Effect of Lacticaseibacillus rhamnosus IDCC 3201 on irritable bowel syndrome with constipation: a randomized, double-blind, and placebo-controlled trial.
We aimed to understand how Lacticaseibacillus rhamnosus IDCC 3201 (RH 3201) affects irritable bowel syndrome with constipation (IBS-C) through a thorough study. In a randomized, double-blind trial, 30 participants took either RH 3201 or a placebo for 8 weeks.
Those taking RH 3201 experienced significant improvements, including fewer bowel discomforts and reduced bloating issues. We also observed an increase in certain beneficial gut bacteria and a link between specific metabolites and symptom relief. Overall, RH 3201 shows promise as an effective treatment for IBS-C.
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9
Probiotics effectively relieve IBS symptoms
DDS-1 and UABla-12 Improve Abdominal Pain Severity and Symptomology in Irritable Bowel Syndrome: Randomized Controlled Trial.
This randomized, double-blind study looked at how two probiotic strains, DDS-1 and UABla-12, could help people with irritable bowel syndrome (IBS). We found that both probiotics notably reduced abdominal pain and other IBS symptoms compared to a placebo after six weeks.
Specifically, DDS-1 showed a significant improvement, with over half of participants reporting relief. UABla-12 also had promising results, helping about a quarter of those in its group. Throughout the study, we observed better stool consistency and overall quality of life for participants taking these probiotics versus those on placebo.
Read More
9
Lactobacillus drink benefits IBS-C
Clinical assessment and cytokines level in constipation-predominant irritable bowel syndrome participants treated with Lactobacillus-containing cultured milk drink.
We explored the impact of a Lactobacillus-containing cultured milk drink on individuals with constipation-predominant irritable bowel syndrome (IBS-C). Over 30 days, participants consumed this drink daily while we assessed their clinical symptoms and inflammatory markers.
Impressively, 97.4% reported improvement in symptoms, along with noticeable reductions in intestinal transit time and fecal pH. Evidence also showed lowered levels of pro-inflammatory cytokines in IBS-C participants, supporting potential adjunctive benefits of this treatment for IBS-C patients.
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Most Useful Reviews
9
Effective for IBS
5 people found this helpful
I've tried various probiotic products from iHerb and found them generally satisfactory, though slightly pricy. I purchased this one for my gastrointestinal issues and irritable bowel syndrome. It's proven effective, as it significantly alleviates my frequent stomach aches. I plan to continue using it.
Read More
9
Constipation relief
1 people found this helpful
Previously struggling with stubborn constipation and having bowel movements only three times a week, I've started taking this after dinner. My bowel movements have improved greatly, now happening almost daily. I'm hopeful it will also help with my vaginitis.
Read More
7.5
Improved bowel movements
7 people found this helpful
High-quality probiotic specifically designed for women. Recommended by my gynaecologist, this probiotic has effectively improved my bowel movements and reduced yeast infection frequency. I’ve not experienced the typical side effects associated with probiotics, such as bloating. The capsules are small and easy to swallow, making this brand my top recommendation.
This randomized, single-blinded trial evaluated the impact of probiotics, specifically Lactobacillus acidophilus and plantarum, on patients with diarrhea-predominant irritable bowel syndrome (IBS-D).
We found that when added to standard IBS treatment, these probiotics significantly improved symptoms over a 12-week period.
Group B, the probiotic group, experienced better results, including fewer days with pain and greater satisfaction with bowel habits. While both groups saw reductions in IBS severity, the probiotics led to complete remission in many patients, which is promising for future treatment guidelines.
Read More
9.5
Effective probiotic IBS treatment
Two Lactobacilli strains as adjuvant therapy in the management of irritable bowel syndrome: a randomized control trial.
This randomized, single-blinded trial evaluated the impact of probiotics, specifically Lactobacillus acidophilus and plantarum, on patients with diarrhea-predominant irritable bowel syndrome (IBS-D).
