' 
![]()
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.5
USERS' SCORE
Good
Based on 6 Reviews
8.8
Supplement Facts
Serving Size: 2 Tablets
Amount Per Serving
%DV
Calories
10
Total Carbohydrate
2 g
<1%*
Glucosamine Hydrochloride
2,000 mg
†
Hyaluronic Acid
3.3 mg
†
Top Medical Research Studies
9.5
Hyaluronic acid eases shoulder arthritis
Retrospective evaluation of the efficacy of ultrasound-guided intra-articular hyaluronic-acid-based injections (Hyalubrix) in patients with glenohumeral osteoarthritis.
Strong relevance to osteoarthritis treatment
We explored the impact of hyaluronic acid (HA) injections, specifically a formulation called Hyalubrix®, on patients suffering from glenohumeral osteoarthritis (GH-OA). The condition often leads to painful and disabling shoulder issues, and we aimed to find out if these injections could provide relief and improve overall quality of life.
By analyzing data collected from standard clinical practice, we focused on how patients rated their pain and shoulder function. Tools such as the Simple Shoulder Test and the Euro-Quality of Life Health Assessment allowed us to track their progress over time. We observed that more than half of the patients reported complete pain relief, while nearly 28% experienced a significant decrease in their discomfort. Such improvements led to noticeable boosts in overall joint function and quality of life.
Our findings affirm that hyaluronic acid injections can be a highly beneficial treatment option for individuals grappling with GH-OA. The positive responses from patients highlight the potential of this therapy to enhance not just physical function but also daily living.
By analyzing data collected from standard clinical practice, we focused on how patients rated their pain and shoulder function. Tools such as the Simple Shoulder Test and the Euro-Quality of Life Health Assessment allowed us to track their progress over time. We observed that more than half of the patients reported complete pain relief, while nearly 28% experienced a significant decrease in their discomfort. Such improvements led to noticeable boosts in overall joint function and quality of life.
Our findings affirm that hyaluronic acid injections can be a highly beneficial treatment option for individuals grappling with GH-OA. The positive responses from patients highlight the potential of this therapy to enhance not just physical function but also daily living.
Read More
9
Hyaluronic acid's treatment effectiveness
Clinical efficacy of cell-free fat extract and its effects on bone marrow edema in patients with early to mid-stage knee osteoarthritis: a clinical trial in comparison with hyaluronic acid.
Focus on hyaluronic acid efficacy
We set out to evaluate how effective hyaluronic acid (HA) is in treating knee osteoarthritis (OA), particularly by comparing it with another promising treatment: cell-free fat extract (CEFFE). In our study, we worked with 48 patients experiencing early to mid-stage knee OA, dividing them into two groups—one receiving HA injections and the other receiving CEFFE injections.
Over the course of treatment, patients received a total of five injections, one per week. To measure the outcomes, we used established rating scales to assess pain, functionality, and overall knee health at multiple follow-up points: three weeks, six weeks, three months, and six months after treatment. Both groups showed improvements in their symptoms, which is encouraging news for patients dealing with this degenerative condition.
However, we found that while HA did provide some benefits, CEFFE was more effective in enhancing knee health and reducing bone marrow edema. This suggests that although hyaluronic acid is still a valuable option for managing symptoms of knee OA, there may be more advanced treatments available that can offer better results.
Over the course of treatment, patients received a total of five injections, one per week. To measure the outcomes, we used established rating scales to assess pain, functionality, and overall knee health at multiple follow-up points: three weeks, six weeks, three months, and six months after treatment. Both groups showed improvements in their symptoms, which is encouraging news for patients dealing with this degenerative condition.
However, we found that while HA did provide some benefits, CEFFE was more effective in enhancing knee health and reducing bone marrow edema. This suggests that although hyaluronic acid is still a valuable option for managing symptoms of knee OA, there may be more advanced treatments available that can offer better results.
Read More
8
Hyaluronic Acid Benefits in Arthritis
In vivo impact on rabbit subchondral bone of viscosupplementation with a hyaluronic acid antioxidant conjugate.
