We focused on a case of pernicious anemia in a 51-year-old Ugandan man who presented with recurring lower limb weakness. After initial treatment for vitamin B12 deficiency years ago and further testing, we confirmed his diagnosis of pernicious anemia marked by low cobalamin levels. Thanks to timely parenteral methylcobalamin therapy, he showed improvement. This case underscores the importance of recognizing vitamin B12 deficiency, especially in rural and resource-limited settings, to address neurological symptoms quickly.
Read More
8
Pernicious anemia misdiagnosed as fibromyalgia
A long-standing undiagnosed case of vitamin B12 deficiency: a case report.
We explored a notable case of a woman suffering from pernicious anemia, an autoimmune condition that can be misdiagnosed due to its vague symptoms like fatigue and cognitive issues.
After years of struggling with these nonspecific symptoms, her low vitamin B12 levels were finally identified as the underlying cause.
Upon receiving treatment with vitamin B12, she experienced neurological improvements, highlighting the importance of recognizing this deficiency, even when traditional anemia indicators are absent.
Read More
8
Nicotinamide suppresses autoimmune activation
Nicotinamide Suppresses Hyperactivation of Dendritic Cells to Control Autoimmune Disease through PARP Dependent Signaling.
We explored the influence of Nicotinamide (NAM), a form of vitamin B3, on dendritic cells (DCs) in autoimmune diseases. Our research indicates that NAM can effectively reduce the overactivation of DCs, helping to ease symptoms in conditions like psoriasis.
Through detailed analysis of available studies, we found that NAM affects DCs via a specific signaling pathway, ultimately offering a potential new direction for treatment. Importantly, these findings highlight NAM’s significant role in managing autoimmune disorders related to immune response regulation.
Read More
Most Useful Reviews
9
Nervous system support
125 people found this helpful
I ordered children's B vitamins to strengthen my nervous system. This complex stabilises my emotional state, improves my mood, and provides extra energy. It’s from a reliable manufacturer. I take it in the morning; the capsules are small and easy to swallow, and while there is a smell, it does not bother me.
Read More
9
Energy boost
121 people found this helpful
These B vitamins are effective! After switching to a vegan, gluten-free diet, my B12 levels dropped significantly. On the advice of my doctor, I tried Solgar, which truly helped me. I felt more energetic from the third day of use, and my sleep improved. While I did experience tachycardia initially, it soon faded. Overall, I recommend these vitamins for managing autoimmune disorder symptoms.
Read More
9
Nervousness relief
6 people found this helpful
I didn't expect the results from this vitamin; however, after taking the first pill, my fatigue, anxiety, and nervousness subsided. I take it during stressful periods and find it essential for managing my autoimmune disorder symptoms. I wholeheartedly recommend these vitamins.
We explored three cases of biotinidase deficiency (BTD) that were misdiagnosed as neuromyelitis optica spectrum disorder (NMOSD) due to similar symptoms and neuroimaging results. Initially, two patients responded to immune therapy but later relapsed, while one showed no improvement. Interestingly, after timely diagnosis and biotin supplementation, two patients exhibited remarkable recoveries in both motor function and vision. This highlights the critical need for accurate diagnosis, as early treatment of BTD can lead to significant improvements.
Read More
8
Pernicious anemia misdiagnosed as fibromyalgia
A long-standing undiagnosed case of vitamin B12 deficiency: a case report.
We explored a notable case of a woman suffering from pernicious anemia, an autoimmune condition that can be misdiagnosed due to its vague symptoms like fatigue and cognitive issues.
After years of struggling with these nonspecific symptoms, her low vitamin B12 levels were finally identified as the underlying cause.
Upon receiving treatment with vitamin B12, she experienced neurological improvements, highlighting the importance of recognizing this deficiency, even when traditional anemia indicators are absent.
Read More
8
Pernicious anemia case in Uganda
Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report.
We focused on a case of pernicious anemia in a 51-year-old Ugandan man who presented with recurring lower limb weakness. After initial treatment for vitamin B12 deficiency years ago and further testing, we confirmed his diagnosis of pernicious anemia marked by low cobalamin levels. Thanks to timely parenteral methylcobalamin therapy, he showed improvement. This case underscores the importance of recognizing vitamin B12 deficiency, especially in rural and resource-limited settings, to address neurological symptoms quickly.
Read More
8
Nicotinamide suppresses autoimmune activation
Nicotinamide Suppresses Hyperactivation of Dendritic Cells to Control Autoimmune Disease through PARP Dependent Signaling.
We explored the influence of Nicotinamide (NAM), a form of vitamin B3, on dendritic cells (DCs) in autoimmune diseases. Our research indicates that NAM can effectively reduce the overactivation of DCs, helping to ease symptoms in conditions like psoriasis.
