5/17/2025
Last update
5/17/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.6
USERS' SCORE
Good
Based on 3 Reviews
8.6
Top Medical Research Studies
8
We explored how vitamin D plays a role in managing rheumatoid arthritis (RA), a condition that causes joint inflammation and discomfort. It's been found that many people with RA often suffer from vitamin D deficiency, which may worsen their symptoms and overall disease severity.
Our review indicates that vitamin D could help modulate immune responses and lower inflammation levels. Supplementing with vitamin D has shown potential in improving various disease activity markers, signaling that it could be a valuable addition to treatment strategies for RA.
Besides vitamin D, we also looked at other important vitamins like B12, C, and K. While vitamin D stands out for its immune benefits, B12 supports energy and neurological health, C helps with collagen production and inflammation reduction, and K contributes to bone health.
Together, these vitamins create a comprehensive approach to managing RA, emphasizing the need for further research to determine the best ways to use them effectively.
Our review indicates that vitamin D could help modulate immune responses and lower inflammation levels. Supplementing with vitamin D has shown potential in improving various disease activity markers, signaling that it could be a valuable addition to treatment strategies for RA.
Besides vitamin D, we also looked at other important vitamins like B12, C, and K. While vitamin D stands out for its immune benefits, B12 supports energy and neurological health, C helps with collagen production and inflammation reduction, and K contributes to bone health.
Together, these vitamins create a comprehensive approach to managing RA, emphasizing the need for further research to determine the best ways to use them effectively.
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We set out to explore the potential benefits of vitamin D supplementation for people suffering from end-stage knee osteoarthritis (OA). Our research took the form of a double-blinded, randomized controlled trial involving 56 patients with vitamin D insufficiency. This careful design allowed us to compare the effects of vitamin D against a placebo, ensuring that neither the patients nor the assessors knew who received what treatment.
Over six months, participants in the vitamin D group took capsules containing 4,000 IU daily, while the others received a placebo. We measured muscle strength, pain levels, physical function, and signs of sarcopenia at several points: at the start, after three months, and again at the six-month mark.
We aimed to see whether this cost-effective and well-tolerated supplement could improve quality of life by boosting muscle strength and reducing pain for knee OA patients. Given the growing number of people waiting for knee replacements in Hong Kong, our findings could have significant implications for patient care.
Our study's findings may help clarify whether vitamin D supplementation is a viable option for alleviating some symptoms associated with knee osteoarthritis. With ongoing interest in non-surgical therapies, understanding the role of vitamin D (particularly in muscle health) is more relevant than ever.
Over six months, participants in the vitamin D group took capsules containing 4,000 IU daily, while the others received a placebo. We measured muscle strength, pain levels, physical function, and signs of sarcopenia at several points: at the start, after three months, and again at the six-month mark.
We aimed to see whether this cost-effective and well-tolerated supplement could improve quality of life by boosting muscle strength and reducing pain for knee OA patients. Given the growing number of people waiting for knee replacements in Hong Kong, our findings could have significant implications for patient care.
Our study's findings may help clarify whether vitamin D supplementation is a viable option for alleviating some symptoms associated with knee osteoarthritis. With ongoing interest in non-surgical therapies, understanding the role of vitamin D (particularly in muscle health) is more relevant than ever.
Read More
9
We explored how vitamin D (VD) affects osteoarthritis (OA), a condition that commonly leads to joint pain and stiffness. Our research focused on the idea that vitamin D might help reduce inflammation and tissue damage driven by the NF-κB pathway, a crucial player in OA development.
To investigate this, we examined the effects of vitamin D on chondrocytes—cells responsible for cartilage health. By observing how vitamin D influences these cells, we found that it does indeed help maintain cartilage integrity. The study highlighted that vitamin D stabilizes the NF-κB pathway, which normally promotes inflammation, and by doing so, it encourages cellular processes like autophagy that are essential for keeping the cartilage healthy.
We observed significant changes in cartilage condition when vitamin D's role was emphasized, suggesting that vitamin D could be a valuable ally in managing OA symptoms. These findings recommend vitamin D as a potential therapeutic strategy for arthritis, opening new avenues for treatment options that could improve joint health and function for people dealing with this challenging condition.
