We investigated how benfotiamine might impact stomach ulcers in male rats. The study involved dividing 30 rats into groups receiving different treatments, including benfotiamine at varying doses, following the induction of ulcers using indomethacin.
Our results showed that benfotiamine notably decreased gastric damage and lowered inflammation markers. Specifically, doses of 100 and 200 mg/kg appeared to enhance antioxidant levels and reduce tissue damage.
However, while these findings are promising, more research is needed to fully understand the mechanisms at play and assess benfotiamine's potential for human treatment.
Read More
8
ImproWin® aids gastric ulcer healing
ImproWin® in the treatment of gastric ulceration of the squamous mucosa in trotting racehorses.
We aimed to determine if ImproWin®, a feed additive, could help improve gastric ulcers in Standardbred and Coldblooded trotting racehorses. By conducting a randomized, double-blinded study, we assessed horses' ulcers before and after three weeks of treatment.
Our results showed a significant reduction in ulcer scores for horses treated with ImproWin®, with 78% classified as responders compared to only 54.8% in the placebo group. This indicates that ImproWin® may be beneficial for aiding the healing of gastric ulcers in affected racehorses.
Read More
8
Folic acid has mixed effects
The dual modulatory effect of folic acid supplementation on indomethacin-induced gastropathy in the rat.
We examined how different doses of folic acid supplementation affect ulcer formation in rats. Male Wistar rats were treated with varying doses for 21 days while gastric ulcers were induced with indomethacin.
We found that a dose of 2 mg/kg significantly reduced gastric lesions, while a higher dose of 3 mg/kg unexpectedly worsened damage. Our results suggest that low doses of folic acid can be protective for the stomach, but high doses could pose risks.
Thus, it appears that moderation is key when considering folic acid for ulcer treatment.
Read More
Most Useful Reviews
9
Effectively treats ulcer
3 people found this helpful
Those suffering from stomach ulcers, mouth ulcers, and daily fatigue should consider this product. I was sceptical initially, but after using the socio-vitamin-non-complex along with Ginga Minggae's herbal supplements, it significantly improved my husband's mouth ulcers. The B vitamins here are especially effective; I highly recommend this, but be cautious as the pills are quite large!
Read More
9
Reduces oral ulcers
1 people found this helpful
Human metabolism requires the B vitamins. After taking them for a while, I no longer experience oral ulcers. The effect is impressive, and I plan to keep taking them.
Read More
9
No more ulcers
1 people found this helpful
I feel great! I've tried various supplements to prevent mouth ulcers with little success. Unexpectedly, I haven't had any since using this product, likely due to its abundant B vitamins. My trust in "Solgar" has definitely grown.
We analyzed the potential connection between folic acid supplementation and gastric ulcers using data from the UK Biobank and advanced statistical methods.
Our findings suggest that folic acid may significantly lower the risk of developing gastric ulcers.
Various robust models reinforced this result, showing consistent outcomes across different analyses.
Ultimately, this research provides genetic evidence supporting the idea that receiving folic acid therapy can be beneficial in reducing gastric ulcer risk.
Read More
9
Benfotiamine improves ulcer healing
The protective effect of benfotiamine on gastric ulcers in male rats: an experimental study.
We investigated how benfotiamine might impact stomach ulcers in male rats. The study involved dividing 30 rats into groups receiving different treatments, including benfotiamine at varying doses, following the induction of ulcers using indomethacin.
Our results showed that benfotiamine notably decreased gastric damage and lowered inflammation markers. Specifically, doses of 100 and 200 mg/kg appeared to enhance antioxidant levels and reduce tissue damage.
However, while these findings are promising, more research is needed to fully understand the mechanisms at play and assess benfotiamine's potential for human treatment.
Read More
9
Effective ulcer treatment in diabetes
Protective effect of Luffa acutangula extracts on gastric ulceration in NIDDM rats: role of gastric mucosal glycoproteins and antioxidants.
We explored the effects of Luffa acutangula extracts on gastric ulcers in diabetic rats. By inducing non-insulin dependent diabetes mellitus (NIDDM) and then creating gastric ulcers, we evaluated the extracts' potential for healing.
The results showed that the methanolic extract significantly boosted healing, improving protective mucosal glycoproteins and antioxidant levels. This was better than the aqueous extract and standard treatments.
Overall, Luffa acutangula appears to offer promising support for treating gastric ulcers in diabetes, highlighting its dual action in managing both conditions.
Read More
9
Effective treatment for oral ulcers
Clinical Evaluation and Therapeutic Effects of Combination Treatment with Mecobalamin + Vitamin E in Recurrent Oral Ulcer.
