Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 26 Researches
7
USERS' SCORE
Good
Based on 25 Reviews
8.1
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Women's Care Probiotic Blend
50 Billion CFU 222 mg
***
Bifido Probiotic BlendBifidobacterium lactis BI-04®, Bifidobacterium lactis DSM 15954, Bifidobacterium infantis Bi-26™
26 Billion CFU
Lacto Probiotic BlendLactobacillus reuteri RC-14®, Lactobacillus plantarum Lp-115®, Lactobacillus rhamnosus GG, Lactobacillus rhamnosus GR-1®, Lactococcus lactis LI-23™, Lactobacillus casei Lc-11®, Lactobacillus paracasei Lpc-37®, Lactobacillus acidophilus La-14®, Lactobacillus brevis Lbr-35™
24 Billion CFU
Top Medical Research Studies
9
We investigated whether a probiotic mix containing Lactobacillus acidophilus could prevent recurrent urinary tract infections (UTIs) in children aged 4 months to 5 years.
The study involved 181 children divided into two groups, one receiving probiotics and the other a placebo, over 18 months.
Results showed that the probiotic group had a lower recurrence of UTIs, with a composite cure rate of 96.7% compared to 83.3% in the placebo group. Overall, using this probiotic mixture may be a promising non-antibiotic option for UTI prevention in young children.
The study involved 181 children divided into two groups, one receiving probiotics and the other a placebo, over 18 months.
Results showed that the probiotic group had a lower recurrence of UTIs, with a composite cure rate of 96.7% compared to 83.3% in the placebo group. Overall, using this probiotic mixture may be a promising non-antibiotic option for UTI prevention in young children.
Read More
8
We explored how well lactobacillus acidophilus and other probiotics can inhibit urinary tract pathogens like E. coli and Enterococcus faecalis. Using specific tests, we found that while all probiotic strains, including L. acidophilus, showed some inhibitory effects, the mixtures of probiotics did not perform better than individual strains. This hints at potential benefits in reducing urinary tract infections, but the advantage of probiotic mixtures remains unclear.
Essentially, these probiotics can help combat urinary infections through their activity, yet further research is needed to determine their practical use.
Essentially, these probiotics can help combat urinary infections through their activity, yet further research is needed to determine their practical use.
Read More
8
We investigated how a biosurfactant called 'surlactin,' derived from Lactobacillus acidophilus, prevents harmful bacteria and yeast from sticking to surfaces that mimic the urinary tract. Using a specialized flow chamber, we observed that surlactin significantly reduced the adhesion of most bacteria tested, particularly effective against common culprits like E. coli and Staphylococcus. Though yeast attachment was also lowered by 50%, their overall numbers remained unchanged. This suggests that while lactobacillus can inhibit some pathogens, it may not be as effective against yeast in the same context.
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Most Useful Reviews
9
No infections
11 people found this helpful
I used to suffer from frequent yeast infections, but since taking this daily for a month, I've had no issues at all. I feel great without any stomach irritation or side effects. It's definitely worth the price.
Read More
9
Impressive results
6 people found this helpful
I've started my elderly mum on this for frequent urinary tract infections. A recent article indicated that probiotics can reduce UTIs in elderly women. She has been on this for two months now and hasn’t had a recurrence. We are impressed.
Read More
10
Frustration resolved
5 people found this helpful
After suffering from recurring yeast infections, I found this probiotic effective when taken every morning. Alongside reducing sugar, I no longer experience infections. Highly recommended!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 26 Researches
7
- All Researches
9
We investigated whether a probiotic mix containing Lactobacillus acidophilus could prevent recurrent urinary tract infections (UTIs) in children aged 4 months to 5 years.
The study involved 181 children divided into two groups, one receiving probiotics and the other a placebo, over 18 months.
Results showed that the probiotic group had a lower recurrence of UTIs, with a composite cure rate of 96.7% compared to 83.3% in the placebo group. Overall, using this probiotic mixture may be a promising non-antibiotic option for UTI prevention in young children.