We found that when added to standard IBS treatment, these probiotics significantly improved symptoms over a 12-week period.
Group B, the probiotic group, experienced better results, including fewer days with pain and greater satisfaction with bowel habits. While both groups saw reductions in IBS severity, the probiotics led to complete remission in many patients, which is promising for future treatment guidelines.
Read More
9
Bifidobacterium lactis improves IBS symptoms
[Clinical efficacy of a modern probiotic for the correction of intestinal microflora in patients with irritable bowel syndrome with diarrhea and antibiotic-associated diarrhea].
We examined the effectiveness of Neobiotic Lactobalance®, a probiotic containing Bifidobacterium lactis, in alleviating symptoms of irritable bowel syndrome (IBS) with diarrhea and antibiotic-associated diarrhea (AAD) in 54 patients.
Over 21 days, participants reported significant symptom relief, with scores for diarrhea and abdominal pain dropping noticeably, indicating improved gut health.
This study highlights how Bifidobacterium lactis can help restore intestinal balance and potentially provide relief from gastrointestinal distress in affected patients.
Read More
9
Probiotics effectively relieve IBS symptoms
DDS-1 and UABla-12 Improve Abdominal Pain Severity and Symptomology in Irritable Bowel Syndrome: Randomized Controlled Trial.
This randomized, double-blind study looked at how two probiotic strains, DDS-1 and UABla-12, could help people with irritable bowel syndrome (IBS). We found that both probiotics notably reduced abdominal pain and other IBS symptoms compared to a placebo after six weeks.
Specifically, DDS-1 showed a significant improvement, with over half of participants reporting relief. UABla-12 also had promising results, helping about a quarter of those in its group. Throughout the study, we observed better stool consistency and overall quality of life for participants taking these probiotics versus those on placebo.
Read More
9
Lactobacillus drink benefits IBS-C
Clinical assessment and cytokines level in constipation-predominant irritable bowel syndrome participants treated with Lactobacillus-containing cultured milk drink.
We explored the impact of a Lactobacillus-containing cultured milk drink on individuals with constipation-predominant irritable bowel syndrome (IBS-C). Over 30 days, participants consumed this drink daily while we assessed their clinical symptoms and inflammatory markers.
Impressively, 97.4% reported improvement in symptoms, along with noticeable reductions in intestinal transit time and fecal pH. Evidence also showed lowered levels of pro-inflammatory cytokines in IBS-C participants, supporting potential adjunctive benefits of this treatment for IBS-C patients.
I've tried various probiotic products from iHerb and found them generally satisfactory, though slightly pricy. I purchased this one for my gastrointestinal issues and irritable bowel syndrome. It's proven effective, as it significantly alleviates my frequent stomach aches. I plan to continue using it.
Read More
9
Constipation relief
1 people found this helpful
Previously struggling with stubborn constipation and having bowel movements only three times a week, I've started taking this after dinner. My bowel movements have improved greatly, now happening almost daily. I'm hopeful it will also help with my vaginitis.
Read More
7.5
Improved bowel movements
7 people found this helpful
High-quality probiotic specifically designed for women. Recommended by my gynaecologist, this probiotic has effectively improved my bowel movements and reduced yeast infection frequency. I’ve not experienced the typical side effects associated with probiotics, such as bloating. The capsules are small and easy to swallow, making this brand my top recommendation.
Read More
9
Bowel issues resolved
A wonderful probiotic that has helped resolve my bowel problems.
Read More
7.5
Notable improvement
I’ve taken this probiotic for over a year, and I've noted a significant improvement in my bowel health and issues related to my vagina.
Irritable Bowel Syndrome (IBS) is a common gastrointestinal disorder characterized by a range of symptoms including abdominal pain, bloating, gas, and altered bowel habits, which can manifest as diarrhea, constipation, or a combination of both. The exact cause of IBS isn't fully understood, but it's believed to stem from a complex interplay of factors including gut sensitivity, changes in gut motility, and psychosocial elements such as stress or anxiety. IBS is often classified into different types based on the predominant symptoms, such as IBS with diarrhea (IBS-D), IBS with constipation (IBS-C), and a mixed type (IBS-M).
