Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 27 Researches
7.6
USERS' SCORE
Good
Based on 4 Reviews
8.7
Top Medical Research Studies
7
We conducted a randomized, double-blind, placebo-controlled trial exploring the effects of methylsulfonylmethane (MSM) on knee osteoarthritis pain. Fifty adults aged 40 to 76 participated, taking either MSM or a placebo for 12 weeks.
While MSM did show improvements in pain and physical function, there was no significant effect on stiffness or overall symptom scores. This means that while MSM might help with certain aspects of osteoarthritis, the overall benefits and long-term safety need more research.
While MSM did show improvements in pain and physical function, there was no significant effect on stiffness or overall symptom scores. This means that while MSM might help with certain aspects of osteoarthritis, the overall benefits and long-term safety need more research.
Read More
5
We explored the effectiveness of methylsulfonylmethane (MSM) in treating knee osteoarthritis in a carefully designed clinical trial. Forty-nine participants received either MSM or a placebo for 12 weeks, and we measured their pain and physical function using various established scales.
Although patients taking MSM reported some improvement in pain and function, these changes were minor. It's still unclear if these results have real clinical significance for those suffering from osteoarthritis.
Although patients taking MSM reported some improvement in pain and function, these changes were minor. It's still unclear if these results have real clinical significance for those suffering from osteoarthritis.
Read More
8
We explored whether chondroitin and glucosamine can slow the progression of osteoarthritis in the temporomandibular joint (TMJ) of rabbits.
In our study, 36 male rabbits were divided into three groups to assess the impact of treatment on collagen levels and inflammation.
The findings suggest that treatment with these compounds can delay collagen degeneration and lower inflammation markers in the joints, which indicates a potential preventive effect on osteoarthritis.
In our study, 36 male rabbits were divided into three groups to assess the impact of treatment on collagen levels and inflammation.
The findings suggest that treatment with these compounds can delay collagen degeneration and lower inflammation markers in the joints, which indicates a potential preventive effect on osteoarthritis.
Read More
Most Useful Reviews
9.5
Improved dog mobility
We and our dogs love these! We use them for ourselves and our older dogs who have arthritis and joint issues. This supplement has significantly improved our dogs’ symptoms, agility, and pain levels. We recommend it to all our dog-loving friends when their pets exhibit arthritis or joint problems.
Read More
9.5
Significant improvement seen
BEST VALUE AND WORKS GREAT. After my previous brand was discontinued, I spent hours comparing various glucosamine, chondroitin, and MSM options. This brand offers the best value in terms of quantity and effectiveness. I’ve been taking G+C+MSM for nearly ten years and can tell a significant difference in my joints, especially in comparison to other formulations. Missing doses leads to intense pain, confirming its efficacy in managing my rheumatoid arthritis.
Read More
7.5
Mixed benefits noted
Good product and value. While I can’t claim a miracle, my husband, our 90-pound Pit Bull, and I all use this product. We each have arthritis and stiffness issues. I started us on two pills a day, and now we’re maintaining on one. My husband feels some relief, and I believe it's helping our dog, Gracie. Although they are large pills, their slick coating makes swallowing easier. I suggest giving it a try, as it may be beneficial for you.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 27 Researches
7.6
- All Researches
9
We investigated how glucosamine, along with other nutrients, combined with exercise compares to exercise alone for knee osteoarthritis. In this double-blinded, controlled trial with 65 participants, those receiving the nutrition supplement showed better improvements in pain and stiffness scores after three months compared to the exercise-only group.
By six months, benefits continued to favor the supplement group, highlighting its earlier effectiveness. This indicates that incorporating glucosamine into arthritis treatment may lead to quicker and more significant relief when paired with exercise.
By six months, benefits continued to favor the supplement group, highlighting its earlier effectiveness. This indicates that incorporating glucosamine into arthritis treatment may lead to quicker and more significant relief when paired with exercise.
Read More
9
We explored an exciting new treatment for rheumatoid arthritis (RA) using a mesoporous silica nanosystem called MSN-TP@PDA-GlcN. This innovative approach combines glucosamine with a powerful anti-inflammatory drug, enabling targeted delivery within the joints.
Our tests showed that this nanosystem effectively reduced inflammation and protected joint tissues without causing toxicity. It released medications steadily in acidic environments found in inflamed joints, offering hope for improved RA treatments.
Thus, MSN-TP@PDA-GlcN presents a promising strategy to combat the debilitating effects of RA.
Our tests showed that this nanosystem effectively reduced inflammation and protected joint tissues without causing toxicity. It released medications steadily in acidic environments found in inflamed joints, offering hope for improved RA treatments.
Thus, MSN-TP@PDA-GlcN presents a promising strategy to combat the debilitating effects of RA.
