Last update
3/27/2026
Research Authors

Overview

SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8
USERS' SCORE
Medium or Average
Based on 40 Reviews
6.5
Supplement Facts
Serving Size: 1 Tablet
Serving Per Container: 150
Amount Per Serving
%DV
Vitamin A (as beta-carotene)
1300 mcg 
100%
Vitamin C (as ascorbic acid)
120 mg
100%
Vitamin D (as ergocalciferol)
15 mcg
100%
Vitamin E (as d-alpha tocopheryl succinate)
9.5 mg
50%
Vitamin K (as phytonadione)
90 mcg
100%
Thiamin (as thiamin mononitrate)
6 mg
429%
Riboflavin (vitamin B2)
5.6 mg
350%
Niacin (as niacinamide)
18 mg
100%
Vitamin B6 (as pyridoxine hydrochloride)
10 mg
500%
Folate (as folic acid)
600 mcg DFE(360 mcg folic acid)
100%
Vitamin B12 (as methylcobalamin)
9 mcg
321%
Biotin
35 mcg
100%
Pantothenic Acid (as calcium pantothenate)
10 mg
143%
Choline (as choline bitartrate)
55 mg
10%
Calcium (as calcium carbonate, calcium citrate)
50 mg
4%
Iron (as iron chelate)
27 mg
100%
Iodine (from kelp (Laminaria digitata))
290 mcg
100%
Magnesium (as magnesium oxide from sea water)
50 mg
13%
Zinc (as zinc citrate)
13 mg
100%
Selenium (as selenium L-methionine complex)
70 mcg
100%
Copper (as copper chelate)
1.3 mg
100%
Manganese (as manganese citrate)
2 mg
77%
Molybdenum (as molybdenum chelate)
50 mcg
100%
Organic Rainbow Superfoods BlendOrganic spirulina, organic beet (root), organic broccoli (floret, stem), organic kale (leaf), organic spinach (leaf), organic blackberry (fruit), organic blueberry (fruit), organic carrot (root), organic cranberry (fruit)
100 mg
Prenatal Botanical & Probiotic BlendGinger (root) Juice Extract, Peppermint (aerial part) Extract, Organic Chlorella, Bacillus coagulans MTCC 5856 (1 million CFU†)
97 mg
📅 Last updated:

Top Medical Research Studies

9
Discontinuing iron improves pregnancy nausea
We explored whether stopping iron-containing prenatal multivitamins could alleviate nausea and vomiting in pregnant women. In a study involving 97 women seeking help for severe nausea, we discovered that two-thirds reported an improvement after switching to alternatives like folic acid or children's vitamins.

This significant finding, backed by both qualitative and quantitative measures, shows that avoiding iron supplements in early pregnancy may be beneficial for many women struggling with nausea.
Read More
8
Prenatal vitamins and nausea outcomes
We aimed to understand how prenatal multivitamins, particularly those containing low doses of iron, affect women with existing gastrointestinal (GI) issues during pregnancy. By comparing women with and without GI conditions, we found that those with GI issues did not have more side effects or lower adherence to taking multivitamins.

In fact, they may have experienced less severe nausea and vomiting compared to women without GI conditions. This suggests that small, low-dose iron prenatal vitamins should still be considered a viable option for pregnant women with such pre-existing conditions.
Read More
7
Prenatal vitamins and nausea insights
We examined how two different prenatal multivitamins impacted nausea in pregnant women. Our study involved 135 participants who tried both PregVit, which contains less iron, and Materna, with a higher iron level.