To investigate this, we examined the effects of vitamin D on chondrocytes—cells responsible for cartilage health. By observing how vitamin D influences these cells, we found that it does indeed help maintain cartilage integrity. The study highlighted that vitamin D stabilizes the NF-κB pathway, which normally promotes inflammation, and by doing so, it encourages cellular processes like autophagy that are essential for keeping the cartilage healthy.
We observed significant changes in cartilage condition when vitamin D's role was emphasized, suggesting that vitamin D could be a valuable ally in managing OA symptoms. These findings recommend vitamin D as a potential therapeutic strategy for arthritis, opening new avenues for treatment options that could improve joint health and function for people dealing with this challenging condition.
Read More
Most Useful Reviews
9
Life-changing solution
10 people found this helpful
This has been transformative for me. Managing my arthritis while only needing to fill the container once a week is invaluable. I can easily track my medication and vitamins. The design is user-friendly, helping me stay on top of my doses without taking up too much space.
Read More
9
User-friendly organizer
2 people found this helpful
This pill organiser is fantastic. I’ve tried various weekly organisers for my mother, who has rheumatoid arthritis, and this is the best. The app reminds her to take her medications, and the magnetic capsules make management easy. I wish I had discovered this sooner; it is worth every penny.
Read More
9
Convenient design
1 people found this helpful
Innovative and large-sized for everything. This surpassed my expectations. I take numerous supplements, and this XL container makes it easier to manage my arthritis treatment. The soft rubber opening allows for easy access, and the magnetic capsules stay in place well. I've tried many pill holders, but this one stands out – highly recommended.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.6
- All Researches
9
We explored how vitamin D (VD) affects osteoarthritis (OA), a condition that commonly leads to joint pain and stiffness. Our research focused on the idea that vitamin D might help reduce inflammation and tissue damage driven by the NF-κB pathway, a crucial player in OA development.
To investigate this, we examined the effects of vitamin D on chondrocytes—cells responsible for cartilage health. By observing how vitamin D influences these cells, we found that it does indeed help maintain cartilage integrity. The study highlighted that vitamin D stabilizes the NF-κB pathway, which normally promotes inflammation, and by doing so, it encourages cellular processes like autophagy that are essential for keeping the cartilage healthy.
We observed significant changes in cartilage condition when vitamin D's role was emphasized, suggesting that vitamin D could be a valuable ally in managing OA symptoms. These findings recommend vitamin D as a potential therapeutic strategy for arthritis, opening new avenues for treatment options that could improve joint health and function for people dealing with this challenging condition.
To investigate this, we examined the effects of vitamin D on chondrocytes—cells responsible for cartilage health. By observing how vitamin D influences these cells, we found that it does indeed help maintain cartilage integrity. The study highlighted that vitamin D stabilizes the NF-κB pathway, which normally promotes inflammation, and by doing so, it encourages cellular processes like autophagy that are essential for keeping the cartilage healthy.
We observed significant changes in cartilage condition when vitamin D's role was emphasized, suggesting that vitamin D could be a valuable ally in managing OA symptoms. These findings recommend vitamin D as a potential therapeutic strategy for arthritis, opening new avenues for treatment options that could improve joint health and function for people dealing with this challenging condition.
Read More
8
We explored the effects of vitamin D supplementation on adults with rheumatoid arthritis (RA), an inflammatory condition affecting millions worldwide. By examining clinical studies that compared vitamin D to either a placebo or standard care, we focused on how these supplements might influence various health outcomes for those suffering from RA.
Our analysis included 11 studies, highlighting several noteworthy findings. We observed a significant improvement in key measures: the Disease Activity Score 28 (DAS-28) showed a meaningful reduction, while levels of C-reactive protein (CRP) and the erythrocyte sedimentation rate (ESR) also decreased. Furthermore, vitamin D supplementation led to an increase in serum vitamin D levels.
