Last update
2/28/2026
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 14 Researches
6.6
USERS' SCORE
Medium or Average
Based on 19 Reviews
6.1
Supplement Facts
Serving Size: 2 Tablets
Amount Per Serving
%DV
Calories
10
Total Carbohydrate
2 g
<1%*
Glucosamine Hydrochloride
2,000 mg
†
Hyaluronic Acid
3.3 mg
†
Top Medical Research Studies
9
We conducted a study to explore whether intraarticular injections of hyaluronic acid (HA) could effectively treat chronic, nonradicular low back pain as compared to glucocorticoids. Sixty patients participated in a well-structured clinical trial where they received either HA or glucocorticoid injections.
Both treatments resulted in significant pain relief, improved function, and enhanced quality of life. Notably, HA was found to be just as effective as glucocorticoids, and showed even better long-term benefits without any reported side effects.
Both treatments resulted in significant pain relief, improved function, and enhanced quality of life. Notably, HA was found to be just as effective as glucocorticoids, and showed even better long-term benefits without any reported side effects.
Read More
9
We examined how cross-linked hyaluronic acid (cHA) hydrogel can help reduce epidural fibrosis after back surgeries, which is a common cause of ongoing pain. In our study with rat models, we compared groups that received cHA to those that did not.
The results showed that cHA treatment led to lower levels of fibrosis and overall healthier spinal structures. The treated groups had more space around the spinal cord and less thickening of protective membranes. Overall, we found that cHA is promising for managing post-surgical back pain by effectively reducing scar tissue formation.
The results showed that cHA treatment led to lower levels of fibrosis and overall healthier spinal structures. The treated groups had more space around the spinal cord and less thickening of protective membranes. Overall, we found that cHA is promising for managing post-surgical back pain by effectively reducing scar tissue formation.
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2
We assessed the effectiveness of hyaluronic acid (HA) injections for lumbar facet joint arthritis in a small pilot study involving thirteen patients. Each participant underwent a thorough evaluation before treatment, using questionnaires to gauge pain levels and disability. After a precise HA injection, we followed up with evaluations six weeks later.
Unfortunately, our findings indicated that there was no significant improvement in back pain or symptoms following the treatment. This suggests that HA may not be effective for managing lumbar facet joint arthritis at this stage.
Unfortunately, our findings indicated that there was no significant improvement in back pain or symptoms following the treatment. This suggests that HA may not be effective for managing lumbar facet joint arthritis at this stage.
Read More
Most Useful Reviews
9
Quick pain relief
1 people found this helpful
It works! I have severe pain from arthritic knees. Seeking quick relief, I took double the recommended dose: two capsules both morning and evening, along with a chondroitin sulfate pill. Within a week, I was walking again with minimal discomfort. Once the pain is completely gone, I plan to reduce the dosage to two capsules a day for maintenance. Research indicates glucosamine is a fundamental cartilage building block, while chondroitin reduces inflammation and cartilage breakdown, making them an excellent pair.
Read More
9
Huge difference
SUPER EFFECTIVE! Upon starting these, I noticed a remarkable improvement in my mobility and pain levels. I couldn't believe how effective they are and would recommend them to anyone experiencing knee pain.
Read More
9
Pain relief achieved
Dad took it, and it was effective; he no longer felt any pain.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 14 Researches
6.6
- All Researches
9
We examined how cross-linked hyaluronic acid (cHA) hydrogel can help reduce epidural fibrosis after back surgeries, which is a common cause of ongoing pain. In our study with rat models, we compared groups that received cHA to those that did not.
The results showed that cHA treatment led to lower levels of fibrosis and overall healthier spinal structures. The treated groups had more space around the spinal cord and less thickening of protective membranes. Overall, we found that cHA is promising for managing post-surgical back pain by effectively reducing scar tissue formation.
The results showed that cHA treatment led to lower levels of fibrosis and overall healthier spinal structures. The treated groups had more space around the spinal cord and less thickening of protective membranes. Overall, we found that cHA is promising for managing post-surgical back pain by effectively reducing scar tissue formation.
Read More
9
We conducted a study to explore whether intraarticular injections of hyaluronic acid (HA) could effectively treat chronic, nonradicular low back pain as compared to glucocorticoids. Sixty patients participated in a well-structured clinical trial where they received either HA or glucocorticoid injections.
