Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 51 Researches
7.5
USERS' SCORE
Good
Based on 1 Review
8.3
Top Medical Research Studies
9
We investigated the impact of prenatal exposure to pyridaben, a common pesticide, on anxiety-like behaviors in offspring. Pregnant mice were given pyridaben, and later, we observed that the exposed offspring displayed increased anxiety levels at five weeks of age.
Our analysis looked into the underlying biological mechanisms and revealed a disruption in vitamin B6 metabolism. Particularly, we found a significant reduction in pyridoxal 5'-phosphate (PLP), the active form of vitamin B6, which plays a crucial role in brain function. Additionally, the levels of GABA, a neurotransmitter that helps regulate anxiety, were also found to be lower in the brains of these offspring.
To see if vitamin B6 could alleviate this anxiety, we administered PLP directly to the affected offspring. Remarkably, we observed an improvement in anxiety-like behaviors following the treatment. This suggests that restoring PLP levels could potentially offset the negative impacts of prenatal pesticide exposure on neurodevelopment, particularly regarding anxiety.
Overall, our findings indicate a meaningful link between vitamin B6 and anxiety, highlighting its importance in developing healthy brain function, especially in the context of environmental stressors.
Our analysis looked into the underlying biological mechanisms and revealed a disruption in vitamin B6 metabolism. Particularly, we found a significant reduction in pyridoxal 5'-phosphate (PLP), the active form of vitamin B6, which plays a crucial role in brain function. Additionally, the levels of GABA, a neurotransmitter that helps regulate anxiety, were also found to be lower in the brains of these offspring.
To see if vitamin B6 could alleviate this anxiety, we administered PLP directly to the affected offspring. Remarkably, we observed an improvement in anxiety-like behaviors following the treatment. This suggests that restoring PLP levels could potentially offset the negative impacts of prenatal pesticide exposure on neurodevelopment, particularly regarding anxiety.
Overall, our findings indicate a meaningful link between vitamin B6 and anxiety, highlighting its importance in developing healthy brain function, especially in the context of environmental stressors.
Read More
9
We explored the effect of vitamin D3 supplementation on anxiety levels among elderly individuals diagnosed with prediabetes. In our study, we randomly assigned participants to receive either a weekly dose of 25,000 IU of vitamin D3 or a placebo, alongside general lifestyle recommendations. Over the course of 12 months, we measured anxiety levels using standardized assessments.
At both the six-month and twelve-month marks, the participants receiving vitamin D3 reported significantly lower anxiety levels compared to those who did not receive the supplementation. Specifically, scores measuring anxiety decreased from 38.02 to 32.35 in the vitamin D group, while control participants’ scores remained much higher throughout the study.
These results indicate that vitamin D3 could be a beneficial and safe option for alleviating anxiety in an older population already facing the challenges of prediabetes. The participants who had vitamin D deficiency or insufficiency at the start of the study experienced similar improvements, emphasizing the treatment's potential across various baseline vitamin D levels.
Overall, our findings support the idea that vitamin D supplementation can effectively help mitigate anxiety symptoms in older adults, and we believe further research is warranted to better understand the mechanisms at play.
At both the six-month and twelve-month marks, the participants receiving vitamin D3 reported significantly lower anxiety levels compared to those who did not receive the supplementation. Specifically, scores measuring anxiety decreased from 38.02 to 32.35 in the vitamin D group, while control participants’ scores remained much higher throughout the study.
These results indicate that vitamin D3 could be a beneficial and safe option for alleviating anxiety in an older population already facing the challenges of prediabetes. The participants who had vitamin D deficiency or insufficiency at the start of the study experienced similar improvements, emphasizing the treatment's potential across various baseline vitamin D levels.
Overall, our findings support the idea that vitamin D supplementation can effectively help mitigate anxiety symptoms in older adults, and we believe further research is warranted to better understand the mechanisms at play.