We explored the effectiveness of mecobalamin and vitamin E in treating recurrent oral ulcers. In a study with 58 patients, those receiving both treatments showed significantly improved healing times and reduced symptoms compared to the control group. They experienced longer periods without ulcer flare-ups and better quality of life scores. Both groups felt pain relief, but the test group had more noticeable benefits. This finding suggests that mecobalamin and vitamin E can be a valuable addition to ulcer treatment, enhancing both comfort and recovery.
Read More
8
ImproWin® aids gastric ulcer healing
ImproWin® in the treatment of gastric ulceration of the squamous mucosa in trotting racehorses.
We aimed to determine if ImproWin®, a feed additive, could help improve gastric ulcers in Standardbred and Coldblooded trotting racehorses. By conducting a randomized, double-blinded study, we assessed horses' ulcers before and after three weeks of treatment.
Our results showed a significant reduction in ulcer scores for horses treated with ImproWin®, with 78% classified as responders compared to only 54.8% in the placebo group. This indicates that ImproWin® may be beneficial for aiding the healing of gastric ulcers in affected racehorses.
Those suffering from stomach ulcers, mouth ulcers, and daily fatigue should consider this product. I was sceptical initially, but after using the socio-vitamin-non-complex along with Ginga Minggae's herbal supplements, it significantly improved my husband's mouth ulcers. The B vitamins here are especially effective; I highly recommend this, but be cautious as the pills are quite large!
Read More
9
Reduces oral ulcers
1 people found this helpful
Human metabolism requires the B vitamins. After taking them for a while, I no longer experience oral ulcers. The effect is impressive, and I plan to keep taking them.
Read More
9
No more ulcers
1 people found this helpful
I feel great! I've tried various supplements to prevent mouth ulcers with little success. Unexpectedly, I haven't had any since using this product, likely due to its abundant B vitamins. My trust in "Solgar" has definitely grown.
Read More
9
Less frequent ulcers
Vitamin B helps reduce mouth ulcers! I tended to get them easily and often felt fatigued. Since starting this, I'm getting fewer ulcers and have come to realise the importance of vitamin B. The ingredients are excellent!
Read More
9
Immediate effect
This B complex product delivered immediate results. I frequently suffered from mouth ulcers. The high-quality ingredients made a noticeable difference. I consider it essential to my supplements.
An ulcer is a sore that develops on the lining of the stomach, small intestine, or colon. It occurs when the digestive tract is damaged or inflamed, often due to an imbalance between stomach acid and the protective factors in the digestive system. The most common types of ulcers include peptic ulcers, which can be further categorized into gastric ulcers (located in the stomach) and duodenal ulcers (found in the first part of the small intestine). Symptoms may include burning stomach pain, bloating, and nausea, which can vary in intensity based on the severity of the condition.
Vitamin B Complex refers to a group of water-soluble vitamins that play important roles in cell metabolism and overall health. This group typically includes eight essential vitamins: B1 (thiamine), B2 (riboflavin), B3 (niacin), B5 (pantothenic acid), B6 (pyridoxine), B7 (biotin), B9 (folate), and B12 (cobalamin). Each of these vitamins contributes uniquely to various bodily functions, such as energy production, red blood cell formation, and nervous system function. For instance, B12 and folate are crucial in preventing anemia, while B6 is vital for brain development and function.
Many people can obtain their daily requirements of B vitamins through a balanced diet that includes whole grains, meats, eggs, nuts, leafy greens, and dairy products. However, certain groups—like vegetarians, pregnant women, and older adults—may benefit from supplementation to meet their nutritional needs. It's important to consult with a healthcare professional before starting any supplement regimen, as excessive intake of certain B vitamins can lead to adverse effects. Overall, ensuring adequate intake of Vitamin B Complex is vital for maintaining energy levels and supporting overall health.
Based on user reviews, the timeline for seeing results from this supplement for ulcers varies, but many users report positive effects relatively quickly. Some users, for example, have noted immediate relief or significant improvement within just a couple of days to a week after starting the supplement. One user highlighted that they experienced pain relief after just two doses when using it for mouth ulcers Read Review. Another user explicitly mentioned that their ulcers had noticeably reduced within a short timeframe of use Read Review.
While some users experience rapid results, others have indicated a longer duration before significant effects are felt, suggesting a few weeks of consistent use might be necessary to achieve optimal benefits. For instance, users who previously relied on other B complex supplements found this product to be more effective over time, indicating an ongoing positive impact on their ulcer management Read Review. Overall, the consensus seems to be that most users begin to notice improvements within a week, but individual experiences may differ.
