5/23/2025
Last update
5/23/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 21 Researches
7.2
USERS' SCORE
Good
Based on 1 Review
8.5
Top Medical Research Studies
8
We're delving into the potential effects of vitamin D on asthma management. The focus of this study is whether vitamin D supplementation can help asthmatic patients reduce their flare-ups and enhance their lung function.
To answer this question, we analyzed several randomized controlled trials that scrutinized the impact of vitamin D on patients with asthma. The findings were promising, as we observed that vitamin D supplementation not only improved lung function, measured through the predicted FEV1 value, but also successfully elevated the levels of serum 25-hydroxyvitamin D in participants.
Overall, this study supports the idea that vitamin D may play a beneficial role in asthma care by potentially reducing the frequency of asthma attacks and improving lung health. It's an exciting area for further research, especially considering the varying results from asthma studies worldwide.
To answer this question, we analyzed several randomized controlled trials that scrutinized the impact of vitamin D on patients with asthma. The findings were promising, as we observed that vitamin D supplementation not only improved lung function, measured through the predicted FEV1 value, but also successfully elevated the levels of serum 25-hydroxyvitamin D in participants.
Overall, this study supports the idea that vitamin D may play a beneficial role in asthma care by potentially reducing the frequency of asthma attacks and improving lung health. It's an exciting area for further research, especially considering the varying results from asthma studies worldwide.
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8
We examined the role of vitamin D supplementation on asthma exacerbations in children with low vitamin D levels. Conducting a double-blind, randomized, placebo-controlled trial allowed us to ensure that our findings would be robust and reliable.
In our study, we aimed to understand if increasing vitamin D levels could lead to fewer severe asthma episodes in children. This approach included both a treatment group receiving vitamin D and a control group receiving a placebo.
However, our results indicated that vitamin D supplementation did not significantly reduce the frequency of severe asthma exacerbations among the children studied. This finding is important, as it adds to our understanding of how vitamin D interacts with respiratory health in pediatric patients.
Ultimately, while vitamin D is often touted for its various health benefits, our research suggests it may not be a game-changer for managing asthma in children with low vitamin D levels.
In our study, we aimed to understand if increasing vitamin D levels could lead to fewer severe asthma episodes in children. This approach included both a treatment group receiving vitamin D and a control group receiving a placebo.
However, our results indicated that vitamin D supplementation did not significantly reduce the frequency of severe asthma exacerbations among the children studied. This finding is important, as it adds to our understanding of how vitamin D interacts with respiratory health in pediatric patients.
Ultimately, while vitamin D is often touted for its various health benefits, our research suggests it may not be a game-changer for managing asthma in children with low vitamin D levels.
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8
Vitamin D benefits asthmatic children
We aimed to understand how vitamin D supplementation affects asthma outcomes, particularly regarding exacerbations in children. In this systematic review, we assessed ten randomized controlled trials, which included 1243 young patients with asthma. Some received vitamin D3, while others were given a placebo, providing a solid basis for comparison.
Our analysis indicated that taking vitamin D could noticeably decrease the frequency of asthma attacks among children. Specifically, the reduction in exacerbations was significant, with a relative risk of 0.62, meaning the children taking vitamin D experienced fewer asthma flare-ups. Moreover, those receiving the standard daily doses of vitamin D showed even more pronounced benefits, which highlights the importance of proper dosage.
Beyond lowering the number of attacks, we also noted improvements in lung function, as indicated by better FEV1 scores among the children in the treatment group. Overall, our findings suggest that vitamin D supplementation offers a valuable strategy for managing asthma in children, helping them breathe easier and potentially improving their quality of life.
Our analysis indicated that taking vitamin D could noticeably decrease the frequency of asthma attacks among children. Specifically, the reduction in exacerbations was significant, with a relative risk of 0.62, meaning the children taking vitamin D experienced fewer asthma flare-ups. Moreover, those receiving the standard daily doses of vitamin D showed even more pronounced benefits, which highlights the importance of proper dosage.
Beyond lowering the number of attacks, we also noted improvements in lung function, as indicated by better FEV1 scores among the children in the treatment group. Overall, our findings suggest that vitamin D supplementation offers a valuable strategy for managing asthma in children, helping them breathe easier and potentially improving their quality of life.
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Most Useful Reviews
9
Prevented flu for asthmatics
507 people found this helpful
Made a huge difference in preventing flu severity for my family. Surrounded by illness, we began taking elderberry gummies to support our immune health, particularly for my daughter who has asthma. We remained healthy during flu season, and when she did catch the flu, her recovery was quick compared to past experiences. This product, along with its liquid counterpart, truly minimised her flu symptoms and ensured her lungs stayed strong. Highly effective in reducing flu duration!
