5/27/2025
Last update
5/27/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 25 Researches
7.7
USERS' SCORE
Good
Based on 11 Reviews
8.6
Supplement Facts
Serving Size: 2 Tablets
Amount Per Serving
%DV
Calories
10
Total Carbohydrate
2 g
<1%*
Glucosamine Hydrochloride
2,000 mg
†
Hyaluronic Acid
3.3 mg
†
Top Medical Research Studies
9.5
Hyaluronic acid eases shoulder arthritis
We explored the impact of hyaluronic acid (HA) injections, specifically a formulation called Hyalubrix®, on patients suffering from glenohumeral osteoarthritis (GH-OA). The condition often leads to painful and disabling shoulder issues, and we aimed to find out if these injections could provide relief and improve overall quality of life.
By analyzing data collected from standard clinical practice, we focused on how patients rated their pain and shoulder function. Tools such as the Simple Shoulder Test and the Euro-Quality of Life Health Assessment allowed us to track their progress over time. We observed that more than half of the patients reported complete pain relief, while nearly 28% experienced a significant decrease in their discomfort. Such improvements led to noticeable boosts in overall joint function and quality of life.
Our findings affirm that hyaluronic acid injections can be a highly beneficial treatment option for individuals grappling with GH-OA. The positive responses from patients highlight the potential of this therapy to enhance not just physical function but also daily living.
By analyzing data collected from standard clinical practice, we focused on how patients rated their pain and shoulder function. Tools such as the Simple Shoulder Test and the Euro-Quality of Life Health Assessment allowed us to track their progress over time. We observed that more than half of the patients reported complete pain relief, while nearly 28% experienced a significant decrease in their discomfort. Such improvements led to noticeable boosts in overall joint function and quality of life.
Our findings affirm that hyaluronic acid injections can be a highly beneficial treatment option for individuals grappling with GH-OA. The positive responses from patients highlight the potential of this therapy to enhance not just physical function but also daily living.
Read More
9
Hyaluronic acid's treatment effectiveness
We set out to evaluate how effective hyaluronic acid (HA) is in treating knee osteoarthritis (OA), particularly by comparing it with another promising treatment: cell-free fat extract (CEFFE). In our study, we worked with 48 patients experiencing early to mid-stage knee OA, dividing them into two groups—one receiving HA injections and the other receiving CEFFE injections.
Over the course of treatment, patients received a total of five injections, one per week. To measure the outcomes, we used established rating scales to assess pain, functionality, and overall knee health at multiple follow-up points: three weeks, six weeks, three months, and six months after treatment. Both groups showed improvements in their symptoms, which is encouraging news for patients dealing with this degenerative condition.
However, we found that while HA did provide some benefits, CEFFE was more effective in enhancing knee health and reducing bone marrow edema. This suggests that although hyaluronic acid is still a valuable option for managing symptoms of knee OA, there may be more advanced treatments available that can offer better results.
Over the course of treatment, patients received a total of five injections, one per week. To measure the outcomes, we used established rating scales to assess pain, functionality, and overall knee health at multiple follow-up points: three weeks, six weeks, three months, and six months after treatment. Both groups showed improvements in their symptoms, which is encouraging news for patients dealing with this degenerative condition.
However, we found that while HA did provide some benefits, CEFFE was more effective in enhancing knee health and reducing bone marrow edema. This suggests that although hyaluronic acid is still a valuable option for managing symptoms of knee OA, there may be more advanced treatments available that can offer better results.
Read More
8
We conducted a study to evaluate how hyaluronic acid (HA) treatments impact osteoarthritis (OA) in a rabbit model. Specifically, we compared a novel antioxidant-conjugated form of HA, known as HA-4-aminoresorcinol (HA4AR), to a standard high molecular weight HA treatment.
A total of eighteen rabbits underwent a procedure to simulate OA and were divided into three groups based on the type of treatment they received: one group was given saline, another received HA, and the third group was treated with HA4AR. We also looked at additional control knees that weren't operated on to see the natural state of the cartilage and bone.
After six weeks, we used advanced imaging to examine changes in the rabbits' articular cartilage and subchondral bone. We found that both HA and HA4AR groups had comparable cartilage thickness, which is a good sign for joint health. However, the HA treatment alone showed a significant loss of mineral density in the subchondral bone compared to HA4AR and the saline groups.
