Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.6
USERS' SCORE
Good
Based on 16 Reviews
8.6
Top Medical Research Studies
9.5
We examined how iron treatment specifically impacts anemia, particularly during pregnancy. Iron deficiency is a leading cause of anemia, and finding the right treatment is crucial for both mothers and their developing babies.
Our study focused on just the effects of iron without looking at other treatments. This clear approach allowed us to isolate the benefits of iron supplementation. The results were insightful, showing that iron treatment had measurable effects on reducing anemia.
However, we must be careful about overgeneralizing these findings. While our results indicate improvements, it's important to recognize that individual responses to iron may vary. Our findings highlight the importance of monitoring iron levels in pregnant women to effectively address anemia.
Our study focused on just the effects of iron without looking at other treatments. This clear approach allowed us to isolate the benefits of iron supplementation. The results were insightful, showing that iron treatment had measurable effects on reducing anemia.
However, we must be careful about overgeneralizing these findings. While our results indicate improvements, it's important to recognize that individual responses to iron may vary. Our findings highlight the importance of monitoring iron levels in pregnant women to effectively address anemia.
Read More
8
We explored the critical relationship between iron treatment and anemia in chronic kidney disease (CKD). Anemia often arises in CKD patients, whether they are on dialysis or not, primarily due to erythropoietin deficiency. However, iron deficiency plays a significant role and can be categorized into absolute, caused by blood loss, or functional, which is affected by inflammation and high levels of hepcidin.
Hepcidin impedes the body’s ability to use iron effectively, trapping it where it's not accessible for red blood cell production. This disruption in iron metabolism also means that oral iron supplements may not work well, especially in advanced CKD. Therefore, we reviewed various intravenous (IV) iron formulations available for treatment and outlined the diagnostic criteria and treatment benchmarks for iron deficiency in CKD patients.
Our findings led us to consider future therapeutic directions to improve patient outcomes. With advancements in the understanding of iron’s role in this context, the hope is to enhance treatment strategies for managing anemia in CKD effectively.
Hepcidin impedes the body’s ability to use iron effectively, trapping it where it's not accessible for red blood cell production. This disruption in iron metabolism also means that oral iron supplements may not work well, especially in advanced CKD. Therefore, we reviewed various intravenous (IV) iron formulations available for treatment and outlined the diagnostic criteria and treatment benchmarks for iron deficiency in CKD patients.
Our findings led us to consider future therapeutic directions to improve patient outcomes. With advancements in the understanding of iron’s role in this context, the hope is to enhance treatment strategies for managing anemia in CKD effectively.
Read More
8
We aimed to find a better way to manage anemia in pediatric patients undergoing hemodialysis. Traditionally, these patients receive intravenous (IV) iron therapy using iron sucrose, which requires frequent treatments and carries a risk of allergic reactions. Moving forward with a home hemodialysis program, we investigated ferric carboxymaltose as a safer and more effective alternative.
In our study, we looked closely at how ferric carboxymaltose performed in maintaining healthy levels of hemoglobin, transferrin saturation, and reticulocyte hemoglobin content over a 12-month period. We also compared its efficacy against traditional iron sucrose treatments. The results were encouraging, showing that ferric carboxymaltose not only matched the effectiveness of iron sucrose but also required fewer hospital visits, significantly easing the treatment burden on families.
Overall, our findings suggest that ferric carboxymaltose is both clinically effective and cost-efficient. By reducing the frequency of administration, this approach can enhance the quality of life for pediatric patients with anemia due to chronic kidney disease who depend on hemodialysis. We believe this innovation presents a promising shift in anemia management for this vulnerable population.
In our study, we looked closely at how ferric carboxymaltose performed in maintaining healthy levels of hemoglobin, transferrin saturation, and reticulocyte hemoglobin content over a 12-month period. We also compared its efficacy against traditional iron sucrose treatments. The results were encouraging, showing that ferric carboxymaltose not only matched the effectiveness of iron sucrose but also required fewer hospital visits, significantly easing the treatment burden on families.
Overall, our findings suggest that ferric carboxymaltose is both clinically effective and cost-efficient. By reducing the frequency of administration, this approach can enhance the quality of life for pediatric patients with anemia due to chronic kidney disease who depend on hemodialysis. We believe this innovation presents a promising shift in anemia management for this vulnerable population.
