' 
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8
USERS' SCORE
Good
Based on 2 Reviews
8.4
Supplement Facts
Serving Size: 2 VegCaps
Amount Per Serving
%DV
Vitamin C (as Ascorbic Acid)
1,235 mg
1,372%
Quercetin
465 mg
*
Bromelain (Supplying 90 MCU)
50 mg
*
Top Medical Research Studies
9
Quercetin reduces sinus inflammation
Quercetin attenuates naso-sinusal inflammation and inflammatory response in lungs and brain on an experimental model of acute rhinosinusitis in rats.
Promising findings for treatment
This study explored how quercetin may help reduce inflammation associated with sinusitis using a rat model. We observed that introducing lipopolysaccharides (LPS) caused significant inflammation in nasal and sinus areas, as well as in the lungs and brain.
When we administered quercetin after the LPS treatment, it notably decreased inflammatory markers like TNF-α and IL-6. The results indicated reduced inflammation in nasal and lung tissues, showcasing quercetin's potential benefits. However, while there were encouraging findings, its effects on brain inflammation were more limited.
When we administered quercetin after the LPS treatment, it notably decreased inflammatory markers like TNF-α and IL-6. The results indicated reduced inflammation in nasal and lung tissues, showcasing quercetin's potential benefits. However, while there were encouraging findings, its effects on brain inflammation were more limited.
Read More
8
Quercetin enhances mucus transport
Quercetin increases cystic fibrosis transmembrane conductance regulator-mediated chloride transport and ciliary beat frequency: therapeutic implications for chronic rhinosinusitis.
High relevance for sinusitis treatment
We explored how quercetin might help sinusitis by boosting chloride secretion and improving ciliary beat frequency in cultured sinonasal cells. In our analysis, this compound showed notable ability to enhance these functions, suggesting it could promote better mucus clearance from the sinuses.
The study involved primary cultures of human and murine sinonasal epithelial cells and demonstrated quercetin's effectiveness in increasing chloride transport. This implies potential therapeutic benefits for individuals suffering from chronic rhinosinusitis.
The study involved primary cultures of human and murine sinonasal epithelial cells and demonstrated quercetin's effectiveness in increasing chloride transport. This implies potential therapeutic benefits for individuals suffering from chronic rhinosinusitis.
Read More
8
Vitamin C aids chloride transport
Effect of L-ascorbate on chloride transport in freshly excised sinonasal epithelia.
Relevant to sinusitis treatment
We explored the effects of L-ascorbate, commonly known as Vitamin C, on chloride transport in sinonasal epithelial tissues. This research is particularly significant as it addresses the common condition of chronic rhinosinusitis (CRS) and its potential link to the function of the cystic fibrosis transmembrane conductance regulator (CFTR) — a key chloride ion channel.
During our investigation, we utilized freshly excised sinonasal tissues from both normal individuals and patients suffering from CRS. The tissues were carefully prepared and tested to understand how L-ascorbate influenced chloride secretion. Our findings revealed that the application of L-ascorbate notably enhanced chloride secretion in these tissues.
This is important because optimal chloride transport is essential for maintaining healthy mucosal surfaces and effective mucociliary clearance. Therefore, since decreased chloride secretion could lead to the worsening of sinus conditions, L-ascorbate presents a promising avenue for therapeutic intervention in improving mucociliary clearance for those affected by chronic sinus issues.
During our investigation, we utilized freshly excised sinonasal tissues from both normal individuals and patients suffering from CRS. The tissues were carefully prepared and tested to understand how L-ascorbate influenced chloride secretion. Our findings revealed that the application of L-ascorbate notably enhanced chloride secretion in these tissues.
This is important because optimal chloride transport is essential for maintaining healthy mucosal surfaces and effective mucociliary clearance. Therefore, since decreased chloride secretion could lead to the worsening of sinus conditions, L-ascorbate presents a promising avenue for therapeutic intervention in improving mucociliary clearance for those affected by chronic sinus issues.
Read More
Most Useful Reviews
7.8
Supports sinus health
An excellent nutritional supplement containing quercetin, bromelain, and vitamin C for sinus health. I take it in courses for two months and then break for three. I really appreciate this product. It has a convenient dosage of two capsules twice a day, taken between meals. I recommend it to anyone suffering from sinusitis.
Read More
7.5
Essential for sinusitis
A good preparation for supporting sinus health. It is an irreplaceable item for people suffering from sinusitis.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8
- All Researches
9
Quercetin reduces sinus inflammation
Quercetin attenuates naso-sinusal inflammation and inflammatory response in lungs and brain on an experimental model of acute rhinosinusitis in rats.
Promising findings for treatment
This study explored how quercetin may help reduce inflammation associated with sinusitis using a rat model. We observed that introducing lipopolysaccharides (LPS) caused significant inflammation in nasal and sinus areas, as well as in the lungs and brain.
When we administered quercetin after the LPS treatment, it notably decreased inflammatory markers like TNF-α and IL-6. The results indicated reduced inflammation in nasal and lung tissues, showcasing quercetin's potential benefits. However, while there were encouraging findings, its effects on brain inflammation were more limited.
When we administered quercetin after the LPS treatment, it notably decreased inflammatory markers like TNF-α and IL-6. The results indicated reduced inflammation in nasal and lung tissues, showcasing quercetin's potential benefits. However, while there were encouraging findings, its effects on brain inflammation were more limited.