Our findings suggest that HA4AR not only helps maintain this vital bone density better than standard HA, but it might also offer improved protective benefits for those dealing with osteoarthritis. Ultimately, our study indicates a promising avenue for further research on antioxidant-conjugated therapies in the treatment of OA.
A total of eighteen rabbits underwent a procedure to simulate OA and were divided into three groups based on the type of treatment they received: one group was given saline, another received HA, and the third group was treated with HA4AR. We also looked at additional control knees that weren't operated on to see the natural state of the cartilage and bone.
After six weeks, we used advanced imaging to examine changes in the rabbits' articular cartilage and subchondral bone. We found that both HA and HA4AR groups had comparable cartilage thickness, which is a good sign for joint health. However, the HA treatment alone showed a significant loss of mineral density in the subchondral bone compared to HA4AR and the saline groups.
Our findings suggest that HA4AR not only helps maintain this vital bone density better than standard HA, but it might also offer improved protective benefits for those dealing with osteoarthritis. Ultimately, our study indicates a promising avenue for further research on antioxidant-conjugated therapies in the treatment of OA.
Read More
Most Useful Reviews
10
Zero knee pain
35 people found this helpful
This is amazing! After suffering from very painful knees for several months, which I suspect was due to arthritis, I started taking glucosamine. After 3 weeks, I am pain-free in both knees. I encourage others to take it consistently every day for best results.
Read More
9
Pain-free existence
1 people found this helpful
Over a year ago, I began to suffer from arthritis, which led to a cortisone shot. I tried various glucosamine brands but none were effective. This product, however, is genuinely impressive, allowing me to live pain-free. I highly recommend it. My family doctor mentioned that other patients have had similar experiences, although some have said it doesn't work.
Read More
9
Increased dosage needed
1 people found this helpful
A pharmacist once told me glucosamine was ineffective, but when arthritis made my thumb, knee, and shoulder painful, I tried it. Initially, I took just two tablets, but after increasing to four a day, I am now literally pain-free! I highly recommend this product.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 25 Researches
7.7
- All Researches
9.5
Hyaluronic acid eases shoulder arthritis
We explored the impact of hyaluronic acid (HA) injections, specifically a formulation called Hyalubrix®, on patients suffering from glenohumeral osteoarthritis (GH-OA). The condition often leads to painful and disabling shoulder issues, and we aimed to find out if these injections could provide relief and improve overall quality of life.
By analyzing data collected from standard clinical practice, we focused on how patients rated their pain and shoulder function. Tools such as the Simple Shoulder Test and the Euro-Quality of Life Health Assessment allowed us to track their progress over time. We observed that more than half of the patients reported complete pain relief, while nearly 28% experienced a significant decrease in their discomfort. Such improvements led to noticeable boosts in overall joint function and quality of life.
Our findings affirm that hyaluronic acid injections can be a highly beneficial treatment option for individuals grappling with GH-OA. The positive responses from patients highlight the potential of this therapy to enhance not just physical function but also daily living.
By analyzing data collected from standard clinical practice, we focused on how patients rated their pain and shoulder function. Tools such as the Simple Shoulder Test and the Euro-Quality of Life Health Assessment allowed us to track their progress over time. We observed that more than half of the patients reported complete pain relief, while nearly 28% experienced a significant decrease in their discomfort. Such improvements led to noticeable boosts in overall joint function and quality of life.
Our findings affirm that hyaluronic acid injections can be a highly beneficial treatment option for individuals grappling with GH-OA. The positive responses from patients highlight the potential of this therapy to enhance not just physical function but also daily living.
Read More
9
Hyaluronic acid's long-term effects unclear
We dug into the effectiveness of hyaluronic acid (HA) as a treatment for knee osteoarthritis (OA). By examining data from 37 randomized controlled trials involving over 5,000 patients, we aimed to understand how well HA works in providing pain relief and improving knee function over the long term.
Our findings show that while hyaluronic acid has its benefits, especially when combined with other treatments like platelet-rich plasma (PRP), its standalone effectiveness for long-term management isn't as clear. Patients who received HA combined with PRP experienced better outcomes, but isolating HA’s effects still leaves some questions.
