Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.7
USERS' SCORE
Good
Based on 4 Reviews
8.5
Top Medical Research Studies
9
We looked into how Vitamin B2 supplementation might help with migraines, focusing on its potential to reduce the number of migraine days, duration, frequency, and pain scores.
Using systematic reviews and meta-analyses, we explored data from multiple reliable databases. Our findings reveal that taking 400 mg of Vitamin B2 daily for three months can significantly cut down on migraine days, duration, frequency, and pain levels.
So, if you're seeking alternatives to pharmaceuticals, Vitamin B2 could be a beneficial option to consider.
Using systematic reviews and meta-analyses, we explored data from multiple reliable databases. Our findings reveal that taking 400 mg of Vitamin B2 daily for three months can significantly cut down on migraine days, duration, frequency, and pain levels.
So, if you're seeking alternatives to pharmaceuticals, Vitamin B2 could be a beneficial option to consider.
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9
We evaluated the effectiveness of riboflavin in young patients suffering from migraines through a retrospective study involving 42 children and adolescents aged six to 18.
After treatment, we observed a significant decrease in headache frequency, intensity, and duration. Patients reported fewer days missed from school and reduced usage of acute medications.
Our findings suggest riboflavin is a safe, affordable, and effective option for preventing migraines in pediatric patients.
After treatment, we observed a significant decrease in headache frequency, intensity, and duration. Patients reported fewer days missed from school and reduced usage of acute medications.
Our findings suggest riboflavin is a safe, affordable, and effective option for preventing migraines in pediatric patients.
Read More
7
We explored the use of vitamin B2, also known as riboflavin, for preventing migraines in adults. The findings suggest that riboflavin can be beneficial, with minimal side effects reported. However, there’s insufficient evidence to recommend it for children.
Coenzyme Q10 showed some promise as well, though with less compelling evidence overall. Other nutraceuticals like feverfew and magnesium may have varying levels of effectiveness but come with cautions about safety and dosage.
Overall, while riboflavin stands out as a possible preventive measure, further research is necessary to establish its full potential.
Coenzyme Q10 showed some promise as well, though with less compelling evidence overall. Other nutraceuticals like feverfew and magnesium may have varying levels of effectiveness but come with cautions about safety and dosage.
Overall, while riboflavin stands out as a possible preventive measure, further research is necessary to establish its full potential.
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Most Useful Reviews
9
Miracle workers
16 people found this helpful
They help with migraines. I've suffered from migraines for 30 years, and in the past year, they have worsened, evolving into "Vestibular Migraines," which are challenging to manage. My ENT recommended Riboflavin and Magnesium Citrate, which have slowed down the seizures associated with my headaches. I take 400 mg daily and find these pills easy to swallow. They turn urine bright yellow, which is natural. I highly recommend this brand.
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9
Good for relief
10 people found this helpful
Best for migraines. Did you know B2 helps with migraines? I stumbled upon this while desperately seeking relief for my son, who has struggled with migraines since a roll-over accident years ago. These help! He ran out at college and forgot to tell me. He returned home with migraines again. I ordered these and they work wonderfully.
Read More
9
Effective prevention
4 people found this helpful
It helps my migraines. I use B2 for migraine prevention, and it's amazing for that purpose. The pills have no taste as you swallow them, and they're the perfect size.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.7
- All Researches
9
We assessed the potential benefits of alpha-lipoic acid (ALA) as a preventive treatment for adolescent migraines in a clinical trial involving 60 participants.
Those who received ALA alongside flunarizine showed a significant decrease in migraine frequency, with an impressive responder rate of 80% compared to 33.3% in the control group.
Other improvements included reduced severity of migraine attacks and better scores in quality of life assessments.
Overall, adding ALA appears to enhance outcomes for adolescents suffering from migraines.
Those who received ALA alongside flunarizine showed a significant decrease in migraine frequency, with an impressive responder rate of 80% compared to 33.3% in the control group.
Other improvements included reduced severity of migraine attacks and better scores in quality of life assessments.
Overall, adding ALA appears to enhance outcomes for adolescents suffering from migraines.
Read More
9
We looked into how Vitamin B2 supplementation might help with migraines, focusing on its potential to reduce the number of migraine days, duration, frequency, and pain scores.
