5/6/2025
Last update
5/6/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.8
USERS' SCORE
Good
Based on 6 Reviews
8.4
Top Medical Research Studies
8
We explored whether chondroitin and glucosamine can slow the progression of osteoarthritis in the temporomandibular joint (TMJ) of rabbits.
In our study, 36 male rabbits were divided into three groups to assess the impact of treatment on collagen levels and inflammation.
The findings suggest that treatment with these compounds can delay collagen degeneration and lower inflammation markers in the joints, which indicates a potential preventive effect on osteoarthritis.
In our study, 36 male rabbits were divided into three groups to assess the impact of treatment on collagen levels and inflammation.
The findings suggest that treatment with these compounds can delay collagen degeneration and lower inflammation markers in the joints, which indicates a potential preventive effect on osteoarthritis.
Read More
7
We investigated how effective crystalline glucosamine sulfate (CGS) is for treating knee osteoarthritis (OA) in a year-long study with 111 participants. They were split into two groups: one received CGS while the other used standard nonsteroidal anti-inflammatory drugs for treatment.
One year later, all patients reported reduced pain, but those taking CGS felt significantly less pain than those on NSAIDs. However, neither group showed any reduction in the progression of joint damage. So, while CGS helped with symptoms, it didn’t stop OA from worsening.
One year later, all patients reported reduced pain, but those taking CGS felt significantly less pain than those on NSAIDs. However, neither group showed any reduction in the progression of joint damage. So, while CGS helped with symptoms, it didn’t stop OA from worsening.
Read More
9
We explored an exciting new treatment for rheumatoid arthritis (RA) using a mesoporous silica nanosystem called MSN-TP@PDA-GlcN. This innovative approach combines glucosamine with a powerful anti-inflammatory drug, enabling targeted delivery within the joints.
Our tests showed that this nanosystem effectively reduced inflammation and protected joint tissues without causing toxicity. It released medications steadily in acidic environments found in inflamed joints, offering hope for improved RA treatments.
Thus, MSN-TP@PDA-GlcN presents a promising strategy to combat the debilitating effects of RA.
Our tests showed that this nanosystem effectively reduced inflammation and protected joint tissues without causing toxicity. It released medications steadily in acidic environments found in inflamed joints, offering hope for improved RA treatments.
Thus, MSN-TP@PDA-GlcN presents a promising strategy to combat the debilitating effects of RA.
Read More
Most Useful Reviews
10
Complete pain relief
2 people found this helpful
I suffered hip joint pain for about six months. I was hesitant to see another doctor, but this product worked wonders. Within a few days, my hip pain improved dramatically, and it was gone completely in a couple of weeks!
Read More
9
Great alternative
2 people found this helpful
Excellent for arthritis. If you suffer from arthritis and prefer to avoid the doctor until absolutely necessary, this is the best product to try.
Read More
9
Effective for knees
1 people found this helpful
Fantastic product. I use this for the osteoarthritis in my knees and joints, and it works effectively.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.8
- All Researches
9
We investigated how glucosamine, along with other nutrients, combined with exercise compares to exercise alone for knee osteoarthritis. In this double-blinded, controlled trial with 65 participants, those receiving the nutrition supplement showed better improvements in pain and stiffness scores after three months compared to the exercise-only group.
By six months, benefits continued to favor the supplement group, highlighting its earlier effectiveness. This indicates that incorporating glucosamine into arthritis treatment may lead to quicker and more significant relief when paired with exercise.
By six months, benefits continued to favor the supplement group, highlighting its earlier effectiveness. This indicates that incorporating glucosamine into arthritis treatment may lead to quicker and more significant relief when paired with exercise.
Read More
9
We explored an exciting new treatment for rheumatoid arthritis (RA) using a mesoporous silica nanosystem called MSN-TP@PDA-GlcN. This innovative approach combines glucosamine with a powerful anti-inflammatory drug, enabling targeted delivery within the joints.
Our tests showed that this nanosystem effectively reduced inflammation and protected joint tissues without causing toxicity. It released medications steadily in acidic environments found in inflamed joints, offering hope for improved RA treatments.