Read More
9
We explored how coal dust exposure leads to anxiety and depression-like behaviors in mice, using a pneumoconiosis model that was established after 28 days of exposure. This model allows us to closely observe the effects of environmental factors on mental health. Through treating the mice with Vitamin D3 for three months, we aimed to see if this treatment could alleviate anxiety symptoms.
Our findings were quite revealing. Vitamin D3 treatment showed a significant positive effect; it reduced signs of anxiety and depression. Specifically, we saw improvements in tests designed to measure these behaviors, along with a decrease in markers of astrocyte activation—cells in the brain that can become overactive in stressful situations. Vitamin D3 also promoted better neuron protection and enhanced the distribution of brain-derived neurotrophic factor (BDNF), a crucial element for brain health.
This study suggests that Vitamin D might serve as a useful approach for managing mood disorders resulting from environmental stressors such as coal dust. These findings also highlight the importance of further exploring Vitamin D3 as a potential treatment avenue for anxiety exacerbated by particulate matter exposure.
Our findings were quite revealing. Vitamin D3 treatment showed a significant positive effect; it reduced signs of anxiety and depression. Specifically, we saw improvements in tests designed to measure these behaviors, along with a decrease in markers of astrocyte activation—cells in the brain that can become overactive in stressful situations. Vitamin D3 also promoted better neuron protection and enhanced the distribution of brain-derived neurotrophic factor (BDNF), a crucial element for brain health.
This study suggests that Vitamin D might serve as a useful approach for managing mood disorders resulting from environmental stressors such as coal dust. These findings also highlight the importance of further exploring Vitamin D3 as a potential treatment avenue for anxiety exacerbated by particulate matter exposure.
Read More
Most Useful Reviews
6
Revitalising energy boost
7 people found this helpful
These vitamins give me life, especially since I've been struggling with anxiety and other health issues. Within a month, my energy and mental focus improved significantly. Despite initially stopping the vitamins, I realised they were beneficial in relieving body aches and anxiety. I've since increased my intake and feel revitalised, which motivates me to pursue a healthier lifestyle.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 51 Researches
7.5
- All Researches
9
Our investigation aimed to understand how vitamin B6 might influence anxiety, particularly among individuals facing mental health challenges like depression and stress. We assessed the mental health of 82 gastric cancer patients compared to 95 healthy individuals, using a questionnaire that evaluated their levels of anxiety and depression.
Interestingly, our findings showed a noteworthy link between vitamin B6 intake and decreased anxiety levels among those with depression. Specifically, vitamin B6 emerged as a significant protective factor, suggesting that higher intake could help reduce anxiety symptoms. This trend underscores the potential importance of certain dietary choices in managing mental health.
Our study also highlighted that other dietary factors could affect mental health. For instance, sugar and salt were found to increase anxiety risks, while foods rich in vitamins, minerals, and phytochemicals were associated with lower incidences of stress and depression. This points to the broader picture that healthy eating patterns may assist in fostering mental well-being and, in turn, impact conditions like gastric cancer.
However, while these initial findings are promising, we acknowledge the need for further research to fully understand these relationships and the underlying mechanisms involved. The interplay between diet, mental health, and physical health, such as cancer risks, is complex and warrants deeper exploration.
Interestingly, our findings showed a noteworthy link between vitamin B6 intake and decreased anxiety levels among those with depression. Specifically, vitamin B6 emerged as a significant protective factor, suggesting that higher intake could help reduce anxiety symptoms. This trend underscores the potential importance of certain dietary choices in managing mental health.
Our study also highlighted that other dietary factors could affect mental health. For instance, sugar and salt were found to increase anxiety risks, while foods rich in vitamins, minerals, and phytochemicals were associated with lower incidences of stress and depression. This points to the broader picture that healthy eating patterns may assist in fostering mental well-being and, in turn, impact conditions like gastric cancer.
However, while these initial findings are promising, we acknowledge the need for further research to fully understand these relationships and the underlying mechanisms involved. The interplay between diet, mental health, and physical health, such as cancer risks, is complex and warrants deeper exploration.
