Last update
2/28/2026
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.3
USERS' SCORE
Good
Based on 4 Reviews
8.1
Supplement Facts
Serving Size: 2 Tablets
Amount Per Serving
%DV
Calories
10
Total Carbohydrate
2 g
<1%*
Glucosamine Hydrochloride
2,000 mg
†
Hyaluronic Acid
3.3 mg
†
Top Medical Research Studies
8
Hyaluronic acid effectiveness evaluated
We explored how hyaluronic acid (HA) injections affect knee osteoarthritis (OA) pain and function. This study involved 128 patients, comparing the impact of a single high-dose injection to triple low-dose injections over 12 months.
Interestingly, the triple low-dose injections demonstrated better results, improving pain and function more effectively than the single high-dose approach.
So, for those dealing with knee OA, multiple, lower dose HA injections might be the way to go for relief.
Interestingly, the triple low-dose injections demonstrated better results, improving pain and function more effectively than the single high-dose approach.
So, for those dealing with knee OA, multiple, lower dose HA injections might be the way to go for relief.
Read More
8
LBSA0103 shows pain relief effectiveness
We aimed to understand how effective and safe LBSA0103, a highly cross-linked hyaluronic acid, is for treating knee osteoarthritis.
Involving over 3,140 participants, this study monitored side effects and pain relief through injections.
While some reported mild side effects, the majority experienced significant relief from knee pain, with more than 80% showing improvement after treatment.
Overall, LBSA0103 was well tolerated and demonstrated a positive effect on reducing pain, particularly in the weeks following treatment.
Involving over 3,140 participants, this study monitored side effects and pain relief through injections.
While some reported mild side effects, the majority experienced significant relief from knee pain, with more than 80% showing improvement after treatment.
Overall, LBSA0103 was well tolerated and demonstrated a positive effect on reducing pain, particularly in the weeks following treatment.
Read More
9
We explored the impact of hyaluronic acid (HA) sheet transplantation on knee pain in a rat arthritis model. This study administered HA sheets to right knees of rats following induced arthritis while left knees underwent sham surgery.
We observed significant pain relief and reduced inflammation in the knees treated with HA. Notably, these sheets decreased cartilage damage and fibrosis, offering hope for chronic knee pain management. However, the full extent of benefits needs further investigation in human subjects.
We observed significant pain relief and reduced inflammation in the knees treated with HA. Notably, these sheets decreased cartilage damage and fibrosis, offering hope for chronic knee pain management. However, the full extent of benefits needs further investigation in human subjects.
Read More
Most Useful Reviews
7.5
Promotes joint health
I purchased this for my mother's knee health. Glucosamine is well-known for its benefits to joints.
Read More
6
Necessary for aging
Glucosamine is essential for those suffering from knee roughness due to age.
Read More
7.5
Effective for knees
The quality is excellent. I recommend it for anyone with knee roughness. The ingredients are safe for long-term use, and it effectively restores skin health without any harm.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.3
- All Researches
9
We explored the effectiveness of a treatment for knee osteoarthritis that combines oral duloxetine with an injection of hyaluronic acid and corticosteroid. Conducted at Beijing Tiantan Hospital, this study involved 150 patients who were randomly assigned to either the combined treatment or the injection alone.
After 24 weeks, results showed that those receiving the combination experienced a significant reduction in pain and improvement in knee function. However, it’s important to note that this study only assessed effects over a short term, so longer follow-ups will be necessary to determine lasting benefits.
After 24 weeks, results showed that those receiving the combination experienced a significant reduction in pain and improvement in knee function. However, it’s important to note that this study only assessed effects over a short term, so longer follow-ups will be necessary to determine lasting benefits.
Read More
9
We explored the effectiveness of hyaluronic acid injections for managing knee pain in patients with hemophilic arthropathy. Research indicated that a significant portion of participants experienced pain relief, with 91% reporting improvement over six years, and 82% of those with knee arthropathy seeing similar results after seven years. While findings varied across studies, it suggests that these injections can be beneficial for several months and can be repeated every six to twelve months. However, the overall data is somewhat diverse and complex.
Read More
9
We explored the impact of hyaluronic acid (HA) sheet transplantation on knee pain in a rat arthritis model. This study administered HA sheets to right knees of rats following induced arthritis while left knees underwent sham surgery.
We observed significant pain relief and reduced inflammation in the knees treated with HA. Notably, these sheets decreased cartilage damage and fibrosis, offering hope for chronic knee pain management. However, the full extent of benefits needs further investigation in human subjects.
