5/23/2025
Last update
5/23/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7
USERS' SCORE
Good
Based on 1 Review
8.4
Top Medical Research Studies
9.5
We explored the potential benefits of vitamin D supplementation for individuals suffering from Chronic Rhinosinusitis (CRS), a common condition marked by inflammation of the nose and sinus linings. In a study involving 200 patients with vitamin D deficiency, we divided participants into two groups: one receiving oral vitamin D supplements and the other receiving a placebo.
Over the course of three months, we observed a significant increase in vitamin D levels among those taking the supplements, rising from an average of 12.31 ng/ml to 29.71 ng/ml. Additionally, the participants reported a notable decrease in symptoms derived from their Total Nasal Symptom Scores (TNSS), which fell by an average of 10.65 points.
This study indicates that many CRS patients suffer from vitamin D deficiency and that supplementation can effectively alleviate their symptoms. Ultimately, our findings suggest that addressing vitamin D levels could become a valuable part of the treatment strategy for CRS.
Over the course of three months, we observed a significant increase in vitamin D levels among those taking the supplements, rising from an average of 12.31 ng/ml to 29.71 ng/ml. Additionally, the participants reported a notable decrease in symptoms derived from their Total Nasal Symptom Scores (TNSS), which fell by an average of 10.65 points.
This study indicates that many CRS patients suffer from vitamin D deficiency and that supplementation can effectively alleviate their symptoms. Ultimately, our findings suggest that addressing vitamin D levels could become a valuable part of the treatment strategy for CRS.
Read More
9
Vitamin D treatment aids sinus health
We explored the impact of intranasal delivery of calcitriol, the active form of vitamin D, on chronic sinonasal inflammation linked to cigarette smoke exposure. In our study, mice were exposed to cigarette smoke for an extended period, which helped recreate the conditions of sinus inflammation often seen in smokers.
After the exposure, we administered calcitriol three times a week for four weeks. We utilized various methods, including micro-CT scans and RNA sequencing, to assess the inflammatory status and overall health of the sinonasal region. Our findings revealed that calcitriol resulted in a significant reduction of inflammation and improved olfactory function. Notably, there was an 18% decrease in nasal opacification, which was markedly better than the 5% reduction seen in mice that only underwent smoke cessation.
Additionally, the treatment led to decreased neutrophil infiltration, a common indicator of inflammation, and improved olfactory function, indicating that calcitriol might be a promising treatment option for modulating sinonasal inflammation. This research underlines the beneficial role that vitamin D can play in addressing inflammation related to smoking and potential sinus issues.
After the exposure, we administered calcitriol three times a week for four weeks. We utilized various methods, including micro-CT scans and RNA sequencing, to assess the inflammatory status and overall health of the sinonasal region. Our findings revealed that calcitriol resulted in a significant reduction of inflammation and improved olfactory function. Notably, there was an 18% decrease in nasal opacification, which was markedly better than the 5% reduction seen in mice that only underwent smoke cessation.
Additionally, the treatment led to decreased neutrophil infiltration, a common indicator of inflammation, and improved olfactory function, indicating that calcitriol might be a promising treatment option for modulating sinonasal inflammation. This research underlines the beneficial role that vitamin D can play in addressing inflammation related to smoking and potential sinus issues.
Read More
8
We aimed to investigate the impact of vitamin D on eosinophil movement in patients suffering from eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP). To do this, we collected nasal tissue samples from different groups, including healthy patients and those with varying forms of sinusitis. Our research utilized various methods, such as enzyme-linked immunosorbent assay (ELISA) for measuring vitamin D and CCL26 levels, as well as observing eosinophil behavior in response to vitamin D treatment.
Our findings indicated that vitamin D discourages eosinophil chemotaxis, which is the movement of eosinophils to areas of inflammation in the nasal passages. We discovered that this effect occurs by reducing the expression of CCL26, a protein involved in the eosinophil recruitment process. Additionally, vitamin D appears to inhibit certain metabolic pathways that normally lead to increased eosinophil movement.
Overall, our results suggest that vitamin D supplementation could be a promising new approach for managing ECRSwNP. By targeting the underlying mechanisms of eosinophil infiltration, vitamin D may offer a way to reduce the recurrence of symptoms and improve the quality of life for those affected by this condition.
Our findings indicated that vitamin D discourages eosinophil chemotaxis, which is the movement of eosinophils to areas of inflammation in the nasal passages. We discovered that this effect occurs by reducing the expression of CCL26, a protein involved in the eosinophil recruitment process. Additionally, vitamin D appears to inhibit certain metabolic pathways that normally lead to increased eosinophil movement.