The study involved 181 children divided into two groups, one receiving probiotics and the other a placebo, over 18 months.
Results showed that the probiotic group had a lower recurrence of UTIs, with a composite cure rate of 96.7% compared to 83.3% in the placebo group. Overall, using this probiotic mixture may be a promising non-antibiotic option for UTI prevention in young children.
Read More
9
We examined how a combination of D-mannose, Salicin, and Lactobacillus acidophilus could help those suffering from recurrent urinary tract infections caused by E. coli. During our study with 85 participants, we introduced this regimen over several weeks and surveyed symptoms through a bladder diary and a scale measuring pain levels.
The results were promising. Participants experienced notable reductions in pain and frequency of symptoms. However, while our findings indicate this approach could be beneficial, further large-scale studies are necessary to confirm its effectiveness.
The results were promising. Participants experienced notable reductions in pain and frequency of symptoms. However, while our findings indicate this approach could be beneficial, further large-scale studies are necessary to confirm its effectiveness.
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9
We explored how locally isolated Lactobacillus species could tackle antibiotic-resistant bacteria responsible for urinary tract infections. Our study involved screening lactic acid bacteria extracted from spoiled produce against various resistant pathogens.
The results were promising, showing that these lactobacilli had antimicrobial activity against six out of seven tested uropathogens. This suggests that using Lactobacillus may be a viable alternative in the battle against UTIs, helping to combat antibiotic resistance effectively.
The results were promising, showing that these lactobacilli had antimicrobial activity against six out of seven tested uropathogens. This suggests that using Lactobacillus may be a viable alternative in the battle against UTIs, helping to combat antibiotic resistance effectively.
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9
We investigated how by-products from Lactobacillus rhamnosus can affect uropathogenic Escherichia coli (UPEC), the bacteria commonly responsible for urinary tract infections (UTIs). Our findings revealed that lactic acid, hydrogen peroxide, and other compounds from these probiotics significantly inhibited the growth of UPEC.
Additionally, they reduced the production of proteins that help the bacteria cling to the urinary tract. This suggests that Lactobacillus rhamnosus and its by-products offer protective benefits against UTIs by combating harmful bacteria and reducing their ability to establish infections.
Additionally, they reduced the production of proteins that help the bacteria cling to the urinary tract. This suggests that Lactobacillus rhamnosus and its by-products offer protective benefits against UTIs by combating harmful bacteria and reducing their ability to establish infections.
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8
We explored the effectiveness of probiotic lactic acid bacteria, particularly Lactobacillus acidophilus, in preventing urinary tract infections linked to catheters.
Through a thorough study involving 120 catheterized patients, we tested various uropathogens and their ability to form biofilms.
Although probiotics showed promise in preventing catheter colonization in vitro, further research is necessary to confirm safety and efficacy in real-life settings.
This suggests a potential step forward in managing catheter-associated urinary infections.
Through a thorough study involving 120 catheterized patients, we tested various uropathogens and their ability to form biofilms.
Although probiotics showed promise in preventing catheter colonization in vitro, further research is necessary to confirm safety and efficacy in real-life settings.
This suggests a potential step forward in managing catheter-associated urinary infections.
Read More
User Reviews
USERS' SCORE
Good
Based on 25 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
No infections
11 people found this helpful
I used to suffer from frequent yeast infections, but since taking this daily for a month, I've had no issues at all. I feel great without any stomach irritation or side effects. It's definitely worth the price.
Read More
9
Impressive results
6 people found this helpful
I've started my elderly mum on this for frequent urinary tract infections. A recent article indicated that probiotics can reduce UTIs in elderly women. She has been on this for two months now and hasn’t had a recurrence. We are impressed.
Read More
10
Frustration resolved
5 people found this helpful
After suffering from recurring yeast infections, I found this probiotic effective when taken every morning. Alongside reducing sugar, I no longer experience infections. Highly recommended!
Read More
9
Chronic condition management
5 people found this helpful
Managing chronic urinary tract infections is challenging. This product, combined with Udo's Probiotic, has kept me infection-free for a record time.