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Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 21 Researches
7.2
- All Researches
9
In this study, we explored how the combination of fluticasone propionate—a popular asthma medication—and vitamin D affects children with bronchial asthma. We involved 110 patients, dividing them into two groups: one received just the asthma medication, while the other was treated with both the medication and vitamin D. We aimed to see how these treatments influenced various aspects of asthma, including immune function and the metabolism of calcium and phosphorus.
The results were quite interesting. We observed that the group receiving both treatments experienced a quicker relief from symptoms like wheezing and shortness of breath. They showed significant improvements in lung function, including better peak flow and reduced carbon dioxide levels in their blood—an important sign of effective asthma management. Additionally, this dual treatment led to enhancements in overall quality of life.
Importantly, those on combination therapy also had notable increases in vitamin D levels, which were associated with higher levels of immunoglobulins and T lymphocyte subsets—both critical components of the immune system. Furthermore, we found that vitamin D might play a significant role in regulating immune responses and calcium-phosphate metabolism.
Overall, the study suggests that adding vitamin D to standard asthma therapies may enhance their effectiveness and benefit immune function, although how much of this effect is directly attributed to vitamin D alone remains to be seen.
The results were quite interesting. We observed that the group receiving both treatments experienced a quicker relief from symptoms like wheezing and shortness of breath. They showed significant improvements in lung function, including better peak flow and reduced carbon dioxide levels in their blood—an important sign of effective asthma management. Additionally, this dual treatment led to enhancements in overall quality of life.
Importantly, those on combination therapy also had notable increases in vitamin D levels, which were associated with higher levels of immunoglobulins and T lymphocyte subsets—both critical components of the immune system. Furthermore, we found that vitamin D might play a significant role in regulating immune responses and calcium-phosphate metabolism.
Overall, the study suggests that adding vitamin D to standard asthma therapies may enhance their effectiveness and benefit immune function, although how much of this effect is directly attributed to vitamin D alone remains to be seen.
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9
We aimed to explore how Vitamin D levels influence the effectiveness of mepolizumab, an innovative treatment for severe eosinophilic asthma. In our study, we observed 32 patients over the course of a year, tracking their asthma control through various measures such as the Asthma Control Questionnaire (ACQ) scores and the frequency of exacerbations.
After analyzing the results, we found that 12 of these patients achieved clinical remission with mepolizumab treatment. Crucially, a notable finding was that those with higher levels of Vitamin D seemed to respond better to the treatment. This suggests that maintaining adequate Vitamin D levels might enhance the overall effectiveness of mepolizumab for asthma sufferers.
Overall, our study indicates that mepolizumab is significantly beneficial for people with severe asthma, helping them achieve better control and reduce their reliance on corticosteroids. The strong relationship between Vitamin D levels and treatment success highlights an exciting area for further research, emphasizing the role this vitamin may play in asthma management.
After analyzing the results, we found that 12 of these patients achieved clinical remission with mepolizumab treatment. Crucially, a notable finding was that those with higher levels of Vitamin D seemed to respond better to the treatment. This suggests that maintaining adequate Vitamin D levels might enhance the overall effectiveness of mepolizumab for asthma sufferers.
Overall, our study indicates that mepolizumab is significantly beneficial for people with severe asthma, helping them achieve better control and reduce their reliance on corticosteroids. The strong relationship between Vitamin D levels and treatment success highlights an exciting area for further research, emphasizing the role this vitamin may play in asthma management.
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8
We conducted a thorough investigation to examine how vitamin C, when combined with pleuran (a natural extract from mushrooms), influences asthma control and respiratory health in children with partially controlled perennial asthma. Our study was a double-blind, placebo-controlled clinical trial involving 230 children aged 7 to 17 years, split evenly into an active treatment group and a placebo group.
Over a 24-week period, children in the active group received both pleuran and vitamin C, while the placebo group received vitamin C alone. It was exciting to find that children younger than 12 years who received the combination treatment showed notable improvement in their control of asthma symptoms compared to those on placebo. Additionally, older children in the active group reported fewer respiratory infections, an important benefit for their overall health.
By the end of our 48-week study, we saw a significant improvement in asthma control in a high percentage of children receiving the active treatment. Notably, this combination appeared safe, with no serious side effects reported. Overall, our findings suggest that while vitamin C's isolated effects can't be fully assessed due to its combination with pleuran, the combined treatment offers promising benefits for managing asthma in children.
Over a 24-week period, children in the active group received both pleuran and vitamin C, while the placebo group received vitamin C alone. It was exciting to find that children younger than 12 years who received the combination treatment showed notable improvement in their control of asthma symptoms compared to those on placebo. Additionally, older children in the active group reported fewer respiratory infections, an important benefit for their overall health.
By the end of our 48-week study, we saw a significant improvement in asthma control in a high percentage of children receiving the active treatment. Notably, this combination appeared safe, with no serious side effects reported. Overall, our findings suggest that while vitamin C's isolated effects can't be fully assessed due to its combination with pleuran, the combined treatment offers promising benefits for managing asthma in children.
