Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.9
USERS' SCORE
Good
Based on 2 Reviews
8.2
Supplement Facts
Serving Size: 2 VegCaps
Amount Per Serving
%DV
Vitamin C (as Ascorbic Acid)
1,235 mg
1,372%
Quercetin
465 mg
*
Bromelain (Supplying 90 MCU)
50 mg
*
Top Medical Research Studies
9
We explored the effects of quercetin, a natural compound with potential benefits for treating osteoarthritis (OA), specifically focusing on its ability to target damaged chondrocytes, the cartilage cells that play a crucial role in joint health. In our study, we utilized specialized nanoparticles to increase the effectiveness of quercetin, overcoming its usual limitations related to absorption and bioavailability.
Our research involved subjecting human chondrocytes to conditions that mimic OA. Afterward, we treated them with either free quercetin or our quercetin-loaded nanoparticles (Q-NP). We found that the Q-NP not only allowed for better cellular absorption but also selectively induced apoptosis, or programmed cell death, in senescent chondrocytes. This is significant because eliminating these unhealthy cells could pave the way for healthier joint repair and function.
In addition to promoting cell death in the right cells, Q-NP led to an increase in oxidative stress and reduced key markers of cellular aging. We also noted that the treatment halted the cell cycle in cells that needed to be eliminated. Overall, our findings suggest that enhancing quercetin delivery through nanoparticles holds great promise for improving osteoarthritis outcomes by actively removing harmful senescent cells from joint tissues.
Our research involved subjecting human chondrocytes to conditions that mimic OA. Afterward, we treated them with either free quercetin or our quercetin-loaded nanoparticles (Q-NP). We found that the Q-NP not only allowed for better cellular absorption but also selectively induced apoptosis, or programmed cell death, in senescent chondrocytes. This is significant because eliminating these unhealthy cells could pave the way for healthier joint repair and function.
In addition to promoting cell death in the right cells, Q-NP led to an increase in oxidative stress and reduced key markers of cellular aging. We also noted that the treatment halted the cell cycle in cells that needed to be eliminated. Overall, our findings suggest that enhancing quercetin delivery through nanoparticles holds great promise for improving osteoarthritis outcomes by actively removing harmful senescent cells from joint tissues.
Read More
9
We investigated how quercetin, a natural compound, can influence the symptoms of osteoarthritis (OA). In our study, we used the cytokine IL-1β to simulate OA in chondrocytes, the cells responsible for maintaining cartilage health. Additionally, we created an animal model by inducing OA through anterior cruciate ligament transection.
Our findings were promising. We observed that quercetin significantly improved cell proliferation while decreasing cell death and inflammation in the chondrocytes affected by IL-1β. This suggests that quercetin actively protects these cells and helps maintain the integrity of cartilage by preventing its degradation.
Interestingly, quercetin also reduced a specific type of cell death known as ferroptosis, which can worsen OA symptoms. By blocking this harmful process, quercetin showed its potential as a therapeutic option. Additionally, we noted that quercetin enhances certain protective pathways in the cells, particularly through the AMPK/Nrf2/Gpx4 signaling pathway.
In the animal model, treatment with quercetin led to less damage in the cartilage, confirming its protective effects in a living organism. Overall, our study provides valuable insights into how quercetin might serve as a beneficial treatment for patients with osteoarthritis by targeting inflammation and cell death pathways to foster healthier joint function.
Our findings were promising. We observed that quercetin significantly improved cell proliferation while decreasing cell death and inflammation in the chondrocytes affected by IL-1β. This suggests that quercetin actively protects these cells and helps maintain the integrity of cartilage by preventing its degradation.
Interestingly, quercetin also reduced a specific type of cell death known as ferroptosis, which can worsen OA symptoms. By blocking this harmful process, quercetin showed its potential as a therapeutic option. Additionally, we noted that quercetin enhances certain protective pathways in the cells, particularly through the AMPK/Nrf2/Gpx4 signaling pathway.
In the animal model, treatment with quercetin led to less damage in the cartilage, confirming its protective effects in a living organism. Overall, our study provides valuable insights into how quercetin might serve as a beneficial treatment for patients with osteoarthritis by targeting inflammation and cell death pathways to foster healthier joint function.
Read More
9
We explored the potential of quercetin, a bioactive compound isolated from the chloroform extract of a specific plant, in fighting arthritis. To understand its effectiveness, we first looked at the safety profile of the extract, confirming that it posed no risk at doses of up to 2000 mg/kg, based on strict safety guidelines.
Next, we evaluated quercetin's impact using a model designed to induce arthritis. Our findings revealed that quercetin has a dose-dependent effect, helping to reduce inflammation and improve key factors associated with mobility and pain relief. Parameters such as thermal latency time—essentially measuring pain response—dorsal flexion, and overall motility showed marked improvement.
With significant bioactive constituents like quercetin at play, this research supports the traditional use of this plant as an effective anti-arthritic treatment option, especially for those suffering from rheumatoid arthritis.
Next, we evaluated quercetin's impact using a model designed to induce arthritis. Our findings revealed that quercetin has a dose-dependent effect, helping to reduce inflammation and improve key factors associated with mobility and pain relief. Parameters such as thermal latency time—essentially measuring pain response—dorsal flexion, and overall motility showed marked improvement.
With significant bioactive constituents like quercetin at play, this research supports the traditional use of this plant as an effective anti-arthritic treatment option, especially for those suffering from rheumatoid arthritis.
Read More
Most Useful Reviews
7.5
Reduces inflammation
By correcting fatty acid metabolism, Quercetin reduces the formation of leukotrienes, which are significantly more inflammatory than histamine. This antioxidant is beneficial in treating arthritis, rheumatism, systemic lupus erythematosus, and ulcerative colitis by neutralising histamine. Additionally, it prevents ulcers and haemorrhages in the digestive tract and supports the nervous, immune, and endocrine systems. Overall, it is incredibly beneficial!
Read More
6
Supports immunity
1 people found this helpful
I always order vitamin C with Quercetin for my mother. It helps to lower cholesterol and acts as a powerful antioxidant in the body, effectively combatting bacteria and viruses. It also assists with arthritis. These vitamins are superb!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.9
- All Researches
9
We investigated how quercetin, a natural compound, can influence the symptoms of osteoarthritis (OA). In our study, we used the cytokine IL-1β to simulate OA in chondrocytes, the cells responsible for maintaining cartilage health. Additionally, we created an animal model by inducing OA through anterior cruciate ligament transection.
Our findings were promising. We observed that quercetin significantly improved cell proliferation while decreasing cell death and inflammation in the chondrocytes affected by IL-1β. This suggests that quercetin actively protects these cells and helps maintain the integrity of cartilage by preventing its degradation.
Interestingly, quercetin also reduced a specific type of cell death known as ferroptosis, which can worsen OA symptoms. By blocking this harmful process, quercetin showed its potential as a therapeutic option. Additionally, we noted that quercetin enhances certain protective pathways in the cells, particularly through the AMPK/Nrf2/Gpx4 signaling pathway.
In the animal model, treatment with quercetin led to less damage in the cartilage, confirming its protective effects in a living organism. Overall, our study provides valuable insights into how quercetin might serve as a beneficial treatment for patients with osteoarthritis by targeting inflammation and cell death pathways to foster healthier joint function.
Our findings were promising. We observed that quercetin significantly improved cell proliferation while decreasing cell death and inflammation in the chondrocytes affected by IL-1β. This suggests that quercetin actively protects these cells and helps maintain the integrity of cartilage by preventing its degradation.
Interestingly, quercetin also reduced a specific type of cell death known as ferroptosis, which can worsen OA symptoms. By blocking this harmful process, quercetin showed its potential as a therapeutic option. Additionally, we noted that quercetin enhances certain protective pathways in the cells, particularly through the AMPK/Nrf2/Gpx4 signaling pathway.
In the animal model, treatment with quercetin led to less damage in the cartilage, confirming its protective effects in a living organism. Overall, our study provides valuable insights into how quercetin might serve as a beneficial treatment for patients with osteoarthritis by targeting inflammation and cell death pathways to foster healthier joint function.
Read More
9
We explored the potential of quercetin, a bioactive compound isolated from the chloroform extract of a specific plant, in fighting arthritis. To understand its effectiveness, we first looked at the safety profile of the extract, confirming that it posed no risk at doses of up to 2000 mg/kg, based on strict safety guidelines.
Next, we evaluated quercetin's impact using a model designed to induce arthritis. Our findings revealed that quercetin has a dose-dependent effect, helping to reduce inflammation and improve key factors associated with mobility and pain relief. Parameters such as thermal latency time—essentially measuring pain response—dorsal flexion, and overall motility showed marked improvement.
With significant bioactive constituents like quercetin at play, this research supports the traditional use of this plant as an effective anti-arthritic treatment option, especially for those suffering from rheumatoid arthritis.
Next, we evaluated quercetin's impact using a model designed to induce arthritis. Our findings revealed that quercetin has a dose-dependent effect, helping to reduce inflammation and improve key factors associated with mobility and pain relief. Parameters such as thermal latency time—essentially measuring pain response—dorsal flexion, and overall motility showed marked improvement.
With significant bioactive constituents like quercetin at play, this research supports the traditional use of this plant as an effective anti-arthritic treatment option, especially for those suffering from rheumatoid arthritis.
Read More
9
We explored how quercetin, when combined with teriflunomide, could potentially enhance treatment for rheumatoid arthritis (RA). This study involved developing a special topical gel that allowed for these compounds to be delivered directly to joint tissues. Using a method known as Box-Behnken design, we created transferosomes loaded with teriflunomide and quercetin, which showed promising results in terms of sustained drug release and improved skin permeability.
Through our testing, we observed that this combination not only decreased the levels of important inflammatory markers like NO, TNF-α, and IL-6 in cultured cells but also showed low toxicity in skin cells. In rats, the gel was confirmed to be non-irritating, allowing us to consider its safety for potential use. Moreover, in an animal model of adjuvant-induced arthritis, the combination gel outperformed other treatments, indicating its effectiveness.
While quercetin was studied alongside teriflunomide, the isolated effects of quercetin on arthritis weren't distinctly established in this context. Thus, while this study shows that the combination can be effective for RA treatment, it does not provide conclusive evidence regarding the specific impact of quercetin alone.
Through our testing, we observed that this combination not only decreased the levels of important inflammatory markers like NO, TNF-α, and IL-6 in cultured cells but also showed low toxicity in skin cells. In rats, the gel was confirmed to be non-irritating, allowing us to consider its safety for potential use. Moreover, in an animal model of adjuvant-induced arthritis, the combination gel outperformed other treatments, indicating its effectiveness.
While quercetin was studied alongside teriflunomide, the isolated effects of quercetin on arthritis weren't distinctly established in this context. Thus, while this study shows that the combination can be effective for RA treatment, it does not provide conclusive evidence regarding the specific impact of quercetin alone.
Read More
9
Quercetin's unclear solo impact
Our exploration into the effects of quercetin on arthritis took a holistic approach, using a combination treatment of Dasatinib and Quercetin on human articular chondrocytes, which are cells in the cartilage. This innovative therapy aimed to tackle the challenges posed by cellular senescence, a condition linked to the worsening of osteoarthritis (OA).
What we found was quite promising. The combination therapy effectively targeted and removed senescent cells from both cartilage tissues and isolated chondrocytes. We observed increased levels of important growth factors such as FGF18, IGF1, and TGFB2, which help promote cartilage health.
While quercetin was part of the treatment, our analysis indicated that Dasatinib played a more significant role in stimulating chondroanabolism—the process of cartilage formation. Notably, quercetin alone did not show the same effectiveness in promoting cartilage health.
Consequently, while quercetin contributes to the overall combination strategy, its isolated benefits on arthritis remain unclear based on our findings. This therapeutic approach may pave the way for developing new treatments aimed at modifying the progression of osteoarthritis.
What we found was quite promising. The combination therapy effectively targeted and removed senescent cells from both cartilage tissues and isolated chondrocytes. We observed increased levels of important growth factors such as FGF18, IGF1, and TGFB2, which help promote cartilage health.
While quercetin was part of the treatment, our analysis indicated that Dasatinib played a more significant role in stimulating chondroanabolism—the process of cartilage formation. Notably, quercetin alone did not show the same effectiveness in promoting cartilage health.
Consequently, while quercetin contributes to the overall combination strategy, its isolated benefits on arthritis remain unclear based on our findings. This therapeutic approach may pave the way for developing new treatments aimed at modifying the progression of osteoarthritis.
Read More
9
Quercetin reduces arthritis inflammation
We examined the potential of quercetin, a well-known flavonoid, in managing rheumatoid arthritis. Using a collagen-induced arthritis model in Wistar rats, we administered quercetin at doses of 50 or 100 mg/kg for four weeks. Throughout this period, we carefully monitored changes in arthritis severity, joint health, and various biochemical markers.
Our findings revealed that quercetin significantly impacts the inflammation associated with arthritis. It appeared to work by inhibiting a specific signaling pathway known as JAK1/STAT3/HIF-1α, which plays a key role in immune system activation and inflammation. Additionally, we looked at how quercetin affects synovial fibroblasts, which are crucial players in joint health. Laboratory tests showed improvements in the metabolism of these cells when treated with quercetin.