Overall, our exploration highlighted the potential of HA in knee OA treatment, particularly when used in conjunction with other injectables. However, if you're considering HA as a solo treatment, the evidence suggests that more research is needed to fully determine how effective it is on its own.
Our findings show that while hyaluronic acid has its benefits, especially when combined with other treatments like platelet-rich plasma (PRP), its standalone effectiveness for long-term management isn't as clear. Patients who received HA combined with PRP experienced better outcomes, but isolating HA’s effects still leaves some questions.
Overall, our exploration highlighted the potential of HA in knee OA treatment, particularly when used in conjunction with other injectables. However, if you're considering HA as a solo treatment, the evidence suggests that more research is needed to fully determine how effective it is on its own.
Read More
9
Hyaluronic acid's treatment effectiveness
We set out to evaluate how effective hyaluronic acid (HA) is in treating knee osteoarthritis (OA), particularly by comparing it with another promising treatment: cell-free fat extract (CEFFE). In our study, we worked with 48 patients experiencing early to mid-stage knee OA, dividing them into two groups—one receiving HA injections and the other receiving CEFFE injections.
Over the course of treatment, patients received a total of five injections, one per week. To measure the outcomes, we used established rating scales to assess pain, functionality, and overall knee health at multiple follow-up points: three weeks, six weeks, three months, and six months after treatment. Both groups showed improvements in their symptoms, which is encouraging news for patients dealing with this degenerative condition.
However, we found that while HA did provide some benefits, CEFFE was more effective in enhancing knee health and reducing bone marrow edema. This suggests that although hyaluronic acid is still a valuable option for managing symptoms of knee OA, there may be more advanced treatments available that can offer better results.
Over the course of treatment, patients received a total of five injections, one per week. To measure the outcomes, we used established rating scales to assess pain, functionality, and overall knee health at multiple follow-up points: three weeks, six weeks, three months, and six months after treatment. Both groups showed improvements in their symptoms, which is encouraging news for patients dealing with this degenerative condition.
However, we found that while HA did provide some benefits, CEFFE was more effective in enhancing knee health and reducing bone marrow edema. This suggests that although hyaluronic acid is still a valuable option for managing symptoms of knee OA, there may be more advanced treatments available that can offer better results.
Read More
9
We aimed to explore how hyaluronic acid (HA) can improve treatments for rheumatoid arthritis (RA) through a novel delivery system. The study developed a specialized liposomal drug depot that incorporates HA and delivers dexamethasone, a common anti-inflammatory medication. This formulation is designed to target the inflamed areas within the joints, minimizing off-target effects.
Our findings revealed that the HA-modified liposomes effectively reduced inflammation and supported cartilage repair. The sustained release of the drug enhanced uptake by inflammatory macrophages, leading to a decrease in harmful inflammatory factors. Furthermore, this innovative approach significantly reduced chondrocyte cell death, which is crucial for preserving cartilage health.
In animal models, the liposomal system showed promising results, helping to heal cartilage and repolarize macrophages involved in inflammation. This combination strategy addresses both the need for reducing inflammation and promoting tissue regeneration, offering a comprehensive solution for managing RA. Overall, our study suggests that HA can play a key role in advancing arthritis treatments through targeted delivery and improved outcomes.
Our findings revealed that the HA-modified liposomes effectively reduced inflammation and supported cartilage repair. The sustained release of the drug enhanced uptake by inflammatory macrophages, leading to a decrease in harmful inflammatory factors. Furthermore, this innovative approach significantly reduced chondrocyte cell death, which is crucial for preserving cartilage health.
In animal models, the liposomal system showed promising results, helping to heal cartilage and repolarize macrophages involved in inflammation. This combination strategy addresses both the need for reducing inflammation and promoting tissue regeneration, offering a comprehensive solution for managing RA. Overall, our study suggests that HA can play a key role in advancing arthritis treatments through targeted delivery and improved outcomes.
Read More
9
Effective combination for arthritis
We conducted a thorough analysis exploring the effectiveness of hyaluronic acid (HA) combined with platelet-rich plasma (PRP) in treating knee osteoarthritis (KOA). The aim was to determine how this combination therapy stacks up against using PRP alone.