Read More
9
We investigated the impact of prenatal exposure to pyridaben, a common pesticide, on anxiety-like behaviors in offspring. Pregnant mice were given pyridaben, and later, we observed that the exposed offspring displayed increased anxiety levels at five weeks of age.
Our analysis looked into the underlying biological mechanisms and revealed a disruption in vitamin B6 metabolism. Particularly, we found a significant reduction in pyridoxal 5'-phosphate (PLP), the active form of vitamin B6, which plays a crucial role in brain function. Additionally, the levels of GABA, a neurotransmitter that helps regulate anxiety, were also found to be lower in the brains of these offspring.
To see if vitamin B6 could alleviate this anxiety, we administered PLP directly to the affected offspring. Remarkably, we observed an improvement in anxiety-like behaviors following the treatment. This suggests that restoring PLP levels could potentially offset the negative impacts of prenatal pesticide exposure on neurodevelopment, particularly regarding anxiety.
Overall, our findings indicate a meaningful link between vitamin B6 and anxiety, highlighting its importance in developing healthy brain function, especially in the context of environmental stressors.
Our analysis looked into the underlying biological mechanisms and revealed a disruption in vitamin B6 metabolism. Particularly, we found a significant reduction in pyridoxal 5'-phosphate (PLP), the active form of vitamin B6, which plays a crucial role in brain function. Additionally, the levels of GABA, a neurotransmitter that helps regulate anxiety, were also found to be lower in the brains of these offspring.
To see if vitamin B6 could alleviate this anxiety, we administered PLP directly to the affected offspring. Remarkably, we observed an improvement in anxiety-like behaviors following the treatment. This suggests that restoring PLP levels could potentially offset the negative impacts of prenatal pesticide exposure on neurodevelopment, particularly regarding anxiety.
Overall, our findings indicate a meaningful link between vitamin B6 and anxiety, highlighting its importance in developing healthy brain function, especially in the context of environmental stressors.
Read More
9
We explored the effects of vitamin D3 on anxiety levels in rats subjected to chronic unpredictable mild stress. In our study, we used a total of 40 male Wistar rats, dividing them into five groups to analyze various treatments. These groups included a control group, a stress group, and groups receiving either vitamin D3, fluoxetine (an antidepressant), or a combination of both.
The chronic mild stress model we applied involved exposing the rats to different physical and social stressors over 21 days. Throughout the study, we monitored changes in behavior through established tests, such as the sucrose preference test and the forced swimming test, while also measuring stress hormone levels.
Our findings revealed that vitamin D3 had a protective effect against anxiety and depressive behaviors similar to fluoxetine, particularly in certain behavioral tests. In groups receiving vitamin D3, we observed lower levels of stress hormone corticosterone compared to those only exposed to stress.
Overall, we concluded that vitamin D3 can offer significant support against anxiety when faced with stress. While it was effective, we noted that the combination with fluoxetine complicates isolating the specific impact of vitamin D3 alone.
The chronic mild stress model we applied involved exposing the rats to different physical and social stressors over 21 days. Throughout the study, we monitored changes in behavior through established tests, such as the sucrose preference test and the forced swimming test, while also measuring stress hormone levels.
Our findings revealed that vitamin D3 had a protective effect against anxiety and depressive behaviors similar to fluoxetine, particularly in certain behavioral tests. In groups receiving vitamin D3, we observed lower levels of stress hormone corticosterone compared to those only exposed to stress.
Overall, we concluded that vitamin D3 can offer significant support against anxiety when faced with stress. While it was effective, we noted that the combination with fluoxetine complicates isolating the specific impact of vitamin D3 alone.
Read More
9
We explored the effect of vitamin D3 supplementation on anxiety levels among elderly individuals diagnosed with prediabetes. In our study, we randomly assigned participants to receive either a weekly dose of 25,000 IU of vitamin D3 or a placebo, alongside general lifestyle recommendations. Over the course of 12 months, we measured anxiety levels using standardized assessments.