We found that PregVit led to lower rates of constipation, making it more tolerable for users. Interestingly, with Materna, higher nausea and vomiting were linked to lower compliance. In contrast, these issues didn’t affect how well women tolerated PregVit.
Read More

Most Useful Reviews

9
Gentle on nausea
31 people found this helpful
These vitamins are brilliant! My nails are long, my hair is shiny, and I feel much better on them (not as fatigued as before). I experience some nausea now and then during this second pregnancy, but these vitamins have never caused any issues for me. I took them on a mostly empty stomach and felt fine. They are easy to swallow, with no after-taste. My midwife also recommends these vitamins. In my first pregnancy, I suffered debilitating migraines from prescribed prenatals, but I discovered that my migraines coincided with those vitamins. This organic, gentle vitamin has been fantastic!
Read More
9
Cured nausea
22 people found this helpful
Superb vitamins. They did not cause any nausea. During my pregnancy, they raised my haemoglobin without the need for iron supplements.
Read More
10
No nausea experienced
4 people found this helpful
It's seriously that amazing! This prenatal duo set is exceptionally good! I researched the recommended daily amounts by the American College of Obstetricians and Gynecologists for 2019: folic acid: 600mcg, iron: 27mg, calcium: 1,000mg, vitamin D: 600 IU, vitamin A: 770 mcg, vitamin C: 85mg, vitamin B6: 1.9mg, vitamin B12: 2.6mcg. They consider Omega-3s with DHA a bonus! The duo combination exceeds expectations! Best of all, I take it on an empty stomach and have absolutely no nausea! Yes! Not even a tummy ache. Plus, the fish tablet has no fishy taste or burps! Seriously, I would recommend this brand to anyone trying to conceive!
Read More

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21st Century Slow Release Iron
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New Chapter Advanced Perfect Prenatal Multivitamin
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Medical Researches

SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8
  • All Researches
9
Discontinuing iron improves pregnancy nausea
We explored whether stopping iron-containing prenatal multivitamins could alleviate nausea and vomiting in pregnant women. In a study involving 97 women seeking help for severe nausea, we discovered that two-thirds reported an improvement after switching to alternatives like folic acid or children's vitamins.

This significant finding, backed by both qualitative and quantitative measures, shows that avoiding iron supplements in early pregnancy may be beneficial for many women struggling with nausea.
Read More
8
Prenatal vitamins and nausea outcomes
We aimed to understand how prenatal multivitamins, particularly those containing low doses of iron, affect women with existing gastrointestinal (GI) issues during pregnancy. By comparing women with and without GI conditions, we found that those with GI issues did not have more side effects or lower adherence to taking multivitamins.

In fact, they may have experienced less severe nausea and vomiting compared to women without GI conditions. This suggests that small, low-dose iron prenatal vitamins should still be considered a viable option for pregnant women with such pre-existing conditions.
Read More
7
Prenatal vitamins and nausea insights
We examined how two different prenatal multivitamins impacted nausea in pregnant women. Our study involved 135 participants who tried both PregVit, which contains less iron, and Materna, with a higher iron level.

We found that PregVit led to lower rates of constipation, making it more tolerable for users. Interestingly, with Materna, higher nausea and vomiting were linked to lower compliance. In contrast, these issues didn’t affect how well women tolerated PregVit.
Read More

User Reviews

USERS' SCORE
Medium or Average
Based on 40 Reviews
6.5
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Gentle on nausea
31 people found this helpful
These vitamins are brilliant! My nails are long, my hair is shiny, and I feel much better on them (not as fatigued as before). I experience some nausea now and then during this second pregnancy, but these vitamins have never caused any issues for me. I took them on a mostly empty stomach and felt fine. They are easy to swallow, with no after-taste. My midwife also recommends these vitamins. In my first pregnancy, I suffered debilitating migraines from prescribed prenatals, but I discovered that my migraines coincided with those vitamins. This organic, gentle vitamin has been fantastic!
Read More
9
Cured nausea
22 people found this helpful
Superb vitamins. They did not cause any nausea. During my pregnancy, they raised my haemoglobin without the need for iron supplements.
Read More
10
No nausea experienced
4 people found this helpful
It's seriously that amazing! This prenatal duo set is exceptionally good! I researched the recommended daily amounts by the American College of Obstetricians and Gynecologists for 2019: folic acid: 600mcg, iron: 27mg, calcium: 1,000mg, vitamin D: 600 IU, vitamin A: 770 mcg, vitamin C: 85mg, vitamin B6: 1.9mg, vitamin B12: 2.6mcg. They consider Omega-3s with DHA a bonus! The duo combination exceeds expectations! Best of all, I take it on an empty stomach and have absolutely no nausea! Yes! Not even a tummy ache. Plus, the fish tablet has no fishy taste or burps! Seriously, I would recommend this brand to anyone trying to conceive!
Read More
0
Caused intense nausea
3 people found this helpful
I had seen these recommended and decided to try them. They were my third brand of prenatals. I experienced no issues with previous vitamins, but after taking my first Rainbow Light yesterday with insufficient food, intense nausea hit me quickly. I couldn't stomach it, and I need to consume a good meal to avoid nausea with these, which is a concern during pregnancy.
Read More
9
Prevented nausea
2 people found this helpful
Fantastic! This is the only supplement I can take without experiencing nausea or constipation. I recommend investing in our health and our baby's. They last for three months.
Read More