Read More
9
Dietary supplement aids arthritis symptoms
We explored the effectiveness of a nutritional supplement containing hydrolyzed collagen, chondroitin sulfate, and glucosamine in reducing pain from osteoarthritis (OA).
In this observational study, 186 patients took the supplement daily for six months. They reported significant decreases in joint pain and improved physical function over that time.
Notably, there were no serious side effects. Overall, our findings suggest this supplement could be beneficial for managing OA symptoms effectively.
In this observational study, 186 patients took the supplement daily for six months. They reported significant decreases in joint pain and improved physical function over that time.
Notably, there were no serious side effects. Overall, our findings suggest this supplement could be beneficial for managing OA symptoms effectively.
Read More
9
MSM and mobilee support cartilage health
We investigated how methylsulfonylmethane (MSM) and a herbal extract called mobilee influence arthritis in human chondrocytes, the cells found in cartilage. By exposing these cells to interleukin (IL)-1β—a protein that can cause joint inflammation—we aimed to understand if these treatments could mitigate the damage commonly associated with osteoarthritis (OA).
We took chondrocytes from the femoral heads of patients undergoing hip replacement surgery and treated them with varying amounts of MSM and mobilee in the presence of IL-1β. Our tests measured cell survival and apoptosis—basically whether the cells lived or died—and assessed the levels of key proteins linked to cartilage breakdown and health.
Our results were encouraging. Both MSM and mobilee appeared to significantly reverse the negative effects brought on by IL-1β. Additionally, they managed to combat the activation of NF-κB, a pathway often implicated in inflammation and cell death. By reducing the levels of harmful enzymes and increasing beneficial proteins, these treatments seem to offer a potential new approach to improving joint health in arthritis patients.
In conclusion, this study suggests that MSM and mobilee could play a beneficial role in protecting cartilage cells from the inflammatory damage caused by IL-1β, providing a strong rationale for their consideration in arthritis treatment.
We took chondrocytes from the femoral heads of patients undergoing hip replacement surgery and treated them with varying amounts of MSM and mobilee in the presence of IL-1β. Our tests measured cell survival and apoptosis—basically whether the cells lived or died—and assessed the levels of key proteins linked to cartilage breakdown and health.
Our results were encouraging. Both MSM and mobilee appeared to significantly reverse the negative effects brought on by IL-1β. Additionally, they managed to combat the activation of NF-κB, a pathway often implicated in inflammation and cell death. By reducing the levels of harmful enzymes and increasing beneficial proteins, these treatments seem to offer a potential new approach to improving joint health in arthritis patients.
In conclusion, this study suggests that MSM and mobilee could play a beneficial role in protecting cartilage cells from the inflammatory damage caused by IL-1β, providing a strong rationale for their consideration in arthritis treatment.
Read More
9
We conducted a thoughtful investigation into how Methylsulfonylmethane (MSM) impacts the treatment of knee osteoarthritis (OA) when paired with glucosamine and chondroitin sulfate. In our study, 147 patients diagnosed with Kellgren-Lawrence grade I-II knee OA were randomly divided into three groups. One group received a combination of glucosamine and chondroitin sulfate, the second group received the same combination with MSM, and the third group was given a placebo.
The patients took their assigned capsules daily for three months, and we measured their pain and mobility before treatment and then at 4, 8, and 12 weeks after starting the regimen. The results revealed that the combination of glucosamine, chondroitin sulfate, and MSM offered noticeable clinical benefits for patients with knee OA. However, those taking only glucosamine and chondroitin sulfate experienced no significant improvement compared to the placebo group.
Our findings highlight the potential advantage of supplementing glucosamine and chondroitin with MSM for managing knee osteoarthritis. Nonetheless, the lack of improvement with glucosamine and chondroitin alone calls into question their effectiveness independently of MSM.
The patients took their assigned capsules daily for three months, and we measured their pain and mobility before treatment and then at 4, 8, and 12 weeks after starting the regimen. The results revealed that the combination of glucosamine, chondroitin sulfate, and MSM offered noticeable clinical benefits for patients with knee OA. However, those taking only glucosamine and chondroitin sulfate experienced no significant improvement compared to the placebo group.
Our findings highlight the potential advantage of supplementing glucosamine and chondroitin with MSM for managing knee osteoarthritis. Nonetheless, the lack of improvement with glucosamine and chondroitin alone calls into question their effectiveness independently of MSM.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Improved dog mobility
We and our dogs love these! We use them for ourselves and our older dogs who have arthritis and joint issues. This supplement has significantly improved our dogs’ symptoms, agility, and pain levels. We recommend it to all our dog-loving friends when their pets exhibit arthritis or joint problems.