Through detailed analysis of available studies, we found that NAM affects DCs via a specific signaling pathway, ultimately offering a potential new direction for treatment. Importantly, these findings highlight NAM’s significant role in managing autoimmune disorders related to immune response regulation.
Read More
7
Vitamin B may indicate GBS severity
Correlation of Serum Vitamin B and Muscle Enzyme (CK-NAC) Level with Severity of Guillain-Barre Syndrome and Its Prediction in Respiratory Failure.
We aimed to see if vitamin B levels could signal the severity of Guillain-Barré syndrome (GBS) and its potential for complications like respiratory failure. Our study involved 50 GBS patients, where we examined their vitamin B and creatine kinase levels alongside their motor abilities.
Interestingly, we found that 44% of patients had low vitamin B levels, which linked strongly to GBS severity. However, while vitamin B showed predictive value, the creatine kinase levels did not relate to GBS severity.
Read More
User Reviews
USERS' SCORE
Good
Based on 16 Reviews
8.6
All Reviews
Positive Reviews
Negative Reviews
9
Nervous system support
125 people found this helpful
I ordered children's B vitamins to strengthen my nervous system. This complex stabilises my emotional state, improves my mood, and provides extra energy. It’s from a reliable manufacturer. I take it in the morning; the capsules are small and easy to swallow, and while there is a smell, it does not bother me.
Read More
9
Energy boost
121 people found this helpful
These B vitamins are effective! After switching to a vegan, gluten-free diet, my B12 levels dropped significantly. On the advice of my doctor, I tried Solgar, which truly helped me. I felt more energetic from the third day of use, and my sleep improved. While I did experience tachycardia initially, it soon faded. Overall, I recommend these vitamins for managing autoimmune disorder symptoms.
Read More
9
Nervousness relief
6 people found this helpful
I didn't expect the results from this vitamin; however, after taking the first pill, my fatigue, anxiety, and nervousness subsided. I take it during stressful periods and find it essential for managing my autoimmune disorder symptoms. I wholeheartedly recommend these vitamins.
Read More
9
Dietary supplement
2 people found this helpful
I've used B vitamins before, but these are effective on my low-carb diet. Without them, I became anxious and craved sweets. I suggest these vitamins if you experience cravings. After three months, I even noticed my husband's snoring stopped. They’ve been beneficial for my autoimmune disorder.
Read More
9
Significant improvement
2 people found this helpful
I took this B vitamin complex following a doctor’s recommendation due to a detected deficiency related to my autoimmune disorder. The vitamins have worked wonders; my health has improved, and test results showed a significant increase in vitamin B levels after use. Highly recommended for those with similar needs!
An autoimmune disorder occurs when the body's immune system mistakenly attacks its own healthy cells and tissues, believing them to be foreign invaders, such as bacteria or viruses. This reaction can lead to inflammation, tissue damage, and impaired function of the affected organs. There are over 80 known autoimmune diseases, including rheumatoid arthritis, lupus, multiple sclerosis, and type 1 diabetes, each with its own specific symptoms and treatment options. The exact cause of these disorders is still unclear, but a combination of genetic, environmental, and hormonal factors is believed to play a role in their development.
Diagnosis of autoimmune disorders often involves a combination of physical examinations, assessment of symptoms, blood tests, and imaging studies to evaluate organ involvement. Treatment typically focuses on managing symptoms and controlling the immune response using medications such as corticosteroids, immunosuppressants, and biologics. In addition to medication, lifestyle modifications, such as stress management and a balanced diet, can be beneficial in managing symptoms. If you suspect you have an autoimmune condition, it's important to consult a healthcare professional for proper evaluation and tailored treatment options.
Vitamin B Complex refers to a group of water-soluble vitamins that play important roles in cell metabolism and overall health. This group typically includes eight essential vitamins: B1 (thiamine), B2 (riboflavin), B3 (niacin), B5 (pantothenic acid), B6 (pyridoxine), B7 (biotin), B9 (folate), and B12 (cobalamin). Each of these vitamins contributes uniquely to various bodily functions, such as energy production, red blood cell formation, and nervous system function. For instance, B12 and folate are crucial in preventing anemia, while B6 is vital for brain development and function.
Many people can obtain their daily requirements of B vitamins through a balanced diet that includes whole grains, meats, eggs, nuts, leafy greens, and dairy products. However, certain groups—like vegetarians, pregnant women, and older adults—may benefit from supplementation to meet their nutritional needs. It's important to consult with a healthcare professional before starting any supplement regimen, as excessive intake of certain B vitamins can lead to adverse effects. Overall, ensuring adequate intake of Vitamin B Complex is vital for maintaining energy levels and supporting overall health.
Based on user reviews, individuals taking this B vitamin complex for managing symptoms of autoimmune disorders typically report seeing results within a few days to a few weeks of use. For example, one user felt a boost in energy and improved sleep just three days after starting the supplement Read Review. Another user noted significant improvements in mood and energy levels within three weeks Read Review.