Overall, our study suggests that quercetin could be a promising option to reduce joint inflammation and improve metabolic health in individuals suffering from rheumatoid arthritis. By targeting multiple pathways, it helps to alleviate the burden of this chronic autoimmune disease effectively.
Our findings revealed that quercetin significantly impacts the inflammation associated with arthritis. It appeared to work by inhibiting a specific signaling pathway known as JAK1/STAT3/HIF-1α, which plays a key role in immune system activation and inflammation. Additionally, we looked at how quercetin affects synovial fibroblasts, which are crucial players in joint health. Laboratory tests showed improvements in the metabolism of these cells when treated with quercetin.
Overall, our study suggests that quercetin could be a promising option to reduce joint inflammation and improve metabolic health in individuals suffering from rheumatoid arthritis. By targeting multiple pathways, it helps to alleviate the burden of this chronic autoimmune disease effectively.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Reduces inflammation
By correcting fatty acid metabolism, Quercetin reduces the formation of leukotrienes, which are significantly more inflammatory than histamine. This antioxidant is beneficial in treating arthritis, rheumatism, systemic lupus erythematosus, and ulcerative colitis by neutralising histamine. Additionally, it prevents ulcers and haemorrhages in the digestive tract and supports the nervous, immune, and endocrine systems. Overall, it is incredibly beneficial!
Read More
6
Supports immunity
1 people found this helpful
I always order vitamin C with Quercetin for my mother. It helps to lower cholesterol and acts as a powerful antioxidant in the body, effectively combatting bacteria and viruses. It also assists with arthritis. These vitamins are superb!
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
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- Kamboj A, Malhotra H, Mukhija H, Babu A. Evaluation of the potential anti-arthritic effects and evaluation of acute oral toxicity of the active fraction of leaves in rat model. J Asian Nat Prod Res. 2024. doi:10.1080/10286020.2024.2422974
- Priya PS, Murugan R, Srileka R, Ramya Ranjan Nayak SP, Margesan T, et al. Synergistic defense: Quercetin and chondroitin sulfate combat bacterial trigger of rheumatoid arthritis, Proteus mirabilis through in-vitro and in-vivo mechanisms. Microb Pathog. 2024;197:107086. doi:10.1016/j.micpath.2024.107086
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- Maurer S, Kirsch V, Ruths L, Brenner RE, Riegger J. Senolytic therapy combining Dasatinib and Quercetin restores the chondrogenic phenotype of human osteoarthritic chondrocytes by the release of pro-anabolic mediators. Aging Cell. 2025;24:e14361. doi:10.1111/acel.14361
- Zhang F, Zhang Y, Zhou J, Cai Y, Li Z, et al. Metabolic effects of quercetin on inflammatory and autoimmune responses in rheumatoid arthritis are mediated through the inhibition of JAK1/STAT3/HIF-1α signaling. Mol Med. 2024;30:170. doi:10.1186/s10020-024-00929-1
- Zhao J, Zheng L, Dai G, Sun Y, He R, et al. Senolytics cocktail dasatinib and quercetin alleviate chondrocyte senescence and facet joint osteoarthritis in mice. Spine J. 2025;25:184. doi:10.1016/j.spinee.2024.09.017
- Yu H, Lou J, Ni L, Yan M, Zhu K, et al. Isoquercetin Ameliorates Osteoarthritis via Nrf2/NF-κB Axis: An In Vitro and In Vivo Study. Chem Biol Drug Des. 2024;104:e14620. doi:10.1111/cbdd.14620
- Karim A, Qaisar R, Suresh S, Jagal J, Rawas-Qalaji M. Nanoparticle-delivered quercetin exhibits enhanced efficacy in eliminating iron-overloaded senescent chondrocytes. Nanomedicine (Lond). 2024;19:2159. doi:10.1080/17435889.2024.2393074
- Chen J, Wu G, Wu J, Jiao Z. Sodium alginate microspheres loaded with Quercetin/Mg nanoparticles as novel drug delivery systems for osteoarthritis therapy. J Orthop Surg Res. 2025;20:300. doi:10.1186/s13018-025-05698-z
- Kan T, Tian Z, Sun L, Kong W, Yan R, et al. Quercetin-Loaded Zeolitic Imidazolate Framework-8 (ZIF-8) Nanoparticles Attenuate Osteoarthritis by Activating Autophagy via the Pi3k/Akt Signaling. ACS Appl Mater Interfaces. 2024;16:40444. doi:10.1021/acsami.4c04649
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