Overall, our results suggest that vitamin D supplementation could be a promising new approach for managing ECRSwNP. By targeting the underlying mechanisms of eosinophil infiltration, vitamin D may offer a way to reduce the recurrence of symptoms and improve the quality of life for those affected by this condition.
Read More
Most Useful Reviews
7.5
Effective for sinus infections
5 people found this helpful
These taste great and I take two before bed. Having chronic sinusitis and a history of infections, I noticed a clear difference when I resumed taking them after stopping for a few weeks—they prevented one of my worst sinus infections! When changes occur in my body, I reflect on my lifestyle changes, and stopping this supplement was the only variable that led to my recent sinus problems. Highly recommend for efficacy and taste!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7
- All Researches
9.5
We explored the potential benefits of vitamin D supplementation for individuals suffering from Chronic Rhinosinusitis (CRS), a common condition marked by inflammation of the nose and sinus linings. In a study involving 200 patients with vitamin D deficiency, we divided participants into two groups: one receiving oral vitamin D supplements and the other receiving a placebo.
Over the course of three months, we observed a significant increase in vitamin D levels among those taking the supplements, rising from an average of 12.31 ng/ml to 29.71 ng/ml. Additionally, the participants reported a notable decrease in symptoms derived from their Total Nasal Symptom Scores (TNSS), which fell by an average of 10.65 points.
This study indicates that many CRS patients suffer from vitamin D deficiency and that supplementation can effectively alleviate their symptoms. Ultimately, our findings suggest that addressing vitamin D levels could become a valuable part of the treatment strategy for CRS.
Over the course of three months, we observed a significant increase in vitamin D levels among those taking the supplements, rising from an average of 12.31 ng/ml to 29.71 ng/ml. Additionally, the participants reported a notable decrease in symptoms derived from their Total Nasal Symptom Scores (TNSS), which fell by an average of 10.65 points.
This study indicates that many CRS patients suffer from vitamin D deficiency and that supplementation can effectively alleviate their symptoms. Ultimately, our findings suggest that addressing vitamin D levels could become a valuable part of the treatment strategy for CRS.
Read More
9
Vitamin D treatment aids sinus health
We explored the impact of intranasal delivery of calcitriol, the active form of vitamin D, on chronic sinonasal inflammation linked to cigarette smoke exposure. In our study, mice were exposed to cigarette smoke for an extended period, which helped recreate the conditions of sinus inflammation often seen in smokers.
After the exposure, we administered calcitriol three times a week for four weeks. We utilized various methods, including micro-CT scans and RNA sequencing, to assess the inflammatory status and overall health of the sinonasal region. Our findings revealed that calcitriol resulted in a significant reduction of inflammation and improved olfactory function. Notably, there was an 18% decrease in nasal opacification, which was markedly better than the 5% reduction seen in mice that only underwent smoke cessation.
Additionally, the treatment led to decreased neutrophil infiltration, a common indicator of inflammation, and improved olfactory function, indicating that calcitriol might be a promising treatment option for modulating sinonasal inflammation. This research underlines the beneficial role that vitamin D can play in addressing inflammation related to smoking and potential sinus issues.
After the exposure, we administered calcitriol three times a week for four weeks. We utilized various methods, including micro-CT scans and RNA sequencing, to assess the inflammatory status and overall health of the sinonasal region. Our findings revealed that calcitriol resulted in a significant reduction of inflammation and improved olfactory function. Notably, there was an 18% decrease in nasal opacification, which was markedly better than the 5% reduction seen in mice that only underwent smoke cessation.
Additionally, the treatment led to decreased neutrophil infiltration, a common indicator of inflammation, and improved olfactory function, indicating that calcitriol might be a promising treatment option for modulating sinonasal inflammation. This research underlines the beneficial role that vitamin D can play in addressing inflammation related to smoking and potential sinus issues.
Read More
8
We explored the effects of L-ascorbate, commonly known as Vitamin C, on chloride transport in sinonasal epithelial tissues. This research is particularly significant as it addresses the common condition of chronic rhinosinusitis (CRS) and its potential link to the function of the cystic fibrosis transmembrane conductance regulator (CFTR) — a key chloride ion channel.
During our investigation, we utilized freshly excised sinonasal tissues from both normal individuals and patients suffering from CRS. The tissues were carefully prepared and tested to understand how L-ascorbate influenced chloride secretion. Our findings revealed that the application of L-ascorbate notably enhanced chloride secretion in these tissues.
This is important because optimal chloride transport is essential for maintaining healthy mucosal surfaces and effective mucociliary clearance. Therefore, since decreased chloride secretion could lead to the worsening of sinus conditions, L-ascorbate presents a promising avenue for therapeutic intervention in improving mucociliary clearance for those affected by chronic sinus issues.