Frequently Asked Questions

9
Managed nausea
1 people found this helpful
The potency is excellent! This vitamin helped control my nausea during pregnancy. It’s the only prenatal I would consider ideal despite the size of the pill.
0
Vomiting episodes
1 people found this helpful
My wife experienced vomiting at least twice weekly during her pregnancy while taking these vitamins, until she stopped using them.
9
Cured nausea
22 people found this helpful
Superb vitamins. They did not cause any nausea. During my pregnancy, they raised my haemoglobin without the need for iron supplements.
0
Empty stomach issues
This vitamin complex may be effective, but it's advisable not to take it in the morning on an empty stomach, as it can cause nausea and vomiting. The tablets are large and have a strong herbal taste which exacerbates nausea during pregnancy.
8
Prenatal vitamins and nausea outcomes
We aimed to understand how prenatal multivitamins, particularly those containing low doses of iron, affect women with existing gastrointestinal (GI) issues during pregnancy. By comparing women with and without GI conditions, we found that those with GI issues did not have more side effects or lower adherence to taking multivitamins.

In fact, they may have experienced less severe nausea and vomiting compared to women without GI conditions. This suggests that small, low-dose iron prenatal vitamins should still be considered a viable option for pregnant women with such pre-existing conditions.
9
Discontinuing iron improves pregnancy nausea
We explored whether stopping iron-containing prenatal multivitamins could alleviate nausea and vomiting in pregnant women. In a study involving 97 women seeking help for severe nausea, we discovered that two-thirds reported an improvement after switching to alternatives like folic acid or children's vitamins.

This significant finding, backed by both qualitative and quantitative measures, shows that avoiding iron supplements in early pregnancy may be beneficial for many women struggling with nausea.
7
Prenatal vitamins and nausea insights
We examined how two different prenatal multivitamins impacted nausea in pregnant women. Our study involved 135 participants who tried both PregVit, which contains less iron, and Materna, with a higher iron level.

We found that PregVit led to lower rates of constipation, making it more tolerable for users. Interestingly, with Materna, higher nausea and vomiting were linked to lower compliance. In contrast, these issues didn’t affect how well women tolerated PregVit.

References

  1. Gill SK, Nguyen P, Koren G. Adherence and tolerability of iron-containing prenatal multivitamins in pregnant women with pre-existing gastrointestinal conditions. J Obstet Gynaecol. 2009;29:594. 10.1080/01443610903114527
  2. Gill SK, Maltepe C, Koren G. The effectiveness of discontinuing iron-containing prenatal multivitamins on reducing the severity of nausea and vomiting of pregnancy. J Obstet Gynaecol. 2009;29:13. 10.1080/01443610802628528
  3. Ahn E, Pairaudeau N, Pairaudeau N, Cérat Y, Couturier B, et al. A randomized cross over trial of tolerability and compliance of a micronutrient supplement with low iron separated from calcium vs high iron combined with calcium in pregnant women [ISRCTN56071145]. BMC Pregnancy Childbirth. 2006;6:10. PubMed
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