However, some users experienced no immediate improvements and expressed that it might take longer to feel the benefits, with one reviewer mentioning a lack of results after six weeks Read Review. Overall, while many users report feeling the effects fairly quickly, individual experiences may vary, and it is not uncommon for some to take longer to notice changes.
Research indicates that certain B vitamins may have significant implications for those dealing with autoimmune disorders. For instance, a study highlighted the importance of recognizing vitamin B12 deficiency in patients with pernicious anemia, an autoimmune condition. When this deficiency was identified and treated, the patient experienced neurological improvements, underscoring the critical role of vitamin B12 in managing autoimmune symptoms [2]. Additionally, in a study on Guillain-Barré syndrome, nearly half of the patients exhibited low vitamin B levels, which were linked to the severity of their condition [1].
Moreover, vitamin B3, specifically Nicotinamide (NAM), showed promise in managing autoimmune diseases by reducing the overactivation of dendritic cells, potentially easing symptoms in conditions such as psoriasis. This suggests that NAM may offer new avenues for treatment in autoimmune disorders [4]. Overall, the evidence points towards a beneficial role for specific B vitamins in understanding and potentially managing autoimmune conditions, although further research is necessary to fully establish their therapeutic efficacy.
Based on user reviews, many individuals have reported significant improvements in symptoms associated with autoimmune disorders after taking this B vitamin complex. Users often mention a boost in energy levels and improved mood, with one person noting a marked reduction in fatigue, anxiety, and nervousness right after the first dose Read Review. Another reviewer experienced relief from severe knee pain and nerve pinching within days, highlighting the supplement’s efficacy in alleviating physical discomfort Read Review.
Additionally, users have praised the B vitamins for promoting better sleep and providing support for the nervous system. One individual reported their hair loss issue resolved within weeks of starting the supplement, attributing it to the vitamins’ effectiveness in managing symptoms post-breastfeeding Read Review. However, individual results can vary, as some users expressed that they did not observe benefits after several weeks of use Read Review. Overall, while many commend the product for its positive impact, it is important to remember that experiences may differ based on personal health conditions and needs.
Based on user reviews, many individuals with autoimmune disorders have reported positive experiences when combining this B vitamin complex with other supplements. For instance, one user shared their success in using the vitamins alongside melatonin, noting that it enhanced their husband's ability to achieve restful sleep after a long day, while also helping him to unwind after stress Read Review. Another review highlighted the effectiveness of the vitamins in stabilizing emotional states, particularly when taken during stressful periods, suggesting a synergistic effect in managing symptoms of autoimmunity Read Review.
Additionally, users appreciated the multifaceted benefits of the B vitamin complex, with one individual noting improvements in anxiety and energy levels as well as a reduction in fatigue after incorporating it into their regimen Read Review. Importantly, some users emphasized the role of these vitamins in supporting overall health and addressing deficiencies associated with their autoimmune conditions, which further supports the notion that this supplement may be beneficial when used in conjunction with other treatments Read Review. Overall, while combining this B vitamin complex with other supplements can provide added benefits for managing autoimmune disorders, user experiences indicate that results may vary based on individual health needs.
Users report positive experiences with Vitamin B Complex in managing symptoms associated with autoimmune disorders. Several reviews highlighted the importance of dosage, with many users following doctor's recommendations for optimal results. For instance, one user noted a significant improvement in energy levels and mood after taking the complex for just a few days, indicating it was effective even at lower doses (Read Review). Another user mentioned that they would increase the dosage to 150 mg based on the results they observed in their children with cerebral palsy, suggesting that adjustments to dosage can be beneficial (Read Review).
However, not all users experienced immediate improvement. One commenter mentioned they did not notice any effects after a month and planned to continue taking the vitamins, suggesting that some users may need longer to adjust to the appropriate dose (Read Review). Overall, personal experiences vary, but many users advocate for starting with a standard dose as advised by healthcare professionals and adjusting as needed based on individual responses.
9
Energy boost
121 people found this helpful
These B vitamins are effective! After switching to a vegan, gluten-free diet, my B12 levels dropped significantly. On the advice of my doctor, I tried Solgar, which truly helped me. I felt more energetic from the third day of use, and my sleep improved. While I did experience tachycardia initially, it soon faded. Overall, I recommend these vitamins for managing autoimmune disorder symptoms.
7.5
Restored calmness
7 people found this helpful
I purchased this complex on my doctor’s recommendation to restore my nervous system. After three weeks, my hair stopped falling out, and I noticed an improvement in my mood and energy. My skin also looks healthier now. I’m very pleased with the results of this product in managing my autoimmune disorder.