Thus, MSN-TP@PDA-GlcN presents a promising strategy to combat the debilitating effects of RA.
Our tests showed that this nanosystem effectively reduced inflammation and protected joint tissues without causing toxicity. It released medications steadily in acidic environments found in inflamed joints, offering hope for improved RA treatments.
Thus, MSN-TP@PDA-GlcN presents a promising strategy to combat the debilitating effects of RA.
Read More
9
Dietary supplement aids arthritis symptoms
We explored the effectiveness of a nutritional supplement containing hydrolyzed collagen, chondroitin sulfate, and glucosamine in reducing pain from osteoarthritis (OA).
In this observational study, 186 patients took the supplement daily for six months. They reported significant decreases in joint pain and improved physical function over that time.
Notably, there were no serious side effects. Overall, our findings suggest this supplement could be beneficial for managing OA symptoms effectively.
In this observational study, 186 patients took the supplement daily for six months. They reported significant decreases in joint pain and improved physical function over that time.
Notably, there were no serious side effects. Overall, our findings suggest this supplement could be beneficial for managing OA symptoms effectively.
Read More
8
We explored whether chondroitin and glucosamine can slow the progression of osteoarthritis in the temporomandibular joint (TMJ) of rabbits.
In our study, 36 male rabbits were divided into three groups to assess the impact of treatment on collagen levels and inflammation.
The findings suggest that treatment with these compounds can delay collagen degeneration and lower inflammation markers in the joints, which indicates a potential preventive effect on osteoarthritis.
In our study, 36 male rabbits were divided into three groups to assess the impact of treatment on collagen levels and inflammation.
The findings suggest that treatment with these compounds can delay collagen degeneration and lower inflammation markers in the joints, which indicates a potential preventive effect on osteoarthritis.
Read More
8
Glucosamine and chondroitin benefits assessed
We examined the effectiveness of glucosamine sulfate (GS) and chondroitin sulfate (CS) for knee osteoarthritis (KOA) through a systematic review. Using a thorough analysis of various studies, we found that both GS and CS offer significant benefits—specifically, CS helps reduce joint pain and improves physical function, while GS decreases joint space narrowing.
However, when combined, they didn't show any significant improvement in symptoms. This suggests that more focused clinical trials are needed to truly understand how these treatments work together.
However, when combined, they didn't show any significant improvement in symptoms. This suggests that more focused clinical trials are needed to truly understand how these treatments work together.
Read More
User Reviews
USERS' SCORE
Good
Based on 6 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
10
Complete pain relief
2 people found this helpful
I suffered hip joint pain for about six months. I was hesitant to see another doctor, but this product worked wonders. Within a few days, my hip pain improved dramatically, and it was gone completely in a couple of weeks!
Read More
9
Great alternative
2 people found this helpful
Excellent for arthritis. If you suffer from arthritis and prefer to avoid the doctor until absolutely necessary, this is the best product to try.
Read More
9
Effective for knees
1 people found this helpful
Fantastic product. I use this for the osteoarthritis in my knees and joints, and it works effectively.
Read More
7.5
Comparable to expensive glucosamine
41 people found this helpful
I have severe osteoarthritis, especially in my feet, ankles, and knees. I had found relief with Dona's Crystalline glucosamine but at a high cost. I tried Puritan's Pride, and to my surprise, it works just as well at a much lower price. My joints feel better overall, and my husband's pain is entirely relieved.