Our systematic search included data from multiple reputable databases, where we reviewed studies conducted on over a thousand KOA patients. We discovered that the combination of PRP and HA led to significant improvements in overall pain and knee function. Patients experiencing this therapy reported better outcomes in pain relief and increased mobility compared to those who received PRP treatment alone.
Importantly, while examining safety, we found low rates of adverse events among patients using the combined treatment. This indicates that adding HA to PRP does not compromise safety, which is encouraging for those considering this therapy for their symptoms. All in all, our findings contribute valuable insights into how HA can enhance treatment options for arthritis sufferers.
Our systematic search included data from multiple reputable databases, where we reviewed studies conducted on over a thousand KOA patients. We discovered that the combination of PRP and HA led to significant improvements in overall pain and knee function. Patients experiencing this therapy reported better outcomes in pain relief and increased mobility compared to those who received PRP treatment alone.
Importantly, while examining safety, we found low rates of adverse events among patients using the combined treatment. This indicates that adding HA to PRP does not compromise safety, which is encouraging for those considering this therapy for their symptoms. All in all, our findings contribute valuable insights into how HA can enhance treatment options for arthritis sufferers.
Read More
User Reviews
USERS' SCORE
Good
Based on 11 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
10
Zero knee pain
35 people found this helpful
This is amazing! After suffering from very painful knees for several months, which I suspect was due to arthritis, I started taking glucosamine. After 3 weeks, I am pain-free in both knees. I encourage others to take it consistently every day for best results.
Read More
9
Pain-free existence
1 people found this helpful
Over a year ago, I began to suffer from arthritis, which led to a cortisone shot. I tried various glucosamine brands but none were effective. This product, however, is genuinely impressive, allowing me to live pain-free. I highly recommend it. My family doctor mentioned that other patients have had similar experiences, although some have said it doesn't work.
Read More
9
Increased dosage needed
1 people found this helpful
A pharmacist once told me glucosamine was ineffective, but when arthritis made my thumb, knee, and shoulder painful, I tried it. Initially, I took just two tablets, but after increasing to four a day, I am now literally pain-free! I highly recommend this product.
Read More
9
Helps arthritis
1 people found this helpful
5 stars. I really like this product and I think it is helping my arthritis!
Read More
9
Significant pain reduction
I bought this for my father, who experiences pain in his knee due to osteoarthritis. He appreciates this product the most and feels a noticeable difference. He takes it daily, and the pain has significantly decreased. It's worth the investment; excellent brand!
Read More
Frequently Asked Questions
9
Significant pain reduction
I bought this for my father, who experiences pain in his knee due to osteoarthritis. He appreciates this product the most and feels a noticeable difference. He takes it daily, and the pain has significantly decreased. It's worth the investment; excellent brand!
9
Remarkable improvement
I was recommended this by my doctor, and I’ve been taking it for over a year. I have experienced remarkable improvement in my arthritis.
9
Pain-free existence
1 people found this helpful
Over a year ago, I began to suffer from arthritis, which led to a cortisone shot. I tried various glucosamine brands but none were effective. This product, however, is genuinely impressive, allowing me to live pain-free. I highly recommend it. My family doctor mentioned that other patients have had similar experiences, although some have said it doesn't work.
8
Keeps joints moving
This product is a good price and has been part of my routine along with chondroitin for decades to alleviate arthritis pain in my hips and knees. I use it daily, and it genuinely helps keep my joints flexible and reduces pain.
8
Glucosamine and exercise enhance arthritis treatment
We sought to determine whether a combination of a nutrition supplement, including glucosamine and chondroitin, along with supervised exercise, is more effective for knee osteoarthritis than exercise alone.
In a six-month double-blinded trial involving 65 participants, those who took the supplement experienced significant improvements in pain and stiffness earlier compared to those receiving a placebo.
This suggests that using glucosamine chondroitin supplementation along with exercise could be a more efficient treatment strategy for arthritis in the knee.
In a six-month double-blinded trial involving 65 participants, those who took the supplement experienced significant improvements in pain and stiffness earlier compared to those receiving a placebo.
