Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.9
USERS' SCORE
Good
Based on 5 Reviews
8.5
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin C (as Ascorbic Acid, Acerola Cherry, Rose Hips)
1,000 mg
1,111%
Top Medical Research Studies
9
We explored the effects of vitamin C on lung cancer, particularly its ability to inhibit pulmonary metastasis—meaning the spread of cancer to the lungs. Using an H22 pulmonary metastasis mouse model, we observed that vitamin C administration, both intraperitoneally and orally, showed promising results.
Through the research, we found that intraperitoneal injections of vitamin C led to an increase in crucial proteins like Nrf2 and HO-1, which are known to help combat cancer. This process resulted in increased cell death in cancer cells through DNA damage and apoptosis, mimicking the effects seen when using pro-oxidant treatments in cells lacking the p53 protein—a critical tumor suppressor.
Furthermore, oral vitamin C not only activated these protective pathways but also spurred the expression of p53 in healthy tumor cells, showcasing its potential as an antimetastatic agent. We noted that vitamin C reduced the proliferation and migration of lung cancer cells while being gentler on normal cells, suggesting a safer therapeutic profile.
Overall, this study highlights vitamin C's dual role in both bolstering the body's defenses against cancer and directly inhibiting the spread of lung cancer, paving the way for its consideration in clinical treatments for pulmonary metastasis.
Through the research, we found that intraperitoneal injections of vitamin C led to an increase in crucial proteins like Nrf2 and HO-1, which are known to help combat cancer. This process resulted in increased cell death in cancer cells through DNA damage and apoptosis, mimicking the effects seen when using pro-oxidant treatments in cells lacking the p53 protein—a critical tumor suppressor.
Furthermore, oral vitamin C not only activated these protective pathways but also spurred the expression of p53 in healthy tumor cells, showcasing its potential as an antimetastatic agent. We noted that vitamin C reduced the proliferation and migration of lung cancer cells while being gentler on normal cells, suggesting a safer therapeutic profile.
Overall, this study highlights vitamin C's dual role in both bolstering the body's defenses against cancer and directly inhibiting the spread of lung cancer, paving the way for its consideration in clinical treatments for pulmonary metastasis.
Read More
7
We examined the connection between vitamin C consumption and lung cancer risk by analyzing various cohort studies. Our investigation included data from 20 different studies, covering both dietary and supplementary forms of vitamin C, utilizing information collected up until April 2022.
Interestingly, when we looked at all the studies together, we found no significant link between vitamin C intake—whether from food or supplements—and the risk of developing lung cancer. The overall analysis indicated a relative risk of 0.90, close to no effect at all.
However, our subgroup analysis revealed something noteworthy. We observed that individuals who consumed dietary vitamin C showed a significant decrease in lung cancer risk, with a relative risk of 0.82. On the other hand, supplementary vitamin C didn't provide any benefits, with a relative risk of 1.01, suggesting no protective effects.
This suggests that while vitamin C from our diet may help reduce lung cancer risk, vitamin C supplements are unlikely to have the same effect. We should consider focusing on dietary sources of this vitamin for potential lung health benefits.
Interestingly, when we looked at all the studies together, we found no significant link between vitamin C intake—whether from food or supplements—and the risk of developing lung cancer. The overall analysis indicated a relative risk of 0.90, close to no effect at all.
However, our subgroup analysis revealed something noteworthy. We observed that individuals who consumed dietary vitamin C showed a significant decrease in lung cancer risk, with a relative risk of 0.82. On the other hand, supplementary vitamin C didn't provide any benefits, with a relative risk of 1.01, suggesting no protective effects.
This suggests that while vitamin C from our diet may help reduce lung cancer risk, vitamin C supplements are unlikely to have the same effect. We should consider focusing on dietary sources of this vitamin for potential lung health benefits.
Read More
8
Vitamin C shows potential in lung cancer
We investigated the effects of pharmacological ascorbate, a form of vitamin C at high concentrations, on non-small cell lung cancer (NSCLC). Our research focused on how P-AscH interacts with cancer cells and uncovers the mechanisms behind its potential benefits.