Direct evaluation of HA treatments
We conducted a study to evaluate how hyaluronic acid (HA) treatments impact osteoarthritis (OA) in a rabbit model. Specifically, we compared a novel antioxidant-conjugated form of HA, known as HA-4-aminoresorcinol (HA4AR), to a standard high molecular weight HA treatment.
A total of eighteen rabbits underwent a procedure to simulate OA and were divided into three groups based on the type of treatment they received: one group was given saline, another received HA, and the third group was treated with HA4AR. We also looked at additional control knees that weren't operated on to see the natural state of the cartilage and bone.
After six weeks, we used advanced imaging to examine changes in the rabbits' articular cartilage and subchondral bone. We found that both HA and HA4AR groups had comparable cartilage thickness, which is a good sign for joint health. However, the HA treatment alone showed a significant loss of mineral density in the subchondral bone compared to HA4AR and the saline groups.
Our findings suggest that HA4AR not only helps maintain this vital bone density better than standard HA, but it might also offer improved protective benefits for those dealing with osteoarthritis. Ultimately, our study indicates a promising avenue for further research on antioxidant-conjugated therapies in the treatment of OA.
A total of eighteen rabbits underwent a procedure to simulate OA and were divided into three groups based on the type of treatment they received: one group was given saline, another received HA, and the third group was treated with HA4AR. We also looked at additional control knees that weren't operated on to see the natural state of the cartilage and bone.
After six weeks, we used advanced imaging to examine changes in the rabbits' articular cartilage and subchondral bone. We found that both HA and HA4AR groups had comparable cartilage thickness, which is a good sign for joint health. However, the HA treatment alone showed a significant loss of mineral density in the subchondral bone compared to HA4AR and the saline groups.
Our findings suggest that HA4AR not only helps maintain this vital bone density better than standard HA, but it might also offer improved protective benefits for those dealing with osteoarthritis. Ultimately, our study indicates a promising avenue for further research on antioxidant-conjugated therapies in the treatment of OA.
Read More
Most Useful Reviews
10
Zero knee pain
This is amazing! After suffering from very painful knees for several months, which I suspect was due to arthritis, I started taking glucosamine. After 3 weeks, I am pain-free in both knees. I encourage others to take it consistently every day for best results.
Read More
9.5
Increased dosage needed
A pharmacist once told me glucosamine was ineffective, but when arthritis made my thumb, knee, and shoulder painful, I tried it. Initially, I took just two tablets, but after increasing to four a day, I am now literally pain-free! I highly recommend this product.
Read More
9.5
Helps arthritis
5 stars. I really like this product and I think it is helping my arthritis!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.5
9.5
Hyaluronic acid eases shoulder arthritis
Retrospective evaluation of the efficacy of ultrasound-guided intra-articular hyaluronic-acid-based injections (Hyalubrix) in patients with glenohumeral osteoarthritis.
Strong relevance to osteoarthritis treatment
We explored the impact of hyaluronic acid (HA) injections, specifically a formulation called Hyalubrix®, on patients suffering from glenohumeral osteoarthritis (GH-OA). The condition often leads to painful and disabling shoulder issues, and we aimed to find out if these injections could provide relief and improve overall quality of life.
By analyzing data collected from standard clinical practice, we focused on how patients rated their pain and shoulder function. Tools such as the Simple Shoulder Test and the Euro-Quality of Life Health Assessment allowed us to track their progress over time. We observed that more than half of the patients reported complete pain relief, while nearly 28% experienced a significant decrease in their discomfort. Such improvements led to noticeable boosts in overall joint function and quality of life.
Our findings affirm that hyaluronic acid injections can be a highly beneficial treatment option for individuals grappling with GH-OA. The positive responses from patients highlight the potential of this therapy to enhance not just physical function but also daily living.
By analyzing data collected from standard clinical practice, we focused on how patients rated their pain and shoulder function. Tools such as the Simple Shoulder Test and the Euro-Quality of Life Health Assessment allowed us to track their progress over time. We observed that more than half of the patients reported complete pain relief, while nearly 28% experienced a significant decrease in their discomfort. Such improvements led to noticeable boosts in overall joint function and quality of life.