Using systematic reviews and meta-analyses, we explored data from multiple reliable databases. Our findings reveal that taking 400 mg of Vitamin B2 daily for three months can significantly cut down on migraine days, duration, frequency, and pain levels.
So, if you're seeking alternatives to pharmaceuticals, Vitamin B2 could be a beneficial option to consider.
Using systematic reviews and meta-analyses, we explored data from multiple reliable databases. Our findings reveal that taking 400 mg of Vitamin B2 daily for three months can significantly cut down on migraine days, duration, frequency, and pain levels.
So, if you're seeking alternatives to pharmaceuticals, Vitamin B2 could be a beneficial option to consider.
Read More
9
We evaluated the effectiveness of riboflavin in young patients suffering from migraines through a retrospective study involving 42 children and adolescents aged six to 18.
After treatment, we observed a significant decrease in headache frequency, intensity, and duration. Patients reported fewer days missed from school and reduced usage of acute medications.
Our findings suggest riboflavin is a safe, affordable, and effective option for preventing migraines in pediatric patients.
After treatment, we observed a significant decrease in headache frequency, intensity, and duration. Patients reported fewer days missed from school and reduced usage of acute medications.
Our findings suggest riboflavin is a safe, affordable, and effective option for preventing migraines in pediatric patients.
Read More
8
We explored how genetic factors related to folate metabolism might be connected to migraines in children. In this study, 54 children aged 7 to 18 with migraines were compared to 115 healthy peers.
Interestingly, the rare 677TT genotype was found more frequently among those with migraines, indicating a potential link to higher homocysteine levels and folate deficiency. Moreover, we noted that treating these children with Cortexin led to significant improvements in their symptoms, including reduced headaches and fatigue.
Interestingly, the rare 677TT genotype was found more frequently among those with migraines, indicating a potential link to higher homocysteine levels and folate deficiency. Moreover, we noted that treating these children with Cortexin led to significant improvements in their symptoms, including reduced headaches and fatigue.
Read More
8
We reviewed the impact of dietary supplements on migraines, especially focusing on Vitamin B. Our findings revealed that nutrients like vitamin B, magnesium, and Coenzyme Q10 play vital roles in energy metabolism and may help alleviate migraine symptoms.
Notably, a daily intake of 400 milligrams of riboflavin over three months resulted in a remarkable 50% reduction in migraine attacks for many users. Additionally, vitamin D and Omega-3 have also shown promise in reducing migraine occurrences, suggesting that these supplements could serve as a cost-effective approach for migraine prevention.
Notably, a daily intake of 400 milligrams of riboflavin over three months resulted in a remarkable 50% reduction in migraine attacks for many users. Additionally, vitamin D and Omega-3 have also shown promise in reducing migraine occurrences, suggesting that these supplements could serve as a cost-effective approach for migraine prevention.
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User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Miracle workers
16 people found this helpful
They help with migraines. I've suffered from migraines for 30 years, and in the past year, they have worsened, evolving into "Vestibular Migraines," which are challenging to manage. My ENT recommended Riboflavin and Magnesium Citrate, which have slowed down the seizures associated with my headaches. I take 400 mg daily and find these pills easy to swallow. They turn urine bright yellow, which is natural. I highly recommend this brand.
Read More
9
Good for relief
10 people found this helpful
Best for migraines. Did you know B2 helps with migraines? I stumbled upon this while desperately seeking relief for my son, who has struggled with migraines since a roll-over accident years ago. These help! He ran out at college and forgot to tell me. He returned home with migraines again. I ordered these and they work wonderfully.
Read More
9
Effective prevention
4 people found this helpful
It helps my migraines. I use B2 for migraine prevention, and it's amazing for that purpose. The pills have no taste as you swallow them, and they're the perfect size.
Read More
7.5
Reduces frequency
11 people found this helpful
Helping menstrual migraines! I started taking this to assist with my migraines. I take two in the morning and two at night, and it definitely helps reduce the frequency of my migraines. It’s also the first product that, when taken with magnesium, effectively reduces menstrual migraines. No negative side effects either. I will definitely continue this product daily.
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Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Strozenko LA, Ponomaryov VS, Sanina OO, Lobanov YF. [The role of genetic polymorphisms in folate metabolism genes in the manifestation of migraine in children]. Zh Nevrol Psikhiatr Im S S Korsakova. 2025;125:47. doi:10.17116/jnevro202512501147
- Tepper SJ, Tepper K. Nutraceuticals and Headache 2024: Riboflavin, Coenzyme Q10, Feverfew, Magnesium, Melatonin, and Butterbur. Curr Pain Headache Rep. 2025;29:33. doi:10.1007/s11916-025-01358-3
- Puliappadamb HM, Satpathy AK, Mishra BR, Maiti R, Jena M. Evaluation of Safety and Efficacy of Add-on Alpha-Lipoic Acid on Migraine Prophylaxis in an Adolescent Population: A Randomized Controlled Trial. J Clin Pharmacol. 2023;63:1398. doi:10.1002/jcph.2331
- Li H, Krall JR, Frankenfeld C, Slavin M. Nutritional intake of riboflavin (vitamin B2) and migraine: a cross-sectional analysis of the National Health and Nutrition Examination Survey (NHANES) 2001-2004. Nutr Neurosci. 2023;26:1068. doi:10.1080/1028415X.2022.2126760
- Li D, Guo Y, Xia M, Zhang J, Zang W. Dietary intake of thiamine and riboflavin in relation to severe headache or migraine: A cross-sectional survey. Headache. 2022;62:1133. doi:10.1111/head.14384
- Liu H, Wang L, Chen C, Dong Z, Yu S. Association between Dietary Niacin Intake and Migraine among American Adults: National Health and Nutrition Examination Survey. Nutrients. 2022;14. doi:10.3390/nu14153052
- Ariyanfar S, Razeghi Jahromi S, Togha M, Ghorbani Z. Review on Headache Related to Dietary Supplements. Curr Pain Headache Rep. 2022;26:193. doi:10.1007/s11916-022-01019-9
- Matin H, Taghian F, Chitsaz A. Artificial intelligence analysis to explore synchronize exercise, cobalamin, and magnesium as new actors to therapeutic of migraine symptoms: a randomized, placebo-controlled trial. Neurol Sci. 2022;43:4413. doi:10.1007/s10072-021-05843-6
- Yamanaka G, Suzuki S, Morishita N, Takeshita M, Kanou K, et al. Experimental and Clinical Evidence of the Effectiveness of Riboflavin on Migraines. Nutrients. 2021;13. doi:10.3390/nu13082612
- Chen YS, Lee HF, Tsai CH, Hsu YY, Fang CJ, et al. Effect of Vitamin B2 supplementation on migraine prophylaxis: a systematic review and meta-analysis. Nutr Neurosci. 2022;25:1801. doi:10.1080/1028415X.2021.1904542
- Das R, Qubty W. Retrospective Observational Study on Riboflavin Prophylaxis in Child and Adolescent Migraine. Pediatr Neurol. 2021;114:5. doi:10.1016/j.pediatrneurol.2020.09.009
- Yamanaka G, Suzuki S, Takeshita M, Go S, Morishita N, et al. Effectiveness of low-dose riboflavin as a prophylactic agent in pediatric migraine. Brain Dev. 2020;42:523. doi:10.1016/j.braindev.2020.04.002
- Liampas IN, Siokas V, Aloizou AM, Tsouris Z, Dastamani M, et al. Pyridoxine, folate and cobalamin for migraine: A systematic review. Acta Neurol Scand. 2020;142:108. doi:10.1111/ane.13251
- Togha M, Razeghi Jahromi S, Ghorbani Z, Martami F, Seifishahpar M. Serum Vitamin B12 and Methylmalonic Acid Status in Migraineurs: A Case-Control Study. Headache. 2019;59:1492. doi:10.1111/head.13618
- Moscano F, Guiducci M, Maltoni L, Striano P, Ledda MG, et al. An observational study of fixed-dose Tanacetum parthenium nutraceutical preparation for prophylaxis of pediatric headache. Ital J Pediatr. 2019;45:36. doi:10.1186/s13052-019-0624-z
- Nattagh-Eshtivani E, Sani MA, Dahri M, Ghalichi F, Ghavami A, et al. The role of nutrients in the pathogenesis and treatment of migraine headaches: Review. Biomed Pharmacother. 2018;102:317. doi:10.1016/j.biopha.2018.03.059