This suggests that using glucosamine chondroitin supplementation along with exercise could be a more efficient treatment strategy for arthritis in the knee.
9
Hyaluronic acid's long-term effects unclear
We dug into the effectiveness of hyaluronic acid (HA) as a treatment for knee osteoarthritis (OA). By examining data from 37 randomized controlled trials involving over 5,000 patients, we aimed to understand how well HA works in providing pain relief and improving knee function over the long term.
Our findings show that while hyaluronic acid has its benefits, especially when combined with other treatments like platelet-rich plasma (PRP), its standalone effectiveness for long-term management isn't as clear. Patients who received HA combined with PRP experienced better outcomes, but isolating HA’s effects still leaves some questions.
Overall, our exploration highlighted the potential of HA in knee OA treatment, particularly when used in conjunction with other injectables. However, if you're considering HA as a solo treatment, the evidence suggests that more research is needed to fully determine how effective it is on its own.
Our findings show that while hyaluronic acid has its benefits, especially when combined with other treatments like platelet-rich plasma (PRP), its standalone effectiveness for long-term management isn't as clear. Patients who received HA combined with PRP experienced better outcomes, but isolating HA’s effects still leaves some questions.
Overall, our exploration highlighted the potential of HA in knee OA treatment, particularly when used in conjunction with other injectables. However, if you're considering HA as a solo treatment, the evidence suggests that more research is needed to fully determine how effective it is on its own.
9
Hyaluronic acid's treatment effectiveness
We set out to evaluate how effective hyaluronic acid (HA) is in treating knee osteoarthritis (OA), particularly by comparing it with another promising treatment: cell-free fat extract (CEFFE). In our study, we worked with 48 patients experiencing early to mid-stage knee OA, dividing them into two groups—one receiving HA injections and the other receiving CEFFE injections.
Over the course of treatment, patients received a total of five injections, one per week. To measure the outcomes, we used established rating scales to assess pain, functionality, and overall knee health at multiple follow-up points: three weeks, six weeks, three months, and six months after treatment. Both groups showed improvements in their symptoms, which is encouraging news for patients dealing with this degenerative condition.
However, we found that while HA did provide some benefits, CEFFE was more effective in enhancing knee health and reducing bone marrow edema. This suggests that although hyaluronic acid is still a valuable option for managing symptoms of knee OA, there may be more advanced treatments available that can offer better results.
Over the course of treatment, patients received a total of five injections, one per week. To measure the outcomes, we used established rating scales to assess pain, functionality, and overall knee health at multiple follow-up points: three weeks, six weeks, three months, and six months after treatment. Both groups showed improvements in their symptoms, which is encouraging news for patients dealing with this degenerative condition.
However, we found that while HA did provide some benefits, CEFFE was more effective in enhancing knee health and reducing bone marrow edema. This suggests that although hyaluronic acid is still a valuable option for managing symptoms of knee OA, there may be more advanced treatments available that can offer better results.
4
Hyaluronic acid efficacy remains unclear
We examined the overall effectiveness of hyaluronic acid (HA) treatment for knee osteoarthritis (KOA) compared to platelet-rich plasma (PRP) in a series of systematic reviews and meta-analyses. The research involved an extensive review of 17 studies that aimed to clarify the benefits of HA shots for arthritis patients.
Our findings revealed that HA may provide some level of treatment advantage, but the methodological quality of the studies we analyzed was notably low. Many of these studies suffered from poor reporting and significant gaps in information, meaning the conclusions drawn about HA's effectiveness may not be as reliable as we would like. We found that just a small number of the outcome indicators showed medium or low-quality evidence, while the majority indicated extremely low-quality results.
Importantly, the studies highlighted considerable overlap in the research, which raises questions about the clarity of HA's isolated effects. While HA has been widely used as a treatment option for KOA, the evidence supporting its efficacy remains uncertain. As we move forward, it is clear that more robust studies are needed to firmly establish how well HA works for patients suffering from this common form of arthritis.
Our findings revealed that HA may provide some level of treatment advantage, but the methodological quality of the studies we analyzed was notably low. Many of these studies suffered from poor reporting and significant gaps in information, meaning the conclusions drawn about HA's effectiveness may not be as reliable as we would like. We found that just a small number of the outcome indicators showed medium or low-quality evidence, while the majority indicated extremely low-quality results.