Managing IBS can be multifaceted, often requiring a tailored approach based on individual symptoms and triggers. Dietary changes are frequently recommended, including low-FODMAP diets, which involve reducing fermentable carbohydrates that can exacerbate symptoms. In addition to dietary adjustments, stress management techniques and medications aimed at addressing specific symptoms, such as anti-diarrheal agents or laxatives, may also be beneficial. Since IBS can significantly impact quality of life, consulting with a healthcare provider or a registered dietitian is essential for developing an effective management plan.
Probiotics are live microorganisms, primarily bacteria, that are intended to provide health benefits when consumed in adequate amounts. These beneficial bacteria are often referred to as "good" or "friendly" bacteria because they help maintain a balanced gut microbiome, which plays a vital role in digestion, immune function, and overall health. Probiotics can be found in various foods such as yogurt, kefir, sauerkraut, and kombucha, as well as in dietary supplements. The most common strains include Lactobacillus and Bifidobacterium, which have been studied for their positive effects on gastrointestinal health, including the alleviation of symptoms related to irritable bowel syndrome (IBS) and diarrhea.
Incorporating probiotics into your diet may help support a healthy gut by competing with harmful bacteria and promoting a more diverse microbiome. However, it's important to note that the specific effects of probiotics can vary widely depending on the strain, dosage, and individual health conditions. While many people may benefit from including probiotics in their diet, it's advisable to consult a healthcare professional before starting any new supplement regimen, especially if you have underlying health issues or concerns. For those looking to explore the world of probiotics, it’s worth experimenting with various sources to find what works best for your body.
Probiotics may offer some benefits for individuals suffering from Irritable Bowel Syndrome (IBS), although results can vary from person to person. Research indicates that certain strains of probiotics can help alleviate symptoms such as bloating, gas, and changes in bowel habits. The mechanism is thought to involve the modulation of gut bacteria, which helps improve gut health and might lead to better digestion and reduced inflammation. For those with IBS, specific strains like Bifidobacterium and Lactobacillus have been examined in studies and have shown promise in reducing abdominal pain and discomfort.
However, it’s important to approach probiotic use with caution, as not all probiotics are created equal. The effectiveness often depends on the specific strain and the dosage. A well-formulated probiotic supplement, combined with a diet tailored to IBS needs, could provide additional support. It's advisable for individuals considering probiotics for IBS to consult with a healthcare provider to ensure that they choose the appropriate strains and dosages tailored for their unique symptoms. Overall, while probiotics may not be a cure-all for IBS, they can be a helpful tool in managing symptoms for some individuals.
Based on user reviews, the timeline for experiencing results from this supplement for Irritable Bowel Syndrome (IBS) can vary. Many users report noticeable improvements within a few weeks of consistent use. For instance, one reviewer mentioned significant alleviation of frequent stomach aches after starting the supplement, highlighting its effectiveness for gastrointestinal issues (Read Review). Another user indicated a shift from having bowel movements only three times a week to nearly daily after integrating this probiotic into their routine, suggesting that some may notice improvements fairly quickly (Read Review).
However, results can differ individually, with some reviewers advocating for a longer usage period to achieve the desired outcome. One user mentioned being on the probiotic for over a year before noting significant improvements in bowel health (Read Review). Therefore, while many individuals see improvements within weeks, it may take continued use over several months to realize the full benefits of the supplement. Overall, patience and consistency seem key when using this probiotic for IBS.
The use of probiotics for managing Irritable Bowel Syndrome (IBS) is increasingly backed by scientific research. Various studies have shown that specific probiotic strains, particularly Bifidobacterium lactis and Lactobacillus rhamnosus, can provide significant symptom relief for individuals suffering from IBS. For instance, research highlights that Bifidobacterium lactis can alleviate abdominal pain and improve overall gut health, demonstrating promising results in treating IBS symptoms. Additionally, a synbiotic approach combining probiotics with fructooligosaccharides has been shown to notably decrease flatulence and enhance bowel habits in diarrhea-predominant IBS patients [7].