2
No soothing effect
I’ve been taking this vitamin complex for one and a half months hoping to relieve my autoimmune disorder symptoms, specifically for soothing effects, but there has been no improvement so far. I plan to continue taking it, as I’ve read it may take longer to see results.
9
Nervousness relief
6 people found this helpful
I didn't expect the results from this vitamin; however, after taking the first pill, my fatigue, anxiety, and nervousness subsided. I take it during stressful periods and find it essential for managing my autoimmune disorder symptoms. I wholeheartedly recommend these vitamins.
8
Quick relief
A B vitamin complex is essential for treating my autoimmune disorder and various discomforts. It alleviated severe knee pain and nerve pinching within days. Whenever my neck pain flares up, I take this, and relief follows swiftly. It aids in joint and back issues too. I also give it to my husband with melatonin for restful sleep after a long day, helping him calm down post-stress.
9
Hair health
1 people found this helpful
After finishing breastfeeding, my hair began to fall out significantly. This B vitamin complex quickly resolved the issue, stopping the hair loss in weeks. It also helps support my nervous system. I will order more and highly recommend it for treating conditions related to autoimmune disorders.
9
Significant improvement
2 people found this helpful
I took this B vitamin complex following a doctor’s recommendation due to a detected deficiency related to my autoimmune disorder. The vitamins have worked wonders; my health has improved, and test results showed a significant increase in vitamin B levels after use. Highly recommended for those with similar needs!
7.5
Improved endurance
8 people found this helpful
I'm very satisfied with this product! I've seen positive results after giving it to my children with cerebral palsy. They've shown increased endurance and a reduction in sensitivity to the weather. I plan to increase the dosage to 150 mg during future orders. I highly recommend it!
8
Pernicious anemia misdiagnosed as fibromyalgia
A long-standing undiagnosed case of vitamin B12 deficiency: a case report.
We explored a notable case of a woman suffering from pernicious anemia, an autoimmune condition that can be misdiagnosed due to its vague symptoms like fatigue and cognitive issues.
After years of struggling with these nonspecific symptoms, her low vitamin B12 levels were finally identified as the underlying cause.
Upon receiving treatment with vitamin B12, she experienced neurological improvements, highlighting the importance of recognizing this deficiency, even when traditional anemia indicators are absent.
7
Vitamin B may indicate GBS severity
Correlation of Serum Vitamin B and Muscle Enzyme (CK-NAC) Level with Severity of Guillain-Barre Syndrome and Its Prediction in Respiratory Failure.
We aimed to see if vitamin B levels could signal the severity of Guillain-Barré syndrome (GBS) and its potential for complications like respiratory failure. Our study involved 50 GBS patients, where we examined their vitamin B and creatine kinase levels alongside their motor abilities.
Interestingly, we found that 44% of patients had low vitamin B levels, which linked strongly to GBS severity. However, while vitamin B showed predictive value, the creatine kinase levels did not relate to GBS severity.
8
Nicotinamide suppresses autoimmune activation
Nicotinamide Suppresses Hyperactivation of Dendritic Cells to Control Autoimmune Disease through PARP Dependent Signaling.
We explored the influence of Nicotinamide (NAM), a form of vitamin B3, on dendritic cells (DCs) in autoimmune diseases. Our research indicates that NAM can effectively reduce the overactivation of DCs, helping to ease symptoms in conditions like psoriasis.
Through detailed analysis of available studies, we found that NAM affects DCs via a specific signaling pathway, ultimately offering a potential new direction for treatment. Importantly, these findings highlight NAM’s significant role in managing autoimmune disorders related to immune response regulation.
References
Jatav VS, Sardana V, Bhushan B, Maheshwari D, Garg S, et al. Correlation of Serum Vitamin B and Muscle Enzyme (CK-NAC) Level with Severity of Guillain-Barre Syndrome and Its Prediction in Respiratory Failure. J Assoc Physicians India. 2025;73:48. 10.59556/japi.73.0892
Mesgarankarimi A, Rezapour M, Tabrizi N. A long-standing undiagnosed case of vitamin B12 deficiency: a case report. J Med Case Rep. 2025;19:151. 10.1186/s13256-025-05149-7
Mswelo VE, David MM, Banturaki A, Munyambalu DK, Hassan HA, et al. Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report. J Med Case Rep. 2025;19:60. 10.1186/s13256-025-05095-4
Cao AP, Wang YY, Shen YY, Liu YH, Liu JY, et al. Nicotinamide Suppresses Hyperactivation of Dendritic Cells to Control Autoimmune Disease through PARP Dependent Signaling. Nutrients. 2024;16. 10.3390/nu16162665
Ali F, Mukhtiar K, Raza M, Ibrahim S. Atypical presentation of biotinidase deficiency: masquerading neuromyelitis optica spectrum disorder. BMJ Case Rep. 2024;17. 10.1136/bcr-2023-258703