We conducted a double-blind, placebo-controlled clinical trial to explore the effectiveness of a zinc oxide/glycine cream in treating cold sores caused by facial and circumoral herpes. By dividing 46 participants into two groups, one receiving the zinc treatment and the other a placebo, we aimed to measure how this formulation affected the duration and severity of cold sore symptoms.
Our results were quite promising! Participants who began using the zinc oxide/glycine cream within the first 24 hours of noticing symptoms experienced cold sore lesions that lasted only an average of 5 days, compared to 6.5 days for those on the placebo. Additionally, we noticed a significant reduction in the overall severity of their symptoms, including blistering, soreness, itching, and tingling.
As for side effects, subjects treated with the zinc cream experienced only minor and reversible issues typical of ionic zinc salt solutions. This indicates that the zinc oxide/glycine cream is not only effective but also safe for treating cold sores, presenting a valuable option for many people seeking relief from this common condition.
Read More
9
Zinc gel aids cold sore healing
[Clinical double-blind trial of topical zinc sulfate for herpes labialis recidivans].
We conducted a double-blind, placebo-controlled clinical trial to assess the impact of zinc sulfate gel on cold sores, specifically herpes labialis recidivans. In our study, patients treated with zinc sulfate gel, known as Virudermin Gel, experienced significantly reduced symptoms and faster healing compared to those who received just the gel without zinc.
The results were promising; the patients using the zinc gel reported less discomfort, and their sores healed more quickly. Importantly, this treatment showed no significant side effects, making it a safe option for managing cold sores. Additionally, the antiseptic properties of zinc sulfate helped prevent any superinfections, adding another layer of benefit to its use.
Overall, our exploration into zinc’s effectiveness provided valuable insights for both patients and healthcare providers seeking reliable cold sore treatment options. With simple application and proven results, zinc sulfate gel could become a go-to remedy for those frequently struggling with herpes labialis recidivans.
Read More
8
Zinc treatment helps cold sores
Recurrent herpes labialis: a pilot study of the efficacy of zinc therapy.
We aimed to understand how zinc might affect the occurrence and duration of cold sores, also known as herpes labialis. In our study, we treated 20 patients, mostly women with an average age of 26.6, who experienced more than six episodes of cold sores each year. They received zinc sulphate at a dose of 22.5 mg twice daily during specific months over a year while we monitored their symptoms for 12 months.
Our results were promising. Patients reported a decrease in the frequency of cold sore episodes, averaging fewer than four instances per year. Moreover, the duration of these episodes was also shortened to around 5.7 days, significantly less than usual for these conditions.
Thus, we can say that systemic zinc sulphate seemed to effectively reduce both the number of cold sore outbreaks and the recovery time. This suggests that zinc might be a beneficial option for individuals who struggle with recurrent cold sores.
Read More
Most Useful Reviews
9
Excellent results reported
111 people found this helpful
At the first hint of a cold, it's essential to take it at night and in the morning! The effects are remarkable!
Read More
10
Effective cold relief
7 people found this helpful
Works brilliantly! This elderberry syrup is remarkably effective, providing relief from cold symptoms within minutes. I take it at the first sign of a cold, and over three months, I've managed to avoid illness! Its benefits are clear, and it will be a staple in my medicine cabinet. Its composition is impeccable, using only natural ingredients, all beneficial for the body. The quality is top-notch, and the large packaging ensures it lasts the entire cold season, being more economical than buying cold powders and much healthier for my well-being! If my review was helpful, please give me a Like❤️
Read More
9
Immune system boost
4 people found this helpful
Sambucol provides excellent immune system support. The entire family uses it at the first signs of a cold, and it genuinely makes a difference. This combination of zinc and vitamin C is beneficial and has a delightful taste.
We investigated how an ascorbic acid-based solution could help treat recurrent cold sores, also known as mucocutaneous herpes. This study was carefully designed as a randomized, double-blind, placebo-controlled trial, which helps ensure the results are reliable and trustworthy.
Participants used a strong solution of Ascoxal, rich in vitamin C, applied to their cold sores multiple times on the first day of the outbreak. We monitored various symptoms daily, including the severity of scabs, redness, and blisters, comparing the experiences of those using the vitamin C solution to a placebo group.
