5/14/2025
Last update
5/14/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 20 Researches
8.4
USERS' SCORE
Good
Based on 41 Reviews
8.5
Supplement Facts
Serving Size: 2 VegCaps
Amount Per Serving
%DV
Vitamin C (as Ascorbic Acid)
1,235 mg
1,372%
Quercetin
465 mg
*
Bromelain (Supplying 90 MCU)
50 mg
*
Top Medical Research Studies
9
Quercetin may alleviate allergy symptoms
We conducted a study involving 66 Japanese adults suffering from allergy symptoms, focusing on the potential of a quercetin-containing supplement. Participants took either the supplement or a placebo daily for four weeks.
Notable results showed that those taking quercetin experienced significant improvements in allergy-related symptoms such as eye itching, sneezing, and nasal discharge. Additionally, their overall quality of life received a boost.
While there were minor side effects, the findings suggest that quercetin might be an effective option for managing certain allergy symptoms.
Notable results showed that those taking quercetin experienced significant improvements in allergy-related symptoms such as eye itching, sneezing, and nasal discharge. Additionally, their overall quality of life received a boost.
While there were minor side effects, the findings suggest that quercetin might be an effective option for managing certain allergy symptoms.
Read More
8
We explored how quercetin may help alleviate allergies by examining its impact on certain immune cells involved in allergic reactions. Using different types of mast cells, we observed that quercetin triggered the production of heme oxygenase-1 (HO-1), which plays a key role in this process.
Interestingly, when we inhibited HO-1, the protective effects of quercetin vanished, suggesting that the Nrf2-HO-1 pathway is crucial for its anti-allergic actions. Our findings strongly indicate that quercetin could be valuable in managing allergic responses.
Interestingly, when we inhibited HO-1, the protective effects of quercetin vanished, suggesting that the Nrf2-HO-1 pathway is crucial for its anti-allergic actions. Our findings strongly indicate that quercetin could be valuable in managing allergic responses.
Read More
9.5
We delved into the effects of quercetin on peanut-induced anaphylactic reactions using a rat model. The study involved sensitized Wistar rats divided into treatment and control groups. After four weeks of quercetin treatment, we observed a significant decrease in plasma histamine levels and anaphylactic responses.
Our results suggest that quercetin effectively mitigates reactions related to peanut allergies, highlighting its potential as an alternative medicine for these food sensitivities. This presents an exciting avenue for those seeking solutions beyond traditional palliative care.
Our results suggest that quercetin effectively mitigates reactions related to peanut allergies, highlighting its potential as an alternative medicine for these food sensitivities. This presents an exciting avenue for those seeking solutions beyond traditional palliative care.
Read More
Most Useful Reviews
9
Highly effective
215 people found this helpful
This is an effective blend of quercetin, bromelain, and vitamin C. I follow my physician’s instructions to relieve symptoms caused by seasonal allergies. The results are significant; I prefer this over antihistamines during this season.
Read More
10
Joyful relief
7 people found this helpful
This product has been a blessing; my allergies have disappeared, and I haven't caught the flu for five years. I recommend it to anyone who suffers from allergies.
Read More
9
No reactions
6 people found this helpful
I give this to my son, starting from late February for his spring allergies. He no longer reacts to March's dampness; his eyes don’t water, and his nose remains clear, even managing without antihistamines last year. If this review helps, a thumbs up would be appreciated!
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 20 Researches
8.4
- All Researches
9.5
We delved into the effects of quercetin on peanut-induced anaphylactic reactions using a rat model. The study involved sensitized Wistar rats divided into treatment and control groups. After four weeks of quercetin treatment, we observed a significant decrease in plasma histamine levels and anaphylactic responses.
Our results suggest that quercetin effectively mitigates reactions related to peanut allergies, highlighting its potential as an alternative medicine for these food sensitivities. This presents an exciting avenue for those seeking solutions beyond traditional palliative care.
Our results suggest that quercetin effectively mitigates reactions related to peanut allergies, highlighting its potential as an alternative medicine for these food sensitivities. This presents an exciting avenue for those seeking solutions beyond traditional palliative care.