Moreover, Lactobacillus rhamnosus has exhibited beneficial effects in both adults and children, leading to reductions in abdominal pain and bloating among IBS patients. One study noted that this probiotic could improve overall quality of life and gut microbiota balance [25]. While not all probiotic interventions yielded statistically significant results, many studies indicate that probiotics can be a valuable addition to IBS management, particularly for those with varying symptom expressions [4], [13]. As research continues to evolve, probiotics are positioned as a safe and well-tolerated option for enhancing IBS treatment outcomes.
Users have reported various improvements in their symptoms after using this probiotic supplement, particularly concerning gastrointestinal health. Many individuals indicated significant relief from issues like frequent stomach aches and constipation. For instance, one reviewer noted a marked decrease in stomach discomfort after starting the product, which they deemed effective for their IBS symptoms (Read Review). Another user shared a transformation from having bowel movements just three times a week to nearly daily, illustrating how it effectively managed their constipation (Read Review).
In addition to improvements in bowel function, several users mentioned beneficial effects on overall health. One reviewer highlighted that the probiotic helped decrease the frequency of yeast infections while also aiding bowel movements (Read Review). Others echoed similar sentiments, reporting enhanced digestive comfort and smoother bowel movements after use (Read Review). While the consensus points to positive results, it's essential to remember that individual experiences may vary, and what works for one person may not yield the same success for another.
Users have reported various experiences when combining this probiotic supplement with other supplements for managing Irritable Bowel Syndrome (IBS). While there is no specific focus on combination with other products, several users highlighted its solo effectiveness, particularly in improving gastrointestinal issues. For example, one reviewer noted a significant reduction in frequent stomach aches from IBS after starting this probiotic, indicating its standalone benefits for digestive health Read Review.
Another user shared a personal success story where they transitioned from having bowel movements just three times a week to almost daily after incorporating this probiotic into their routine Read Review. Additionally, the probiotic has been praised for not only enhancing bowel movements but also for its benefits in reducing yeast infection frequency, which signifies a potential for complementary health effects when used alongside other female-focused supplements Read Review. However, individual experiences may vary, and some users may prefer to experiment with combinations to find the most beneficial regimen for their specific IBS symptoms.
Based on user reviews, there is a consensus that the right dose of probiotics can significantly alleviate symptoms associated with Irritable Bowel Syndrome (IBS). Users report notable improvements in bowel health and frequency of bowel movements after integrating probiotics into their routine. For example, one user mentioned experiencing a shift from having bowel movements just three times a week to almost daily after using a probiotic supplement Read Review. Another review highlights a significant reduction in stomach aches, emphasizing the effectiveness of this approach in managing IBS symptoms Read Review.
Moreover, users appreciate the quality and formulation of the probiotics, with some specifically pointing out that they haven't faced common side effects such as bloating, which can be an issue when starting a new supplement Read Review. Overall, it's clear that while individual experiences may vary, many users find that probiotics can be a highly effective tool in managing their IBS symptoms when taken in appropriate doses.
9
Effective for IBS
5 people found this helpful
I've tried various probiotic products from iHerb and found them generally satisfactory, though slightly pricy. I purchased this one for my gastrointestinal issues and irritable bowel syndrome. It's proven effective, as it significantly alleviates my frequent stomach aches. I plan to continue using it.
9
Constipation relief
1 people found this helpful
Previously struggling with stubborn constipation and having bowel movements only three times a week, I've started taking this after dinner. My bowel movements have improved greatly, now happening almost daily. I'm hopeful it will also help with my vaginitis.
7.5
Notable improvement
I’ve taken this probiotic for over a year, and I've noted a significant improvement in my bowel health and issues related to my vagina.