Our findings were promising: the active treatment resulted in fewer days with scabbing and less severe symptoms overall. Moreover, those using the vitamin C solution showed reduced persistence of scabs compared to the placebo group, along with a lower frequency of detected herpes virus after treatment.
In conclusion, this brief course of vitamin C treatment appears to have significant clinical benefits against cold sores, opening the door for future research on more extensive and frequent treatment regimes.
Read More
9
Zinc impacts cold sore recovery
Comparative analysis of salivary zinc level in recurrent herpes labialis.
We explored the connection between zinc levels and recurrent herpes labialis (RHL), commonly known as cold sores. In a study involving 80 individuals, we compared the salivary zinc levels of healthy people with those experiencing RHL during both the acute and convalescent phases.
The findings revealed that patients in the acute phase had significantly lower zinc levels (160.8 ng/ml) compared to when they were recovering (205.7 ng/ml). Both those phases showed lower zinc levels than the healthy individuals' average. This suggests that zinc levels are not just lower when cold sores are present, but also improve after the lesions heal.
Our results indicate that maintaining adequate zinc levels might be beneficial for people suffering from cold sores. Incorporating zinc supplements could play a role in both treating and preventing these uncomfortable outbreaks. We found that increasing serum zinc might help RHL patients, shedding light on a potential supportive treatment strategy for cold sores.
Read More
9
Zinc may relieve cold sores
Safety and effectiveness of an L-lysine, zinc, and herbal-based product on the treatment of facial and circumoral herpes.
We conducted a small pilot study to investigate how a combination of L-lysine, zinc, and herbal ingredients could help treat cold sores caused by the Herpes simplex virus. Our goal was to observe the changes in symptoms such as itching, burning, and soreness among participants over the course of treatment.
Thirty individuals, split evenly between genders, participated in our open-label study. We monitored their symptoms through various methods, including self-reported outcomes, photographs, and daily diaries. By the sixth day of treatment, most participants showed considerable improvement, with some experiencing full resolution of their symptoms.
While we didn't isolate the effect of zinc alone, its inclusion in the treatment mix seems promising. By the end of our study, we found that 87 percent of participants had improved symptomatically, which indicates that the combination treatment may effectively relieve cold sore symptoms. Importantly, no adverse effects were reported during the study, which adds to our understanding of these treatments' safety.
Read More
9
Zinc cream alleviates cold sores
A randomized clinical trial on the treatment of oral herpes with topical zinc oxide/glycine.
We conducted a double-blind, placebo-controlled clinical trial to explore the effectiveness of a zinc oxide/glycine cream in treating cold sores caused by facial and circumoral herpes. By dividing 46 participants into two groups, one receiving the zinc treatment and the other a placebo, we aimed to measure how this formulation affected the duration and severity of cold sore symptoms.
Our results were quite promising! Participants who began using the zinc oxide/glycine cream within the first 24 hours of noticing symptoms experienced cold sore lesions that lasted only an average of 5 days, compared to 6.5 days for those on the placebo. Additionally, we noticed a significant reduction in the overall severity of their symptoms, including blistering, soreness, itching, and tingling.
As for side effects, subjects treated with the zinc cream experienced only minor and reversible issues typical of ionic zinc salt solutions. This indicates that the zinc oxide/glycine cream is not only effective but also safe for treating cold sores, presenting a valuable option for many people seeking relief from this common condition.
Read More
9
Zinc gel aids cold sore healing
[Clinical double-blind trial of topical zinc sulfate for herpes labialis recidivans].
We conducted a double-blind, placebo-controlled clinical trial to assess the impact of zinc sulfate gel on cold sores, specifically herpes labialis recidivans. In our study, patients treated with zinc sulfate gel, known as Virudermin Gel, experienced significantly reduced symptoms and faster healing compared to those who received just the gel without zinc.
The results were promising; the patients using the zinc gel reported less discomfort, and their sores healed more quickly. Importantly, this treatment showed no significant side effects, making it a safe option for managing cold sores. Additionally, the antiseptic properties of zinc sulfate helped prevent any superinfections, adding another layer of benefit to its use.
Overall, our exploration into zinc’s effectiveness provided valuable insights for both patients and healthcare providers seeking reliable cold sore treatment options. With simple application and proven results, zinc sulfate gel could become a go-to remedy for those frequently struggling with herpes labialis recidivans.