Read More
9.5
The study looked into how plant-made influenza vaccines interact with the immune system, particularly concerning allergies. We followed 280 participants over six months, monitoring for allergic reactions and measuring specific antibodies.
While some subjects produced temporary IgG and occasionally IgE antibodies, no allergic symptoms were reported. Importantly, the study found these antibody responses were not tied to allergy worsening, indicating that these vaccines may be safe for those with known plant allergies.
While some subjects produced temporary IgG and occasionally IgE antibodies, no allergic symptoms were reported. Importantly, the study found these antibody responses were not tied to allergy worsening, indicating that these vaccines may be safe for those with known plant allergies.
Read More
9
Quercetin shows promise in allergies
We delved into the potential of quercetin as a therapeutic option for treating allergic rhinitis, a common condition affecting roughly 40% of the global population. This study utilized various in-silico approaches, such as network pharmacology and molecular docking, to identify compounds from traditional medicinal plants and assess their effectiveness.
Among the 241 compounds analyzed, quercetin stood out due to its strong binding affinities with important targets linked to inflammatory and immune pathways. Our assessments indicated that quercetin could interact effectively with key cytokines involved in allergic reactions, potentially reducing allergy symptoms.
While the study highlighted promising implications for quercetin, it did not isolate its effects from other examined compounds. Therefore, further experimental testing is needed to affirm its benefits and effectiveness in real-world allergy treatment situations.
Among the 241 compounds analyzed, quercetin stood out due to its strong binding affinities with important targets linked to inflammatory and immune pathways. Our assessments indicated that quercetin could interact effectively with key cytokines involved in allergic reactions, potentially reducing allergy symptoms.
While the study highlighted promising implications for quercetin, it did not isolate its effects from other examined compounds. Therefore, further experimental testing is needed to affirm its benefits and effectiveness in real-world allergy treatment situations.
Read More
9
We investigated how a specific leaf extract affects allergic inflammation in immune cell lines.
Our study revealed that this extract notably reduced the release of allergy-related chemicals like histamine. It also decreased inflammatory responses by limiting the activity of certain enzymes involved in inflammation.
The findings suggest that the active compounds in the extract, specifically quercetin and kaempferol, could offer therapeutic benefits in managing allergies.
Our study revealed that this extract notably reduced the release of allergy-related chemicals like histamine. It also decreased inflammatory responses by limiting the activity of certain enzymes involved in inflammation.
The findings suggest that the active compounds in the extract, specifically quercetin and kaempferol, could offer therapeutic benefits in managing allergies.
Read More
9
Quercetin may alleviate allergy symptoms
We conducted a study involving 66 Japanese adults suffering from allergy symptoms, focusing on the potential of a quercetin-containing supplement. Participants took either the supplement or a placebo daily for four weeks.
Notable results showed that those taking quercetin experienced significant improvements in allergy-related symptoms such as eye itching, sneezing, and nasal discharge. Additionally, their overall quality of life received a boost.
While there were minor side effects, the findings suggest that quercetin might be an effective option for managing certain allergy symptoms.
Notable results showed that those taking quercetin experienced significant improvements in allergy-related symptoms such as eye itching, sneezing, and nasal discharge. Additionally, their overall quality of life received a boost.
While there were minor side effects, the findings suggest that quercetin might be an effective option for managing certain allergy symptoms.
Read More
User Reviews
USERS' SCORE
Good
Based on 41 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Highly effective
215 people found this helpful
This is an effective blend of quercetin, bromelain, and vitamin C. I follow my physician’s instructions to relieve symptoms caused by seasonal allergies. The results are significant; I prefer this over antihistamines during this season.
Read More
10
Joyful relief
7 people found this helpful
This product has been a blessing; my allergies have disappeared, and I haven't caught the flu for five years. I recommend it to anyone who suffers from allergies.
Read More
9
No reactions
6 people found this helpful
I give this to my son, starting from late February for his spring allergies. He no longer reacts to March's dampness; his eyes don’t water, and his nose remains clear, even managing without antihistamines last year. If this review helps, a thumbs up would be appreciated!