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8
We investigated how vitamin D3 can impact asthma, particularly when used alongside 7,4'-dihydroxyflavone (74DHF). This study took a thorough approach, combining various methods from target identification to bioinformatics analysis and experimental validation.
Our findings highlighted that the combination of 74DHF and vitamin D3 may work together to reduce inflammation associated with asthma. Specifically, we observed that this combination inhibits certain inflammatory responses and impacts gene expressions linked to asthma pathology.
Furthermore, we identified 47 overlapping targets and analyzed multiple pathways related to asthma, reinforcing the idea that vitamin D3, along with 74DHF, could play a role in asthma management. By deciphering these interactions, this research opens the way for developing effective combination therapies in asthma treatment.
Our findings highlighted that the combination of 74DHF and vitamin D3 may work together to reduce inflammation associated with asthma. Specifically, we observed that this combination inhibits certain inflammatory responses and impacts gene expressions linked to asthma pathology.
Furthermore, we identified 47 overlapping targets and analyzed multiple pathways related to asthma, reinforcing the idea that vitamin D3, along with 74DHF, could play a role in asthma management. By deciphering these interactions, this research opens the way for developing effective combination therapies in asthma treatment.
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8
We looked into how prenatal exposure to vitamin D can affect asthma outcomes in children. By analyzing data from two large randomized controlled trials, we refined our understanding of how vitamin D levels during pregnancy influence lung development and respiratory health in offspring.
Our study involved 1,319 mother-child pairs, and we focused on measuring the levels of 25-hydroxyvitamin D (25[OH]D) during pregnancy. We found that higher levels of this vitamin in the bloodstream were linked to better respiratory outcomes for children, such as lower rates of asthma and improved lung function.
Specifically, we noted that children exposed to higher prenatal vitamin D levels were less likely to experience asthma or wheezing at ages three and six. Furthermore, those with increased vitamin D exposure showed better lung function as measured by standard tests between ages six and eight.
These results highlight the potential benefits of ensuring adequate vitamin D levels during pregnancy, opening a conversation about prenatal nutrition and its long-term effects on children's health.
Our study involved 1,319 mother-child pairs, and we focused on measuring the levels of 25-hydroxyvitamin D (25[OH]D) during pregnancy. We found that higher levels of this vitamin in the bloodstream were linked to better respiratory outcomes for children, such as lower rates of asthma and improved lung function.
Specifically, we noted that children exposed to higher prenatal vitamin D levels were less likely to experience asthma or wheezing at ages three and six. Furthermore, those with increased vitamin D exposure showed better lung function as measured by standard tests between ages six and eight.
These results highlight the potential benefits of ensuring adequate vitamin D levels during pregnancy, opening a conversation about prenatal nutrition and its long-term effects on children's health.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Prevented flu for asthmatics
507 people found this helpful
Made a huge difference in preventing flu severity for my family. Surrounded by illness, we began taking elderberry gummies to support our immune health, particularly for my daughter who has asthma. We remained healthy during flu season, and when she did catch the flu, her recovery was quick compared to past experiences. This product, along with its liquid counterpart, truly minimised her flu symptoms and ensured her lungs stayed strong. Highly effective in reducing flu duration!
Read More
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References
- Jesenak M, Hrubisko M, Chudek J, Bystron J, Rennerova Z, et al. Beneficial effects of pleuran on asthma control and respiratory tract-infection frequency in children with perennial asthma. Sci Rep. 2025;15:7146. 10.1038/s41598-025-91830-2
- Chen Z, Liu X, Feng X, Lyu A, Zhou W. A systematic pharmacological strategy-based to decode the synergistic mechanism of 7,4'-dihydroxyflavone in combination with vitamin D3 against asthma. J Ethnopharmacol. 2025;344:119513. 10.1016/j.jep.2025.119513
- Shadid ILC, Brustad N, Chawes BL, Moes DJAR, Weiss ST, et al. Pharmacokinetic modeling of prenatal vitamin D exposure and the impact on offspring asthma and pulmonary function. Biomed Pharmacother. 2025;183:117859. 10.1016/j.biopha.2025.117859
- Doumat G, El Zein J, Mehta GD, Zhu Z, Espinola JA, et al. Association between vitamin D status at 3 years and eosinophilic asthma in 6-year-old children with a history of severe bronchiolitis. Thorax. 2025;80:180. 10.1136/thorax-2024-222099
- Asseri AA. Serum Vitamin D Profiles of Children with Asthma in Southwest Saudi: A Comparative Cross-Sectional Study. Int J Gen Med. 2024;17:6323. 10.2147/IJGM.S503293
- Ahoon M, Farid-Hosseini R, Tehrani H, Rafat-Panah H, Ahanchian H, et al. Evaluation the Effect of Supplements Containing Vitamin D and Trace Elements in Patients with Moderate to Severe Asthma. Rep Biochem Mol Biol. 2024;13:40. 10.61186/rbmb.13.1.40
- Wu D, Wang J, Wei Y, Zhang X, Hou Z. Correlation Analysis of Serum 25-Hydroxyvitamin D Levels With Immune Function and Calcium-Phosphate Metabolism in Patients With Bronchial Asthma Treated With Combination Therapy. Physiol Res. 2024;73:841.
