acid ratio, which is beneficial for overall health.
Moreover, we observed that EPA led to a decrease in triglyceride levels and tender joint counts among RA patients. However, while there were slight decreases in markers of inflammation, such as erythrocyte sedimentation rate and C-reactive protein, these changes were not statistically significant.
Overall, our analysis supports the idea that EPA has positive effects on lipid profiles and joint tenderness for those with RA, although not all inflammatory markers showed significant improvement.
Our findings revealed that EPA supplementation significantly increased levels of both eicosapentaenoic acid and docosahexaenoic acid (DHA). Additionally, we noted a reduction in the omega-6 to omega-3 fatty acid ratio, which is beneficial for overall health.
Moreover, we observed that EPA led to a decrease in triglyceride levels and tender joint counts among RA patients. However, while there were slight decreases in markers of inflammation, such as erythrocyte sedimentation rate and C-reactive protein, these changes were not statistically significant.
Overall, our analysis supports the idea that EPA has positive effects on lipid profiles and joint tenderness for those with RA, although not all inflammatory markers showed significant improvement.
Read More
8
We explored the effects of eicosapentaenoic acid (EPA) on chondrocytes, the cells responsible for maintaining cartilage health. Specifically, we examined how these cells respond to stress from palmitic acid (PA) and high glucose levels, both of which are linked to conditions like osteoarthritis.
Our research highlighted that exposure to PA increases inflammatory responses and degenerative processes in chondrocytes. These stresses lead to the overproduction of certain harmful enzymes and inflammatory compounds that can contribute to joint pain and degradation.
Encouragingly, when we introduced EPA, we observed a notable reduction in these inflammatory effects. Not only did EPA help suppress the detrimental responses caused by PA and high glucose, but it also significantly lowered the expression of enzymes associated with degeneration.
Our findings suggest that maintaining a balance between saturated fats and omega-3 fatty acids like EPA is crucial for cartilage health. This emphasizes the importance of dietary choices in managing conditions like osteoarthritis, particularly in individuals with metabolic disorders.
Our research highlighted that exposure to PA increases inflammatory responses and degenerative processes in chondrocytes. These stresses lead to the overproduction of certain harmful enzymes and inflammatory compounds that can contribute to joint pain and degradation.
Encouragingly, when we introduced EPA, we observed a notable reduction in these inflammatory effects. Not only did EPA help suppress the detrimental responses caused by PA and high glucose, but it also significantly lowered the expression of enzymes associated with degeneration.
Our findings suggest that maintaining a balance between saturated fats and omega-3 fatty acids like EPA is crucial for cartilage health. This emphasizes the importance of dietary choices in managing conditions like osteoarthritis, particularly in individuals with metabolic disorders.
Read More
8
Dietary compliance and EPA impact
We observed participants in the ADIRA trial, which aimed to see how different diets could affect rheumatoid arthritis. The study divided fifty patients into two groups: one followed an anti-inflammatory diet rich in whole grains, fruits, vegetables, and seafood, while the other consumed a control diet heavy in meat and high-fat dairy products for ten weeks. After this period, participants switched diets, allowing researchers to monitor their compliance with the prescribed eating patterns.
Our focus was on how well participants adhered to their diets, particularly regarding important dietary components like eicosapentaenoic acid (EPA), a fatty acid found in seafood known for its potential anti-inflammatory benefits. By analyzing blood samples for dietary biomarkers, we could assess their intake of whole grains, cooking oils, seafood, and fats and how these relate to the expected positive effects on arthritis.
The findings suggested that participants generally complied well with the diet emphasizing whole grains, cooking fats, seafood, and overall dietary fat quality, which is where EPA features prominently. However, we noted some uncertainty about compliance regarding fruit and vegetable intake, making it unclear if these elements were adequately incorporated into their diets.
Overall, while our study highlighted the compliance to an anti-inflammatory diet's key components, the specific impact of eicosapentaenoic acid on arthritis symptoms requires further investigation to draw solid conclusions about its effectiveness.
Our focus was on how well participants adhered to their diets, particularly regarding important dietary components like eicosapentaenoic acid (EPA), a fatty acid found in seafood known for its potential anti-inflammatory benefits. By analyzing blood samples for dietary biomarkers, we could assess their intake of whole grains, cooking oils, seafood, and fats and how these relate to the expected positive effects on arthritis.
The findings suggested that participants generally complied well with the diet emphasizing whole grains, cooking fats, seafood, and overall dietary fat quality, which is where EPA features prominently. However, we noted some uncertainty about compliance regarding fruit and vegetable intake, making it unclear if these elements were adequately incorporated into their diets.
Overall, while our study highlighted the compliance to an anti-inflammatory diet's key components, the specific impact of eicosapentaenoic acid on arthritis symptoms requires further investigation to draw solid conclusions about its effectiveness.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
10
Remarkable pain relief
4 people found this helpful
I struggled with walking and severe pain when going to bed, especially in my lower back and left hip. After starting Pharmepa RESTORE—taking it for seven days—my pain significantly diminished, allowing me to walk and work for longer. I am grateful for Pharmepa RESTORE; it acts quickly to alleviate pain caused by arthritis. Although I still experience some pain when getting up at night, I often forget about the issue throughout the day. Thank you for your help; I wish to continue using these products.
Read More
9
Less joint stiffness
2 people found this helpful
It works great for me. I had severe joint pain after my daughter was born, likely due to psoriatic arthritis. I researched ways to help my condition safely while nursing and found pure EPA helpful. After a few days of taking Pharmepa RESTORE, I experienced a significant improvement: much less joint stiffness and pain. I can walk up the stairs in the morning pain-free! It's also easy to swallow without the fishy aftertaste found in other products.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Wang W, Xu Y, Zhou J, Zang Y. Effects of omega-3 supplementation on lipid metabolism, inflammation, and disease activity in rheumatoid arthritis: a meta-analysis of randomized controlled trials. Clin Rheumatol. 2024;43:2479. 10.1007/s10067-024-07040-0
- Jannas-Vela S, Candia AA, Peñailillo L, Barrios-Troncoso P, Zapata-Urzúa J, et al. Role of specialized pro-resolving mediators on inflammation, cardiometabolic health, disease progression, and quality of life after omega-3 PUFA supplementation and aerobic exercise training in individuals with rheumatoid arthritis: a randomized 16-week, placebo-controlled interventional trial. F1000Res. 2023;12:942. 10.12688/f1000research.138392.1
- Deng C, Presle N, Pizard A, Guillaume C, Bianchi A, et al. Beneficial Impact of Eicosapentaenoic Acid on the Adverse Effects Induced by Palmitate and Hyperglycemia on Healthy Rat Chondrocyte. Int J Mol Sci. 2024;25. 10.3390/ijms25031810
- Poggioli R, Hirani K, Jogani VG, Ricordi C. Modulation of inflammation and immunity by omega-3 fatty acids: a possible role for prevention and to halt disease progression in autoimmune, viral, and age-related disorders. Eur Rev Med Pharmacol Sci. 2023;27:7380. 10.26355/eurrev_202308_33310
- Wadell AT, Bärebring L, Hulander E, Gjertsson I, Landberg R, et al. Dietary biomarkers and food records indicate compliance to study diets in the ADIRA (Anti-inflammatory Diet In Rheumatoid Arthritis) trial. Front Nutr. 2023;10:1209787. 10.3389/fnut.2023.1209787
- Marchand NE, Choi MY, Oakes EG, Cook NR, Stevens E, et al. Over-the-counter fish oil supplementation and pro-resolving and pro-inflammatory lipid mediators in rheumatoid arthritis. Prostaglandins Leukot Essent Fatty Acids. 2023;190:102542. 10.1016/j.plefa.2023.102542
- Lindqvist HM, Winkvist A, Gjertsson I, Calder PC, Armando AM, et al. Influence of Dietary n-3 Long Chain Polyunsaturated Fatty Acid Intake on Oxylipins in Erythrocytes of Women with Rheumatoid Arthritis. Molecules. 2023;28. 10.3390/molecules28020717
- Kuang X, Shao X, Li H, Jiang D, Gao T, et al. Lipid extract from blue mussel (Mytilus edulis) improves glycemic traits in Chinese type 2 diabetic mellitus patients: a double-blind randomized controlled trial. J Sci Food Agric. 2023;103:2970. 10.1002/jsfa.12346
- Gkiouras K, Grammatikopoulou MG, Myrogiannis I, Papamitsou T, Rigopoulou EI, et al. Efficacy of n-3 fatty acid supplementation on rheumatoid arthritis' disease activity indicators: a systematic review and meta-analysis of randomized placebo-controlled trials. Crit Rev Food Sci Nutr. 2024;64:16. 10.1080/10408398.2022.2104210
- Stonehouse W, Benassi-Evans B, Bednarz J, Vincent AD, Hall S, et al. Krill oil improved osteoarthritic knee pain in adults with mild to moderate knee osteoarthritis: a 6-month multicenter, randomized, double-blind, placebo-controlled trial. Am J Clin Nutr. 2022;116:672. 10.1093/ajcn/nqac125
- Eckert T, Jährling-Butkus M, Louton H, Burg-Roderfeld M, Zhang R, et al. Efficacy of Chondroprotective Food Supplements Based on Collagen Hydrolysate and Compounds Isolated from Marine Organisms. Mar Drugs. 2021;19. 10.3390/md19100542
- Ceotto BH, Figueroba SR, Ferreira LEN, Amorim KS, Sánchez JB, et al. The effect of association of aspirin and omega 3 in rat temporomandibular joint with induced arthritis. Ann Anat. 2022;239:151812. 10.1016/j.aanat.2021.151812
- Fan Z, Ross RP, Stanton C, Hou B, Zhao J, et al. CCFM1074 Alleviates Collagen-Induced Arthritis in Rats Balancing Treg/Th17 and Modulating the Metabolites and Gut Microbiota. Front Immunol. 2021;12:680073. 10.3389/fimmu.2021.680073
- Sasahara I, Yamamoto A, Takeshita M, Suga Y, Suzuki K, et al. l-Serine and EPA Relieve Chronic Low-Back and Knee Pain in Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. J Nutr. 2020;150:2278. 10.1093/jn/nxaa156
- Brown Z, Metcalf R, Bednarz J, Spargo L, Lee A, et al. Modifiable Lifestyle Factors Associated With Response to Treatment in Early Rheumatoid Arthritis. ACR Open Rheumatol. 2020;2:371. 10.1002/acr2.11132
- Tsubosaka M, Kihara S, Hayashi S, Nagata J, Kuwahara T, et al. Gelatin hydrogels with eicosapentaenoic acid can prevent osteoarthritis progression in vivo in a mouse model. J Orthop Res. 2020;38:2157. 10.1002/jor.24688