At both the six-month and twelve-month marks, the participants receiving vitamin D3 reported significantly lower anxiety levels compared to those who did not receive the supplementation. Specifically, scores measuring anxiety decreased from 38.02 to 32.35 in the vitamin D group, while control participants’ scores remained much higher throughout the study.
These results indicate that vitamin D3 could be a beneficial and safe option for alleviating anxiety in an older population already facing the challenges of prediabetes. The participants who had vitamin D deficiency or insufficiency at the start of the study experienced similar improvements, emphasizing the treatment's potential across various baseline vitamin D levels.
Overall, our findings support the idea that vitamin D supplementation can effectively help mitigate anxiety symptoms in older adults, and we believe further research is warranted to better understand the mechanisms at play.
At both the six-month and twelve-month marks, the participants receiving vitamin D3 reported significantly lower anxiety levels compared to those who did not receive the supplementation. Specifically, scores measuring anxiety decreased from 38.02 to 32.35 in the vitamin D group, while control participants’ scores remained much higher throughout the study.
These results indicate that vitamin D3 could be a beneficial and safe option for alleviating anxiety in an older population already facing the challenges of prediabetes. The participants who had vitamin D deficiency or insufficiency at the start of the study experienced similar improvements, emphasizing the treatment's potential across various baseline vitamin D levels.
Overall, our findings support the idea that vitamin D supplementation can effectively help mitigate anxiety symptoms in older adults, and we believe further research is warranted to better understand the mechanisms at play.
Read More
9
We explored how coal dust exposure leads to anxiety and depression-like behaviors in mice, using a pneumoconiosis model that was established after 28 days of exposure. This model allows us to closely observe the effects of environmental factors on mental health. Through treating the mice with Vitamin D3 for three months, we aimed to see if this treatment could alleviate anxiety symptoms.
Our findings were quite revealing. Vitamin D3 treatment showed a significant positive effect; it reduced signs of anxiety and depression. Specifically, we saw improvements in tests designed to measure these behaviors, along with a decrease in markers of astrocyte activation—cells in the brain that can become overactive in stressful situations. Vitamin D3 also promoted better neuron protection and enhanced the distribution of brain-derived neurotrophic factor (BDNF), a crucial element for brain health.
This study suggests that Vitamin D might serve as a useful approach for managing mood disorders resulting from environmental stressors such as coal dust. These findings also highlight the importance of further exploring Vitamin D3 as a potential treatment avenue for anxiety exacerbated by particulate matter exposure.
Our findings were quite revealing. Vitamin D3 treatment showed a significant positive effect; it reduced signs of anxiety and depression. Specifically, we saw improvements in tests designed to measure these behaviors, along with a decrease in markers of astrocyte activation—cells in the brain that can become overactive in stressful situations. Vitamin D3 also promoted better neuron protection and enhanced the distribution of brain-derived neurotrophic factor (BDNF), a crucial element for brain health.