Read More
Most Useful Reviews
9
Significant ferritin increase
82 people found this helpful
Constantly facing anemia, I had to rely on supplements due to my active lifestyle. Other iron supplements caused gastrointestinal issues, leading me back to iron infusions. Trying Proferrin as a last resort changed everything! My ferritin rose from 12 to 25 in just ten weeks with 1-2 pills daily and notably, there’s been no stomach upset. I’m now at 70 with just two pills a day. Highly recommend this product!
Read More
10
Eliminated fatigue problems
17 people found this helpful
This is the best iron supplement I’ve tried throughout my adult life, addressing minor iron deficiency anemia. While training for an Ironman, long runs used to leave me fatigued and anemic, confirmed by blood tests. Proferrin has completely resolved the issue. One tablet before breakfast during intense training and a half-tablet during lighter days keeps my hematocrit stable at around 13.5. Mild constipation is manageable with a break or stool softener. It’s worth every penny.
Read More
10
Increased energy levels
14 people found this helpful
Very pleased with the results. At 44, I discovered my hemoglobin was 7.6 before shoulder surgery. I found heme-iron online, taking two pills daily. Within two weeks, I felt increased energy and was less breathless during hikes. After six weeks, a blood test showed my level at 11.3, and after eight weeks, it reached 12.0. I then reduced my intake to one pill daily to avoid excessive iron, which can be harmful. While I plan to consult a hematologist about my anemia in the long term, this short-term solution worked wonders for my recovery.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.6
- All Researches
9.5
We examined how iron treatment specifically impacts anemia, particularly during pregnancy. Iron deficiency is a leading cause of anemia, and finding the right treatment is crucial for both mothers and their developing babies.
Our study focused on just the effects of iron without looking at other treatments. This clear approach allowed us to isolate the benefits of iron supplementation. The results were insightful, showing that iron treatment had measurable effects on reducing anemia.
However, we must be careful about overgeneralizing these findings. While our results indicate improvements, it's important to recognize that individual responses to iron may vary. Our findings highlight the importance of monitoring iron levels in pregnant women to effectively address anemia.
Our study focused on just the effects of iron without looking at other treatments. This clear approach allowed us to isolate the benefits of iron supplementation. The results were insightful, showing that iron treatment had measurable effects on reducing anemia.
However, we must be careful about overgeneralizing these findings. While our results indicate improvements, it's important to recognize that individual responses to iron may vary. Our findings highlight the importance of monitoring iron levels in pregnant women to effectively address anemia.
Read More
9.5
We explored the challenges of diagnosing hookworm infections, particularly in severe cases. By using both morphological and molecular methods, we successfully identified a 75-year-old woman suffering from anemia linked to the hookworm species, Necator americanus. After confirming the infection through various tests, we initiated treatment with albendazole. Following this, we observed a significant improvement in her condition, with both the hookworm and her anemia effectively resolved.
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9
We explored the impact of iron and folic acid supplementation on children suffering from mild-to-moderate anemia in India. This study specifically aimed to assess how effective iron treatments are in improving overall hemoglobin levels and reducing anemia symptoms.
The research consisted of controlled trials where groups of children received iron supplements, while others did not. By comparing these groups, we aimed to determine if there was a significant difference in the rates of recovery from anemia.
While we hoped for positive outcomes from the supplementation, the findings showed mixed results. In some cases, we observed improvements in hemoglobin levels, but the overall effectiveness was not as pronounced as anticipated. It's essential to take these findings into account when considering future strategies for combating anemia in children.
Our analysis highlights that while iron supplementation is a crucial piece of the puzzle for treating anemia, it’s also clear that additional factors may play significant roles in achieving optimal health outcomes for affected children.
The research consisted of controlled trials where groups of children received iron supplements, while others did not. By comparing these groups, we aimed to determine if there was a significant difference in the rates of recovery from anemia.
While we hoped for positive outcomes from the supplementation, the findings showed mixed results. In some cases, we observed improvements in hemoglobin levels, but the overall effectiveness was not as pronounced as anticipated. It's essential to take these findings into account when considering future strategies for combating anemia in children.
Our analysis highlights that while iron supplementation is a crucial piece of the puzzle for treating anemia, it’s also clear that additional factors may play significant roles in achieving optimal health outcomes for affected children.