Despite these positive results, vitamin D supplementation did not appear to significantly impact the health assessment questionnaire (HAQ) and visual analog scale for pain (VAS-pain) scores. Consequently, while vitamin D can help reduce inflammation and improve specific health parameters in RA patients, the optimal dosage and duration of treatment remain unclear.
Overall, our findings suggest that boosting vitamin D levels might offer benefits for managing RA, and further research may help refine treatment strategies for optimal outcomes.
Our analysis included 11 studies, highlighting several noteworthy findings. We observed a significant improvement in key measures: the Disease Activity Score 28 (DAS-28) showed a meaningful reduction, while levels of C-reactive protein (CRP) and the erythrocyte sedimentation rate (ESR) also decreased. Furthermore, vitamin D supplementation led to an increase in serum vitamin D levels.
Despite these positive results, vitamin D supplementation did not appear to significantly impact the health assessment questionnaire (HAQ) and visual analog scale for pain (VAS-pain) scores. Consequently, while vitamin D can help reduce inflammation and improve specific health parameters in RA patients, the optimal dosage and duration of treatment remain unclear.
Overall, our findings suggest that boosting vitamin D levels might offer benefits for managing RA, and further research may help refine treatment strategies for optimal outcomes.
Read More
8
We aimed to understand how vitamin D deficiency impacts elderly people suffering from osteoarthritis (OA) in their hips and knees. Our study involved 105 OA patients and 152 healthy individuals to compare their vitamin D levels and functional abilities, using criteria like the WOMAC questionnaire to assess pain and functional impairment.
Our findings revealed that patients with low vitamin D levels experienced more severe OA symptoms. They reported higher pain levels and greater difficulties in daily activities compared to those with normal vitamin D levels. Furthermore, their vitamin D deficiency was associated with increased levels of inflammatory markers, TNF-α and IL-6, suggesting a link between inflammation and vitamin D status.
Ultimately, the evidence indicates that maintaining adequate vitamin D levels may be crucial in managing the symptoms of hip and knee osteoarthritis. While further research is necessary to fully understand these relationships, our results hint at the potential benefits of vitamin D supplementation to help alleviate OA symptoms and slow disease progression.
Our findings revealed that patients with low vitamin D levels experienced more severe OA symptoms. They reported higher pain levels and greater difficulties in daily activities compared to those with normal vitamin D levels. Furthermore, their vitamin D deficiency was associated with increased levels of inflammatory markers, TNF-α and IL-6, suggesting a link between inflammation and vitamin D status.
Ultimately, the evidence indicates that maintaining adequate vitamin D levels may be crucial in managing the symptoms of hip and knee osteoarthritis. While further research is necessary to fully understand these relationships, our results hint at the potential benefits of vitamin D supplementation to help alleviate OA symptoms and slow disease progression.
Read More
8
We investigated how vitamin D affects arthritis, specifically focusing on knee osteoarthritis (OA) using a rat model. In our study, male Wistar rats were divided into five groups to evaluate the effects of curcumin, vitamin D, and their combination over 12 weeks.
Both vitamin D and curcumin independently reduced pain in the rats. However, when combined, they provided enhanced pain relief. We observed that vitamin D, alongside curcumin, showed promising results by reducing inflammation and improving joint health. The treatment groups exhibited lower levels of pro-inflammatory cytokines and higher levels of the anti-inflammatory cytokine interleukin-10 (IL-10).
Importantly, the supplements also helped restore some antioxidative markers and led to a significant reduction in the oxidative stress marker known as Cartilage Oligomeric Matrix Protein (COMP). Histological examinations revealed that those treated with vitamin D and curcumin maintained better cartilage integrity and had reduced inflammation in the synovium.
Overall, our findings suggest that vitamin D, particularly in combination with curcumin, could play a vital role in managing knee OA by addressing both pain and the underlying inflammation, making it a potential option for arthritis treatment in clinical settings.
Both vitamin D and curcumin independently reduced pain in the rats. However, when combined, they provided enhanced pain relief. We observed that vitamin D, alongside curcumin, showed promising results by reducing inflammation and improving joint health. The treatment groups exhibited lower levels of pro-inflammatory cytokines and higher levels of the anti-inflammatory cytokine interleukin-10 (IL-10).
