' 
SCIENTIFIC SCORE
Possibly Effective
Based on 58 Researches
7.5
USERS' SCORE
Good
Based on 1 Reviews
8.5
Top Medical Research Studies
9
Vitamin B6 treatment alleviates anxiety
Pyridoxal 5'-phosphate alleviates prenatal pyridaben exposure-induced anxiety-like behaviors in offspring.
Strong relevance to anxiety treatment
We investigated the impact of prenatal exposure to pyridaben, a common pesticide, on anxiety-like behaviors in offspring. Pregnant mice were given pyridaben, and later, we observed that the exposed offspring displayed increased anxiety levels at five weeks of age.
Our analysis looked into the underlying biological mechanisms and revealed a disruption in vitamin B6 metabolism. Particularly, we found a significant reduction in pyridoxal 5'-phosphate (PLP), the active form of vitamin B6, which plays a crucial role in brain function. Additionally, the levels of GABA, a neurotransmitter that helps regulate anxiety, were also found to be lower in the brains of these offspring.
To see if vitamin B6 could alleviate this anxiety, we administered PLP directly to the affected offspring. Remarkably, we observed an improvement in anxiety-like behaviors following the treatment. This suggests that restoring PLP levels could potentially offset the negative impacts of prenatal pesticide exposure on neurodevelopment, particularly regarding anxiety.
Overall, our findings indicate a meaningful link between vitamin B6 and anxiety, highlighting its importance in developing healthy brain function, especially in the context of environmental stressors.
Our analysis looked into the underlying biological mechanisms and revealed a disruption in vitamin B6 metabolism. Particularly, we found a significant reduction in pyridoxal 5'-phosphate (PLP), the active form of vitamin B6, which plays a crucial role in brain function. Additionally, the levels of GABA, a neurotransmitter that helps regulate anxiety, were also found to be lower in the brains of these offspring.
To see if vitamin B6 could alleviate this anxiety, we administered PLP directly to the affected offspring. Remarkably, we observed an improvement in anxiety-like behaviors following the treatment. This suggests that restoring PLP levels could potentially offset the negative impacts of prenatal pesticide exposure on neurodevelopment, particularly regarding anxiety.
Overall, our findings indicate a meaningful link between vitamin B6 and anxiety, highlighting its importance in developing healthy brain function, especially in the context of environmental stressors.
Read More
9
CYP11A1, Autism Symptoms, Vitamin D3
Placenta-specific CYP11A1 overexpression lead to autism-like symptom in offspring with altered steroid hormone biosynthesis in the placenta-brain axis and rescued by vitamin D intervention.
Significant vitamin D3 anxiety improvements
We explored how overexpression of the CYP11A1 enzyme in the placenta can impact offspring and potentially lead to autism-like behaviors, particularly focusing on anxiety. Using a specialized murine model, we looked closely at how this genetic change affected social interactions and anxiety levels in the mice.
Our findings highlighted a significant increase in anxiety-related behaviors, which we measured through various tests like the open field and elevated plus maze assessments. Interestingly, we observed that supplementing with vitamin D3 led to noticeable improvements in these anxiety behaviors, suggesting a protective role for vitamin D3 against the adverse effects caused by altered hormone levels from the Cyp11a1 overexpression.
Additionally, we found that vitamin D3 treatment not only helped in behavioral aspects but also corrected underlying neuroinflammatory responses—specifically the activation of microglia in the brain. This suggests that addressing vitamin D levels during pregnancy could be a potential strategy to mitigate these changes and improve outcomes for offspring at risk of autism spectrum disorders.
Our findings highlighted a significant increase in anxiety-related behaviors, which we measured through various tests like the open field and elevated plus maze assessments. Interestingly, we observed that supplementing with vitamin D3 led to noticeable improvements in these anxiety behaviors, suggesting a protective role for vitamin D3 against the adverse effects caused by altered hormone levels from the Cyp11a1 overexpression.
Additionally, we found that vitamin D3 treatment not only helped in behavioral aspects but also corrected underlying neuroinflammatory responses—specifically the activation of microglia in the brain. This suggests that addressing vitamin D levels during pregnancy could be a potential strategy to mitigate these changes and improve outcomes for offspring at risk of autism spectrum disorders.