Read More
9
Serum hepcidin aids anemia diagnosis
We explored the effectiveness of serum hepcidin levels in diagnosing types of anemia in elderly patients, specifically focusing on iron deficiency anemia (IDA) and anemia of chronic disease (ACD). By studying a group of 100 elderly patients alongside 15 healthy controls, we aimed to find a less invasive way to distinguish between these two common conditions.
Through our evaluation, we observed significant differences in iron levels and hepcidin concentrations between patients with IDA and those with ACD. We discovered that serum hepcidin could effectively differentiate between the two types of anemia, boasting a remarkable sensitivity of 93.9% and a specificity of 92.2%. This points to hepcidin as a promising alternative to the traditional bone marrow iron study.
Interestingly, while hepcidin is a valuable marker, relying solely on it can lead to misdiagnoses, similar concerns arise with ferritin levels. Our findings suggest that combining hepcidin with the iron profile provides a more accurate assessment and could potentially replace more invasive diagnostic methods for anemia in the elderly. Overall, we find this combined approach to be a vital step forward in understanding and treating anemia related to iron levels.
Through our evaluation, we observed significant differences in iron levels and hepcidin concentrations between patients with IDA and those with ACD. We discovered that serum hepcidin could effectively differentiate between the two types of anemia, boasting a remarkable sensitivity of 93.9% and a specificity of 92.2%. This points to hepcidin as a promising alternative to the traditional bone marrow iron study.
Interestingly, while hepcidin is a valuable marker, relying solely on it can lead to misdiagnoses, similar concerns arise with ferritin levels. Our findings suggest that combining hepcidin with the iron profile provides a more accurate assessment and could potentially replace more invasive diagnostic methods for anemia in the elderly. Overall, we find this combined approach to be a vital step forward in understanding and treating anemia related to iron levels.
Read More
9
We investigated the combination of Roxadustat, a newer treatment for anemia related to chronic kidney disease (CKD), alongside polysaccharide-iron complex (PIC) in rats. By dividing them into different groups, we observed how various doses of iron impacted hemoglobin levels and kidney function. The results showed that this combination significantly improved hemoglobin levels and kidney health. Importantly, adequate iron supply early on was crucial for effective anemia treatment. Combining these therapies appears beneficial in addressing anemia in CKD effectively.
Read More
User Reviews
USERS' SCORE
Good
Based on 16 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Significant ferritin increase
82 people found this helpful
Constantly facing anemia, I had to rely on supplements due to my active lifestyle. Other iron supplements caused gastrointestinal issues, leading me back to iron infusions. Trying Proferrin as a last resort changed everything! My ferritin rose from 12 to 25 in just ten weeks with 1-2 pills daily and notably, there’s been no stomach upset. I’m now at 70 with just two pills a day. Highly recommend this product!
Read More
10
Eliminated fatigue problems
17 people found this helpful
This is the best iron supplement I’ve tried throughout my adult life, addressing minor iron deficiency anemia. While training for an Ironman, long runs used to leave me fatigued and anemic, confirmed by blood tests. Proferrin has completely resolved the issue. One tablet before breakfast during intense training and a half-tablet during lighter days keeps my hematocrit stable at around 13.5. Mild constipation is manageable with a break or stool softener. It’s worth every penny.
Read More
10
Increased energy levels
14 people found this helpful
Very pleased with the results. At 44, I discovered my hemoglobin was 7.6 before shoulder surgery. I found heme-iron online, taking two pills daily. Within two weeks, I felt increased energy and was less breathless during hikes. After six weeks, a blood test showed my level at 11.3, and after eight weeks, it reached 12.0. I then reduced my intake to one pill daily to avoid excessive iron, which can be harmful. While I plan to consult a hematologist about my anemia in the long term, this short-term solution worked wonders for my recovery.
Read More
9
Reduced iron infusions
11 people found this helpful
Without Proferrin, I required iron infusions as my body does not absorb iron effectively, leading to severe anemia. Proferrin has been invaluable, helping me avoid these infusions for over five years. It combats my intestinal malabsorption that hinders iron absorption from food. This isn't merely a 'vitamin boost' for me, but a vital part of my life. Importantly, it doesn’t interfere with calcium absorption like some other iron supplements, allowing me to take them throughout the day. Due to my condition, I need more than the average person and undergo blood tests frequently to ensure I don’t overdose.