During our investigation, we utilized freshly excised sinonasal tissues from both normal individuals and patients suffering from CRS. The tissues were carefully prepared and tested to understand how L-ascorbate influenced chloride secretion. Our findings revealed that the application of L-ascorbate notably enhanced chloride secretion in these tissues.
This is important because optimal chloride transport is essential for maintaining healthy mucosal surfaces and effective mucociliary clearance. Therefore, since decreased chloride secretion could lead to the worsening of sinus conditions, L-ascorbate presents a promising avenue for therapeutic intervention in improving mucociliary clearance for those affected by chronic sinus issues.
Read More
8
We evaluated the impact of antioxidants, specifically vitamin C, on acute maxillary sinusitis treatment through a study involving different treatment approaches. Patients received a mix of dibunol and vitamin C, delivered into the sinuses, while others only had traditional treatments like ampicillin and hydrocortisone.
This study involved control groups that helped us compare the effectiveness of the antioxidant treatment. Stunningly, we found that those receiving the antioxidant mixture demonstrated substantial improvements, with shorter treatment times and fewer overall interventions compared to the control group.
Additionally, positive changes in certain blood markers indicated that the antioxidant approach markedly enhanced the body's response to infection. These findings underscore the potential benefits of including vitamin C as part of a sinusitis treatment plan, especially when dealing with acute flare-ups.
This study involved control groups that helped us compare the effectiveness of the antioxidant treatment. Stunningly, we found that those receiving the antioxidant mixture demonstrated substantial improvements, with shorter treatment times and fewer overall interventions compared to the control group.
Additionally, positive changes in certain blood markers indicated that the antioxidant approach markedly enhanced the body's response to infection. These findings underscore the potential benefits of including vitamin C as part of a sinusitis treatment plan, especially when dealing with acute flare-ups.
Read More
8
We aimed to investigate the impact of vitamin D on eosinophil movement in patients suffering from eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP). To do this, we collected nasal tissue samples from different groups, including healthy patients and those with varying forms of sinusitis. Our research utilized various methods, such as enzyme-linked immunosorbent assay (ELISA) for measuring vitamin D and CCL26 levels, as well as observing eosinophil behavior in response to vitamin D treatment.
Our findings indicated that vitamin D discourages eosinophil chemotaxis, which is the movement of eosinophils to areas of inflammation in the nasal passages. We discovered that this effect occurs by reducing the expression of CCL26, a protein involved in the eosinophil recruitment process. Additionally, vitamin D appears to inhibit certain metabolic pathways that normally lead to increased eosinophil movement.
Overall, our results suggest that vitamin D supplementation could be a promising new approach for managing ECRSwNP. By targeting the underlying mechanisms of eosinophil infiltration, vitamin D may offer a way to reduce the recurrence of symptoms and improve the quality of life for those affected by this condition.
Our findings indicated that vitamin D discourages eosinophil chemotaxis, which is the movement of eosinophils to areas of inflammation in the nasal passages. We discovered that this effect occurs by reducing the expression of CCL26, a protein involved in the eosinophil recruitment process. Additionally, vitamin D appears to inhibit certain metabolic pathways that normally lead to increased eosinophil movement.
Overall, our results suggest that vitamin D supplementation could be a promising new approach for managing ECRSwNP. By targeting the underlying mechanisms of eosinophil infiltration, vitamin D may offer a way to reduce the recurrence of symptoms and improve the quality of life for those affected by this condition.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Effective for sinus infections
5 people found this helpful
These taste great and I take two before bed. Having chronic sinusitis and a history of infections, I noticed a clear difference when I resumed taking them after stopping for a few weeks—they prevented one of my worst sinus infections! When changes occur in my body, I reflect on my lifestyle changes, and stopping this supplement was the only variable that led to my recent sinus problems. Highly recommend for efficacy and taste!
Read More
Frequently Asked Questions
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References
- Cho DY, Hwang PH, Illek B. Effect of L-ascorbate on chloride transport in freshly excised sinonasal epithelia. Am J Rhinol Allergy. 2009;23:294. 10.2500/ajra.2009.23.3316
- Nikolaev MP, Logunov AI, Tsyrulńikova LG, Dzhalilov DS. [Clinical and biochemical aspects in the treatment of acute maxillary sinusitis with antioxidants]. Vestn Otorinolaringol. 1994.