Based on the available research, certain supplements show promise in supporting gastric ulcers. Notably, folic acid has been linked to a reduced risk of developing ulcers in several studies. A prominent investigation leveraging data from the UK Biobank indicates that folic acid may significantly lower the risk of gastric ulcers, suggesting its protective benefits in gastric health [1]. Furthermore, another study examining its effects in rats demonstrated that low doses of folic acid were effective in reducing gastric lesions, highlighting its potential as a protective agent against ulcer formation [4].
On the other hand, benfotiamine, a derivative of thiamine, showcased potential benefits in animal studies, where it notably decreased gastric damage and inflammation markers in rats [2]. Other substances like nicotinamide have also been shown to provide significant protection against gastric lesions, likely due to their ability to promote gastric mucus conservation and antioxidant activity [6]. While these findings are encouraging, it’s essential to approach supplementation for ulcers with caution and consult with a healthcare provider, especially given that some supplements may require specific dosing to avoid adverse effects.
Many users have reported significant improvements in their symptoms after using this B complex supplement, particularly for mouth ulcers. Notably, one user mentioned that after integrating this product into their routine, they experienced no oral ulcers for an extended period, attributing this success to the product's rich B vitamin content Read Review. Others have expressed similar sentiments, highlighting that their frequency of mouth ulcers has diminished, with one individual noting an impressive reduction that encouraged continued use Read Review.
Additionally, some users have experienced relatively quick relief, with one user claiming that their mouth ulcer pain was soothed after just two doses of the supplement, illustrating the potential for rapid improvement Read Review. There's a consensus among users that not only have their ulcer symptoms improved, but they also feel an overall enhancement in their well-being, with reduced fatigue being a common theme Read Review. While these anecdotal experiences largely lean towards positive outcomes, it is essential to remember that individual results can vary and what works for one person may not necessarily apply to another.
Users report positive experiences when combining this B complex supplement with other supplements for managing ulcers. One user noted that integrating the product with herbal supplements like Ginga Minggae significantly improved their husband's mouth ulcers, suggesting enhanced effectiveness when used together Read Review. Similarly, another user mentioned that the supplement helped soothe mouth ulcer pain quickly when taken alongside a product called "immune 4" Read Review.
Additionally, some users have found that combining this B complex supplement with other vitamins, such as vitamin C and iron, has also yielded impressive results. One reviewer stated that since beginning this regimen, they have been free from recurrent mouth ulcers, indicating a positive synergistic effect Read Review. Overall, these user reviews suggest that the B complex supplement may work well in conjunction with other dietary supplements, enhancing their collective benefits for ulcer management.
Based on user reviews, many individuals have found Vitamin B Complex to be beneficial in reducing the frequency and severity of mouth ulcers. Specific doses were not referenced, but users indicated that consistent use of B vitamins has resulted in noticeable improvements in their conditions. For instance, one user stated, "Since I started this supplement, I’m less prone to mouth ulcers," highlighting the potential effectiveness of regular intake (Read Review). Another mentioned immediate results, contributing to their decision to view this complex as essential for oral health (Read Review).
Additionally, several reviews suggest that users feel empowered by incorporating B vitamins into their regimen, with anecdotal evidence pointing towards reduced occurrences of ulcers. For example, one reviewer noted an impressive effect on their symptoms after consistent use, stating they "no longer experience oral ulcers" after incorporating Vitamin B into their routine (Read Review). While specific dosages were not explicitly mentioned in the reviews, it is clear that incorporating B Complex into a daily health routine is seen as valuable by many users for managing their ulcer symptoms.
7.5
Soothes ulcer pain
This product helped soothe my mouth ulcer pain after just two doses, especially when combined with “immune 4”.
9
Immediate effect
This B complex product delivered immediate results. I frequently suffered from mouth ulcers. The high-quality ingredients made a noticeable difference. I consider it essential to my supplements.
9
Effective prevention
I find this product beneficial. I previously took Solgar B Complex 50 for my frequent stomatitis, but this seems more effective, reducing the number of mouth ulcers. I intend to keep using it.
9
No more ulcers
1 people found this helpful
I feel great! I've tried various supplements to prevent mouth ulcers with little success. Unexpectedly, I haven't had any since using this product, likely due to its abundant B vitamins. My trust in "Solgar" has definitely grown.
9
Reduces oral ulcers
1 people found this helpful
Human metabolism requires the B vitamins. After taking them for a while, I no longer experience oral ulcers. The effect is impressive, and I plan to keep taking them.
9
Less frequent ulcers
Vitamin B helps reduce mouth ulcers! I tended to get them easily and often felt fatigued. Since starting this, I'm getting fewer ulcers and have come to realise the importance of vitamin B. The ingredients are excellent!
9
Effectively treats ulcer
3 people found this helpful
Those suffering from stomach ulcers, mouth ulcers, and daily fatigue should consider this product. I was sceptical initially, but after using the socio-vitamin-non-complex along with Ginga Minggae's herbal supplements, it significantly improved my husband's mouth ulcers. The B vitamins here are especially effective; I highly recommend this, but be cautious as the pills are quite large!