7.5
Improved bowel movements
7 people found this helpful
High-quality probiotic specifically designed for women. Recommended by my gynaecologist, this probiotic has effectively improved my bowel movements and reduced yeast infection frequency. I’ve not experienced the typical side effects associated with probiotics, such as bloating. The capsules are small and easy to swallow, making this brand my top recommendation.
6
Smooth bowel movements
It's a very good product. After taking it, I have experienced no discomfort, and my bowel movements have become notably smoother. I will continue using it.
8
Synbiotics improved IBS-D symptoms
The Effectiveness of Synbiotic Preparation Containing and Probiotic Strains and Short Chain Fructooligosaccharides in Patients with Diarrhea Predominant Irritable Bowel Syndrome-A Randomized Double-Blind, Placebo-Controlled Study.
We investigated how a synbiotic supplement, which combines various probiotic strains and fructooligosaccharides, influences symptoms in adults suffering from diarrhea-predominant irritable bowel syndrome (IBS-D).
In a well-structured study involving eighty participants, half received the synbiotics while the others got a placebo for eight weeks.
The results showed significant improvement in symptom severity, particularly regarding flatulence and bowel movements, with no notable side effects. This indicates that synbiotics can genuinely help alleviate issues for those with IBS-D.
7
Probiotics modestly improve IBS
Lactobacillus acidophilus CL1285, Lactobacillus casei LBC80R and Lactobacillus rhamnosus CLR2 improve quality-of-life and IBS symptoms: a double-blind, randomised, placebo-controlled study.
We examined the effects of a combination of Lactobacillus acidophilus CL1285 and other probiotics compared to a placebo in treating irritable bowel syndrome (IBS). Over 12 weeks, 113 participants reported significant improvements in abdominal pain, stool consistency, and overall quality of life.
Interestingly, those with diarrhea-predominant IBS and female participants noticed the most benefits. Though there were some mild adverse effects, serious issues were not reported. Overall, while some gains were observed, pain intensity and a few symptom relief measures did not show substantial improvement.
7
Probiotics show mixed IBS benefits
The Efficacy and Safety of Single-Strain Probiotic Formulations Containing or in Adult Patients with Irritable Bowel Syndrome-A Randomized Double-Blind Placebo-Controlled Three-Arm Interventional Trial.
We conducted a study to evaluate the effects of two probiotics, NORDBIOTIC™ BI040 and NORDBIOTIC™ BC300, on individuals with irritable bowel syndrome (IBS). Involving 123 participants diagnosed using standardized criteria, the research was carefully designed as a randomized, double-blind, placebo-controlled trial over a 12-week period.
While both probiotics significantly improved IBS symptoms over time, the differences between the treatment and placebo were not statistically significant at first. However, noteworthy improvements were noticed during follow-up, particularly in pain reduction and bowel satisfaction, showcasing the varied benefits of each strain. Importantly, both treatments were safely tolerated by patients involved in the trial.
5
Probiotics improve diarrhea in IBS
Effect of administering a multi-species probiotic mixture on the changes in fecal microbiota and symptoms of irritable bowel syndrome: a randomized, double-blind, placebo-controlled trial.
We evaluated how a multi-species probiotic mixture influences symptoms of irritable bowel syndrome (IBS) in a randomized, double-blind, placebo-controlled trial with 81 participants. While the probiotic group showed a notable increase in good bacteria and a higher percentage of patients reporting symptom relief, overall changes in total symptom scores did not differ significantly between the probiotic and placebo groups. Notably, we found that the probiotics improved diarrhea symptoms over the trial period.
