Last update
5/20/2025
Research Authors

Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Moderately Good
Based on 38 Reviews
7.8
Supplement Facts
Serving Size: 1 Vegetable capsule
Amount Per Serving
%DV
Thiamin (vitamin B1) (as thiamin mononitrate)
100 mg
8,333%
Riboflavin (vitamin B2)
100 mg
7,692%
Niacin (vitamin B3) (as niacinamide)
100 mg
625%
Vitamin B6 (as pyridoxine HCl)
100 mg
5,882%
Folate
666 mcg DFE(400 mcg folic acid)
167%
Vitamin B12 (as cyanocobalamin)
100 mcg
4,167%
Biotin (as d-biotin)
100 mcg
333%
Pantothenic Acid (vitamin B5) (as d-calcium pantothenate)
100 mg
2,000%
Choline (as choline bitartrate)
20 mg
4%
Inositol
100 mg
**

Top Medical Research Studies

We examined the effects of vitamin B12 injections, combined with folic acid, on 38 patients with myalgic encephalomyelitis (ME), also known as chronic fatigue syndrome.

Participants were split into "Good" and "Mild" responders based on their improvement. Good responders reported greater progress with more frequent injections and higher doses of both supplements.

However, for Mild responders, the improvement was limited, suggesting that while there is potential for benefit, the response can vary widely among individuals. Overall, further investigation is needed to explore optimal treatment strategies.
Read More

Most Useful Reviews

7.5
Increased energy
211 people found this helpful
The bright yellow capsules are large but easy to swallow. After taking them for two months, I experienced increased energy, reduced irritability, and less mood fluctuation, which greatly helped with my chronic fatigue syndrome. I felt more strength to engage in activities and noticed a gradual improvement in my overall mood. It's important to take a break of six months after a two-month course.
Read More
10
Immunity boost
9 people found this helpful
I take one capsule half an hour after eating, preferably in the morning. I've felt a surge of strength and endurance. My immunity has improved, and the recurrent herpes on my lips has disappeared. I now feel energised and no longer suffer from chronic fatigue syndrome.
Read More
9
Improved sleep
4 people found this helpful
After a year of taking B vitamins recommended by my doctor for chronic fatigue syndrome, I noticed increased energy, improved sleep quality, and less irritability. Additionally, my nails became stronger and digestion regularised. I am very pleased with the results.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
  • All Researches
We examined the effects of vitamin B12 injections, combined with folic acid, on 38 patients with myalgic encephalomyelitis (ME), also known as chronic fatigue syndrome.

Participants were split into "Good" and "Mild" responders based on their improvement. Good responders reported greater progress with more frequent injections and higher doses of both supplements.

However, for Mild responders, the improvement was limited, suggesting that while there is potential for benefit, the response can vary widely among individuals. Overall, further investigation is needed to explore optimal treatment strategies.
Read More

User Reviews

USERS' SCORE
Moderately Good
Based on 38 Reviews
7.8
  • All Reviews
  • Positive Reviews
  • Negative Reviews
7.5
Increased energy
211 people found this helpful
The bright yellow capsules are large but easy to swallow. After taking them for two months, I experienced increased energy, reduced irritability, and less mood fluctuation, which greatly helped with my chronic fatigue syndrome. I felt more strength to engage in activities and noticed a gradual improvement in my overall mood. It's important to take a break of six months after a two-month course.
Read More
10
Immunity boost
9 people found this helpful
I take one capsule half an hour after eating, preferably in the morning. I've felt a surge of strength and endurance. My immunity has improved, and the recurrent herpes on my lips has disappeared. I now feel energised and no longer suffer from chronic fatigue syndrome.
Read More
9
Improved sleep
4 people found this helpful
After a year of taking B vitamins recommended by my doctor for chronic fatigue syndrome, I noticed increased energy, improved sleep quality, and less irritability. Additionally, my nails became stronger and digestion regularised. I am very pleased with the results.
Read More
9
Stress resistance
3 people found this helpful
This vitamin B complex has noticeably enhanced my resistance to stress and improved brain function within just three days. My fatigue has decreased significantly, which is beneficial for my chronic fatigue syndrome. The quality and efficacy of these vitamins are commendable.
Read More
9
Wakes you up
2 people found this helpful
This vitamin offering is quite effective in reducing fatigue. It provides a wakefulness effect which has helped to alleviate my chronic fatigue syndrome significantly compared to other brands.
Read More

Frequently Asked Questions

9
Stress resistance
3 people found this helpful
This vitamin B complex has noticeably enhanced my resistance to stress and improved brain function within just three days. My fatigue has decreased significantly, which is beneficial for my chronic fatigue syndrome. The quality and efficacy of these vitamins are commendable.
7.5
Increased energy
211 people found this helpful
The bright yellow capsules are large but easy to swallow. After taking them for two months, I experienced increased energy, reduced irritability, and less mood fluctuation, which greatly helped with my chronic fatigue syndrome. I felt more strength to engage in activities and noticed a gradual improvement in my overall mood. It's important to take a break of six months after a two-month course.
9
Improved sleep
4 people found this helpful
After a year of taking B vitamins recommended by my doctor for chronic fatigue syndrome, I noticed increased energy, improved sleep quality, and less irritability. Additionally, my nails became stronger and digestion regularised. I am very pleased with the results.
7.5
Feeling better
2 people found this helpful
I've been taking Solgar B-Complex for three months to manage my chronic fatigue syndrome due to multiple sclerosis and I feel significantly better. It has positively impacted my energy levels.
9
Helps depression
These vitamins were recommended by my endocrinologist! I had complaints of chronic fatigue syndrome and depression. After taking them (along with vitamin D), I feel fantastic! I now have the energy to manage my household and children with ease.
6
Lack of effectiveness
1 people found this helpful
I’ve dealt with chronic fatigue syndrome and body tension for a long time. Despite taking various vitamin B supplements, I haven’t found them to be effective for muscular fatigue.
We examined the effects of vitamin B12 injections, combined with folic acid, on 38 patients with myalgic encephalomyelitis (ME), also known as chronic fatigue syndrome.

Participants were split into "Good" and "Mild" responders based on their improvement. Good responders reported greater progress with more frequent injections and higher doses of both supplements.

However, for Mild responders, the improvement was limited, suggesting that while there is potential for benefit, the response can vary widely among individuals. Overall, further investigation is needed to explore optimal treatment strategies.

References

  1. Regland B, Forsmark S, Halaouate L, Matousek M, Peilot B, et al. Response to vitamin B12 and folic acid in myalgic encephalomyelitis and fibromyalgia. PLoS One. 2015;10:e0124648. 10.1371/journal.pone.0124648
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