This study suggests that Vitamin D might serve as a useful approach for managing mood disorders resulting from environmental stressors such as coal dust. These findings also highlight the importance of further exploring Vitamin D3 as a potential treatment avenue for anxiety exacerbated by particulate matter exposure.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
6
Revitalising energy boost
7 people found this helpful
These vitamins give me life, especially since I've been struggling with anxiety and other health issues. Within a month, my energy and mental focus improved significantly. Despite initially stopping the vitamins, I realised they were beneficial in relieving body aches and anxiety. I've since increased my intake and feel revitalised, which motivates me to pursue a healthier lifestyle.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
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- Ding X, Wen Y, Ma X, Zhang Y, Cheng Y, et al. Pyridoxal 5'-phosphate alleviates prenatal pyridaben exposure-induced anxiety-like behaviors in offspring. Environ Sci Ecotechnol. 2023;13:100224. doi:10.1016/j.ese.2022.100224
- Field DT, Cracknell RO, Eastwood JR, Scarfe P, Williams CM, et al. High-dose Vitamin B6 supplementation reduces anxiety and strengthens visual surround suppression. Hum Psychopharmacol. 2022;37:e2852. doi:10.1002/hup.2852
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- Gammoh O, Ibrahim A, Yehya A, Alqudah A, Qnais E, et al. Exploring the Roles of Vitamins C and D and Etifoxine in Combination with Citalopram in Depression/Anxiety Model: A Focus on ICAM-1, SIRT1 and Nitric Oxide. Int J Mol Sci. 2024;25. doi:10.3390/ijms25041960
- Gizzi G, Fiorani F, Cataldi S, Mandarano M, Delvecchio E, et al. Exploring the Influence of / Polymorphic Variants on Adolescent Mental Health and Response to Vitamin D Supplementation in Embryonic Hippocampal Cell Lines. Genes (Basel). 2024;15. doi:10.3390/genes15070913
- Al-Ramadhan FR, Abulmeaty MMA, Alquraishi M, Razak S, Alhussain MH. Effect of Vitamin D3 on Depressive Behaviors of Rats Exposed to Chronic Unpredictable Mild Stress. Biomedicines. 2023;11. doi:10.3390/biomedicines11082112
- Lapmanee S, Bhubhanil S, Sriwong S, Yuajit C, Wongchitrat P, et al. Oral calcium and vitamin D supplements differentially alter exploratory, anxiety-like behaviors and memory in male rats. PLoS One. 2023;18:e0290106. doi:10.1371/journal.pone.0290106
- Pereira ADS, Miron VV, Castro MFV, Bottari NB, Assmann CE, et al. Neuromodulatory effect of the combination of metformin and vitamin D triggered by purinergic signaling in type 1 diabetes induced-rats. Mol Cell Endocrinol. 2023;563:111852. doi:10.1016/j.mce.2023.111852
- Zaromytidou E, Koufakis T, Dimakopoulos G, Drivakou D, Konstantinidou S, et al. Vitamin D Alleviates Anxiety and Depression in Elderly People with Prediabetes: A Randomized Controlled Study. Metabolites. 2022;12. doi:10.3390/metabo12100884
- Tokarchuk A, Abenavoli L, Kobyliak N, Khomenko M, Revun M, et al. Nutrition program, physical activity and gut microbiota modulation: a randomized controlled trial to promote a healthy lifestyle in students with vitamin D3 deficiency. Minerva Med. 2022;113:683. doi:10.23736/S0026-4806.22.07992-7
- Zou Y, Mu M, Zhang S, Li C, Tian K, et al. Vitamin D3 suppresses astrocyte activation and ameliorates coal dust-induced mood disorders in mice. J Affect Disord. 2022;303:138. doi:10.1016/j.jad.2022.02.026
- Guzek D, Kołota A, Lachowicz K, Skolmowska D, Stachoń M, et al. Influence of Vitamin D Supplementation on Mental Health in Diabetic Patients: A Systematic Review. Nutrients. 2021;13. doi:10.3390/nu13113678
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- Tsoukalas D, Zlatian O, Mitroi M, Renieri E, Tsatsakis A, et al. A Novel Nutraceutical Formulation Can Improve Motor Activity and Decrease the Stress Level in a Murine Model of Middle-Age Animals. J Clin Med. 2021;10. doi:10.3390/jcm10040624