We observed significant pain relief and reduced inflammation in the knees treated with HA. Notably, these sheets decreased cartilage damage and fibrosis, offering hope for chronic knee pain management. However, the full extent of benefits needs further investigation in human subjects.
Read More
8
We assessed the effects of a combination of hyaluronic acid and chondroitin sulfate on knee pain and mobility in a group of 21 patients. Over six months, participants reported a significant drop in pain levels, from near unbearable at 7.48 to a more manageable 5.24. Mobility also improved, showing a 35.61% increase by the six-month mark. Importantly, no serious side effects were noted. This treatment may enhance joint function and quality of life, easing daily activities for those with knee osteoarthritis.
Read More
8
Hyaluronic acid effectiveness evaluated
We explored how hyaluronic acid (HA) injections affect knee osteoarthritis (OA) pain and function. This study involved 128 patients, comparing the impact of a single high-dose injection to triple low-dose injections over 12 months.
Interestingly, the triple low-dose injections demonstrated better results, improving pain and function more effectively than the single high-dose approach.
So, for those dealing with knee OA, multiple, lower dose HA injections might be the way to go for relief.
Interestingly, the triple low-dose injections demonstrated better results, improving pain and function more effectively than the single high-dose approach.
So, for those dealing with knee OA, multiple, lower dose HA injections might be the way to go for relief.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Promotes joint health
I purchased this for my mother's knee health. Glucosamine is well-known for its benefits to joints.
Read More
6
Necessary for aging
Glucosamine is essential for those suffering from knee roughness due to age.
Read More
7.5
Effective for knees
The quality is excellent. I recommend it for anyone with knee roughness. The ingredients are safe for long-term use, and it effectively restores skin health without any harm.
Read More
7.5
Helps arthritis symptoms
This glucosamine is effective in helping with my knee arthritis.
Read More
Frequently Asked Questions
8
We assessed the effects of a combination of hyaluronic acid and chondroitin sulfate on knee pain and mobility in a group of 21 patients. Over six months, participants reported a significant drop in pain levels, from near unbearable at 7.48 to a more manageable 5.24. Mobility also improved, showing a 35.61% increase by the six-month mark. Importantly, no serious side effects were noted. This treatment may enhance joint function and quality of life, easing daily activities for those with knee osteoarthritis.
We examined the effectiveness of hyaluronic acid (HA) alongside platelet-rich plasma (PRP) for treating anterior knee pain caused by chondromalacia patellae. In a study involving 43 patients, those receiving PRP and HA reported an improvement in pain and quality of life compared to a control group undergoing standard physiotherapy. Although previous studies showed mixed results, our findings support the combination treatment's potential to alleviate knee pain effectively. This suggests that HA may play a significant role in enhancing treatment outcomes for anterior knee pain.
8
Hyaluronic acid effectiveness evaluated
We explored how hyaluronic acid (HA) injections affect knee osteoarthritis (OA) pain and function. This study involved 128 patients, comparing the impact of a single high-dose injection to triple low-dose injections over 12 months.
Interestingly, the triple low-dose injections demonstrated better results, improving pain and function more effectively than the single high-dose approach.
So, for those dealing with knee OA, multiple, lower dose HA injections might be the way to go for relief.
Interestingly, the triple low-dose injections demonstrated better results, improving pain and function more effectively than the single high-dose approach.
So, for those dealing with knee OA, multiple, lower dose HA injections might be the way to go for relief.
8
LBSA0103 shows pain relief effectiveness
We aimed to understand how effective and safe LBSA0103, a highly cross-linked hyaluronic acid, is for treating knee osteoarthritis.
Involving over 3,140 participants, this study monitored side effects and pain relief through injections.
While some reported mild side effects, the majority experienced significant relief from knee pain, with more than 80% showing improvement after treatment.
Overall, LBSA0103 was well tolerated and demonstrated a positive effect on reducing pain, particularly in the weeks following treatment.
Involving over 3,140 participants, this study monitored side effects and pain relief through injections.
While some reported mild side effects, the majority experienced significant relief from knee pain, with more than 80% showing improvement after treatment.
Overall, LBSA0103 was well tolerated and demonstrated a positive effect on reducing pain, particularly in the weeks following treatment.