Read More
9
Vitamin D3 aids anxiety reduction
Vitamin D Alleviates Anxiety and Depression in Elderly People with Prediabetes: A Randomized Controlled Study.
Highly relevant anxiety treatment study
We explored the effect of vitamin D3 supplementation on anxiety levels among elderly individuals diagnosed with prediabetes. In our study, we randomly assigned participants to receive either a weekly dose of 25,000 IU of vitamin D3 or a placebo, alongside general lifestyle recommendations. Over the course of 12 months, we measured anxiety levels using standardized assessments.
At both the six-month and twelve-month marks, the participants receiving vitamin D3 reported significantly lower anxiety levels compared to those who did not receive the supplementation. Specifically, scores measuring anxiety decreased from 38.02 to 32.35 in the vitamin D group, while control participants’ scores remained much higher throughout the study.
These results indicate that vitamin D3 could be a beneficial and safe option for alleviating anxiety in an older population already facing the challenges of prediabetes. The participants who had vitamin D deficiency or insufficiency at the start of the study experienced similar improvements, emphasizing the treatment's potential across various baseline vitamin D levels.
Overall, our findings support the idea that vitamin D supplementation can effectively help mitigate anxiety symptoms in older adults, and we believe further research is warranted to better understand the mechanisms at play.
At both the six-month and twelve-month marks, the participants receiving vitamin D3 reported significantly lower anxiety levels compared to those who did not receive the supplementation. Specifically, scores measuring anxiety decreased from 38.02 to 32.35 in the vitamin D group, while control participants’ scores remained much higher throughout the study.
These results indicate that vitamin D3 could be a beneficial and safe option for alleviating anxiety in an older population already facing the challenges of prediabetes. The participants who had vitamin D deficiency or insufficiency at the start of the study experienced similar improvements, emphasizing the treatment's potential across various baseline vitamin D levels.
Overall, our findings support the idea that vitamin D supplementation can effectively help mitigate anxiety symptoms in older adults, and we believe further research is warranted to better understand the mechanisms at play.
Read More
Most Useful Reviews
8
Revitalising energy boost
These vitamins give me life, especially since I've been struggling with anxiety and other health issues. Within a month, my energy and mental focus improved significantly. Despite initially stopping the vitamins, I realised they were beneficial in relieving body aches and anxiety. I've since increased my intake and feel revitalised, which motivates me to pursue a healthier lifestyle.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 58 Researches
7.5
9
Vitamin B6 potentially reduces anxiety
Mental Health Conditions, Including Depression and Stress, Are Associated with Increased Odds of Gastric Cancer-Insights into the Role of Diet: A Case-Control Study.
Mentions importance of vitamin B6
Our investigation aimed to understand how vitamin B6 might influence anxiety, particularly among individuals facing mental health challenges like depression and stress. We assessed the mental health of 82 gastric cancer patients compared to 95 healthy individuals, using a questionnaire that evaluated their levels of anxiety and depression.
Interestingly, our findings showed a noteworthy link between vitamin B6 intake and decreased anxiety levels among those with depression. Specifically, vitamin B6 emerged as a significant protective factor, suggesting that higher intake could help reduce anxiety symptoms. This trend underscores the potential importance of certain dietary choices in managing mental health.
Our study also highlighted that other dietary factors could affect mental health. For instance, sugar and salt were found to increase anxiety risks, while foods rich in vitamins, minerals, and phytochemicals were associated with lower incidences of stress and depression. This points to the broader picture that healthy eating patterns may assist in fostering mental well-being and, in turn, impact conditions like gastric cancer.
However, while these initial findings are promising, we acknowledge the need for further research to fully understand these relationships and the underlying mechanisms involved. The interplay between diet, mental health, and physical health, such as cancer risks, is complex and warrants deeper exploration.
Interestingly, our findings showed a noteworthy link between vitamin B6 intake and decreased anxiety levels among those with depression. Specifically, vitamin B6 emerged as a significant protective factor, suggesting that higher intake could help reduce anxiety symptoms. This trend underscores the potential importance of certain dietary choices in managing mental health.
Our study also highlighted that other dietary factors could affect mental health. For instance, sugar and salt were found to increase anxiety risks, while foods rich in vitamins, minerals, and phytochemicals were associated with lower incidences of stress and depression. This points to the broader picture that healthy eating patterns may assist in fostering mental well-being and, in turn, impact conditions like gastric cancer.