Our findings affirm that hyaluronic acid injections can be a highly beneficial treatment option for individuals grappling with GH-OA. The positive responses from patients highlight the potential of this therapy to enhance not just physical function but also daily living.
Read More
9
Hyaluronic acid's long-term effects unclear
Long-term effectiveness of intra-articular injectables in patients with knee osteoarthritis: a systematic review and Bayesian network meta-analysis.
Combines HA with other treatments
We dug into the effectiveness of hyaluronic acid (HA) as a treatment for knee osteoarthritis (OA). By examining data from 37 randomized controlled trials involving over 5,000 patients, we aimed to understand how well HA works in providing pain relief and improving knee function over the long term.
Our findings show that while hyaluronic acid has its benefits, especially when combined with other treatments like platelet-rich plasma (PRP), its standalone effectiveness for long-term management isn't as clear. Patients who received HA combined with PRP experienced better outcomes, but isolating HA’s effects still leaves some questions.
Overall, our exploration highlighted the potential of HA in knee OA treatment, particularly when used in conjunction with other injectables. However, if you're considering HA as a solo treatment, the evidence suggests that more research is needed to fully determine how effective it is on its own.
Our findings show that while hyaluronic acid has its benefits, especially when combined with other treatments like platelet-rich plasma (PRP), its standalone effectiveness for long-term management isn't as clear. Patients who received HA combined with PRP experienced better outcomes, but isolating HA’s effects still leaves some questions.
Overall, our exploration highlighted the potential of HA in knee OA treatment, particularly when used in conjunction with other injectables. However, if you're considering HA as a solo treatment, the evidence suggests that more research is needed to fully determine how effective it is on its own.
Read More
9
Hyaluronic acid's treatment effectiveness
Clinical efficacy of cell-free fat extract and its effects on bone marrow edema in patients with early to mid-stage knee osteoarthritis: a clinical trial in comparison with hyaluronic acid.
Focus on hyaluronic acid efficacy
We set out to evaluate how effective hyaluronic acid (HA) is in treating knee osteoarthritis (OA), particularly by comparing it with another promising treatment: cell-free fat extract (CEFFE). In our study, we worked with 48 patients experiencing early to mid-stage knee OA, dividing them into two groups—one receiving HA injections and the other receiving CEFFE injections.
Over the course of treatment, patients received a total of five injections, one per week. To measure the outcomes, we used established rating scales to assess pain, functionality, and overall knee health at multiple follow-up points: three weeks, six weeks, three months, and six months after treatment. Both groups showed improvements in their symptoms, which is encouraging news for patients dealing with this degenerative condition.
However, we found that while HA did provide some benefits, CEFFE was more effective in enhancing knee health and reducing bone marrow edema. This suggests that although hyaluronic acid is still a valuable option for managing symptoms of knee OA, there may be more advanced treatments available that can offer better results.
Over the course of treatment, patients received a total of five injections, one per week. To measure the outcomes, we used established rating scales to assess pain, functionality, and overall knee health at multiple follow-up points: three weeks, six weeks, three months, and six months after treatment. Both groups showed improvements in their symptoms, which is encouraging news for patients dealing with this degenerative condition.
However, we found that while HA did provide some benefits, CEFFE was more effective in enhancing knee health and reducing bone marrow edema. This suggests that although hyaluronic acid is still a valuable option for managing symptoms of knee OA, there may be more advanced treatments available that can offer better results.
Read More
9
Hyaluronic acid improves arthritis treatment
Locally administered liposomal drug depot enhances rheumatoid arthritis treatment by inhibiting inflammation and promoting cartilage repair.
Moderate relevance due to complexity
We aimed to explore how hyaluronic acid (HA) can improve treatments for rheumatoid arthritis (RA) through a novel delivery system. The study developed a specialized liposomal drug depot that incorporates HA and delivers dexamethasone, a common anti-inflammatory medication. This formulation is designed to target the inflamed areas within the joints, minimizing off-target effects.