Through our experiments, we observed that treatment with P-AscH causes oxidative stress in cancer cells. This stress leads to disruptions in their energy production, triggering a cascade of events that results in cell death and a decrease in their ability to survive cloning.
One key finding of our study is that P-AscH appears to target DNA and the cellular responses that repair DNA damage. We found that levels of DNA damage markers increased as a result of P-AscH treatment, while DNA repair mechanisms were found to be misaligned. Notably, using a substance called catalase alongside P-AscH reversed some of these damaging effects, indicating that hydrogen peroxide—a byproduct of P-AscH—plays a significant role in the process.
Overall, our research sheds light on the promising role of pharmacological ascorbate as a potential treatment for lung cancer. This could pave the way for new therapeutic strategies aimed at improving outcomes for patients with NSCLC.
Through our experiments, we observed that treatment with P-AscH causes oxidative stress in cancer cells. This stress leads to disruptions in their energy production, triggering a cascade of events that results in cell death and a decrease in their ability to survive cloning.
One key finding of our study is that P-AscH appears to target DNA and the cellular responses that repair DNA damage. We found that levels of DNA damage markers increased as a result of P-AscH treatment, while DNA repair mechanisms were found to be misaligned. Notably, using a substance called catalase alongside P-AscH reversed some of these damaging effects, indicating that hydrogen peroxide—a byproduct of P-AscH—plays a significant role in the process.
Overall, our research sheds light on the promising role of pharmacological ascorbate as a potential treatment for lung cancer. This could pave the way for new therapeutic strategies aimed at improving outcomes for patients with NSCLC.
Read More
Most Useful Reviews
9
Cold prevention
I take it to prevent cancer and colds. Since starting, I can spend my days without catching a cold!
Read More
9
Indispensable for prevention
The perfect product for someone like me who is quite lazy! I previously took vitamins three times a day, which was a hassle. Now, I take it together, and it is essential for preventing cancer and colds.
Read More
9
High intake recommended
I take it with collagen for my skin. Vitamin C has been shown to be effective in cancer control, so it's wise to consume it in large amounts. Being water-soluble, excess is flushed out in urine, preventing overdose. I take about 10 tablets daily.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.9
- All Researches
9
We explored how high-dose ascorbic acid, commonly known as vitamin C, can enhance the effectiveness of anti-PD1 therapy in treating non-small cell lung cancer (NSCLC). Through a combination of laboratory and animal studies, we aimed to understand if this vitamin could help overcome challenges that some patients face with immunotherapy resistance.
Our findings showed that when we pretreat lung cancer cells with high doses of vitamin C, they become more sensitive to the immune system's attacks. Specifically, we observed that vitamin C intensified the ability of CD8+ T cells—key players in the body's immune response—to destroy cancer cells. The results were particularly striking when vitamin C was combined with anti-PD1 therapy, significantly boosting tumor-killing effects and enhancing immune activity.
Additionally, our analysis revealed that vitamin C treatment altered various immune-related pathways, potentially improving the overall anti-tumor response. This suggests that high-dose vitamin C could serve as a valuable ally in lung cancer therapy, particularly in aiding the effects of established immunotherapies like anti-PD1.
The insights from this study could lead to new strategies for enhancing treatment options for patients battling lung cancer, promising a more effective approach in utilizing immune therapies.
Our findings showed that when we pretreat lung cancer cells with high doses of vitamin C, they become more sensitive to the immune system's attacks. Specifically, we observed that vitamin C intensified the ability of CD8+ T cells—key players in the body's immune response—to destroy cancer cells. The results were particularly striking when vitamin C was combined with anti-PD1 therapy, significantly boosting tumor-killing effects and enhancing immune activity.
Additionally, our analysis revealed that vitamin C treatment altered various immune-related pathways, potentially improving the overall anti-tumor response. This suggests that high-dose vitamin C could serve as a valuable ally in lung cancer therapy, particularly in aiding the effects of established immunotherapies like anti-PD1.
The insights from this study could lead to new strategies for enhancing treatment options for patients battling lung cancer, promising a more effective approach in utilizing immune therapies.