Read More
9.5
Significant improvement seen
BEST VALUE AND WORKS GREAT. After my previous brand was discontinued, I spent hours comparing various glucosamine, chondroitin, and MSM options. This brand offers the best value in terms of quantity and effectiveness. I’ve been taking G+C+MSM for nearly ten years and can tell a significant difference in my joints, especially in comparison to other formulations. Missing doses leads to intense pain, confirming its efficacy in managing my rheumatoid arthritis.
Read More
7.5
Mixed benefits noted
Good product and value. While I can’t claim a miracle, my husband, our 90-pound Pit Bull, and I all use this product. We each have arthritis and stiffness issues. I started us on two pills a day, and now we’re maintaining on one. My husband feels some relief, and I believe it's helping our dog, Gracie. Although they are large pills, their slick coating makes swallowing easier. I suggest giving it a try, as it may be beneficial for you.
Read More
8.8
Significant pain relief
Very good quality. I'm 34 and already face arthritis issues. My wrist and elbow are consistently in pain. After using a different brand for 2 months with little relief, I switched to this one 2 weeks ago and have noticed substantial relief in my pain. I'm very happy.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Park YB, Kim JH. Effectiveness and Safety of SYSADOAs Used in Eastern and Western Regions for the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials-SYSADOAs Are Effective and Safe for Knee OA. Medicina (Kaunas). 2025;61. doi:10.3390/medicina61020331
- Liu W, Yu Y, Zhang Z, Li Z, Wu Y, et al. Nutrition supplementation combined with exercise versus exercise alone in treating knee osteoarthritis: a double-blinded, randomised, placebo-controlled trial. Age Ageing. 2025;54. doi:10.1093/ageing/afaf010
- Amarase C, Tanavalee A, Ngarmukos S, Tanavalee C, Jaruthien N, et al. Comparison of functional performance outcomes between oral patented crystalline glucosamine sulfate and platelet-rich plasma among knee osteoarthritis patients: a propensity score matching analysis. Aging Clin Exp Res. 2024;36:168. doi:10.1007/s40520-024-02814-7
- Malaguez GG, Artuzi FE, Quevedo AS, Puricelli E, Ponzoni D. Can treatment with chondroitin and glucosamine sulphate prevent changes in the articular disc caused by temporomandibular joint osteoarthritis?. J Oral Rehabil. 2024;51:2289. doi:10.1111/joor.13814
- Wu YZ, Chen WY, Zeng Y, Ji QL, Yang Y, et al. Inflammation-Responsive Mesoporous Silica Nanoparticles with Synergistic Anti-inflammatory and Joint Protection Effects for Rheumatoid Arthritis Treatment. Pharm Res. 2024;41:1493. doi:10.1007/s11095-024-03732-z
- Mazurov VI, Belyaeva IB, Trofimov EA, Itskovich IE, Burulev AL. [Comparative efficacy of a combination of undenatured type II collagen, Boswellic acids, methylsulfonylmethane, vitamins C and D and a combination of chondroitin sulfate and glucosamine hydrochloride in the treatment of primary osteoarthritis of the knee joint]. Ter Arkh. 2023;95:1141. doi:10.26442/00403660.2023.12.202540
- Rabade A, Viswanatha GL, Nandakumar K, Kishore A. Evaluation of efficacy and safety of glucosamine sulfate, chondroitin sulfate, and their combination regimen in the management of knee osteoarthritis: a systematic review and meta-analysis. Inflammopharmacology. 2024;32:1759. doi:10.1007/s10787-024-01460-9
- Alves JC, Santos A, Lafuente P. Evaluation of different substance combinations in a multiple-session mesotherapy protocol for the management of osteoarthritis in dogs: a retrospective study. J Am Vet Med Assoc. 2024;262:1. doi:10.2460/javma.23.10.0588
- Vu HM, Tran HD, Nguyen AK, Han BO, Hoang BX. Effectiveness of Bach Nien Kien Health Supplement in the Treatment of Patients With Symptomatic Knee Osteoarthritis. In Vivo. 2024;38:963. doi:10.21873/invivo.13528
- Puigdellívol Grifell J, Comellas Berenguer C, Steinbacher G, Kranjcec T, Álvarez Díaz P, et al. Open, Observational, Single-Arm, Multicenter Study Assessing the Effectiveness of a Dietary Supplement Containing Hydrolyzed Collagen, Chondroitin Sulfate, and Glucosamine for Osteoarthritis Pain Reduction. J Diet Suppl. 2024;21:374. doi:10.1080/19390211.2023.2284982
- Wang F, Liu G, Shi J, Wang J, Zheng S, et al. Effects of glucosamine hydrochloride combined with non-steroidal anti-inflammatory drugs on symptoms and HSS scores in patients with knee osteoarthritis. Pak J Pharm Sci. 2023;36:1337.