Our findings revealed that the HA-modified liposomes effectively reduced inflammation and supported cartilage repair. The sustained release of the drug enhanced uptake by inflammatory macrophages, leading to a decrease in harmful inflammatory factors. Furthermore, this innovative approach significantly reduced chondrocyte cell death, which is crucial for preserving cartilage health.
In animal models, the liposomal system showed promising results, helping to heal cartilage and repolarize macrophages involved in inflammation. This combination strategy addresses both the need for reducing inflammation and promoting tissue regeneration, offering a comprehensive solution for managing RA. Overall, our study suggests that HA can play a key role in advancing arthritis treatments through targeted delivery and improved outcomes.
Our findings revealed that the HA-modified liposomes effectively reduced inflammation and supported cartilage repair. The sustained release of the drug enhanced uptake by inflammatory macrophages, leading to a decrease in harmful inflammatory factors. Furthermore, this innovative approach significantly reduced chondrocyte cell death, which is crucial for preserving cartilage health.
In animal models, the liposomal system showed promising results, helping to heal cartilage and repolarize macrophages involved in inflammation. This combination strategy addresses both the need for reducing inflammation and promoting tissue regeneration, offering a comprehensive solution for managing RA. Overall, our study suggests that HA can play a key role in advancing arthritis treatments through targeted delivery and improved outcomes.
Read More
9
Effective combination for arthritis
A meta-analysis and systematic review of the clinical efficacy and safety of platelet-rich plasma combined with hyaluronic acid (PRP + HA) versus PRP monotherapy for knee osteoarthritis (KOA).
Significant findings with limitations
We conducted a thorough analysis exploring the effectiveness of hyaluronic acid (HA) combined with platelet-rich plasma (PRP) in treating knee osteoarthritis (KOA). The aim was to determine how this combination therapy stacks up against using PRP alone.
Our systematic search included data from multiple reputable databases, where we reviewed studies conducted on over a thousand KOA patients. We discovered that the combination of PRP and HA led to significant improvements in overall pain and knee function. Patients experiencing this therapy reported better outcomes in pain relief and increased mobility compared to those who received PRP treatment alone.
Importantly, while examining safety, we found low rates of adverse events among patients using the combined treatment. This indicates that adding HA to PRP does not compromise safety, which is encouraging for those considering this therapy for their symptoms. All in all, our findings contribute valuable insights into how HA can enhance treatment options for arthritis sufferers.
Our systematic search included data from multiple reputable databases, where we reviewed studies conducted on over a thousand KOA patients. We discovered that the combination of PRP and HA led to significant improvements in overall pain and knee function. Patients experiencing this therapy reported better outcomes in pain relief and increased mobility compared to those who received PRP treatment alone.
Importantly, while examining safety, we found low rates of adverse events among patients using the combined treatment. This indicates that adding HA to PRP does not compromise safety, which is encouraging for those considering this therapy for their symptoms. All in all, our findings contribute valuable insights into how HA can enhance treatment options for arthritis sufferers.
Read More
User Reviews
USERS' SCORE
Good
Based on 6 Reviews
8.8
10
Zero knee pain
This is amazing! After suffering from very painful knees for several months, which I suspect was due to arthritis, I started taking glucosamine. After 3 weeks, I am pain-free in both knees. I encourage others to take it consistently every day for best results.
9.5
Increased dosage needed
A pharmacist once told me glucosamine was ineffective, but when arthritis made my thumb, knee, and shoulder painful, I tried it. Initially, I took just two tablets, but after increasing to four a day, I am now literally pain-free! I highly recommend this product.
9.5
Helps arthritis
5 stars. I really like this product and I think it is helping my arthritis!
8.8
Reduced joint pain
I'm happy to find this product again! After my orthopedic doctor recommended it for my osteoarthritis and severe cartilage loss in one knee, my joint pain has reduced significantly, providing much more freedom of movement.
8.8
Supports dog mobility
We provide this supplement to our dogs and ourselves. One of our dogs, a 13-year-old weighing 100 pounds, has arthritis, yet he still loves to chase cars, thanks to this product. His mobility has greatly improved.