Read More
9
Hormone-free relief
5 people found this helpful
This review is an appeal to those suffering from allergies. For years, I struggled with this issue and underwent various treatments. My allergist suggested trying this remedy, and I bought another can after the first use without experiencing any allergic reactions. I've been without hormones for several years now, thanks to this remedy.
Read More
9
Essential for allergies
5 people found this helpful
I take quercitin daily, one in the morning and one at night. It effectively aids with allergies and acts as a cancer fighter. I wouldn’t want to be without it.
Read More
Frequently Asked Questions
10
Miraculous effect
Very good; I had allergies recently, which caused my nose to run. I took it twice daily on an empty stomach for two days. The allergy symptoms were almost completely cured, which felt miraculous. I continued taking it for a week.
9
No reactions
6 people found this helpful
I give this to my son, starting from late February for his spring allergies. He no longer reacts to March's dampness; his eyes don’t water, and his nose remains clear, even managing without antihistamines last year. If this review helps, a thumbs up would be appreciated!
9
Keeps allergies at bay
2 people found this helpful
I have been using QBC Plex for decades. It keeps allergies at bay, and I no longer have a runny nose!
10
Joyful relief
7 people found this helpful
This product has been a blessing; my allergies have disappeared, and I haven't caught the flu for five years. I recommend it to anyone who suffers from allergies.
9
No more exacerbations
1 people found this helpful
My son uses this during allergy season, and last spring there were no exacerbations.
9
Helpful for seasonal allergies
1 people found this helpful
It significantly helped with seasonal allergies; we purchased it based on a recommendation and take it with zinc.
8
Environmental reaction relief
1 people found this helpful
I use this as a mast cell stabiliser, and it really helps with my environmental reactions.
9
Works wonders
1 people found this helpful
Works wonders instead of antihistamines; it's amazing for allergies.
7.5
Condition improved overall
3 people found this helpful
Excellent remedy for allergies. My husband suffers from seasonal allergies. After adjusting our diet and undergoing several cleansing programmes, we began taking this supplement, one capsule twice daily, as an antihistamine. It lasts a month and has contributed to his improved condition.
7.5
Teenage help
12 people found this helpful
I use this product for my teenager's seasonal allergies. It helps significantly. We take two in the morning and evening, which improves her condition without needing antihistamines.
9
Quercetin may alleviate allergy symptoms
We conducted a study involving 66 Japanese adults suffering from allergy symptoms, focusing on the potential of a quercetin-containing supplement. Participants took either the supplement or a placebo daily for four weeks.
Notable results showed that those taking quercetin experienced significant improvements in allergy-related symptoms such as eye itching, sneezing, and nasal discharge. Additionally, their overall quality of life received a boost.
While there were minor side effects, the findings suggest that quercetin might be an effective option for managing certain allergy symptoms.
Notable results showed that those taking quercetin experienced significant improvements in allergy-related symptoms such as eye itching, sneezing, and nasal discharge. Additionally, their overall quality of life received a boost.
While there were minor side effects, the findings suggest that quercetin might be an effective option for managing certain allergy symptoms.
9
We investigated how a specific leaf extract affects allergic inflammation in immune cell lines.
Our study revealed that this extract notably reduced the release of allergy-related chemicals like histamine. It also decreased inflammatory responses by limiting the activity of certain enzymes involved in inflammation.
The findings suggest that the active compounds in the extract, specifically quercetin and kaempferol, could offer therapeutic benefits in managing allergies.
Our study revealed that this extract notably reduced the release of allergy-related chemicals like histamine. It also decreased inflammatory responses by limiting the activity of certain enzymes involved in inflammation.
The findings suggest that the active compounds in the extract, specifically quercetin and kaempferol, could offer therapeutic benefits in managing allergies.
9.5
We delved into the effects of quercetin on peanut-induced anaphylactic reactions using a rat model. The study involved sensitized Wistar rats divided into treatment and control groups. After four weeks of quercetin treatment, we observed a significant decrease in plasma histamine levels and anaphylactic responses.