Read More
9
We explored the effects of vitamin C on lung cancer, particularly its ability to inhibit pulmonary metastasis—meaning the spread of cancer to the lungs. Using an H22 pulmonary metastasis mouse model, we observed that vitamin C administration, both intraperitoneally and orally, showed promising results.
Through the research, we found that intraperitoneal injections of vitamin C led to an increase in crucial proteins like Nrf2 and HO-1, which are known to help combat cancer. This process resulted in increased cell death in cancer cells through DNA damage and apoptosis, mimicking the effects seen when using pro-oxidant treatments in cells lacking the p53 protein—a critical tumor suppressor.
Furthermore, oral vitamin C not only activated these protective pathways but also spurred the expression of p53 in healthy tumor cells, showcasing its potential as an antimetastatic agent. We noted that vitamin C reduced the proliferation and migration of lung cancer cells while being gentler on normal cells, suggesting a safer therapeutic profile.
Overall, this study highlights vitamin C's dual role in both bolstering the body's defenses against cancer and directly inhibiting the spread of lung cancer, paving the way for its consideration in clinical treatments for pulmonary metastasis.
Through the research, we found that intraperitoneal injections of vitamin C led to an increase in crucial proteins like Nrf2 and HO-1, which are known to help combat cancer. This process resulted in increased cell death in cancer cells through DNA damage and apoptosis, mimicking the effects seen when using pro-oxidant treatments in cells lacking the p53 protein—a critical tumor suppressor.
Furthermore, oral vitamin C not only activated these protective pathways but also spurred the expression of p53 in healthy tumor cells, showcasing its potential as an antimetastatic agent. We noted that vitamin C reduced the proliferation and migration of lung cancer cells while being gentler on normal cells, suggesting a safer therapeutic profile.
Overall, this study highlights vitamin C's dual role in both bolstering the body's defenses against cancer and directly inhibiting the spread of lung cancer, paving the way for its consideration in clinical treatments for pulmonary metastasis.
Read More
8
We examined the effects of vitamin C, specifically pharmacological ascorbate, when used alongside a new drug called rucosopasem manganese (RUC) in the treatment of non-small cell lung cancer (NSCLC). The study revealed that this combination not only radio-sensitizes the cancer cells but also amplifies the levels of harmful free radicals known as hydroxyl radicals in the cells.
Importantly, we found that this dual approach did not harm normal lung cells, making it a promising strategy. Furthermore, when used together, RUC and vitamin C exhibited greater cancer-fighting properties than either agent alone. Our findings indicated that these treatments work synergistically, supporting the idea that a well-timed combination therapy could make standard treatments like chemotherapy more effective.
In experiments with NSCLC cells and tumor models, RUC and vitamin C showed substantial improvements in overall survival rates. This suggests that harnessing the unique oxidative environments of cancer cells can lead to enhanced anticancer effects. While our results are encouraging, it’s crucial to note that the study emphasized the specific combination's efficacy rather than isolated effects of vitamin C alone, leaving its independent role less clear.
Importantly, we found that this dual approach did not harm normal lung cells, making it a promising strategy. Furthermore, when used together, RUC and vitamin C exhibited greater cancer-fighting properties than either agent alone. Our findings indicated that these treatments work synergistically, supporting the idea that a well-timed combination therapy could make standard treatments like chemotherapy more effective.
In experiments with NSCLC cells and tumor models, RUC and vitamin C showed substantial improvements in overall survival rates. This suggests that harnessing the unique oxidative environments of cancer cells can lead to enhanced anticancer effects. While our results are encouraging, it’s crucial to note that the study emphasized the specific combination's efficacy rather than isolated effects of vitamin C alone, leaving its independent role less clear.
Read More
8
We explored the impact of high-dose intravenous vitamin C (IVC) on non-small cell lung cancer (NSCLC) through a comprehensive study. Our investigation focused on understanding how gene expression changes in NSCLC cells when treated with this vitamin. We used advanced RNA sequencing techniques to identify significant genetic alterations in cells exposed to pharmacological levels of vitamin C.
Notably, we discovered two specific genes, SERPINE1 and SERPINB7, that showed reduced expression after vitamin C treatment. By linking patient data from our study and established databases, we found that low levels of these genes were associated with poorer survival outcomes in NSCLC patients receiving standard treatments. However, when patients included IVC alongside their standard care, higher levels of these genes correlated with longer overall survival.
These findings suggest that SERPINE1 and SERPINB7 could serve as potential biomarkers to predict how well patients respond to vitamin C treatments in addition to their usual care for lung cancer. While more research is needed to validate these results further, our exploration indicates promising avenues for enhancing treatment strategies in NSCLC.
Notably, we discovered two specific genes, SERPINE1 and SERPINB7, that showed reduced expression after vitamin C treatment. By linking patient data from our study and established databases, we found that low levels of these genes were associated with poorer survival outcomes in NSCLC patients receiving standard treatments. However, when patients included IVC alongside their standard care, higher levels of these genes correlated with longer overall survival.
These findings suggest that SERPINE1 and SERPINB7 could serve as potential biomarkers to predict how well patients respond to vitamin C treatments in addition to their usual care for lung cancer. While more research is needed to validate these results further, our exploration indicates promising avenues for enhancing treatment strategies in NSCLC.
Read More
8
Vitamin C shows potential in lung cancer
We investigated the effects of pharmacological ascorbate, a form of vitamin C at high concentrations, on non-small cell lung cancer (NSCLC). Our research focused on how P-AscH interacts with cancer cells and uncovers the mechanisms behind its potential benefits.
Through our experiments, we observed that treatment with P-AscH causes oxidative stress in cancer cells. This stress leads to disruptions in their energy production, triggering a cascade of events that results in cell death and a decrease in their ability to survive cloning.
One key finding of our study is that P-AscH appears to target DNA and the cellular responses that repair DNA damage. We found that levels of DNA damage markers increased as a result of P-AscH treatment, while DNA repair mechanisms were found to be misaligned. Notably, using a substance called catalase alongside P-AscH reversed some of these damaging effects, indicating that hydrogen peroxide—a byproduct of P-AscH—plays a significant role in the process.
Overall, our research sheds light on the promising role of pharmacological ascorbate as a potential treatment for lung cancer. This could pave the way for new therapeutic strategies aimed at improving outcomes for patients with NSCLC.
Through our experiments, we observed that treatment with P-AscH causes oxidative stress in cancer cells. This stress leads to disruptions in their energy production, triggering a cascade of events that results in cell death and a decrease in their ability to survive cloning.
One key finding of our study is that P-AscH appears to target DNA and the cellular responses that repair DNA damage. We found that levels of DNA damage markers increased as a result of P-AscH treatment, while DNA repair mechanisms were found to be misaligned. Notably, using a substance called catalase alongside P-AscH reversed some of these damaging effects, indicating that hydrogen peroxide—a byproduct of P-AscH—plays a significant role in the process.
Overall, our research sheds light on the promising role of pharmacological ascorbate as a potential treatment for lung cancer. This could pave the way for new therapeutic strategies aimed at improving outcomes for patients with NSCLC.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Cold prevention
I take it to prevent cancer and colds. Since starting, I can spend my days without catching a cold!
Read More
9
Indispensable for prevention
The perfect product for someone like me who is quite lazy! I previously took vitamins three times a day, which was a hassle. Now, I take it together, and it is essential for preventing cancer and colds.
Read More
9
High intake recommended
I take it with collagen for my skin. Vitamin C has been shown to be effective in cancer control, so it's wise to consume it in large amounts. Being water-soluble, excess is flushed out in urine, preventing overdose. I take about 10 tablets daily.
Read More
7.5
Effective cancer prevention
An essential daily supplement! It maintains healthy capillaries, teeth, and cartilage, while also suppressing melanin production in the skin, preventing sunburn, and boosting resistance to illnesses like stress and colds. The antioxidant effects of vitamin C have garnered attention, with expectations that it can help in preventing cancer, arteriosclerosis, and ageing. Thus, it is a vital daily supplement.
Read More
7.5
Improved immunity
My immunity has improved! I take 2000mg daily to help prevent cancer and allergies. It seems to have boosted my immune system, as I haven't had the flu, coronavirus, or any gastroenteritis in the years since I began taking it. I highly recommend it.
Read More
Frequently Asked Questions
9
Cold prevention
I take it to prevent cancer and colds. Since starting, I can spend my days without catching a cold!
7.5
Improved immunity
My immunity has improved! I take 2000mg daily to help prevent cancer and allergies. It seems to have boosted my immune system, as I haven't had the flu, coronavirus, or any gastroenteritis in the years since I began taking it. I highly recommend it.
7.5
Effective cancer prevention
An essential daily supplement! It maintains healthy capillaries, teeth, and cartilage, while also suppressing melanin production in the skin, preventing sunburn, and boosting resistance to illnesses like stress and colds. The antioxidant effects of vitamin C have garnered attention, with expectations that it can help in preventing cancer, arteriosclerosis, and ageing. Thus, it is a vital daily supplement.
9
Indispensable for prevention
The perfect product for someone like me who is quite lazy! I previously took vitamins three times a day, which was a hassle. Now, I take it together, and it is essential for preventing cancer and colds.
9
High intake recommended
I take it with collagen for my skin. Vitamin C has been shown to be effective in cancer control, so it's wise to consume it in large amounts. Being water-soluble, excess is flushed out in urine, preventing overdose. I take about 10 tablets daily.
9
We explored how high-dose ascorbic acid, commonly known as vitamin C, can enhance the effectiveness of anti-PD1 therapy in treating non-small cell lung cancer (NSCLC). Through a combination of laboratory and animal studies, we aimed to understand if this vitamin could help overcome challenges that some patients face with immunotherapy resistance.
Our findings showed that when we pretreat lung cancer cells with high doses of vitamin C, they become more sensitive to the immune system's attacks. Specifically, we observed that vitamin C intensified the ability of CD8+ T cells—key players in the body's immune response—to destroy cancer cells. The results were particularly striking when vitamin C was combined with anti-PD1 therapy, significantly boosting tumor-killing effects and enhancing immune activity.
Additionally, our analysis revealed that vitamin C treatment altered various immune-related pathways, potentially improving the overall anti-tumor response. This suggests that high-dose vitamin C could serve as a valuable ally in lung cancer therapy, particularly in aiding the effects of established immunotherapies like anti-PD1.
The insights from this study could lead to new strategies for enhancing treatment options for patients battling lung cancer, promising a more effective approach in utilizing immune therapies.
Our findings showed that when we pretreat lung cancer cells with high doses of vitamin C, they become more sensitive to the immune system's attacks. Specifically, we observed that vitamin C intensified the ability of CD8+ T cells—key players in the body's immune response—to destroy cancer cells. The results were particularly striking when vitamin C was combined with anti-PD1 therapy, significantly boosting tumor-killing effects and enhancing immune activity.
Additionally, our analysis revealed that vitamin C treatment altered various immune-related pathways, potentially improving the overall anti-tumor response. This suggests that high-dose vitamin C could serve as a valuable ally in lung cancer therapy, particularly in aiding the effects of established immunotherapies like anti-PD1.
The insights from this study could lead to new strategies for enhancing treatment options for patients battling lung cancer, promising a more effective approach in utilizing immune therapies.
8
We examined the effects of vitamin C, specifically pharmacological ascorbate, when used alongside a new drug called rucosopasem manganese (RUC) in the treatment of non-small cell lung cancer (NSCLC). The study revealed that this combination not only radio-sensitizes the cancer cells but also amplifies the levels of harmful free radicals known as hydroxyl radicals in the cells.
Importantly, we found that this dual approach did not harm normal lung cells, making it a promising strategy. Furthermore, when used together, RUC and vitamin C exhibited greater cancer-fighting properties than either agent alone. Our findings indicated that these treatments work synergistically, supporting the idea that a well-timed combination therapy could make standard treatments like chemotherapy more effective.
In experiments with NSCLC cells and tumor models, RUC and vitamin C showed substantial improvements in overall survival rates. This suggests that harnessing the unique oxidative environments of cancer cells can lead to enhanced anticancer effects. While our results are encouraging, it’s crucial to note that the study emphasized the specific combination's efficacy rather than isolated effects of vitamin C alone, leaving its independent role less clear.
Importantly, we found that this dual approach did not harm normal lung cells, making it a promising strategy. Furthermore, when used together, RUC and vitamin C exhibited greater cancer-fighting properties than either agent alone. Our findings indicated that these treatments work synergistically, supporting the idea that a well-timed combination therapy could make standard treatments like chemotherapy more effective.
In experiments with NSCLC cells and tumor models, RUC and vitamin C showed substantial improvements in overall survival rates. This suggests that harnessing the unique oxidative environments of cancer cells can lead to enhanced anticancer effects. While our results are encouraging, it’s crucial to note that the study emphasized the specific combination's efficacy rather than isolated effects of vitamin C alone, leaving its independent role less clear.
9
We explored the effects of vitamin C on lung cancer, particularly its ability to inhibit pulmonary metastasis—meaning the spread of cancer to the lungs. Using an H22 pulmonary metastasis mouse model, we observed that vitamin C administration, both intraperitoneally and orally, showed promising results.
Through the research, we found that intraperitoneal injections of vitamin C led to an increase in crucial proteins like Nrf2 and HO-1, which are known to help combat cancer. This process resulted in increased cell death in cancer cells through DNA damage and apoptosis, mimicking the effects seen when using pro-oxidant treatments in cells lacking the p53 protein—a critical tumor suppressor.
Furthermore, oral vitamin C not only activated these protective pathways but also spurred the expression of p53 in healthy tumor cells, showcasing its potential as an antimetastatic agent. We noted that vitamin C reduced the proliferation and migration of lung cancer cells while being gentler on normal cells, suggesting a safer therapeutic profile.
Overall, this study highlights vitamin C's dual role in both bolstering the body's defenses against cancer and directly inhibiting the spread of lung cancer, paving the way for its consideration in clinical treatments for pulmonary metastasis.
Through the research, we found that intraperitoneal injections of vitamin C led to an increase in crucial proteins like Nrf2 and HO-1, which are known to help combat cancer. This process resulted in increased cell death in cancer cells through DNA damage and apoptosis, mimicking the effects seen when using pro-oxidant treatments in cells lacking the p53 protein—a critical tumor suppressor.
Furthermore, oral vitamin C not only activated these protective pathways but also spurred the expression of p53 in healthy tumor cells, showcasing its potential as an antimetastatic agent. We noted that vitamin C reduced the proliferation and migration of lung cancer cells while being gentler on normal cells, suggesting a safer therapeutic profile.
Overall, this study highlights vitamin C's dual role in both bolstering the body's defenses against cancer and directly inhibiting the spread of lung cancer, paving the way for its consideration in clinical treatments for pulmonary metastasis.
7
We examined the connection between vitamin C consumption and lung cancer risk by analyzing various cohort studies. Our investigation included data from 20 different studies, covering both dietary and supplementary forms of vitamin C, utilizing information collected up until April 2022.
Interestingly, when we looked at all the studies together, we found no significant link between vitamin C intake—whether from food or supplements—and the risk of developing lung cancer. The overall analysis indicated a relative risk of 0.90, close to no effect at all.
However, our subgroup analysis revealed something noteworthy. We observed that individuals who consumed dietary vitamin C showed a significant decrease in lung cancer risk, with a relative risk of 0.82. On the other hand, supplementary vitamin C didn't provide any benefits, with a relative risk of 1.01, suggesting no protective effects.
This suggests that while vitamin C from our diet may help reduce lung cancer risk, vitamin C supplements are unlikely to have the same effect. We should consider focusing on dietary sources of this vitamin for potential lung health benefits.
Interestingly, when we looked at all the studies together, we found no significant link between vitamin C intake—whether from food or supplements—and the risk of developing lung cancer. The overall analysis indicated a relative risk of 0.90, close to no effect at all.
However, our subgroup analysis revealed something noteworthy. We observed that individuals who consumed dietary vitamin C showed a significant decrease in lung cancer risk, with a relative risk of 0.82. On the other hand, supplementary vitamin C didn't provide any benefits, with a relative risk of 1.01, suggesting no protective effects.
This suggests that while vitamin C from our diet may help reduce lung cancer risk, vitamin C supplements are unlikely to have the same effect. We should consider focusing on dietary sources of this vitamin for potential lung health benefits.
8
We explored the impact of high-dose intravenous vitamin C (IVC) on non-small cell lung cancer (NSCLC) through a comprehensive study. Our investigation focused on understanding how gene expression changes in NSCLC cells when treated with this vitamin. We used advanced RNA sequencing techniques to identify significant genetic alterations in cells exposed to pharmacological levels of vitamin C.
Notably, we discovered two specific genes, SERPINE1 and SERPINB7, that showed reduced expression after vitamin C treatment. By linking patient data from our study and established databases, we found that low levels of these genes were associated with poorer survival outcomes in NSCLC patients receiving standard treatments. However, when patients included IVC alongside their standard care, higher levels of these genes correlated with longer overall survival.
These findings suggest that SERPINE1 and SERPINB7 could serve as potential biomarkers to predict how well patients respond to vitamin C treatments in addition to their usual care for lung cancer. While more research is needed to validate these results further, our exploration indicates promising avenues for enhancing treatment strategies in NSCLC.
Notably, we discovered two specific genes, SERPINE1 and SERPINB7, that showed reduced expression after vitamin C treatment. By linking patient data from our study and established databases, we found that low levels of these genes were associated with poorer survival outcomes in NSCLC patients receiving standard treatments. However, when patients included IVC alongside their standard care, higher levels of these genes correlated with longer overall survival.
These findings suggest that SERPINE1 and SERPINB7 could serve as potential biomarkers to predict how well patients respond to vitamin C treatments in addition to their usual care for lung cancer. While more research is needed to validate these results further, our exploration indicates promising avenues for enhancing treatment strategies in NSCLC.
References
- Kim HS, Kwon SH, Choi OK, Lim T. High-dose ascorbic acid synergizes with anti-PD1 therapy in non-small cell lung cancer and models. Front Immunol. 2024;15:1512605. doi:10.3389/fimmu.2024.1512605
- Pulliam CF, Fath MA, Sho S, Johnson ST, Wagner BA, et al. Pharmacological ascorbate combined with rucosopasem selectively radio-chemo-sensitizes NSCLC via generation of HO. Redox Biol. 2025;80:103505. doi:10.1016/j.redox.2025.103505
- Munef A, Lafi Z, Shalan N. Investigating anti-cancer activity of dual-loaded liposomes with thymoquinone and vitamin C. Ther Deliv. 2024;15:267. doi:10.4155/tde-2023-0140
- Man S, Bi J, Liu F, Xie W, Ma L. Vitamin C Inhibited Pulmonary Metastasis through Activating Nrf2/HO-1 Pathway. Mol Nutr Food Res. 2024;68:e2300706. doi:10.1002/mnfr.202300706
- Tran DV, Luu XQ, Tran HTT, Myung SK. Dietary and supplementary vitamin C intake and the risk of lung cancer: A meta‑analysis of cohort studies. Oncol Lett. 2024;27:10. doi:10.3892/ol.2023.14144
- Ou J, Liao Q, Du Y, Xi W, Meng Q, et al. SERPINE1 and SERPINB7 as potential biomarkers for intravenous vitamin C treatment in non-small-cell lung cancer. Free Radic Biol Med. 2023;209:96. doi:10.1016/j.freeradbiomed.2023.10.391
- Sanookpan K, Chantaravisoot N, Kalpongnukul N, Chuenjit C, Wattanathamsan O, et al. Pharmacological Ascorbate Elicits Anti-Cancer Activities against Non-Small Cell Lung Cancer through Hydrogen-Peroxide-Induced-DNA-Damage. Antioxidants (Basel). 2023;12. doi:10.3390/antiox12091775
- Wang N, Ali A, Liu Z, Chi H, Lv Z, et al. Monofunctional dimetallic Ru(η6-arene) complexes inhibit NOTCH1 signaling pathway and synergistically enhance anticancer effect in combination with cisplatin or vitamin C. Eur J Med Chem. 2023;258:115536. doi:10.1016/j.ejmech.2023.115536