At the first hint of a cold, it's essential to take it at night and in the morning! The effects are remarkable!
Read More
10
Effective cold relief
7 people found this helpful
Works brilliantly! This elderberry syrup is remarkably effective, providing relief from cold symptoms within minutes. I take it at the first sign of a cold, and over three months, I've managed to avoid illness! Its benefits are clear, and it will be a staple in my medicine cabinet. Its composition is impeccable, using only natural ingredients, all beneficial for the body. The quality is top-notch, and the large packaging ensures it lasts the entire cold season, being more economical than buying cold powders and much healthier for my well-being! If my review was helpful, please give me a Like❤️
Read More
9
Immune system boost
4 people found this helpful
Sambucol provides excellent immune system support. The entire family uses it at the first signs of a cold, and it genuinely makes a difference. This combination of zinc and vitamin C is beneficial and has a delightful taste.
Read More
10
Prevention tool
3 people found this helpful
A stellar remedy for colds! The syrup’s composition is flawless, made solely from natural ingredients, ideally suited for the body’s needs. This highly effective syrup works from the moment it’s taken! My symptoms have always improved following early usage at the first sign of a cold. I’ve consistently avoided illness for three months! The advantages are clear. The quality is unparalleled; the large packaging will easily last an entire cold season, making it significantly more economical than buying cold powders! I wish you good health and longevity! And thanks for the Like, kind soul!)
Read More
10
Prevents illness
3 people found this helpful
For my two-year-old daughter, this syrup has been a lifesaver since starting kindergarten! Previously, I struggled with her falling ill every fortnight. However, after giving her this syrup at night, we’ve avoided any colds or illnesses for three months. It truly works wonders!
Cold sores, also known as fever blisters, are small, fluid-filled blisters that typically appear on or around the lips, although they can also occur in other areas of the face. They are caused by the herpes simplex virus (HSV), primarily HSV-1, and are highly contagious. The initial outbreak may be accompanied by symptoms such as fever, swollen lymph nodes, and a general feeling of malaise. Once infected, the virus remains dormant in the body and can reactivate, leading to recurring outbreaks, often triggered by stress, illness, or exposure to sunlight.
Treatment options for cold sores often focus on alleviating symptoms and speeding up healing. Over-the-counter creams containing antiviral medication like docosanol can help reduce the duration of an outbreak when applied early on. Prescription medications may be recommended for more severe cases. Home remedies, such as applying ice, using aloe vera, or taking lysine supplements, may also offer some relief. Prevention strategies include avoiding known triggers and practicing good hygiene, like not sharing utensils or personal items with infected individuals.
Elderberry (Sambucus) refers to a genus of flowering plants in the family Adoxaceae, comprising several species known for their small berries and traditional medicinal uses. The most commonly recognized species is the European elder, Sambucus nigra, which has been utilized in folk medicine for centuries due to its rich nutrient profile, including antioxidants, vitamins A and C, and dietary fiber. Elderberries are typically fragrant clusters of small, dark purple to black berries that are used in a variety of culinary applications, such as jams, syrups, and wine.
In recent years, elderberry has gained popularity for its potential health benefits, particularly for supporting immune health. Many people consume elderberry supplements or syrups to help alleviate symptoms of colds and flu, with some studies suggesting they may reduce the duration and severity of viral infections. However, it’s important to note that raw elderberries, as well as other parts of the elderberry plant, can be toxic if consumed in large amounts. Therefore, it's recommended to use elderberry products that are properly processed and prepared to ensure safety and efficacy.
Elderberry (Sambucus) has gained popularity for its potential health benefits, including its role in supporting the immune system. While some studies suggest that elderberry may help reduce the severity and duration of colds and flu, its specific effectiveness against cold sores, which are caused by the herpes simplex virus, is less documented. Cold sores typically require antiviral treatments for effective management, and while elderberry might provide general immune support, it should not be relied upon as a primary treatment for cold sores.
Based on user reviews, it appears that many individuals experience relief from cold sores and cold symptoms within a short time frame when taking the supplement at the onset of symptoms. Users commonly report that they see noticeable effects almost immediately after consumption, particularly when taken at the first hint of illness. For instance, one review mentioned, "It works from the first moments of intake and instantly alleviated my cold" Read Review. Another user stated that "as soon as the first signs of a cold manifest, I start administering it, and the cold goes away immediately!" Read Review.