References
- Dima A, Dragosloveanu M, Romila AR, Cristea A, Marinică G, et al. Can Hyaluronic Acid Combined with Chondroitin Sulfate in Viscosupplementation of Knee Osteoarthritis Improve Pain Symptoms and Mobility?. Biomolecules. 2024;14. 10.3390/biom14070832
- Ostojic M, Hakam HT, Lovrekovic B, Ramadanov N, Prill R. Treatment of anterior knee pain due to chondromalacia patellae with platelet-rich plasma and hyaluronic acid in young and middle-aged adults, a cohort study. Arch Orthop Trauma Surg. 2024;144:3969. 10.1007/s00402-024-05363-w
- Safali S, Ertaş ES, Özdemir A, Cataklı D. Evaluation of single and multiple hyaluronic acid injections at different concentrations with high molecular weight in the treatment of knee osteoarthritis. BMC Musculoskelet Disord. 2024;25:164. 10.1186/s12891-024-07200-y
- Li D, Hang R, Meng L, Zhao Z, Zhao C, et al. Co-treatment with Oral Duloxetine and Intraarticular Injection of Corticosteroid plus Hyaluronic Acid Reduces Pain in the Treatment of Knee Osteoarthritis. Pain Physician. 2024;27:E45. PubMed
- Rodriguez-Merchan EC. The role of intraarticular injections of hyaluronic acid in joint pain relief in hemophilic arthropathy. Expert Rev Hematol. 2023;16:811. 10.1080/17474086.2023.2271660
- Hill WS, Dohnalek MH, Ha Y, Kim SJ, Jung JC, et al. A Multicenter, Randomized, Double-Blinded, Placebo-Controlled Clinical Trial to Evaluate the Efficacy and Safety of a Krill Oil, Astaxanthin, and Oral Hyaluronic Acid Complex on Joint Health in People with Mild Osteoarthritis. Nutrients. 2023;15. 10.3390/nu15173769
- Colombini A, Doro G, Ragni E, Forte L, de Girolamo L, et al. Treatment with CR500® improves algofunctional scores in patients with knee osteoarthritis: a post-market confirmatory interventional, single arm clinical investigation. BMC Musculoskelet Disord. 2023;24:647. 10.1186/s12891-023-06754-7
- Kim JG, Kim KI, Park KB, Park YG, Bae JH, et al. Safety and effectiveness of intra-articular injection of a highly cross-linked hyaluronic acid, LBSA0103 (Synovian): Results from a post-marketing surveillance study in South Korea. PLoS One. 2023;18:e0287222. 10.1371/journal.pone.0287222
- Ferkel E, Manjoo A, Martins D, Bhandari M, Sethi P, et al. Intra-articular Hyaluronic Acid Treatments for Knee Osteoarthritis: A Systematic Review of Product Properties. Cartilage. 2023;14:424. 10.1177/19476035231154530
- Sconza C, Di Matteo B, Queirazza P, Dina A, Amenta R, et al. Ozone Therapy versus Hyaluronic Acid Injections for Pain Relief in Patients with Knee Osteoarthritis: Preliminary Findings on Molecular and Clinical Outcomes from a Randomized Controlled Trial. Int J Mol Sci. 2023;24. 10.3390/ijms24108788
- Saviola G, Da Campo G, Bianchini MC, Abdi-Ali L, Comini L, et al. Intra-articular clodronate in patients with knee osteoarthritis non-responder to intra-articular hyaluronic acid - a case report series of 9 patients with 8-month follow-up. Clin Ter. 2023;174:245. 10.7417/CT.2023.2528
- Qu Z, Koga H, Tsuji K, Tang G, Yang Y, et al. Hyaluronic acid sheet transplantation attenuates infrapatellar fat pad fibrosis and pain in a rat arthritis model. J Orthop Res. 2023;41:2442. 10.1002/jor.25580
- Küçükakkaş O, Aydin T, Yurdakul OV. Evaluation of the effect of intra-articular platelet-rich plasma and hyaluronic acid injections on femoral cartilage thickness in chronic knee osteoarthritis. Acta Orthop Belg. 2022;88:811. 10.52628/88.4.10243
- Mao B, Pan Y, Zhang Z, Yu Z, Li J, et al. Efficacy and Safety of Hyaluronic Acid Intra-articular Injection after Arthroscopic Knee Surgery: A Systematic Review and Meta-analysis. Orthop Surg. 2023;15:16. 10.1111/os.13602
- Arai T, Suzuki-Narita M, Takeuchi J, Tajiri I, Inage K, et al. Analgesic effects and arthritic changes following intra-articular injection of diclofenac etalhyaluronate in a rat knee osteoarthritis model. BMC Musculoskelet Disord. 2022;23:960. 10.1186/s12891-022-05937-y
Data last updated:
