Last update
5/22/2025
Research Authors

Overview

SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 282 Reviews
8.7
Supplement Facts
Serving Size:  3 Tablets
Amount Per Serving
%DV
Vitamin C (as Ascorbic Acid)
100 mg
111%
Calcium (from Calcium Phosphate, Calcium Stearate)
30 mg
2%
L-Lysine (from L-Lysine Hydrochloride)
1.5 g
†
Garlic Bulb (deodorized)
200 mg
†
Echinacea purpurea Aerial Parts Extract 4:1 
100 mg
†
Propolis 
25 mg
†
Licorice Root Extract 4:1
15 mg
†

Top Medical Research Studies

9
Lysine aids cold adaptation mechanisms
We set out to uncover how certain amino acids, particularly lysine, help with cold acclimation. Over three months, 20 men were monitored for physiological changes after being exposed to cold.

We found that continuous exposure led to faster cold-induced vasodilation and improved finger temperature. Notably, lysine was the only amino acid that significantly changed and positively correlated with these improvements in cold response.

In mouse trials, lysine supplementation helped maintain core body temperature during cold exposure, indicating its role in supporting metabolic adjustments to the cold.
Read More

Most Useful Reviews

10
No stomach issues
487 people found this helpful
After years of suffering from occasional cold sores, I decided to try this product based on reviews. I switched from daily L-Lysine supplements to taking these only at the first sign of an outbreak. Recently, I felt the tingling and took three tablets. To my astonishment, the cold sore was gone by morning! This product truly works without causing stomach issues!
Read More
9
Rare outbreaks now
322 people found this helpful
Lysine is a gift from God! Thanks to the internet, I learned about lysine and decided to try it. From a young age, cold sores plagued me, but now, at sixty, I rarely experience outbreaks. I went a year without one! Although I don't take it daily, only when I feel an outbreak coming. It’s remarkably effective. I’m grateful to those who developed this product for making it available to the world!
Read More
10
Saved from cold sores
320 people found this helpful
This product is simply incredible! During a period of immense stress, I would usually develop a cold sore within days. Instead, I started this product three times a day, which saved me from suffering! I felt the itch but no sore manifested, even after days without sleep. I cannot believe how well it has performed, allowing me to continue my regular activities. I highly recommend it, as I've had no cold sores since discovering it!
Read More

Medical Researches

SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
  • All Researches
9
Lysine aids cold adaptation mechanisms
We set out to uncover how certain amino acids, particularly lysine, help with cold acclimation. Over three months, 20 men were monitored for physiological changes after being exposed to cold.

We found that continuous exposure led to faster cold-induced vasodilation and improved finger temperature. Notably, lysine was the only amino acid that significantly changed and positively correlated with these improvements in cold response.

In mouse trials, lysine supplementation helped maintain core body temperature during cold exposure, indicating its role in supporting metabolic adjustments to the cold.
Read More

User Reviews

USERS' SCORE
Good
Based on 282 Reviews
8.7
  • All Reviews
  • Positive Reviews
  • Negative Reviews
10
No stomach issues
487 people found this helpful
After years of suffering from occasional cold sores, I decided to try this product based on reviews. I switched from daily L-Lysine supplements to taking these only at the first sign of an outbreak. Recently, I felt the tingling and took three tablets. To my astonishment, the cold sore was gone by morning! This product truly works without causing stomach issues!
Read More
9
Rare outbreaks now
322 people found this helpful
Lysine is a gift from God! Thanks to the internet, I learned about lysine and decided to try it. From a young age, cold sores plagued me, but now, at sixty, I rarely experience outbreaks. I went a year without one! Although I don't take it daily, only when I feel an outbreak coming. It’s remarkably effective. I’m grateful to those who developed this product for making it available to the world!
Read More
10
Saved from cold sores
320 people found this helpful
This product is simply incredible! During a period of immense stress, I would usually develop a cold sore within days. Instead, I started this product three times a day, which saved me from suffering! I felt the itch but no sore manifested, even after days without sleep. I cannot believe how well it has performed, allowing me to continue my regular activities. I highly recommend it, as I've had no cold sores since discovering it!
Read More
9
Miracle product
56 people found this helpful
Nature's cold sore cure! If this company has stock, I'd be a shareholder. This is a wonder drug. If you suffer from cold sores, stop reading and buy this. I used to have frequent breakouts, but after taking this daily for nearly a year, I've had only one full outbreak. When I feel a tingle, I start taking a handful daily, and the blemish usually resolves within a day. This has also strengthened my immune system, as I’ve only been ill once in the past year.
Read More
10
No more outbreaks
41 people found this helpful
Impressed. I purposely waited to give this product a review because I wanted to see if it actually works. I should start by saying that I haven't had any canker/cold sores for six months since I first tried this product. I'm in graduate school and going into medical school, so I'm constantly stressed, and of course, just as one cold sore was healing, I would feel another one coming. I’ve tried absolutely everything, even lysine supplements from other brands, acyclovir, and all sorts of remedies. I started this product six months ago, taking three pills every morning, and since then I have not had any outbreaks! I am astounded! One bottle lasts me about three months. Highly recommend to anyone who suffers from cold/canker sores. It's been a year, and I've not had a cold sore since!
Read More

Frequently Asked Questions

9
Effective against cold
18 people found this helpful
An excellent immune formula that I've purchased twice already (first 90 capsules, then 180). It has consistently helped me at the initial signs of a cold. As soon as my throat began to hurt, I took three capsules before bed, and by morning, I was back to feeling normal. The formula contains lysine, vitamin C, calcium, propolis, and echinacea extract.
9
Effective remedy
1 people found this helpful
Good Remedy! At first, I was sceptical about its effectiveness, but this product works! We use it at the first sign of a cold, and within a couple of days, we're healthy again!
9
Effective for cold
1 people found this helpful
Best for cold. I bought this on a blogger's recommendation and am truly grateful. A child in kindergarten often catches colds; I take this medication and recover in a maximum of two days, whereas before it took me two weeks. I usually take three tablets at once. Sometimes that's enough; other times, I take it the next day, and the cold disappears. However, it hasn't worked for everyone; my friend did not benefit from it. I find it economical, as it's more effective when taken at the first sign of a cold rather than as a preventive.
9
Year without cold
5 people found this helpful
I have not been ill with a cold for an entire year! After taking three tablets on an empty stomach for a month, I successfully avoided illness. I highly recommend it for the autumn period, especially to fend off snot and viruses. Just be aware that there is a subtle garlic smell.
10
Improved family immunity
It's really effective; the whole family began using it, and during winter we didn’t catch a cold at all. Our immunity has improved significantly.
9
Effective against illness
1 people found this helpful
In our family, superlysin is a lifesaver. As soon as we begin to feel unwell, we take three tablets in the morning and 1000mg of vitamin C in the evening. The illness recedes much quicker and is often without fever. We also use it preventively in the same dosage when in contact with sick individuals, and it helps us avoid getting sick. I’m uncertain if superlysin fosters stable immunity, but as a tool for combating illness, it performs wonderfully. The capsules are quite large; taking three may be a challenge if your throat hurts, but the benefits are worthwhile. No lingering illnesses or complications have occurred in our family while using superlysin. I highly recommend it!
9
Speeds recovery from cold
1 people found this helpful
Good working complex! I took these vitamins for the first time and managed to experience their benefits for both myself and my husband. They truly help to cope with a cold faster. I consume three a day with food, as I have some stomach issues and not on an empty stomach, as suggested in the reviews. I also add vitamin D, vitamin C, elderberry and colostrum to my regimen. It helps tremendously, so I advise everyone to try it!
9
Effective for cold sores
2 people found this helpful
Very effective at battling cold sores. I take two tablets per hour upon feeling the initial tingling of an oncoming cold sore and continue until it starts healing. I also use topical calendula cream. It's vital to reduce or remove arginine-containing foods from your diet, such as chicken soup and nuts, to decrease the frequency of cold sores. Avoid high arginine foods if you have a cold sore, as lysine and arginine work against each other in skin healing.
10
Effective cold remedy
An excellent immune formula, I have purchased it twice already (first 90 capsules, then 180). It has repeatedly helped me at the first sign of a cold. As soon as my throat began to hurt, I took three capsules before bedtime, and in the morning all the cold symptoms had vanished. It contains lysine, vitamin C, calcium, propolis and echinacea extract.
10
Symptoms disappeared
Excellent immune formula, I've purchased it twice (first 90 capsules, then 180). It helped me immensely at the first sign of a cold. As soon as my throat started to hurt, I took three capsules before bed and by morning all cold symptoms had vanished. The formula includes lysine, vitamin C, calcium, propolis, and echinacea extract.
9
Lysine aids cold adaptation mechanisms
We set out to uncover how certain amino acids, particularly lysine, help with cold acclimation. Over three months, 20 men were monitored for physiological changes after being exposed to cold.

We found that continuous exposure led to faster cold-induced vasodilation and improved finger temperature. Notably, lysine was the only amino acid that significantly changed and positively correlated with these improvements in cold response.

In mouse trials, lysine supplementation helped maintain core body temperature during cold exposure, indicating its role in supporting metabolic adjustments to the cold.

References

  1. Xue C, Zhu S, Li Y, Chen X, Lu L, et al. Cold exposure accelerates lysine catabolism to promote cold acclimation via remodeling hepatic histone crotonylation. Environ Int. 2024;192:109015. 10.1016/j.envint.2024.109015
image