However, while these initial findings are promising, we acknowledge the need for further research to fully understand these relationships and the underlying mechanisms involved. The interplay between diet, mental health, and physical health, such as cancer risks, is complex and warrants deeper exploration.
Read More
9
Vitamin B6 treatment alleviates anxiety
Pyridoxal 5'-phosphate alleviates prenatal pyridaben exposure-induced anxiety-like behaviors in offspring.
Strong relevance to anxiety treatment
We investigated the impact of prenatal exposure to pyridaben, a common pesticide, on anxiety-like behaviors in offspring. Pregnant mice were given pyridaben, and later, we observed that the exposed offspring displayed increased anxiety levels at five weeks of age.
Our analysis looked into the underlying biological mechanisms and revealed a disruption in vitamin B6 metabolism. Particularly, we found a significant reduction in pyridoxal 5'-phosphate (PLP), the active form of vitamin B6, which plays a crucial role in brain function. Additionally, the levels of GABA, a neurotransmitter that helps regulate anxiety, were also found to be lower in the brains of these offspring.
To see if vitamin B6 could alleviate this anxiety, we administered PLP directly to the affected offspring. Remarkably, we observed an improvement in anxiety-like behaviors following the treatment. This suggests that restoring PLP levels could potentially offset the negative impacts of prenatal pesticide exposure on neurodevelopment, particularly regarding anxiety.
Overall, our findings indicate a meaningful link between vitamin B6 and anxiety, highlighting its importance in developing healthy brain function, especially in the context of environmental stressors.
Our analysis looked into the underlying biological mechanisms and revealed a disruption in vitamin B6 metabolism. Particularly, we found a significant reduction in pyridoxal 5'-phosphate (PLP), the active form of vitamin B6, which plays a crucial role in brain function. Additionally, the levels of GABA, a neurotransmitter that helps regulate anxiety, were also found to be lower in the brains of these offspring.
To see if vitamin B6 could alleviate this anxiety, we administered PLP directly to the affected offspring. Remarkably, we observed an improvement in anxiety-like behaviors following the treatment. This suggests that restoring PLP levels could potentially offset the negative impacts of prenatal pesticide exposure on neurodevelopment, particularly regarding anxiety.
Overall, our findings indicate a meaningful link between vitamin B6 and anxiety, highlighting its importance in developing healthy brain function, especially in the context of environmental stressors.
Read More
9
CYP11A1, Autism Symptoms, Vitamin D3
Placenta-specific CYP11A1 overexpression lead to autism-like symptom in offspring with altered steroid hormone biosynthesis in the placenta-brain axis and rescued by vitamin D intervention.
Significant vitamin D3 anxiety improvements
We explored how overexpression of the CYP11A1 enzyme in the placenta can impact offspring and potentially lead to autism-like behaviors, particularly focusing on anxiety. Using a specialized murine model, we looked closely at how this genetic change affected social interactions and anxiety levels in the mice.
Our findings highlighted a significant increase in anxiety-related behaviors, which we measured through various tests like the open field and elevated plus maze assessments. Interestingly, we observed that supplementing with vitamin D3 led to noticeable improvements in these anxiety behaviors, suggesting a protective role for vitamin D3 against the adverse effects caused by altered hormone levels from the Cyp11a1 overexpression.
Additionally, we found that vitamin D3 treatment not only helped in behavioral aspects but also corrected underlying neuroinflammatory responses—specifically the activation of microglia in the brain. This suggests that addressing vitamin D levels during pregnancy could be a potential strategy to mitigate these changes and improve outcomes for offspring at risk of autism spectrum disorders.
Our findings highlighted a significant increase in anxiety-related behaviors, which we measured through various tests like the open field and elevated plus maze assessments. Interestingly, we observed that supplementing with vitamin D3 led to noticeable improvements in these anxiety behaviors, suggesting a protective role for vitamin D3 against the adverse effects caused by altered hormone levels from the Cyp11a1 overexpression.
Additionally, we found that vitamin D3 treatment not only helped in behavioral aspects but also corrected underlying neuroinflammatory responses—specifically the activation of microglia in the brain. This suggests that addressing vitamin D levels during pregnancy could be a potential strategy to mitigate these changes and improve outcomes for offspring at risk of autism spectrum disorders.