Both treatments resulted in significant pain relief, improved function, and enhanced quality of life. Notably, HA was found to be just as effective as glucocorticoids, and showed even better long-term benefits without any reported side effects.
Both treatments resulted in significant pain relief, improved function, and enhanced quality of life. Notably, HA was found to be just as effective as glucocorticoids, and showed even better long-term benefits without any reported side effects.
Read More
8
We examined the effects of hyaluronic acid in healing back pain linked to disc degeneration. In our study, New Zealand white rabbits undergoing a partial nucleotomy received either PGA/HA implants or bioactivated fibrin, while controls underwent the procedure without any treatment.
Our results indicated that the use of PGA/HA implants led to more effective tissue repair, evidenced by a significant increase in type II collagen content, compared to the untreated controls. However, there was no change in the water content of the discs over the six-month period, highlighting that while tissue repair may improve, it may not directly enhance disc hydration or overall disc function.
Our results indicated that the use of PGA/HA implants led to more effective tissue repair, evidenced by a significant increase in type II collagen content, compared to the untreated controls. However, there was no change in the water content of the discs over the six-month period, highlighting that while tissue repair may improve, it may not directly enhance disc hydration or overall disc function.
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8
Sacroiliac joint pain treatment review
We explored the complex nature of chronic pain in the sacroiliac joint, which has long sparked debate due to its anatomical position. This makes accurate diagnosis challenging, often requiring advanced techniques like guided injections.
While there are various treatment options available for sacroiliac joint syndrome, no single method has proven to be ideal. However, using hyaluronic acid through intra-articular viscosupplementation has shown promise in delivering long-lasting pain relief, promoting healthy joint function, and enhancing synovial fluid properties.
While there are various treatment options available for sacroiliac joint syndrome, no single method has proven to be ideal. However, using hyaluronic acid through intra-articular viscosupplementation has shown promise in delivering long-lasting pain relief, promoting healthy joint function, and enhancing synovial fluid properties.
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7
Safety and feasibility confirmed
We explored the safety and feasibility of using hyaluronic acid alongside specially prepared stem cells to treat chronic low back pain. In a small study involving eight patients, everyone received a single injection while being monitored over six months.
Thankfully, there were no reported complications, and six out of eight participants showed meaningful improvements in pain and disability scores. While radiological changes were noted in four patients, the overall findings highlight the potential of this treatment as a safe option for chronic disc-related pain. However, further research is needed to confirm its effectiveness.
Thankfully, there were no reported complications, and six out of eight participants showed meaningful improvements in pain and disability scores. While radiological changes were noted in four patients, the overall findings highlight the potential of this treatment as a safe option for chronic disc-related pain. However, further research is needed to confirm its effectiveness.
Read More
User Reviews
USERS' SCORE
Medium or Average
Based on 19 Reviews
6.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Quick pain relief
1 people found this helpful
It works! I have severe pain from arthritic knees. Seeking quick relief, I took double the recommended dose: two capsules both morning and evening, along with a chondroitin sulfate pill. Within a week, I was walking again with minimal discomfort. Once the pain is completely gone, I plan to reduce the dosage to two capsules a day for maintenance. Research indicates glucosamine is a fundamental cartilage building block, while chondroitin reduces inflammation and cartilage breakdown, making them an excellent pair.
Read More
9
Huge difference
SUPER EFFECTIVE! Upon starting these, I noticed a remarkable improvement in my mobility and pain levels. I couldn't believe how effective they are and would recommend them to anyone experiencing knee pain.
Read More
9
Pain relief achieved
Dad took it, and it was effective; he no longer felt any pain.
Read More
7.5
Economical option
I've found a good glucosamine option with an effective dosage of 1000mg and an economical package of 150 tablets. Glucosamine significantly helps with my joint and muscle pain. The quality and ingredients are excellent.
Read More
7.5
Effective for back pain
4 people found this helpful
This should be taken by anyone who has joint and back pain. I have suffered from back pain and had spinal surgery. At 46, my mother also experiences back pain and joint issues at 76. We have been using Aflutop every six months for five years; it helps, but that’s only 20 injections. Glucosamine, which our bodies produce naturally and cannot harm us, is essential. After taking it with my mother for three months, my pain ceased (though I did have 15 massage sessions on my back). My mother's pain has decreased significantly. I’m hard to convince but if it helped me, glucosamine is indeed effective.
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Frequently Asked Questions
0
Shoulder pain decreased
I liked this drug as it helped ease the pain in my left shoulder, especially after driving. Within a few weeks, the pain significantly reduced.