Our results suggest that quercetin effectively mitigates reactions related to peanut allergies, highlighting its potential as an alternative medicine for these food sensitivities. This presents an exciting avenue for those seeking solutions beyond traditional palliative care.
Our results suggest that quercetin effectively mitigates reactions related to peanut allergies, highlighting its potential as an alternative medicine for these food sensitivities. This presents an exciting avenue for those seeking solutions beyond traditional palliative care.
7
We investigated how quercetin works alongside fucoidan to help manage allergies, particularly type I hypersensitivity like hay fever. Our findings showed that when quercetin was taken together with fucoidan, even lower amounts could still provide significant anti-allergic effects.
Interestingly, taking just 50 μg of quercetin in combination with fucoidan produced similar benefits as higher doses alone. This suggests that the combination of these ingredients could lessen the need for larger fucoidan servings while still being effective.
It seems we’ve found a promising food combination that enhances allergy relief!
Interestingly, taking just 50 μg of quercetin in combination with fucoidan produced similar benefits as higher doses alone. This suggests that the combination of these ingredients could lessen the need for larger fucoidan servings while still being effective.
It seems we’ve found a promising food combination that enhances allergy relief!
9
Quercetin shows promise in allergies
We delved into the potential of quercetin as a therapeutic option for treating allergic rhinitis, a common condition affecting roughly 40% of the global population. This study utilized various in-silico approaches, such as network pharmacology and molecular docking, to identify compounds from traditional medicinal plants and assess their effectiveness.
Among the 241 compounds analyzed, quercetin stood out due to its strong binding affinities with important targets linked to inflammatory and immune pathways. Our assessments indicated that quercetin could interact effectively with key cytokines involved in allergic reactions, potentially reducing allergy symptoms.
While the study highlighted promising implications for quercetin, it did not isolate its effects from other examined compounds. Therefore, further experimental testing is needed to affirm its benefits and effectiveness in real-world allergy treatment situations.
Among the 241 compounds analyzed, quercetin stood out due to its strong binding affinities with important targets linked to inflammatory and immune pathways. Our assessments indicated that quercetin could interact effectively with key cytokines involved in allergic reactions, potentially reducing allergy symptoms.
While the study highlighted promising implications for quercetin, it did not isolate its effects from other examined compounds. Therefore, further experimental testing is needed to affirm its benefits and effectiveness in real-world allergy treatment situations.
References
- Islam KMT, Mahmud S. In-silico exploring pathway and mechanism-based therapeutics for allergic rhinitis: Network pharmacology, molecular docking, ADMET, quantum chemistry and machine learning based QSAR approaches. Comput Biol Med. 2025;187:109754. 10.1016/j.compbiomed.2025.109754
- Bunddulam P, Nakamura M, Zorig A, Hinata Y, Takasugi M, et al. Effects of Leaf Extract on Allergic Inflammation in Immune Cell Lines. Prev Nutr Food Sci. 2025;30:68. 10.3746/pnf.2025.30.1.68
- Kaag S, Lorentz A. Effects of Dietary Components on Mast Cells: Possible Use as Nutraceuticals for Allergies?. Cells. 2023;12. 10.3390/cells12222602