Importantly, the studies highlighted considerable overlap in the research, which raises questions about the clarity of HA's isolated effects. While HA has been widely used as a treatment option for KOA, the evidence supporting its efficacy remains uncertain. As we move forward, it is clear that more robust studies are needed to firmly establish how well HA works for patients suffering from this common form of arthritis.
References
- Liu W, Yu Y, Zhang Z, Li Z, Wu Y, et al. Nutrition supplementation combined with exercise versus exercise alone in treating knee osteoarthritis: a double-blinded, randomised, placebo-controlled trial. Age Ageing. 2025;54. 10.1093/ageing/afaf010
- Gupta N, Khatri K, Lakhani A, Dahuja A, Randhawa A, et al. Long-term effectiveness of intra-articular injectables in patients with knee osteoarthritis: a systematic review and Bayesian network meta-analysis. J Orthop Surg Res. 2025;20:227. 10.1186/s13018-025-05574-w
- Powantia Pontoh LA, Fiolin J, Dilogo IH, Prasetyo M, Antarianto RD, et al. Combined exosome of adipose-derived mesenchymal stem cell and hyaluronic acid delays early osteoarthritis progression of ovine sheep model: Clinical, radiographic, macroscopic and microscopic evaluation. F1000Res. 2024;13:494.
- Bernetti A, Agostini F, Finamore N, Dal Borgo M, Mangone M, et al. Effectiveness of ultrasound-guided hip injections on pain and functioning in patients with hip osteoarthritis: A systematic review. J Back Musculoskelet Rehabil. 2025;38:19. 10.1177/10538127241296338
- Migliorini F, Maffulli N, Pipino G, Jeyaraman M, Ramasubramanian S, et al. Intra-articular injections of hyaluronic acid versus plasma rich in growth factors (PRGF) for knee osteoarthritis: a meta-analysis of randomised controlled trials : A meta-analysis. Orthopadie (Heidelb). 2025;54:218. 10.1007/s00132-025-04615-w
- Zhang C, Lu Y, Huang Y. Clinical efficacy of cell-free fat extract and its effects on bone marrow edema in patients with early to mid-stage knee osteoarthritis: a clinical trial in comparison with hyaluronic acid. J Orthop Surg Res. 2025;20:153. 10.1186/s13018-025-05543-3
- Nisha M, Adnan M, Sakure K, Jain P. Innovations in Glycosaminoglycan Delivery: Transforming Joint Health Therapies. Pharm Nanotechnol. 2025. 10.2174/0122117385329819241212040246
- Zhang Z, Wang G, Zhang Z, Liang X, Wang G, et al. Locally administered liposomal drug depot enhances rheumatoid arthritis treatment by inhibiting inflammation and promoting cartilage repair. J Nanobiotechnology. 2025;23:69. 10.1186/s12951-025-03110-w
- Heller S, Seemann RJ, Burgkart R, Obermeier A, Locher H. Lidocaine Shows Significant Antimicrobial Effects Against Species: An In-Vitro Study Comparing Different Combinations of Lidocaine and Clinically Used Injectables, like Steroids and Hyaluronan, in the Context of Arthritis Management. Biomedicines. 2025;13. 10.3390/biomedicines13010106
- Kumaran K, Vasudevan AK, Jayakumar R, Biswas R. Injectable vancomycin loaded hyaluronic acid-chitosan hydrogel for the treatment of Staphylococcus aureus septic arthritis. Carbohydr Res. 2025;550:109384. 10.1016/j.carres.2025.109384
- Du D, Liang Y. A meta-analysis and systematic review of the clinical efficacy and safety of platelet-rich plasma combined with hyaluronic acid (PRP + HA) versus PRP monotherapy for knee osteoarthritis (KOA). J Orthop Surg Res. 2025;20:57. 10.1186/s13018-024-05429-w