Additionally, some users noted that consistent use over a few days leads to sustained benefits, with significant improvements often reported by day two of treatment Read Review. Overall, while the speed at which effects are felt may vary among individuals, taking the supplement promptly seems crucial for achieving the best results against cold sores and related symptoms.
Based on the available scientific research, several studies suggest that supplements containing zinc and vitamin C may offer benefits for treating and managing cold sores caused by the herpes simplex virus. For instance, a pilot study highlighted the promising effects of a lignin and vitamin C combination, noting that early treatment led to reduced severity and frequency of cold sore episodes [1]. Another study demonstrated that using an ascorbic acid-based solution significantly decreased the duration of scabbing and severity of symptoms in participants, compared to those using a placebo [2].
Zinc's role also appears noteworthy, with multiple studies indicating that zinc supplementation may help in reducing both the frequency and duration of cold sore outbreaks. For instance, a study found that participants receiving zinc sulfate demonstrated significant symptom relief and faster healing [11]. Moreover, consistently low levels of zinc were associated with longer recovery times from cold sores, suggesting that maintaining adequate zinc levels might be beneficial [6]. While more extensive studies are needed to isolate each component's effects, the current body of research supports the potential of zinc and vitamin C as substantial adjuncts in the management of cold sores.
Based on user reviews, many individuals have reported significant improvements in their cold and cold sore symptoms when using elderberry syrup. Users frequently highlight the syrup's remarkable efficacy when consumed at the first hint of a cold. For example, one user mentioned, "At the first hint of a cold, it’s essential to take it at night and in the morning! The effects are remarkable!" Read Review. Another user emphasized, "I give this to my 4-year-old child at the first sign of a cold; all symptoms disappear immediately" Read Review.
Moreover, many families have reported extended periods of illness-free living after beginning to use the product regularly. One parent noted, “We’ve avoided any colds or illnesses for three months" Read Review. Others have shared similar experiences, stating that their children’s symptoms are mild, resolving swiftly after use Read Review. Overall, while every individual may respond differently, the general consensus among users points to the syrup being a reliable remedy that can contribute to improved immunity and swift symptom relief when taken early.
Based on user reviews, many individuals have reported positive experiences when combining elderberry syrup with other supplements, particularly those that provide additional immune support, such as vitamin C and zinc. Users note that this combination enhances the overall effectiveness against cold symptoms and cold sores. One review stated, "The combination of zinc and vitamin C is beneficial and has a delightful taste" Read Review. Another individual recommends a syrup that includes vitamin C and zinc, emphasizing its effectiveness with cold sores in particular Read Review.
The consensus among users suggests that taking elderberry syrup in conjunction with these additional supplements can lead to quicker relief and reduced intensity of symptoms. Several families have reported that using elderberry syrup as a preventive measure in tandem with these other supplements resulted in fewer incidences of illness and faster recovery times. One parent noted a significant improvement in their child's health when combining such remedies Read Review. This highlights the potential benefits of a multifaceted approach to managing cold sore symptoms, leveraging both elderberry syrup and supportive supplements.
Based on user reviews, it appears that many individuals find success with Elderberry Sambucus when used at the first signs of a cold or cold sore. For instance, several users emphasize the importance of taking the syrup immediately when symptoms begin. One review mentions, "Take it at the first sign of a cold; it works wonders!" indicating that early administration maximizes its benefits Read Review.
Dosage also varies among users, but a common practice involves giving a teaspoon or 10 ml dose, particularly for children. One user states they give their daughter one teaspoon at the initial signs of a cold and have noted swift recovery Read Review. Overall, users agree that adhering to a regime of taking the elderberry syrup right at the onset of symptoms yields the best chance for alleviating cold-related discomfort, often leading to a more rapid recovery Read Review.
9
Instant relief
3 people found this helpful
This elderberry syrup is incredibly effective! It works from the first moments of intake and instantly alleviated my cold. I’ve never been ill for three months after starting it! Its natural ingredients are beneficial, and it is now a staple in my first aid kit during the cold season.
9
Instant effectiveness noted
1 people found this helpful
Fabulous! It's a shame I didn't purchase it sooner. With this remedy, my child rarely falls ill. As soon as the first signs of a cold manifest, I start administering it, and the cold goes away immediately!