9
No more ulcers
I take a mix of vitamin C, iron, and other supplements from the same manufacturer. The capsules are quite large and initially difficult to swallow, but I've grown accustomed to it. Since beginning this regimen, I've been free from the cracked corners of my mouth and ulcers I often experienced in autumn and winter. Vitamin B complex is truly important!
7.5
Prevents mouth ulcers
Since I started this supplement, I'm less prone to mouth ulcers. It's effective for skin issues too. I believe it's a valuable addition to my regimen.
9.5
Folic acid may reduce ulcers
Causal association of folic acid supplementary therapy and gastric ulcer: a Mendelian randomisation study.
We analyzed the potential connection between folic acid supplementation and gastric ulcers using data from the UK Biobank and advanced statistical methods.
Our findings suggest that folic acid may significantly lower the risk of developing gastric ulcers.
Various robust models reinforced this result, showing consistent outcomes across different analyses.
Ultimately, this research provides genetic evidence supporting the idea that receiving folic acid therapy can be beneficial in reducing gastric ulcer risk.
8
Folic acid has mixed effects
The dual modulatory effect of folic acid supplementation on indomethacin-induced gastropathy in the rat.
We examined how different doses of folic acid supplementation affect ulcer formation in rats. Male Wistar rats were treated with varying doses for 21 days while gastric ulcers were induced with indomethacin.
We found that a dose of 2 mg/kg significantly reduced gastric lesions, while a higher dose of 3 mg/kg unexpectedly worsened damage. Our results suggest that low doses of folic acid can be protective for the stomach, but high doses could pose risks.
Thus, it appears that moderation is key when considering folic acid for ulcer treatment.
9
Benfotiamine improves ulcer healing
The protective effect of benfotiamine on gastric ulcers in male rats: an experimental study.
We investigated how benfotiamine might impact stomach ulcers in male rats. The study involved dividing 30 rats into groups receiving different treatments, including benfotiamine at varying doses, following the induction of ulcers using indomethacin.
Our results showed that benfotiamine notably decreased gastric damage and lowered inflammation markers. Specifically, doses of 100 and 200 mg/kg appeared to enhance antioxidant levels and reduce tissue damage.
However, while these findings are promising, more research is needed to fully understand the mechanisms at play and assess benfotiamine's potential for human treatment.
8
Nicotinamide shows ulcer protection
Nicotinamide alleviates indomethacin-induced gastric ulcers: a novel antiulcer agent.
We explored the effects of nicotinamide on gastric ulcers caused by indomethacin in a laboratory setting. Using a well-established model, we compared the treatment of nicotinamide with sucralfate, a known antiulcer drug.
Our findings revealed that nicotinamide significantly reduced the severity of gastric lesions. It also helped restore vital biochemical parameters affected by the ulcer-inducing drug.
The protective effect of nicotinamide appears to stem from its ability to conserve gastric mucus and nitric oxide, improve gastric microvascular permeability, and exert antioxidant actions.
References
Li F, Huang F, Tang Y, Zhang F, Jiang H, et al. Causal association of folic acid supplementary therapy and gastric ulcer: a Mendelian randomisation study. Br J Nutr. 2024;132:1348. doi:10.1017/S0007114524002368
Shokati Sayyad M, Khanjani MH, Amirbeik M, Seyedabadi M, Talebpour Amiri F, et al. The protective effect of benfotiamine on gastric ulcers in male rats: an experimental study. J Mol Histol. 2024;55:863. doi:10.1007/s10735-024-10237-x
Hellings IR, Larsen S. ImproWin® in the treatment of gastric ulceration of the squamous mucosa in trotting racehorses. Acta Vet Scand. 2014;56:13. doi:10.1186/1751-0147-56-13
Ajeigbe K, Oladejo E, Emikpe B, Asuk A, Olaleye S. The dual modulatory effect of folic acid supplementation on indomethacin-induced gastropathy in the rat. Turk J Gastroenterol. 2012;23:639.
Pimple BP, Kadam PV, Patil MJ. Protective effect of Luffa acutangula extracts on gastric ulceration in NIDDM rats: role of gastric mucosal glycoproteins and antioxidants. Asian Pac J Trop Med. 2012;5:610. doi:10.1016/S1995-7645(12)60126-6
Cui J, Lin W, Ma X, Wang J. Clinical Evaluation and Therapeutic Effects of Combination Treatment with Mecobalamin + Vitamin E in Recurrent Oral Ulcer. Clin Ther. 2022;44:123. doi:10.1016/j.clinthera.2021.10.015