Importantly, the supplements also helped restore some antioxidative markers and led to a significant reduction in the oxidative stress marker known as Cartilage Oligomeric Matrix Protein (COMP). Histological examinations revealed that those treated with vitamin D and curcumin maintained better cartilage integrity and had reduced inflammation in the synovium.
Overall, our findings suggest that vitamin D, particularly in combination with curcumin, could play a vital role in managing knee OA by addressing both pain and the underlying inflammation, making it a potential option for arthritis treatment in clinical settings.
Read More
8
We explored the potential of calcitriol, a form of vitamin D, in treating rheumatoid arthritis (RA) through its interaction with mesenchymal stem cells (MSCs) in a mouse model. The study initiated by inducing arthritis in BALB/c mice using collagen, which mimicked the inflammatory processes seen in human RA.
The mice were then divided into groups receiving either untreated MSCs or those treated with calcitriol. This setup allowed us to evaluate the difference in immune responses from these treatments over a week.
Our findings highlighted that MSCs treated with calcitriol showed improved regulatory functions and reduced the inflammatory responses in immune cells, particularly affecting splenocytes. Notably, there was a significant increase in beneficial cytokines while the levels of pro-inflammatory cytokines decreased compared to the untreated group.
This suggests that vitamin D, in combination with MSCs, could play a valuable role in modulating immune responses in RA, indicating a promising pathway for future therapies. However, the specific isolated effects of vitamin D alone remain less clear due to the combination approach taken in this study.
The mice were then divided into groups receiving either untreated MSCs or those treated with calcitriol. This setup allowed us to evaluate the difference in immune responses from these treatments over a week.
Our findings highlighted that MSCs treated with calcitriol showed improved regulatory functions and reduced the inflammatory responses in immune cells, particularly affecting splenocytes. Notably, there was a significant increase in beneficial cytokines while the levels of pro-inflammatory cytokines decreased compared to the untreated group.
This suggests that vitamin D, in combination with MSCs, could play a valuable role in modulating immune responses in RA, indicating a promising pathway for future therapies. However, the specific isolated effects of vitamin D alone remain less clear due to the combination approach taken in this study.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Life-changing solution
10 people found this helpful
This has been transformative for me. Managing my arthritis while only needing to fill the container once a week is invaluable. I can easily track my medication and vitamins. The design is user-friendly, helping me stay on top of my doses without taking up too much space.
Read More
9
User-friendly organizer
2 people found this helpful
This pill organiser is fantastic. I’ve tried various weekly organisers for my mother, who has rheumatoid arthritis, and this is the best. The app reminds her to take her medications, and the magnetic capsules make management easy. I wish I had discovered this sooner; it is worth every penny.
Read More
9
Convenient design
1 people found this helpful
Innovative and large-sized for everything. This surpassed my expectations. I take numerous supplements, and this XL container makes it easier to manage my arthritis treatment. The soft rubber opening allows for easy access, and the magnetic capsules stay in place well. I've tried many pill holders, but this one stands out – highly recommended.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Ranjbar M, Rahimlou M, Fallah M, Djafarian K, Mohammadi H. Effects of vitamin D supplementation in patients with rheumatoid arthritis: A systematic review and meta-analysis. Heliyon. 2025;11:e42463. 10.1016/j.heliyon.2025.e42463