- Wang F, Liu G, Shi J, Wang J, Zheng S, et al. Effects of glucosamine hydrochloride combined with non-steroidal anti-inflammatory drugs on symptoms and HSS scores in patients with knee osteoarthritis. Pak J Pharm Sci. 2023;36:921.
- Filipović K, Zvekić-Svorcan J, Demesi Drljan C, Cvetković M, Marinković D, et al. GLUCOSAMINE SULFATE EFFICACY IN TREATING KNEE OSTEOARTHRITIS: A FOLLOW-UP STUDY. Acta Clin Croat. 2022;61:436. doi:10.20471/acc.2022.61.03.09
- Derwich M, Górski B, Amm E, Pawłowska E. Oral Glucosamine in the Treatment of Temporomandibular Joint Osteoarthritis: A Systematic Review. Int J Mol Sci. 2023;24. doi:10.3390/ijms24054925
- Akpınar K, Şimşek EK, Özen ÖI, Haberal B. The effect of MSM in the treatment of ankle arthrosis: Is MSM as effective as methylprednisolone or hyaluronic acid?. J Orthop Res. 2024;42:1527. doi:10.1002/jor.25795
- Toguchi A, Noguchi N, Kanno T, Yamada A. Methylsulfonylmethane Improves Knee Quality of Life in Participants with Mild Knee Pain: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. 2023;15. doi:10.3390/nu15132995
- Qin DE, Liang W, Yu Y, Whelan EC, Yuan X, et al. Modified Simiaowan prevents and treats gouty arthritis via the Nrf2/NLRP3 inflammasome signaling pathway. J Ethnopharmacol. 2024;318:116906. doi:10.1016/j.jep.2023.116906
- Cheleschi S, Fioravanti A, De Palma A, Corallo C, Franci D, et al. Methylsulfonylmethane and mobilee prevent negative effect of IL-1β in human chondrocyte cultures via NF-κB signaling pathway. Int Immunopharmacol. 2018;65:129. doi:10.1016/j.intimp.2018.10.004
- Lubis AMT, Siagian C, Wonggokusuma E, Marsetyo AF, Setyohadi B. Comparison of Glucosamine-Chondroitin Sulfate with and without Methylsulfonylmethane in Grade I-II Knee Osteoarthritis: A Double Blind Randomized Controlled Trial. Acta Med Indones. 2017;49:105.
- Notarnicola A, Maccagnano G, Moretti L, Pesce V, Tafuri S, et al. Methylsulfonylmethane and boswellic acids versus glucosamine sulfate in the treatment of knee arthritis: Randomized trial. Int J Immunopathol Pharmacol. 2016;29:140. doi:10.1177/0394632015622215
- Panuccio E, Memeo A, Richetta S. [Evaluation of the combined treatment of oral viscosupplementation with hyaluronic acid intra-articular injection on symptomatic knee osteoarthritis]. Clin Ter. 2015;166:e321. doi:10.7417/T.2015.1886
- Alekseeva LI, Sharapova EP, Kashevarova NG, Taskina EA, Anikin SG, et al. [Use of ARTRA MSM FORTE in patients with knee osteoarthritis: Results of a randomized open-label comparative study of the efficacy and tolerability of the drug]. Ter Arkh. 2015;87:49. doi:10.17116/terarkh2015871249-54
- Ezaki J, Hashimoto M, Hosokawa Y, Ishimi Y. Assessment of safety and efficacy of methylsulfonylmethane on bone and knee joints in osteoarthritis animal model. J Bone Miner Metab. 2013;31:16. doi:10.1007/s00774-012-0378-9
- Notarnicola A, Tafuri S, Fusaro L, Moretti L, Pesce V, et al. The "MESACA" study: methylsulfonylmethane and boswellic acids in the treatment of gonarthrosis. Adv Ther. 2011;28:894. doi:10.1007/s12325-011-0068-3
- Debbi EM, Agar G, Fichman G, Ziv YB, Kardosh R, et al. Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study. BMC Complement Altern Med. 2011;11:50. doi:10.1186/1472-6882-11-50
- Brien S, Prescott P, Bashir N, Lewith H, Lewith G. Systematic review of the nutritional supplements dimethyl sulfoxide (DMSO) and methylsulfonylmethane (MSM) in the treatment of osteoarthritis. Osteoarthritis Cartilage. 2008;16:1277. doi:10.1016/j.joca.2008.03.002
- Kim LS, Axelrod LJ, Howard P, Buratovich N, Waters RF. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. Osteoarthritis Cartilage. 2006;14:286.