- Rosser FJ, Han YY, Forno E, Guilbert TW, Bacharier LB, et al. Vitamin D Supplementation, Long-Term PM Exposure, and Severe Asthma Exacerbations in Children with Low Vitamin D: A Analysis of a Double-Blind, Randomized, Placebo-controlled Trial (VDKA). Am J Respir Crit Care Med. 2025;211:266. 10.1164/rccm.202407-1353RL
- Jha RS. Achieving clinical remission in asthma with mepolizumab: a subanalysis on vitamin D as a predictor of response. J Asthma. 2024. 10.1080/02770903.2024.2419435
- Fedora K, Setyoningrum RA, Aina Q, Rosyidah LN, Ni'mah NL, et al. Vitamin D supplementation decrease asthma exacerbations in children: a systematic review and meta-analysis of randomized controlled trials. Ann Med. 2024;56:2400313. 10.1080/07853890.2024.2400313
- Stichova J, Slanina P, Chovancova Z, Baros J, Litzman M, et al. Low CD46 expression on activated CD4 T cells predict improved Th1 cell reactivity to calcitriol in majority of patients with allergic eosinophilic asthma and healthy donors. Front Allergy. 2024;5:1462579. 10.3389/falgy.2024.1462579
- Peng B, Xiong Y, Ouyang T, He Q, Qi S, et al. High ratio of epi-25-(OH)-vitamin D3 to 25-(OH)-vitamin D3 increases the risk of asthma attack in American asthma adults: a population study. BMC Public Health. 2024;24:2670. 10.1186/s12889-024-20185-6
- El Abd A, Dasari H, Dodin P, Trottier H, Ducharme FM. Associations between vitamin D status and biomarkers linked with inflammation in patients with asthma: a systematic review and meta-analysis of interventional and observational studies. Respir Res. 2024;25:344. 10.1186/s12931-024-02967-z
- Peng B, Chen MW, Peng CR, Liu YY, Liu D. Association between serum 25-hydroxyvitamin D and asthma: Evidence from the National Health and Nutrition Examination Survey (NHANES) 2011-2018. J Asthma. 2025;62:303. 10.1080/02770903.2024.2400604
- Chang-Chien J, Huang JL, Tsai HJ, Wang SL, Kuo ML, et al. Vitamin D ameliorates particulate matter induced mitochondrial damages and calcium dyshomeostasis in BEAS-2B human bronchial epithelial cells. Respir Res. 2024;25:321. 10.1186/s12931-024-02951-7
- Niu H, He H, Zhao Z, Lu X, Zhao G. Asthmatic patients with vitamin D deficiency: Can vitamin D supplementation make a difference. Technol Health Care. 2024;32:3985. 10.3233/THC-231462
- Changhai L, Zaichun W, Bo Y, Dan L, Shaohua W. Micronutrients and Allergic Diseases: A Mendelian Randomization Study. Int Arch Allergy Immunol. 2025;186:41. 10.1159/000540376
- Cheng C, Lin J, Zhang Z, Zhang L. Association between dietary zinc intake and asthma in overweight or obese children and adolescents: A cross-sectional analysis of NHANES. World Allergy Organ J. 2024;17:100900. 10.1016/j.waojou.2024.100900
- Atef Abdelsattar Ibrahim H, Mohsen M, Salep Aziz Hanna B, Mahmoud D, Mohamed Abdelhamid El-Khashab K. Childhood asthma biomarkers including zinc: An exploratory cross-sectional study. World J Clin Pediatr. 2024;13:87866. 10.5409/wjcp.v13.i1.87866
- Srivastava S, Tiwari V, Singh S, Karoli R, Bhattacharya P, et al. Low Serum Levels of Zinc, Selenium, and Vitamin D3 Are Biomarkers of Airway Inflammation and Poor Asthma Control: A Two-Centre Study. Cureus. 2023;15:e41082. 10.7759/cureus.41082
- Xue M, Wang Q, Pang B, Zhang X, Zhang Y, et al. Association Between Circulating Zinc and Risk for Childhood Asthma and Wheezing: A Meta-analysis on 21 Articles and 2205 Children. Biol Trace Elem Res. 2024;202:442. 10.1007/s12011-023-03690-4