- Wang J, Jiang Y, Chen X, Ma J, Li Y, et al. Serum 25-hydroxyvitamin D levels and peripheral blood eosinophil percentages as predictive indicators for eosinophilic chronic sinusitis with nasal polyps. Eur Arch Otorhinolaryngol. 2025. 10.1007/s00405-025-09263-6
- Huang W, Zhang Y, Li Y, Ma J, Li X, et al. Vitamin D impedes eosinophil chemotaxis via inhibiting glycolysis-induced CCL26 expression in eosinophilic chronic rhinosinusitis with nasal polyps. Cell Commun Signal. 2025;23:104. 10.1186/s12964-025-02078-2
- Langerude L, McQuiston A, Atkinson C, Mulligan JK. Intranasal Calcitriol Accelerates Improvement of Sinonasal Inflammation and Olfactory Impairment in Mice After Cessation of Chronic Cigarette-Smoke Exposure. Int Forum Allergy Rhinol. 2025. 10.1002/alr.23504
- Brociek-Piłczyńska A, Trebinska-Stryjewska A, Jurkiewicz D. Preoperative serum 25(OH)D status and its correlation with an early endoscopic sinus surgery outcome and chronic rhinosinusitis severity. Otolaryngol Pol. 2024;78:1. 10.5604/01.3001.0054.7429
- Alharthi GNA, Alzarei A. The Correlation Between Vitamin D Deficiency and Chronic Rhinosinusitis: A Systematic Review. Cureus. 2024;16:e55955. 10.7759/cureus.55955
- Bagheri P, Nouri M, Eskandarzadeh H, Darvishi M. Evaluation of Serum Levels of Vitamin D3 and IgE in Patients with Chronic and Allergic Sinusitis: A Cross-sectional Study. Recent Adv Inflamm Allergy Drug Discov. 2024;18:108. 10.2174/0127722708281623240116100806
- Pantazidou G, Papaioannou I, Skoulakis C, Petinaki E, Hajiioannou J. Vitamin D Levels in Chronic Rhinosinusitis in Patients With or Without Nasal Polyposis: A Systematic Review. Cureus. 2023;15:e46275. 10.7759/cureus.46275
- De Luca P, D'Ascanio L, Cingolani C, Latini G, Grigaliute E, et al. A Supplement with Ribes Nigrum, Boswellia Serrata, Bromelain and Vitamin D to Stop Local Inflammation in Chronic Sinusitis: A Case-Control Study. J Clin Med. 2023;12. 10.3390/jcm12082929
- Wang L, Zhao Y, Yao S, Lou H, Zhang L. Vitamin D Improves the Effect of Glucocorticoids on Attenuating Lipopolysaccharide-Induced IL-6 Production via TLR4/NF-κB Pathway in Human Respiratory Epithelial Cells. Int Arch Allergy Immunol. 2022;183:1017. 10.1159/000524855
- Kalińczak-Górna P, Radajewski K, Burduk P. Relationship between the Severity of Inflammatory Changes in Chronic Sinusitis and the Level of Vitamin D before and after the FESS Procedure. J Clin Med. 2021;10. 10.3390/jcm10132836
- Kagoya R, Kondo K, Kishimoto-Urata M, Shimizu Y, Kikuta S, et al. A murine model of eosinophilic chronic rhinosinusitis using the topical application of a vitamin D3 analog. Allergy. 2021;76:1432. 10.1111/all.14627
- Baruah B, Gupta A, Kumar A, Kumar A. The role of oral vitamin D3 supplementation in the treatment of Chronic Rhinosinusitis in adults with Vitamin D deficiency. J Family Med Prim Care. 2020;9:2877. 10.4103/jfmpc.jfmpc_448_20
- Kowalik K, Waniewska-Łęczycka M, Sarnowska E, Rusetska N, Sierdziński J, et al. Role of chromatin remodeling complex SWI/SNF and VDR in chronic rhinosinusitis. Adv Clin Exp Med. 2020;29:313. 10.17219/acem/117683
- Zand V, Baradaranfar M, Vaziribozorg S, Mandegari M, Mansourimanesh M, et al. Correlation of Serum Vitamin D Levels with Chronic Rhinosinusitis Disease Severity. Iran J Otorhinolaryngol. 2020;32:35. 10.22038/ijorl.2019.31926.2050
- Ma SW, Ende JA, Alvarado R, Christensen JM, Kalish L, et al. Topical Vitamin D May Modulate Human Sinonasal Mucosal Responses to House Dust Mite Antigen. Am J Rhinol Allergy. 2020;34:471. 10.1177/1945892420905432
- Faghih Habibi A, Gerami H, Banan R, Kazemnezhad Leily E, Khoshkhat P, et al. Serum 25-Hydroxy Vitamin D in Chronic Rhinosinusitis with and Without Nasal Polyposis: A Case-Control Study. Iran J Otorhinolaryngol. 2019;31:19.
- Ghazizadeh M, Roshanaie E, Barati B. Comparison of serum zinc levels between patients with sinonasal neutrophilic and eosinophilic inflammatory polyposis and healthy individuals. Immun Inflamm Dis. 2024;12:e70016. 10.1002/iid3.70016