9
Effective early aid
We really appreciated this product! It’s an excellent supplement for initial cold symptoms. Following the recommended dosage in the early days of illness resulted in significant improvement by day two. The children enjoyed the syrup’s sweet taste and pleasant aroma, and the packaging was good. Those with allergies should consult a physician!
9
Excellent results reported
111 people found this helpful
At the first hint of a cold, it's essential to take it at night and in the morning! The effects are remarkable!
9
Symptom relief
I give this to my 4-year-old child at the first sign of a cold, with 10 ml at bedtime. All symptoms disappear immediately. It's a fantastic remedy! I have reordered multiple times, and for a year, my child has not fallen ill, whereas before, he would take sick leave every month.
10
Prevents illness
3 people found this helpful
For my two-year-old daughter, this syrup has been a lifesaver since starting kindergarten! Previously, I struggled with her falling ill every fortnight. However, after giving her this syrup at night, we’ve avoided any colds or illnesses for three months. It truly works wonders!
7.5
Mild colds
3 people found this helpful
I give my daughter one teaspoon at the initial signs of a cold. Over the past three years, we’ve only needed two teaspoons and her colds are generally mild and resolve quickly.
9
Immune system boost
4 people found this helpful
Sambucol provides excellent immune system support. The entire family uses it at the first signs of a cold, and it genuinely makes a difference. This combination of zinc and vitamin C is beneficial and has a delightful taste.
9
Cough relief
1 people found this helpful
Black Elderberry Syrup with Vitamin C and Zinc is an excellent syrup with a delightful taste; this is my second purchase. It effectively aids with cold sores and helps to quickly alleviate coughing. I highly recommend you try it!
9
Works effectively
Take it when you first catch a cold; it works wonders!
9
Must-have in winter
An excellent remedy and a must-have during the cold season! It should be taken at the first sign of a cold, as it helps prevent illness. The formula also contains vitamin C and zinc.
8
Vitamin C shows potential for cold sores
A clinical pilot study of lignin--ascorbic acid combination treatment of herpes simplex virus.
We conducted a clinical pilot study to evaluate the effects of a combination treatment of lignin—a substance derived from pine cones—mixed with vitamin C on cold sores caused by the herpes simplex virus type 1 (HSV-1). Our study included 48 healthy participants, ranging from 4 to 61 years old, who had active lesions of HSV-1.
Participants received a daily dose of the lignin-ascorbic acid treatment for one month. Notably, those who began the treatment within the first 48 hours after the onset of symptoms did not develop typical cold sore lesions. For others who started later, we observed a shorter duration of cold sores and less severe symptoms compared to their previous outbreaks.
Many participants reported a reduction in both the severity and frequency of their cold sore episodes during treatment. Although the results suggest some benefits of this combination treatment, it’s important to note that vitamin C was part of the blend, making it challenging to evaluate its individual effect on cold sores directly.
Thus, while the combination of lignin and vitamin C appears promising for preventing and treating HSV-1 infection, further studies isolating vitamin C's effects would be helpful to understand its specific role in managing cold sores.
9
Vitamin C alleviates cold sores
Topical treatment of recurrent mucocutaneous herpes with ascorbic acid-containing solution.
We investigated how an ascorbic acid-based solution could help treat recurrent cold sores, also known as mucocutaneous herpes. This study was carefully designed as a randomized, double-blind, placebo-controlled trial, which helps ensure the results are reliable and trustworthy.
Participants used a strong solution of Ascoxal, rich in vitamin C, applied to their cold sores multiple times on the first day of the outbreak. We monitored various symptoms daily, including the severity of scabs, redness, and blisters, comparing the experiences of those using the vitamin C solution to a placebo group.
Our findings were promising: the active treatment resulted in fewer days with scabbing and less severe symptoms overall. Moreover, those using the vitamin C solution showed reduced persistence of scabs compared to the placebo group, along with a lower frequency of detected herpes virus after treatment.
In conclusion, this brief course of vitamin C treatment appears to have significant clinical benefits against cold sores, opening the door for future research on more extensive and frequent treatment regimes.
9
Zinc gel aids cold sore healing
[Clinical double-blind trial of topical zinc sulfate for herpes labialis recidivans].