Read More
9
Yeast infection control
3 people found this helpful
This probiotic is of high quality and effective. I have heard that some probiotics cause bloating, but I have had no negative reactions. The capsules are easy to swallow and smell like plain yoghurt. Taken once daily, this probiotic has helped me manage my urinary tract infection.
Read More
Frequently Asked Questions
9
Quick healing
2 people found this helpful
I had a severe urinary tract infection. Using kefir and two ultimate flora capsules resolved it within three days, healing completely within a week—all without chemicals!
2
No benefit experienced
4 people found this helpful
I have always suffered from urinary tract infections. After taking the capsules based on praise, I used them for 20 days. I still had pain and ended up in hospital with a confirmed infection. I did not find any benefit. Every body reacts differently.
9
Infection prevention
2 people found this helpful
I had recurring urinary tract infections and my doctor recommended this product. It has helped immensely, and I haven’t experienced an infection in four months.
9
No infections
11 people found this helpful
I used to suffer from frequent yeast infections, but since taking this daily for a month, I've had no issues at all. I feel great without any stomach irritation or side effects. It's definitely worth the price.
10
Frustration resolved
5 people found this helpful
After suffering from recurring yeast infections, I found this probiotic effective when taken every morning. Alongside reducing sugar, I no longer experience infections. Highly recommended!
9
Three years clear
I have used René Life Ultima Flora consistently and haven’t suffered from urinary tract infections in the past three years.
9
Chronic condition management
5 people found this helpful
Managing chronic urinary tract infections is challenging. This product, combined with Udo's Probiotic, has kept me infection-free for a record time.
9
Maintenance strategy
3 people found this helpful
It has been effective! I have recurrent yeast infections and take one tablet a day for three months, then every other day. My infections have not returned.
9
We investigated whether a probiotic mix containing Lactobacillus acidophilus could prevent recurrent urinary tract infections (UTIs) in children aged 4 months to 5 years.
The study involved 181 children divided into two groups, one receiving probiotics and the other a placebo, over 18 months.
Results showed that the probiotic group had a lower recurrence of UTIs, with a composite cure rate of 96.7% compared to 83.3% in the placebo group. Overall, using this probiotic mixture may be a promising non-antibiotic option for UTI prevention in young children.
The study involved 181 children divided into two groups, one receiving probiotics and the other a placebo, over 18 months.
Results showed that the probiotic group had a lower recurrence of UTIs, with a composite cure rate of 96.7% compared to 83.3% in the placebo group. Overall, using this probiotic mixture may be a promising non-antibiotic option for UTI prevention in young children.
7
We explored how specific Lactobacillus strains, especially L. acidophilus, can prevent urinary tract infections (UTIs) by testing their effects on harmful bacteria's ability to stick to bladder cells.
The study found that L. acidophilus significantly reduced the adherence of uropathogenic bacteria by up to 53.7%, suggesting its potential role in UTI prevention.
In contrast, another strain, L. plantarum, showed minimal effectiveness. Overall, our findings indicate a promising benefit of Lactobacillus in combating UTIs.
The study found that L. acidophilus significantly reduced the adherence of uropathogenic bacteria by up to 53.7%, suggesting its potential role in UTI prevention.
In contrast, another strain, L. plantarum, showed minimal effectiveness. Overall, our findings indicate a promising benefit of Lactobacillus in combating UTIs.
4
Probiotics show no significant benefits
We set out to explore whether probiotics, specifically Lactobacillus acidophilus, could effectively prevent urinary tract infections (UTIs) in children with persistent primary vesicoureteral reflux.
In our randomized controlled study, we divided 120 children into two groups—one receiving probiotics and the other antibiotics—to see which was more effective.
Surprisingly, the results showed no significant difference in UTI recurrence rates between the two groups, suggesting that probiotics may not offer additional benefits over conventional antibiotic treatments in this context.
In our randomized controlled study, we divided 120 children into two groups—one receiving probiotics and the other antibiotics—to see which was more effective.