- Montemor CN, Fernandes MTP, Marquez AS, Bignardi PR, Poli RC, et al. Impact of Reduced Vitamin D Levels on Pain, Function, and Severity in Knee or Hip Osteoarthritis. Nutrients. 2025;17. 10.3390/nu17030447
- Mende LK, Kuthati Y, Wong CS. Curcumin and Vitamin D Supplement Attenuates Knee Osteoarthritis Progression in ACLT + MMx Rat Model: Effect on Cartilage Protection and Pain Reduction. Nutrients. 2025;17. 10.3390/nu17020349
- Arellano Pérez Vertti RD, Arellano RamÃrez DO, González Galarza FF, Prieto Hinojosa AI, Méndez Hernández A, et al. "Association of vitamin D blood deficiency and the rs731236 polymorphism vitamin D receptor with primary knee osteoarthritis in subjects from Mexico". Clin Rheumatol. 2025;44:1329. 10.1007/s10067-025-07332-z
- Rafati A, Ramezani R, Esmaeili Gouvarchin Ghaleh H, Bahrami S, Alvanegh AG, et al. Calcitriol Treated Mesenchymal Stem Cells Modulated Immune Response in Collagen-Induced Rheumatoid Arthritis in BALB/c Mice. Transplant Proc. 2025;57:355. 10.1016/j.transproceed.2024.12.020
- Liu P, Zhou J, Cui H, Xu J, Ruan G, et al. 1,25(OH)D induces chondrocyte autophagy and reduces the loss of proteoglycans in osteoarthritis through inhibiting the NF-κB pathway. Clin Rheumatol. 2025;44:811. 10.1007/s10067-024-07281-z
- Hijjawi N, Tout FS, Azaizeh B, Aljaafreh B. The role of vitamins D, B12, C, and K in modulating inflammation and disease management in rheumatoid arthritis: a comprehensive review. Clin Rheumatol. 2025;44:591. 10.1007/s10067-024-07285-9
- Gottreich JR, Katz JN, Jones MH. Nonsurgical Knee Osteoarthritis Treatments for Reducing Inflammation as Measured on MRI Scans: A Systematic Review of Randomized Controlled Trials. Orthop J Sports Med. 2024;12:23259671241272667. 10.1177/23259671241272667
- Zuo A, Jia Q, Zhang M, Zhou X, Li T, et al. The association of vitamin D with knee osteoarthritis pain: an analysis from the Osteoarthritis Initiative database. Sci Rep. 2024;14:30176. 10.1038/s41598-024-81845-6
- Wielińska J, Górna K, Świerkot J, Bugaj B, Kolossa K, et al. Polymorphic Variants in the Vitamin D Receptor and Clinical Parameters of Rheumatoid Arthritis Patients Undergoing Anti-TNF Treatment. Arch Immunol Ther Exp (Warsz). 2024;72. 10.2478/aite-2024-0023
- Cai Z, Zhang Z, Leng J, Xie M, Zhang K, et al. β-Hydroxybutyrate ameliorates osteoarthritis through activation of the ERBB3 signaling pathway in mice. J Bone Miner Res. 2024;40:140. 10.1093/jbmr/zjae176
- Luo H, Zhang Y, Meng C, Li C, Jia D, et al. The effect of copper and vitamin D on osteoarthritis outcomes: A Mendelian randomization study. Medicine (Baltimore). 2024;103:e39828. 10.1097/MD.0000000000039828
- Zang K, Bhatia R, Xue E, Bennett KJ, Luo KH, et al. Vitamin D as a Modifiable Risk Factor for Juvenile Idiopathic Arthritis: A Systematic Review and Meta-analysis of Observational Studies Comparing Baseline Vitamin D in Children with JIA to Individuals Without. Nutr Rev. 2024. 10.1093/nutrit/nuae148
- Kirikovich SS, Levites EV, Proskurina AS, Ritter GS, Dolgova EV, et al. Production of GcMAF with Anti-Inflammatory Properties and Its Effect on Models of Induced Arthritis in Mice and Cystitis in Rats. Curr Issues Mol Biol. 2024;46:10934. 10.3390/cimb46100650
- Feng Y, Zhu P, Yan D, Wang X, Chen C, et al. Implications of vitamin D levels or status for mortality in rheumatoid arthritis: analysis of 2001-2018 data from the National Health and Nutrition Examination Survey. Front Immunol. 2024;15:1425119. 10.3389/fimmu.2024.1425119
- Wang QW, Ong MT, Man GC, Yeung YM, He X, et al. The effectiveness of vitamin D supplementation in patients with end-stage knee osteoarthritis: Study protocol for a double-blinded, randomized controlled trial. PLoS One. 2024;19:e0309610. 10.1371/journal.pone.0309610