We conducted a double-blind, placebo-controlled clinical trial to assess the impact of zinc sulfate gel on cold sores, specifically herpes labialis recidivans. In our study, patients treated with zinc sulfate gel, known as Virudermin Gel, experienced significantly reduced symptoms and faster healing compared to those who received just the gel without zinc.
The results were promising; the patients using the zinc gel reported less discomfort, and their sores healed more quickly. Importantly, this treatment showed no significant side effects, making it a safe option for managing cold sores. Additionally, the antiseptic properties of zinc sulfate helped prevent any superinfections, adding another layer of benefit to its use.
Overall, our exploration into zinc’s effectiveness provided valuable insights for both patients and healthcare providers seeking reliable cold sore treatment options. With simple application and proven results, zinc sulfate gel could become a go-to remedy for those frequently struggling with herpes labialis recidivans.
9
Zinc impacts cold sore recovery
Comparative analysis of salivary zinc level in recurrent herpes labialis.
We explored the connection between zinc levels and recurrent herpes labialis (RHL), commonly known as cold sores. In a study involving 80 individuals, we compared the salivary zinc levels of healthy people with those experiencing RHL during both the acute and convalescent phases.
The findings revealed that patients in the acute phase had significantly lower zinc levels (160.8 ng/ml) compared to when they were recovering (205.7 ng/ml). Both those phases showed lower zinc levels than the healthy individuals' average. This suggests that zinc levels are not just lower when cold sores are present, but also improve after the lesions heal.
Our results indicate that maintaining adequate zinc levels might be beneficial for people suffering from cold sores. Incorporating zinc supplements could play a role in both treating and preventing these uncomfortable outbreaks. We found that increasing serum zinc might help RHL patients, shedding light on a potential supportive treatment strategy for cold sores.
References
Lopez BS, Yamamoto M, Utsumi K, Aratsu C, Sakagami H. A clinical pilot study of lignin--ascorbic acid combination treatment of herpes simplex virus. In Vivo. 2009;23:1011.
Hovi T, Hirvimies A, Stenvik M, Vuola E, Pippuri R. Topical treatment of recurrent mucocutaneous herpes with ascorbic acid-containing solution. Antiviral Res. 1995;27:263.
Terezhalmy GT, Bottomley WK, Pelleu GB. The use of water-soluble bioflavonoid-ascorbic acid complex in the treatment of recurrent herpes labialis. Oral Surg Oral Med Oral Pathol. 1978;45:56.
Ranjbar Z, Zahed M, Ranjbar MA, Shirmardan Z. Comparative study of serum zinc concentration in recurrent herpes labialis patients and healthy individuals. BMC Oral Health. 2020;20:296. doi:10.1186/s12903-020-01277-2
Houston DM, Bugert J, Denyer SP, Heard CM. Anti-inflammatory activity of Punica granatum L. (Pomegranate) rind extracts applied topically to ex vivo skin. Eur J Pharm Biopharm. 2017;112:30. doi:10.1016/j.ejpb.2016.11.014
Khozeimeh F, Jafari N, Attar AM, Jafari S, Ataie M. Comparative analysis of salivary zinc level in recurrent herpes labialis. Dent Res J (Isfahan). 2012;9:19. doi:10.4103/1735-3327.92922
Opstelten W, Neven AK, Eekhof J. Treatment and prevention of herpes labialis. Can Fam Physician. 2008;54:1683.
Femiano F, Gombos F, Scully C. Recurrent herpes labialis: a pilot study of the efficacy of zinc therapy. J Oral Pathol Med. 2005;34:423.
Singh BB, Udani J, Vinjamury SP, Der-Martirosian C, Gandhi S, et al. Safety and effectiveness of an L-lysine, zinc, and herbal-based product on the treatment of facial and circumoral herpes. Altern Med Rev. 2005;10:123.
Godfrey HR, Godfrey NJ, Godfrey JC, Riley D. A randomized clinical trial on the treatment of oral herpes with topical zinc oxide/glycine. Altern Ther Health Med. 2001;7:49.
Kneist W, Hempel B, Borelli S. [Clinical double-blind trial of topical zinc sulfate for herpes labialis recidivans]. Arzneimittelforschung. 1995;45:624.
Brody I. Topical treatment of recurrent herpes simplex and post-herpetic erythema multiforme with low concentrations of zinc sulphate solution. Br J Dermatol. 1981;104:191.