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- Mengelberg A, Leathem J, Podd J, Hill S, Conlon C. The effects of docosahexaenoic acid supplementation on cognition and well-being in mild cognitive impairment: A 12-month randomised controlled trial. Int J Geriatr Psychiatry. 2022;37. doi:10.1002/gps.5707
- Zambrano E, Rodríguez-González GL, Reyes-Castro LA, Bautista CJ, Castro-Rodríguez DC, et al. DHA Supplementation of Obese Rats throughout Pregnancy and Lactation Modifies Milk Composition and Anxiety Behavior of Offspring. Nutrients. 2021;13. doi:10.3390/nu13124243
- Tang Q, Li S, Fang C, Yu H. Evaluating the reparative effects and the mechanism of action of docosahexaenoic acid on azithromycin-induced lipid metabolism dysfunction. Food Chem Toxicol. 2022;159:112699. doi:10.1016/j.fct.2021.112699
- Neto J, Jantsch J, de Oliveira S, Braga MF, Castro LFDS, et al. DHA/EPA supplementation decreases anxiety-like behaviour, but it does not ameliorate metabolic profile in obese male rats. Br J Nutr. 2022;128:964. doi:10.1017/S0007114521003998
- Ponomarenko AI, Tyrtyshnaia AA, Pislyagin EA, Dyuizen IV, Sultanov RM, et al. N-docosahexaenoylethanolamine reduces neuroinflammation and cognitive impairment after mild traumatic brain injury in rats. Sci Rep. 2021;11:756. doi:10.1038/s41598-020-80818-9
- Demers G, Roy J, Machuca-Parra AI, Dashtehei Pour Z, Bairamian D, et al. Fish oil supplementation alleviates metabolic and anxiodepressive effects of diet-induced obesity and associated changes in brain lipid composition in mice. Int J Obes (Lond). 2020;44:1936. doi:10.1038/s41366-020-0623-6
- Demin KA, Kolesnikova TO, Galstyan DS, Krotova NA, Ilyin NP, et al. The Utility of Prolonged Chronic Unpredictable Stress to Study the Effects of Chronic Fluoxetine, Eicosapentaenoic Acid, and Lipopolysaccharide on Anxiety-Like Behavior and Hippocampal Transcriptomic Responses in Male Rats. J Neurosci Res. 2025;103:e70025. doi:10.1002/jnr.70025
- Nguyen N, Woodside DB, Lam E, Quehenberger O, German JB, et al. Fatty Acids and Their Lipogenic Enzymes in Anorexia Nervosa Clinical Subtypes. Int J Mol Sci. 2024;25. doi:10.3390/ijms25105516
- Wang HF, Liu WC, Zailani H, Yang CC, Chen TB, et al. A 12-week randomized double-blind clinical trial of eicosapentaenoic acid intervention in episodic migraine. Brain Behav Immun. 2024;118:459. doi:10.1016/j.bbi.2024.03.019
- Xue Y, Wang L, Liu T, Zhao T, Xie K, et al. Omega-3 polyunsaturated fatty acids supplementation improves memory in first-diagnosed, drug-naïve patients with depression: Secondary analysis of data from a randomized controlled trial. J Affect Disord. 2024;350:403. doi:10.1016/j.jad.2024.01.149
- Kelaiditis CF, Gibson EL, Dyall SC. Effects of long-chain omega-3 polyunsaturated fatty acids on reducing anxiety and/or depression in adults; A systematic review and meta-analysis of randomised controlled trials. Prostaglandins Leukot Essent Fatty Acids. 2023;192:102572. doi:10.1016/j.plefa.2023.102572
- Kishi T, Sakuma K, Iwata N. Mitochondrial modulators for obsessive-compulsive and related disorders: a systematic review and meta-analysis. Transl Psychiatry. 2022;12:263. doi:10.1038/s41398-022-02026-5
- Wang CC, Du L, Shi HH, Ding L, Yanagita T, et al. Dietary EPA-Enriched Phospholipids Alleviate Chronic Stress and LPS-Induced Depression- and Anxiety-Like Behavior by Regulating Immunity and Neuroinflammation. Mol Nutr Food Res. 2021;65:e2100009. doi:10.1002/mnfr.202100009
- Nakajima S, Fukasawa K, Gotoh M, Murakami-Murofushi K, Kunugi H. Saturated fatty acid is a principal cause of anxiety-like behavior in diet-induced obese rats in relation to serum lysophosphatidyl choline level. Int J Obes (Lond). 2020;44:727. doi:10.1038/s41366-019-0468-z
- Provensi G, Schmidt SD, Boehme M, Bastiaanssen TFS, Rani B, et al. Preventing adolescent stress-induced cognitive and microbiome changes by diet. Proc Natl Acad Sci U S A. 2019;116:9644. doi:10.1073/pnas.1820832116