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Eskesen D, Jespersen L, Michelsen B, Whorwell PJ, Müller-Lissner S, et al. Effect of the probiotic strain Bifidobacterium animalis subsp. lactis, BB-12®, on defecation frequency in healthy subjects with low defecation frequency and abdominal discomfort: a randomised, double-blind, placebo-controlled, parallel-group trial. Br J Nutr. 2015;114:1638. 10.1017/S0007114515003347
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Mokhtar NM, Jaafar NM, Alfian E, Mohd Rathi ND, Abdul Rani R, et al. Clinical assessment and cytokines level in constipation-predominant irritable bowel syndrome participants treated with Lactobacillus-containing cultured milk drink. Acta Gastroenterol Belg. 2021;84:585. 10.51821/84.4.009
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Preston K, Krumian R, Hattner J, de Montigny D, Stewart M, et al. Lactobacillus acidophilus CL1285, Lactobacillus casei LBC80R and Lactobacillus rhamnosus CLR2 improve quality-of-life and IBS symptoms: a double-blind, randomised, placebo-controlled study. Benef Microbes. 2018;9:697. 10.3920/BM2017.0105
Bogovič Matijašić B, Obermajer T, Lipoglavšek L, Sernel T, Locatelli I, et al. Effects of synbiotic fermented milk containing Lactobacillus acidophilus La-5 and Bifidobacterium animalis ssp. lactis BB-12 on the fecal microbiota of adults with irritable bowel syndrome: A randomized double-blind, placebo-controlled trial. J Dairy Sci. 2016;99:5008. 10.3168/jds.2015-10743
Barbaro MR, Bianco F, Cremon C, Marasco G, Stanghellini V, et al. A Probiotic Mixture of LR 32, BL 04, and BB 536 Counteracts the Increase in Permeability Induced by the Mucosal Mediators of Irritable Bowel Syndrome by Acting on Zonula Occludens 1. Int J Mol Sci. 2025;26. 10.3390/ijms26062656
Kwon H, Nam EH, Kim H, Jo H, Bang WY, et al. Effect of Lacticaseibacillus rhamnosus IDCC 3201 on irritable bowel syndrome with constipation: a randomized, double-blind, and placebo-controlled trial. Sci Rep. 2024;14:22384. 10.1038/s41598-024-72887-x
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Nocerino R, Di Costanzo M, Bedogni G, Cosenza L, Maddalena Y, et al. Dietary Treatment with Extensively Hydrolyzed Casein Formula Containing the Probiotic Lactobacillus rhamnosus GG Prevents the Occurrence of Functional Gastrointestinal Disorders in Children with Cow's Milk Allergy. J Pediatr. 2019;213:137. 10.1016/j.jpeds.2019.06.004
Hojsak I. Probiotics in Functional Gastrointestinal Disorders. Adv Exp Med Biol. 2019;1125:121. 10.1007/5584_2018_321
Han X, Lee A, Huang S, Gao J, Spence JR, et al. Lactobacillus rhamnosus GG prevents epithelial barrier dysfunction induced by interferon-gamma and fecal supernatants from irritable bowel syndrome patients in human intestinal enteroids and colonoids. Gut Microbes. 2019;10:59. 10.1080/19490976.2018.1479625
Wegh CAM, Benninga MA, Tabbers MM. Effectiveness of Probiotics in Children With Functional Abdominal Pain Disorders and Functional Constipation: A Systematic Review. J Clin Gastroenterol. 2018;52 Suppl 1, Proceedings from the 9th Probiotics, Prebiotics and New Foods, Nutraceuticals and Botanicals for Nutrition & Human and Microbiota Health Meeting, held in Rome, Italy from September 10 to 12, 2017:S10. 10.1097/MCG.0000000000001054
Darbaky Y, Evrard B, Patrier S, Falenta J, Garcin S, et al. Oral probiotic treatment of Lactobacillus rhamnosus Lcr35 prevents visceral hypersensitivity to a colonic inflammation and an acute psychological stress. J Appl Microbiol. 2017;122:188. 10.1111/jam.13320
Cruchet S, Furnes R, Maruy A, Hebel E, Palacios J, et al. The use of probiotics in pediatric gastroenterology: a review of the literature and recommendations by Latin-American experts. Paediatr Drugs. 2015;17:199. 10.1007/s40272-015-0124-6