Read More
9
Vitamin D3 alleviates anxiety behavior
Effect of Vitamin D3 on Depressive Behaviors of Rats Exposed to Chronic Unpredictable Mild Stress.
Relevant but not definitive evidence
We explored the effects of vitamin D3 on anxiety levels in rats subjected to chronic unpredictable mild stress. In our study, we used a total of 40 male Wistar rats, dividing them into five groups to analyze various treatments. These groups included a control group, a stress group, and groups receiving either vitamin D3, fluoxetine (an antidepressant), or a combination of both.
The chronic mild stress model we applied involved exposing the rats to different physical and social stressors over 21 days. Throughout the study, we monitored changes in behavior through established tests, such as the sucrose preference test and the forced swimming test, while also measuring stress hormone levels.
Our findings revealed that vitamin D3 had a protective effect against anxiety and depressive behaviors similar to fluoxetine, particularly in certain behavioral tests. In groups receiving vitamin D3, we observed lower levels of stress hormone corticosterone compared to those only exposed to stress.
Overall, we concluded that vitamin D3 can offer significant support against anxiety when faced with stress. While it was effective, we noted that the combination with fluoxetine complicates isolating the specific impact of vitamin D3 alone.
The chronic mild stress model we applied involved exposing the rats to different physical and social stressors over 21 days. Throughout the study, we monitored changes in behavior through established tests, such as the sucrose preference test and the forced swimming test, while also measuring stress hormone levels.
Our findings revealed that vitamin D3 had a protective effect against anxiety and depressive behaviors similar to fluoxetine, particularly in certain behavioral tests. In groups receiving vitamin D3, we observed lower levels of stress hormone corticosterone compared to those only exposed to stress.
Overall, we concluded that vitamin D3 can offer significant support against anxiety when faced with stress. While it was effective, we noted that the combination with fluoxetine complicates isolating the specific impact of vitamin D3 alone.
Read More
9
Vitamin D3 aids anxiety reduction
Vitamin D Alleviates Anxiety and Depression in Elderly People with Prediabetes: A Randomized Controlled Study.
Highly relevant anxiety treatment study
We explored the effect of vitamin D3 supplementation on anxiety levels among elderly individuals diagnosed with prediabetes. In our study, we randomly assigned participants to receive either a weekly dose of 25,000 IU of vitamin D3 or a placebo, alongside general lifestyle recommendations. Over the course of 12 months, we measured anxiety levels using standardized assessments.
At both the six-month and twelve-month marks, the participants receiving vitamin D3 reported significantly lower anxiety levels compared to those who did not receive the supplementation. Specifically, scores measuring anxiety decreased from 38.02 to 32.35 in the vitamin D group, while control participants’ scores remained much higher throughout the study.
These results indicate that vitamin D3 could be a beneficial and safe option for alleviating anxiety in an older population already facing the challenges of prediabetes. The participants who had vitamin D deficiency or insufficiency at the start of the study experienced similar improvements, emphasizing the treatment's potential across various baseline vitamin D levels.
Overall, our findings support the idea that vitamin D supplementation can effectively help mitigate anxiety symptoms in older adults, and we believe further research is warranted to better understand the mechanisms at play.
At both the six-month and twelve-month marks, the participants receiving vitamin D3 reported significantly lower anxiety levels compared to those who did not receive the supplementation. Specifically, scores measuring anxiety decreased from 38.02 to 32.35 in the vitamin D group, while control participants’ scores remained much higher throughout the study.
These results indicate that vitamin D3 could be a beneficial and safe option for alleviating anxiety in an older population already facing the challenges of prediabetes. The participants who had vitamin D deficiency or insufficiency at the start of the study experienced similar improvements, emphasizing the treatment's potential across various baseline vitamin D levels.
Overall, our findings support the idea that vitamin D supplementation can effectively help mitigate anxiety symptoms in older adults, and we believe further research is warranted to better understand the mechanisms at play.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Reviews
8.5
8
Revitalising energy boost
These vitamins give me life, especially since I've been struggling with anxiety and other health issues. Within a month, my energy and mental focus improved significantly. Despite initially stopping the vitamins, I realised they were beneficial in relieving body aches and anxiety. I've since increased my intake and feel revitalised, which motivates me to pursue a healthier lifestyle.
Read More