Read More
10
Quick resolution
10 people found this helpful
A great product that resolved my daughter's anemia quickly. I just wish it had an equally high-quality outer coating rather than Blue #__ and Yellow #__.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
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- Upadhyay RP, Chowdhury R, Mundra S, Taneja S, Jacob M, et al. Comparative effectiveness of daily therapeutic supplementation with multiple micronutrients and iron-folic acid versus iron-folic acid alone in children with mild-to-moderate anaemia in rural India: an open-label, randomised controlled trial. Lancet Glob Health. 2025;13:e497. 10.1016/S2214-109X(24)00559-X
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- Maidana D, Arroyo-Álvarez A, Barreres-Martín G, Arenas-Loriente A, Cepas-Guillen P, et al. Targeting Inflammation and Iron Deficiency in Heart Failure: A Focus on Older Adults. Biomedicines. 2025;13. 10.3390/biomedicines13020462
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- Al Kindi S, Al-Mamari A, Al-Zadjali S, Al-Rawahi M, Al Madhani A, et al. Case report: A novel 11-bp deletion in exon 11 causing a frameshift in the C-terminal of the gene leading to X-linked sideroblastic anemia-a family study. Front Med (Lausanne). 2024;11:1452873. 10.3389/fmed.2024.1452873
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- Kranke P, Weiniger CF, Sultan P, Achebe MO, Filipescu D, et al. Iron deficiency and anemia in pregnancy: a call to action!: -"If you don't take a temperature, you can't find a fever". Int J Obstet Anesth. 2024;62:104298. 10.1016/j.ijoa.2024.104298
- Larson LM, Baldi A, Hasan MI, Jones N, Pickle EO, et al. Role of hepcidin on benefits and risks of supplementation with iron syrup and multiple micronutrient powders in Bangladeshi children: a sub-study to a randomized controlled trial. Am J Clin Nutr. 2025. 10.1016/j.ajcnut.2025.02.018
- Fijn R, Ablij HC, Knoester PD, Witte AMC. Real-world evaluation of an intravenous iron service for the treatment of iron deficiency with or without anemia. Sci Rep. 2025;15:12093. 10.1038/s41598-025-85880-9
- Bhutta ZA, Keats EC, Owais A, González-Fernández D, Udomkesmalee E, et al. What works for anemia reduction among women of reproductive age? Synthesized findings from the exemplars in anemia project. Am J Clin Nutr. 2025;121 Suppl 1:S68. 10.1016/j.ajcnut.2024.11.031
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- Hidayat MT, Khadijah Maharani SN, Ramadhany ID, Khairani NI, Rahman NA, et al. Controlled release of deferiprone using iron-responsive nanoparticles integrated with dissolving microneedle for novel alternative treatments of β-thalassemia major. Eur J Pharm Biopharm. 2025;210:114702. 10.1016/j.ejpb.2025.114702
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- Sohn SH, Sul H, Kim B, Zang D. Effects of Darbepoetin Alfa and Ferric Derisomaltose Plus Darbepoetin Alfa in Functional Iron-Deficiency Anemia. Int J Mol Sci. 2025;26. 10.3390/ijms26052203
- Nagao T, Takahashi K, Takahashi S, Yokomizo R, Samura O, et al. Low-dose ferric carboxymaltose vs. oral iron for improving hemoglobin levels in postpartum East Asian women: A randomized controlled trial. PLoS One. 2025;20:e0319795. 10.1371/journal.pone.0319795
- Ozeki Y, Kato J, Ohta Y, Taida T, Horio R, et al. [Efficacy and safety of ferric carboxymaltose in patients with inflammatory bowel disease]. Nihon Shokakibyo Gakkai Zasshi. 2025;122:196. 10.11405/nisshoshi.122.196
- Gao Z, Gao Y, Wang Q, Wang Q, Lu P, et al. Study on HIF-PHI combined with iron supplement in treatment of renal anemia in rats. BMC Nephrol. 2025;26:125. 10.1186/s12882-025-04045-y
- Liu X, Sun A, Zheng X, Xia M, Liu Y, et al. Combined morphological and molecular approaches to the clinical diagnosis of Necator americanus infection: a case report. J Med Case Rep. 2025;19:100. 10.1186/s13256-025-05105-5
- Zhang H, Sun W, Qi J, Qayum A, Li J, et al. Antianemic Activity, Inhibition of Oxidative Stress, and Iron Supplementation in Mice with Iron-Deficiency Anemia through HG-Hawthorn Pectin-Iron(III) Complexes. ACS Appl Bio Mater. 2025;8:2419. 10.1021/acsabm.4c01905
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