Read More
8
Quercetin enhances mucus transport
Quercetin increases cystic fibrosis transmembrane conductance regulator-mediated chloride transport and ciliary beat frequency: therapeutic implications for chronic rhinosinusitis.
High relevance for sinusitis treatment
We explored how quercetin might help sinusitis by boosting chloride secretion and improving ciliary beat frequency in cultured sinonasal cells. In our analysis, this compound showed notable ability to enhance these functions, suggesting it could promote better mucus clearance from the sinuses.
The study involved primary cultures of human and murine sinonasal epithelial cells and demonstrated quercetin's effectiveness in increasing chloride transport. This implies potential therapeutic benefits for individuals suffering from chronic rhinosinusitis.
The study involved primary cultures of human and murine sinonasal epithelial cells and demonstrated quercetin's effectiveness in increasing chloride transport. This implies potential therapeutic benefits for individuals suffering from chronic rhinosinusitis.
Read More
8
Vitamin C aids chloride transport
Effect of L-ascorbate on chloride transport in freshly excised sinonasal epithelia.
Relevant to sinusitis treatment
We explored the effects of L-ascorbate, commonly known as Vitamin C, on chloride transport in sinonasal epithelial tissues. This research is particularly significant as it addresses the common condition of chronic rhinosinusitis (CRS) and its potential link to the function of the cystic fibrosis transmembrane conductance regulator (CFTR) — a key chloride ion channel.
During our investigation, we utilized freshly excised sinonasal tissues from both normal individuals and patients suffering from CRS. The tissues were carefully prepared and tested to understand how L-ascorbate influenced chloride secretion. Our findings revealed that the application of L-ascorbate notably enhanced chloride secretion in these tissues.
This is important because optimal chloride transport is essential for maintaining healthy mucosal surfaces and effective mucociliary clearance. Therefore, since decreased chloride secretion could lead to the worsening of sinus conditions, L-ascorbate presents a promising avenue for therapeutic intervention in improving mucociliary clearance for those affected by chronic sinus issues.
During our investigation, we utilized freshly excised sinonasal tissues from both normal individuals and patients suffering from CRS. The tissues were carefully prepared and tested to understand how L-ascorbate influenced chloride secretion. Our findings revealed that the application of L-ascorbate notably enhanced chloride secretion in these tissues.
This is important because optimal chloride transport is essential for maintaining healthy mucosal surfaces and effective mucociliary clearance. Therefore, since decreased chloride secretion could lead to the worsening of sinus conditions, L-ascorbate presents a promising avenue for therapeutic intervention in improving mucociliary clearance for those affected by chronic sinus issues.
Read More
8
Vitamin C aids sinusitis recovery
[Clinical and biochemical aspects in the treatment of acute maxillary sinusitis with antioxidants].
Examines mixed antioxidant approach
We evaluated the impact of antioxidants, specifically vitamin C, on acute maxillary sinusitis treatment through a study involving different treatment approaches. Patients received a mix of dibunol and vitamin C, delivered into the sinuses, while others only had traditional treatments like ampicillin and hydrocortisone.
This study involved control groups that helped us compare the effectiveness of the antioxidant treatment. Stunningly, we found that those receiving the antioxidant mixture demonstrated substantial improvements, with shorter treatment times and fewer overall interventions compared to the control group.
Additionally, positive changes in certain blood markers indicated that the antioxidant approach markedly enhanced the body's response to infection. These findings underscore the potential benefits of including vitamin C as part of a sinusitis treatment plan, especially when dealing with acute flare-ups.
This study involved control groups that helped us compare the effectiveness of the antioxidant treatment. Stunningly, we found that those receiving the antioxidant mixture demonstrated substantial improvements, with shorter treatment times and fewer overall interventions compared to the control group.
Additionally, positive changes in certain blood markers indicated that the antioxidant approach markedly enhanced the body's response to infection. These findings underscore the potential benefits of including vitamin C as part of a sinusitis treatment plan, especially when dealing with acute flare-ups.
Read More
7
Quercetin reduces inflammation in sinusitis
Quercetin inhibits expression of inflammatory cytokines through attenuation of NF-kappaB and p38 MAPK in HMC-1 human mast cell line.
Moderate relevance to sinusitis treatment.
We explored how quercetin affects sinusitis by examining its impact on human mast cells. Specifically, we focused on the expression of inflammatory cytokines after stimulating the cells.
Quercetin showed promise by reducing the gene expression and production of key inflammatory signals like TNF-alpha and IL-6. It did this by dampening the activation of NF-kappaB and p38 MAPK pathways, both crucial for inflammation.
This suggests that quercetin may be beneficial for managing conditions like sinusitis linked to mast cell activity.
Quercetin showed promise by reducing the gene expression and production of key inflammatory signals like TNF-alpha and IL-6. It did this by dampening the activation of NF-kappaB and p38 MAPK pathways, both crucial for inflammation.
This suggests that quercetin may be beneficial for managing conditions like sinusitis linked to mast cell activity.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
7.8
Supports sinus health
An excellent nutritional supplement containing quercetin, bromelain, and vitamin C for sinus health. I take it in courses for two months and then break for three. I really appreciate this product. It has a convenient dosage of two capsules twice a day, taken between meals. I recommend it to anyone suffering from sinusitis.
Read More
7.5
Essential for sinusitis
A good preparation for supporting sinus health. It is an irreplaceable item for people suffering from sinusitis.