- Mizuno M, Fujioka A, Bitani S, Minato KI, Sakakibara H. Anti-Allergic Activity of Fucoidan Can Be Enhanced by Coexistence with Quercetin. Int J Mol Sci. 2022;23. 10.3390/ijms232012163
- Yamada S, Shirai M, Inaba Y, Takara T. Effects of repeated oral intake of a quercetin-containing supplement on allergic reaction: a randomized, placebo-controlled, double-blind parallel-group study. Eur Rev Med Pharmacol Sci. 2022;26:4331. 10.26355/eurrev_202206_29072
- Afify SM, Pali-Schöll I, Hufnagl K, Hofstetter G, El-Bassuoni MA, et al. Bovine Holo-Beta-Lactoglobulin Cross-Protects Against Pollen Allergies in an Innate Manner in BALB/c Mice: Potential Model for the Farm Effect. Front Immunol. 2021;12:611474. 10.3389/fimmu.2021.611474
- Ding Y, Che D, Li C, Cao J, Wang J, et al. Quercetin inhibits Mrgprx2-induced pseudo-allergic reaction via PLCγ-IP3R related Ca fluctuations. Int Immunopharmacol. 2019;66:185. 10.1016/j.intimp.2018.11.025
- Carbone ML, Lulli D, Passarelli F, Pastore S. Topical Plant Polyphenols Prevent Type I Interferon Signaling in the Skin and Suppress Contact Hypersensitivity. Int J Mol Sci. 2018;19. 10.3390/ijms19092652
- Takasugi M, Muta E, Yamada K, Arai H. A new method to evaluate anti-allergic effect of food component by measuring leukotriene B from a mouse mast cell line. Cytotechnology. 2018;70:177. 10.1007/s10616-017-0129-9
- Kim M, Lim SJ, Kang SW, Um BH, Nho CW. Aceriphyllum rossii extract and its active compounds, quercetin and kaempferol inhibit IgE-mediated mast cell activation and passive cutaneous anaphylaxis. J Agric Food Chem. 2014;62:3750. 10.1021/jf405486c
- Shishehbor F, Behroo L, Ghafouriyan Broujerdnia M, Namjoyan F, Latifi SM. Quercetin effectively quells peanut-induced anaphylactic reactions in the peanut sensitized rats. Iran J Allergy Asthma Immunol. 2010;9:27.
- Matsushima M, Takagi K, Ogawa M, Hirose E, Ota Y, et al. Heme oxygenase-1 mediates the anti-allergic actions of quercetin in rodent mast cells. Inflamm Res. 2009;58:705. 10.1007/s00011-009-0039-1
- Cruz EA, Da-Silva SA, Muzitano MF, Silva PM, Costa SS, et al. Immunomodulatory pretreatment with Kalanchoe pinnata extract and its quercitrin flavonoid effectively protects mice against fatal anaphylactic shock. Int Immunopharmacol. 2008;8:1616. 10.1016/j.intimp.2008.07.006
- Shaik YB, Castellani ML, Perrella A, Conti F, Salini V, et al. Role of quercetin (a natural herbal compound) in allergy and inflammation. J Biol Regul Homeost Agents. 2006;20:47.
- Rogerio AP, Kanashiro A, Fontanari C, da Silva EV, Lucisano-Valim YM, et al. Anti-inflammatory activity of quercetin and isoquercitrin in experimental murine allergic asthma. Inflamm Res. 2007;56:402.
- Jesenak M, Hrubisko M, Chudek J, Bystron J, Rennerova Z, et al. Beneficial effects of pleuran on asthma control and respiratory tract-infection frequency in children with perennial asthma. Sci Rep. 2025;15:7146. 10.1038/s41598-025-91830-2
- Abram DM, Fernandes LGR, Perez-Riverol A, Regina Brochetto-Braga M, Zollner RL. Cross-Reactive Carbohydrate Determinant in , and Venoms: Identification of Allergic Sensitization and Cross-Reactivity. Toxins (Basel). 2020;12. 10.3390/toxins12100649
- Ward BJ, Landry N, Trépanier S, Mercier G, Dargis M, et al. Human antibody response to N-glycans present on plant-made influenza virus-like particle (VLP) vaccines. Vaccine. 2014;32:6098. 10.1016/j.vaccine.2014.08.079
- Secor ER, Carson WF, Cloutier MM, Guernsey LA, Schramm CM, et al. Bromelain exerts anti-inflammatory effects in an ovalbumin-induced murine model of allergic airway disease. Cell Immunol. 2005;237:68.
- Braun JM, Schneider B, Beuth HJ. Therapeutic use, efficiency and safety of the proteolytic pineapple enzyme Bromelain-POS in children with acute sinusitis in Germany. In Vivo. 2005;19:417.