Surprisingly, the results showed no significant difference in UTI recurrence rates between the two groups, suggesting that probiotics may not offer additional benefits over conventional antibiotic treatments in this context.
8
We examined the potential of Lactobacillus probiotics to fend off recurrent urinary tract infections (UTIs) in females. By analyzing nine clinical trials involving 726 patients, we found that certain strains, particularly Lactobacillus rhamnosus and Lactobacillus reuteri, might effectively reduce the risk of recurrent UTIs.
While results are promising, with a notably lower risk ratio of recurrent episodes, it's important to note the presence of significant variability between studies and short follow-up times. This calls for further, more rigorous research to confirm these benefits and establish standardized practices in the future.
While results are promising, with a notably lower risk ratio of recurrent episodes, it's important to note the presence of significant variability between studies and short follow-up times. This calls for further, more rigorous research to confirm these benefits and establish standardized practices in the future.
References
- Mahgoub MA, Abbass AAG, Abaza AF, Shoukry MS. Probiotic lactic acid bacteria as a means of preventing in vitro urinary catheter colonization and biofilm formation. J Egypt Public Health Assoc. 2023;97:30. doi:10.1186/s42506-022-00124-2
- Sadeghi-Bojd S, Naghshizadian R, Mazaheri M, Ghane Sharbaf F, Assadi F. Efficacy of Probiotic Prophylaxis After The First Febrile Urinary Tract Infection in Children With Normal Urinary Tracts. J Pediatric Infect Dis Soc. 2020;9:305. doi:10.1093/jpids/piz025
- Del Popolo G, Nelli F. Recurrent bacterial symptomatic cystitis: A pilot study on a new natural option for treatment. Arch Ital Urol Androl. 2018;90:101. doi:10.4081/aiua.2018.2.101
- de Llano DG, Arroyo A, Cárdenas N, Rodríguez JM, Moreno-Arribas MV, et al. Strain-specific inhibition of the adherence of uropathogenic bacteria to bladder cells by probiotic Lactobacillus spp. Pathog Dis. 2017;75. doi:10.1093/femspd/ftx043
- Shim YH, Lee SJ, Lee JW. Antimicrobial activity of lactobacillus strains against uropathogens. Pediatr Int. 2016;58:1009. doi:10.1111/ped.12949
- Manzoor A, Ul-Haq I, Baig S, Qazi JI, Seratlic S. Efficacy of Locally Isolated Lactic Acid Bacteria Against Antibiotic-Resistant Uropathogens. Jundishapur J Microbiol. 2016;9:e18952. doi:10.5812/jjm.18952
- Lee SJ, Lee JW. Probiotics prophylaxis in infants with primary vesicoureteral reflux. Pediatr Nephrol. 2015;30:609. doi:10.1007/s00467-014-2988-z
- Rodrigues F, Maia MJ, das Neves J, Sarmento B, Amaral MH, et al. Vaginal suppositories containing Lactobacillus acidophilus: development and characterization. Drug Dev Ind Pharm. 2015;41:1518. doi:10.3109/03639045.2014.963864
- Mohseni MJ, Aryan Z, Emamzadeh-Fard S, Paydary K, Mofid V, et al. Combination of probiotics and antibiotics in the prevention of recurrent urinary tract infection in children. Iran J Pediatr. 2013;23:430.
- Chapman CM, Gibson GR, Todd S, Rowland I. Comparative in vitro inhibition of urinary tract pathogens by single- and multi-strain probiotics. Eur J Nutr. 2013;52:1669. doi:10.1007/s00394-013-0501-2
- Lee SJ, Shim YH, Cho SJ, Lee JW. Probiotics prophylaxis in children with persistent primary vesicoureteral reflux. Pediatr Nephrol. 2007;22:1315.