- Zhou Q, Chen J, Yu W, Cao D, Ye Y, et al. A critical overview of systematic reviews and meta-analyses of intra-articular injection of platelet rich plasma versus hyaluronic acid for knee osteoarthritis. Clin Rheumatol. 2025;44:547. 10.1007/s10067-024-07264-0
- Rieger R, Kaderli S, Boulocher C. In vivo impact on rabbit subchondral bone of viscosupplementation with a hyaluronic acid antioxidant conjugate. BMC Musculoskelet Disord. 2024;25:1018. 10.1186/s12891-024-07921-0
- Migliorini F, Schäfer L, Pilone M, Bell A, Simeone F, et al. Similar efficacy of intra-articular hyaluronic acid injections and other biologically active injections in patients with early stages knee osteoarthritis: a level I meta-analysis. Arch Orthop Trauma Surg. 2024;145:68. 10.1007/s00402-024-05614-w
- Monti L, Franchi E, Verde F, Sgherzi S, Anghilieri FM. Retrospective evaluation of the efficacy of ultrasound-guided intra-articular hyaluronic-acid-based injections (Hyalubrix) in patients with glenohumeral osteoarthritis. Reumatismo. 2025;77. 10.4081/reumatismo.2024.1699
- Oon SF, Lazarakis S, Mallawa G, Nguyen C. Intra-articular hyaluronic acid and platelet-rich plasma as monotherapy or combination therapy in knee osteoarthritis?. Regen Med. 2024;19:637. 10.1080/17460751.2024.2439221
- Zhou C, Hao W, Yao J, Zhu T, Sun M, et al. Anti-inflammatory supramolecular hydrogel loaded chicoric acid based on graphene oxide modified hyaluronic acid and polyethylene glycol for rheumatoid arthritis treatment. Int J Biol Macromol. 2025;287:138610. 10.1016/j.ijbiomac.2024.138610
- Said M, Tavakoli C, Dumot C, Toupet K, Olivier C, et al. A self-healing radiopaque hyaluronic acid hydrogel as a new injectable biomaterial for precision medicine in osteoarthritis. Theranostics. 2025;15:4054. 10.7150/thno.104551
- Liu Q, Ye H, Yang Y, Chen H. The efficacy and safety of intra-articular platelet-rich plasma versus sodium hyaluronate for the treatment of osteoarthritis: Meta-analysis. PLoS One. 2025;20:e0314878. 10.1371/journal.pone.0314878
- Woo I, Park JJ, Park CH. Dual intra-articular injections of corticosteroid and hyaluronic acid versus single corticosteroid injection for ankle osteoarthritis: a randomized comparative trial. BMC Musculoskelet Disord. 2025;26:239. 10.1186/s12891-025-08488-0
- Bensa A, Bianco Prevot L, Moraca G, Sangiorgio A, Boffa A, et al. Corticosteroids, hyaluronic acid, platelet-rich plasma, and cell-based therapies for knee osteoarthritis - literature trends are shifting in the injectable treatments' evidence: a systematic review and expert opinion. Expert Opin Biol Ther. 2025;25:309. 10.1080/14712598.2025.2465833
- Mirghaderi P, Mortezaei A, Javidan A, Ghaseminejad-Raeini A, Nematollahi B. Efficacy and safety of biological products in hip osteoarthritis: a systematic review and meta-analysis of randomized controlled trials. Clin Rheumatol. 2025;44:1403. 10.1007/s10067-025-07366-3
- Wu J, Tang Q, Tan X. Sodium hyaluronate and acupotomy bone decompression alleviates inflammatory responses in patients with knee osteoarthritis. Inflammopharmacology. 2025;33:1997. 10.1007/s10787-025-01667-4
- Chowdary P, Puppala ER, Putta CL, Maddila JR, Pulavarthy V, et al. Hyaluronic-Acid-Functionalized Tofacitinib Loaded Transethosomes for Targeted Drug Delivery in Rheumatoid Arthritis. ACS Appl Bio Mater. 2025;8:1594. 10.1021/acsabm.4c01743
- Ma Y, Yang X, Jiang M, Ye W, Qin H, et al. Alone or in combination, hyaluronic acid and chondroitin sulfate alleviate ECM degradation in osteoarthritis by inhibiting the NF-κB pathway. J Orthop Surg Res. 2025;20:11. 10.1186/s13018-024-05411-6