Read More
9
Effective powder capsules
30 people found this helpful
These are powder-filled capsules rather than solid pills. My husband has taken these for 40 years. After a few weeks, he could get into a tall truck without pain and has experienced minimal pain from osteoarthritis throughout the years.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Park YB, Kim JH. Effectiveness and Safety of SYSADOAs Used in Eastern and Western Regions for the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials-SYSADOAs Are Effective and Safe for Knee OA. Medicina (Kaunas). 2025;61. 10.3390/medicina61020331
- Liu W, Yu Y, Zhang Z, Li Z, Wu Y, et al. Nutrition supplementation combined with exercise versus exercise alone in treating knee osteoarthritis: a double-blinded, randomised, placebo-controlled trial. Age Ageing. 2025;54. 10.1093/ageing/afaf010
- Amarase C, Tanavalee A, Ngarmukos S, Tanavalee C, Jaruthien N, et al. Comparison of functional performance outcomes between oral patented crystalline glucosamine sulfate and platelet-rich plasma among knee osteoarthritis patients: a propensity score matching analysis. Aging Clin Exp Res. 2024;36:168. 10.1007/s40520-024-02814-7
- Malaguez GG, Artuzi FE, Quevedo AS, Puricelli E, Ponzoni D. Can treatment with chondroitin and glucosamine sulphate prevent changes in the articular disc caused by temporomandibular joint osteoarthritis?. J Oral Rehabil. 2024;51:2289. 10.1111/joor.13814
- Wu YZ, Chen WY, Zeng Y, Ji QL, Yang Y, et al. Inflammation-Responsive Mesoporous Silica Nanoparticles with Synergistic Anti-inflammatory and Joint Protection Effects for Rheumatoid Arthritis Treatment. Pharm Res. 2024;41:1493. 10.1007/s11095-024-03732-z
- Mazurov VI, Belyaeva IB, Trofimov EA, Itskovich IE, Burulev AL. [Comparative efficacy of a combination of undenatured type II collagen, Boswellic acids, methylsulfonylmethane, vitamins C and D and a combination of chondroitin sulfate and glucosamine hydrochloride in the treatment of primary osteoarthritis of the knee joint]. Ter Arkh. 2023;95:1141. 10.26442/00403660.2023.12.202540
- Rabade A, Viswanatha GL, Nandakumar K, Kishore A. Evaluation of efficacy and safety of glucosamine sulfate, chondroitin sulfate, and their combination regimen in the management of knee osteoarthritis: a systematic review and meta-analysis. Inflammopharmacology. 2024;32:1759. 10.1007/s10787-024-01460-9
- Alves JC, Santos A, Lafuente P. Evaluation of different substance combinations in a multiple-session mesotherapy protocol for the management of osteoarthritis in dogs: a retrospective study. J Am Vet Med Assoc. 2024;262:1. 10.2460/javma.23.10.0588
- Vu HM, Tran HD, Nguyen AK, Han BO, Hoang BX. Effectiveness of Bach Nien Kien Health Supplement in the Treatment of Patients With Symptomatic Knee Osteoarthritis. In Vivo. 2024;38:963. 10.21873/invivo.13528
- Puigdellívol Grifell J, Comellas Berenguer C, Steinbacher G, Kranjcec T, Álvarez Díaz P, et al. Open, Observational, Single-Arm, Multicenter Study Assessing the Effectiveness of a Dietary Supplement Containing Hydrolyzed Collagen, Chondroitin Sulfate, and Glucosamine for Osteoarthritis Pain Reduction. J Diet Suppl. 2024;21:374. 10.1080/19390211.2023.2284982
- Wang F, Liu G, Shi J, Wang J, Zheng S, et al. Effects of glucosamine hydrochloride combined with non-steroidal anti-inflammatory drugs on symptoms and HSS scores in patients with knee osteoarthritis. Pak J Pharm Sci. 2023;36:1337.
- Wang F, Liu G, Shi J, Wang J, Zheng S, et al. Effects of glucosamine hydrochloride combined with non-steroidal anti-inflammatory drugs on symptoms and HSS scores in patients with knee osteoarthritis. Pak J Pharm Sci. 2023;36:921.
- Filipović K, Zvekić-Svorcan J, Demesi Drljan C, Cvetković M, Marinković D, et al. GLUCOSAMINE SULFATE EFFICACY IN TREATING KNEE OSTEOARTHRITIS: A FOLLOW-UP STUDY. Acta Clin Croat. 2022;61:436. 10.20471/acc.2022.61.03.09
- Derwich M, Górski B, Amm E, Pawłowska E. Oral Glucosamine in the Treatment of Temporomandibular Joint Osteoarthritis: A Systematic Review. Int J Mol Sci. 2023;24. 10.3390/ijms24054925