- Juárez Tomás MS, Ocaña VS, Wiese B, Nader-Macías ME. Growth and lactic acid production by vaginal Lactobacillus acidophilus CRL 1259, and inhibition of uropathogenic Escherichia coli. J Med Microbiol. 2003;52:1117. doi:10.1099/jmm.0.05155-0
- Velraeds MM, van de Belt-Gritter B, van der Mei HC, Reid G, Busscher HJ. Interference in initial adhesion of uropathogenic bacteria and yeasts to silicone rubber by a Lactobacillus acidophilus biosurfactant. J Med Microbiol. 1998;47:1081.
- Reid G, Bruce AW, McGroarty JA, Cheng KJ, Costerton JW. Is there a role for lactobacilli in prevention of urogenital and intestinal infections?. Clin Microbiol Rev. 1990;3:335.
- Kyser AJ, Greiner A, Harris V, Patel R, Frieboes HB, et al. 3D-Bioprinted Urinary Catheters Enable Sustained Probiotic Recovery Under Flow and Improve Bladder Colonization In Vivo. Probiotics Antimicrob Proteins. 2025. doi:10.1007/s12602-024-10428-8
- Ghane M, Babaeekhou L, Ketabi SS. Antibiofilm Activity of Kefir Probiotic Lactobacilli Against Uropathogenic (UPEC). Avicenna J Med Biotechnol. 2020;12:221.
- Toh SL, Lee BB, Ryan S, Simpson JM, Clezy K, et al. Probiotics [LGG-BB12 or RC14-GR1] versus placebo as prophylaxis for urinary tract infection in persons with spinal cord injury [ProSCIUTTU]: a randomised controlled trial. Spinal Cord. 2019;57:550. doi:10.1038/s41393-019-0251-y
- Kara SS, Volkan B, Erten I. GG can protect malnourished children. Benef Microbes. 2019;10:237. doi:10.3920/BM2018.0071
- Ng QX, Peters C, Venkatanarayanan N, Goh YY, Ho CYX, et al. Use of Lactobacillus spp. to prevent recurrent urinary tract infections in females. Med Hypotheses. 2018;114:49. doi:10.1016/j.mehy.2018.03.001
- Montorsi F, Gandaglia G, Salonia A, Briganti A, Mirone V. Effectiveness of a Combination of Cranberries, Lactobacillus rhamnosus, and Vitamin C for the Management of Recurrent Urinary Tract Infections in Women: Results of a Pilot Study. Eur Urol. 2016;70:912. doi:10.1016/j.eururo.2016.05.042
- Lee JW, Lee JH, Sung SH, Lee SJ. Preventive effects of Lactobacillus mixture on experimental E. coli urinary tract infection in infant rats. Yonsei Med J. 2013;54:489. doi:10.3349/ymj.2013.54.2.489
- Beerepoot MA, ter Riet G, Nys S, van der Wal WM, de Borgie CA, et al. Lactobacilli vs antibiotics to prevent urinary tract infections: a randomized, double-blind, noninferiority trial in postmenopausal women. Arch Intern Med. 2012;172:704. doi:10.1001/archinternmed.2012.777
- Karlsson M, Scherbak N, Khalaf H, Olsson PE, Jass J. Substances released from probiotic Lactobacillus rhamnosus GR-1 potentiate NF-κB activity in Escherichia coli-stimulated urinary bladder cells. FEMS Immunol Med Microbiol. 2012;66:147. doi:10.1111/j.1574-695X.2012.00994.x
- Cadieux PA, Burton J, Devillard E, Reid G. Lactobacillus by-products inhibit the growth and virulence of uropathogenic Escherichia coli. J Physiol Pharmacol. 2009;60 Suppl 6:13.
- Anukam KC, Hayes K, Summers K, Reid G. Probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 may help downregulate TNF-Alpha, IL-6, IL-8, IL-10 and IL-12 (p70) in the neurogenic bladder of spinal cord injured patient with urinary tract infections: a two-case study. Adv Urol. 2009;2009:680363. doi:10.1155/2009/680363
- Falagas ME, Betsi GI, Tokas T, Athanasiou S. Probiotics for prevention of recurrent urinary tract infections in women: a review of the evidence from microbiological and clinical studies. Drugs. 2006;66:1253.