7.5
Effective for back pain
4 people found this helpful
This should be taken by anyone who has joint and back pain. I have suffered from back pain and had spinal surgery. At 46, my mother also experiences back pain and joint issues at 76. We have been using Aflutop every six months for five years; it helps, but that’s only 20 injections. Glucosamine, which our bodies produce naturally and cannot harm us, is essential. After taking it with my mother for three months, my pain ceased (though I did have 15 massage sessions on my back). My mother's pain has decreased significantly. I’m hard to convince but if it helped me, glucosamine is indeed effective.
0
Knee pain relief
3 people found this helpful
I have ordered this product multiple times. I'm very pleased with it as it truly works for my knee pain. If I skip even a day, the pain returns, so I consistently take it.
9
Quick pain relief
1 people found this helpful
It works! I have severe pain from arthritic knees. Seeking quick relief, I took double the recommended dose: two capsules both morning and evening, along with a chondroitin sulfate pill. Within a week, I was walking again with minimal discomfort. Once the pain is completely gone, I plan to reduce the dosage to two capsules a day for maintenance. Research indicates glucosamine is a fundamental cartilage building block, while chondroitin reduces inflammation and cartilage breakdown, making them an excellent pair.
0
Effective cartilage restoration
1 people found this helpful
Glucosamine from Schiff is impressive! It restores joint cartilage and reduces inflammation and pain. I've tried many brands, but this one stands out. I take two tablets daily with vitamin C. If you find this useful, please like it!
0
Aching shoulder support
2 people found this helpful
After separating both my shoulders in construction accidents, I experience significant aching when doing manual work. This product, combined with Advil, helps keep my pain manageable.
7
Safety and feasibility confirmed
We explored the safety and feasibility of using hyaluronic acid alongside specially prepared stem cells to treat chronic low back pain. In a small study involving eight patients, everyone received a single injection while being monitored over six months.
Thankfully, there were no reported complications, and six out of eight participants showed meaningful improvements in pain and disability scores. While radiological changes were noted in four patients, the overall findings highlight the potential of this treatment as a safe option for chronic disc-related pain. However, further research is needed to confirm its effectiveness.
Thankfully, there were no reported complications, and six out of eight participants showed meaningful improvements in pain and disability scores. While radiological changes were noted in four patients, the overall findings highlight the potential of this treatment as a safe option for chronic disc-related pain. However, further research is needed to confirm its effectiveness.
7
We explored the impact of combining therapeutic exercise with dietary supplements, including hyaluronic acid, on chronic low back pain. In this study, 60 patients were split into two groups—one receiving only exercise and the other incorporating these supplements.
The results showed that those taking supplements, alongside their exercise regimen, experienced more significant relief from pain and improved quality of life compared to those who exercised alone. Thus, using hyaluronic acid with rehabilitation exercises could be a beneficial approach for managing chronic low back pain.
The results showed that those taking supplements, alongside their exercise regimen, experienced more significant relief from pain and improved quality of life compared to those who exercised alone. Thus, using hyaluronic acid with rehabilitation exercises could be a beneficial approach for managing chronic low back pain.
4
We examined the effectiveness of hyaluronic acid in managing chronic low back pain originating from facet joint osteoarthritis. Our systematic review analyzed various injectable treatments, focusing on outcomes from randomized clinical trials.
While steroids and local anesthetics showed promising results, hyaluronic acid did not demonstrate significant benefits, unlike other treatments we explored.
Overall, injections for this type of back pain are encouraging, especially with medial branch blocks, but the role of hyaluronic acid remains unclear.
While steroids and local anesthetics showed promising results, hyaluronic acid did not demonstrate significant benefits, unlike other treatments we explored.
Overall, injections for this type of back pain are encouraging, especially with medial branch blocks, but the role of hyaluronic acid remains unclear.
7
Hyaluronic acid shows limited benefit
We evaluated the safety and effectiveness of injecting mesenchymal precursor cells and hyaluronic acid (HA) in individuals suffering from chronic low back pain linked to degenerative disc disease. In a multicenter study involving 100 participants, we measured their pain and disability levels using visual scales and questionnaires at various intervals over three years.
Unfortunately, our findings did not show significant improvements in back pain relief attributable to HA. While there were some safety and effectiveness indicators for the treatment, the overall benefits of HA weren't substantial enough to draw strong conclusions.
Unfortunately, our findings did not show significant improvements in back pain relief attributable to HA. While there were some safety and effectiveness indicators for the treatment, the overall benefits of HA weren't substantial enough to draw strong conclusions.
References
- Lee DH, Park KS, Shin HE, Kim SB, Choi H, et al. Safety and Feasibility of Intradiscal Administration of Matrilin-3-Primed Adipose-Derived Mesenchymal Stromal Cell Spheroids for Chronic Discogenic Low Back Pain: Phase 1 Clinical Trial. Int J Mol Sci. 2023;24. 10.3390/ijms242316827
- Goode AP, Cleveland RJ, Kraus VB, Taylor KA, George SZ, et al. Biomarkers and longitudinal changes in lumbar spine degeneration and low back pain: the Johnston County Osteoarthritis Project. Osteoarthritis Cartilage. 2023;31:809. 10.1016/j.joca.2023.02.005
- Shavlovskaya OA. [Complex effects of physical exertion with dietary supplements Cartilox in pain syndrome effectiveness and safety evaluation]. Vopr Kurortol Fizioter Lech Fiz Kult. 2022;99:20. 10.17116/kurort20229904120
- Baroncini A, Maffulli N, Eschweiler J, Knobe M, Tingart M, et al. Management of facet joints osteoarthritis associated with chronic low back pain: A systematic review. Surgeon. 2021;19:e512. 10.1016/j.surge.2020.12.004
- Farì G, Santagati D, Pignatelli G, Scacco V, Renna D, et al. Collagen Peptides, in Association with Vitamin C, Sodium Hyaluronate, Manganese and Copper, as Part of the Rehabilitation Project in the Treatment of Chronic Low Back Pain. Endocr Metab Immune Disord Drug Targets. 2022;22:108. 10.2174/1871530321666210210153619
- Amirdelfan K, Bae H, McJunkin T, DePalma M, Kim K, et al. Allogeneic mesenchymal precursor cells treatment for chronic low back pain associated with degenerative disc disease: a prospective randomized, placebo-controlled 36-month study of safety and efficacy. Spine J. 2021;21:212. 10.1016/j.spinee.2020.10.004
- Annaswamy TM, Armstead C, Carlson L, Elkins NJ, Kocak D, et al. Intra-articular Triamcinolone Versus Hyaluronate Injections for Low Back Pain With Symptoms Suggestive of Lumbar Zygapophyseal Joint Arthropathy: A Pragmatic, Double-Blind Randomized Controlled Trial. Am J Phys Med Rehabil. 2018;97:278. 10.1097/PHM.0000000000000879
- Kumar H, Ha DH, Lee EJ, Park JH, Shim JH, et al. Safety and tolerability of intradiscal implantation of combined autologous adipose-derived mesenchymal stem cells and hyaluronic acid in patients with chronic discogenic low back pain: 1-year follow-up of a phase I study. Stem Cell Res Ther. 2017;8:262. 10.1186/s13287-017-0710-3
- Wu CY, Huang YH, Lee JS, Tai TW, Wu PT, et al. Efficacy of topical cross-linked hyaluronic acid hydrogel in preventing post laminectomy/laminotomy fibrosis in a rat model. J Orthop Res. 2016;34:299. 10.1002/jor.23001
- Endres M, Zenclussen ML, Casalis PA, Freymann U, Gil Garcia S, et al. Augmentation and repair tissue formation of the nucleus pulposus after partial nucleotomy in a rabbit model. Tissue Cell. 2014;46:505. 10.1016/j.tice.2014.09.003
- Cleary M, Keating C, Poynton AR. Viscosupplementation in lumbar facet joint arthropathy: a pilot study. J Spinal Disord Tech. 2008;21:29. 10.1097/BSD.0b013e318057720c
- Fuchs S, Erbe T, Fischer HL, Tibesku CO. Intraarticular hyaluronic acid versus glucocorticoid injections for nonradicular pain in the lumbar spine. J Vasc Interv Radiol. 2005;16:1493. PubMed
- Calvillo O, Skaribas I, Turnipseed J. Anatomy and pathophysiology of the sacroiliac joint. Curr Rev Pain. 2000;4:356. PubMed
- Srejic U, Calvillo O, Kabakibou K. Viscosupplementation: a new concept in the treatment of sacroiliac joint syndrome: a preliminary report of four cases. Reg Anesth Pain Med. 1999;24:84. PubMed
Data last updated:
