Last update
3/7/2026
Research Authors

Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Moderately Good
Based on 28 Reviews
7.9
Supplement Facts
Serving Size: 1 Vegetable capsule
Amount Per Serving
%DV
Thiamin (vitamin B1) (as thiamin mononitrate)
100 mg
8,333%
Riboflavin (vitamin B2)
100 mg
7,692%
Niacin (vitamin B3) (as niacinamide)
100 mg
625%
Vitamin B6 (as pyridoxine HCl)
100 mg
5,882%
Folate
666 mcg DFE(400 mcg folic acid)
167%
Vitamin B12 (as cyanocobalamin)
100 mcg
4,167%
Biotin (as d-biotin)
100 mcg
333%
Pantothenic Acid (vitamin B5) (as d-calcium pantothenate)
100 mg
2,000%
Choline (as choline bitartrate)
20 mg
4%
Inositol
100 mg
**
📅 Last updated:

Top Medical Research Studies

We examined the effects of vitamin B12 injections, combined with folic acid, on 38 patients with myalgic encephalomyelitis (ME), also known as chronic fatigue syndrome.

Participants were split into "Good" and "Mild" responders based on their improvement. Good responders reported greater progress with more frequent injections and higher doses of both supplements.

However, for Mild responders, the improvement was limited, suggesting that while there is potential for benefit, the response can vary widely among individuals. Overall, further investigation is needed to explore optimal treatment strategies.
Read More

Most Useful Reviews

9
Stress resistance
3 people found this helpful
This vitamin B complex has noticeably enhanced my resistance to stress and improved brain function within just three days. My fatigue has decreased significantly, which is beneficial for my chronic fatigue syndrome. The quality and efficacy of these vitamins are commendable.
Read More
9
Wakes you up
2 people found this helpful
This vitamin offering is quite effective in reducing fatigue. It provides a wakefulness effect which has helped to alleviate my chronic fatigue syndrome significantly compared to other brands.
Read More
9
Stress resistance enhanced
1 people found this helpful
I ordered this complex for seasonal prophylaxis and stress protection. By the fourth day, I noticed improved stress resistance, easier mornings, and reduced fatigue. My skin and hair also improved significantly, with my hair growing thicker. A quality complex with an optimal vitamin ratio.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
  • All Researches
We examined the effects of vitamin B12 injections, combined with folic acid, on 38 patients with myalgic encephalomyelitis (ME), also known as chronic fatigue syndrome.

Participants were split into "Good" and "Mild" responders based on their improvement. Good responders reported greater progress with more frequent injections and higher doses of both supplements.

However, for Mild responders, the improvement was limited, suggesting that while there is potential for benefit, the response can vary widely among individuals. Overall, further investigation is needed to explore optimal treatment strategies.
Read More

User Reviews

USERS' SCORE
Moderately Good
Based on 28 Reviews
7.9
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Stress resistance
3 people found this helpful
This vitamin B complex has noticeably enhanced my resistance to stress and improved brain function within just three days. My fatigue has decreased significantly, which is beneficial for my chronic fatigue syndrome. The quality and efficacy of these vitamins are commendable.
Read More
9
Wakes you up
2 people found this helpful
This vitamin offering is quite effective in reducing fatigue. It provides a wakefulness effect which has helped to alleviate my chronic fatigue syndrome significantly compared to other brands.
Read More
9
Stress resistance enhanced
1 people found this helpful
I ordered this complex for seasonal prophylaxis and stress protection. By the fourth day, I noticed improved stress resistance, easier mornings, and reduced fatigue. My skin and hair also improved significantly, with my hair growing thicker. A quality complex with an optimal vitamin ratio.
Read More
9
Significant improvement
This is a brand I consistently consume as a B vitamin nutritional supplement. After taking B vitamins and magnesium, my chronic fatigue improved significantly. I am highly satisfied and plan to continue unless any special issues arise!
Read More
9
Improved overall well-being
I've long known the significance of B vitamins but struggled to get enough from food. After choosing B100 from Solgar, I can confirm it works! It enhances my energy and overall well-being. My mood, skin, and hair improved significantly after a few weeks of use. I'm pleased with Solgar’s quality and purity, and I feel more energetic and stable.
Read More

Frequently Asked Questions

9
Stress resistance
3 people found this helpful
This vitamin B complex has noticeably enhanced my resistance to stress and improved brain function within just three days. My fatigue has decreased significantly, which is beneficial for my chronic fatigue syndrome. The quality and efficacy of these vitamins are commendable.
We examined the effects of vitamin B12 injections, combined with folic acid, on 38 patients with myalgic encephalomyelitis (ME), also known as chronic fatigue syndrome.

Participants were split into "Good" and "Mild" responders based on their improvement. Good responders reported greater progress with more frequent injections and higher doses of both supplements.

However, for Mild responders, the improvement was limited, suggesting that while there is potential for benefit, the response can vary widely among individuals. Overall, further investigation is needed to explore optimal treatment strategies.

References

  1. Regland B, Forsmark S, Halaouate L, Matousek M, Peilot B, et al. Response to vitamin B12 and folic acid in myalgic encephalomyelitis and fibromyalgia. PLoS One. 2015;10:e0124648. 10.1371/journal.pone.0124648
Data last updated:
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