Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8
USERS' SCORE
Moderately Good
Based on 17 Reviews
7.4
Supplement Facts
Serving Size: 1 Vegetable Capsule
Amount Per Serving
%DV
Thiamin (vitamin B1) (as thiamine mononitrate)
50 mcg
4,167%
Riboflavin (vitamin B2)
50 mg
3,846%
Niacin (vitamin B3) (as niacinamide)
50 mg
313%
Vitamin B6 (as pyridoxine HCl)
50 mg
2,941%
Folate
666 mcg DFE(400 mcg folic acid)
167%
Vitamin B12 (as cyanocobalamin)
50 mcg
2,083%
Biotin (as D-biotin)
50 mcg
167%
Pantothenic Acid (vitamin B5) (as D-ca pantothenate)
50 mg
1,000%
Choline (as choline bitartrate)
21 mg
4%
Inositol
50 mg
**
Herbal Powdered Blend(kelp [plant] , acerola extract complex [fruit], alfalfa [leaf and stem], parsley [leaf], rose hips [fruit], watercress [herb])
3.5 mg
**
Top Medical Research Studies
9
We investigated how vitamin B6 supports heart recovery after heart attacks by promoting new blood vessel growth, known as angiogenesis. In laboratory tests, vitamin B6 improved cell migration and tubule formation, vital for forming new blood vessels.
Remarkably, long-term vitamin B6 supplementation showed significant improvements in heart function and reduced inflammation in mice following heart attacks. This suggests that vitamin B6 could be a beneficial aid for heart recovery, harnessing a specific pathway involving a protein called AMPK.
Remarkably, long-term vitamin B6 supplementation showed significant improvements in heart function and reduced inflammation in mice following heart attacks. This suggests that vitamin B6 could be a beneficial aid for heart recovery, harnessing a specific pathway involving a protein called AMPK.
Read More
8
Folate slows artery thickness increase
We examined the link between folate and vitamin B12 levels and changes in carotid intima-media thickness (cIMT), a marker of early heart disease, over eight years in a group of 5061 adults in Brazil.
Our results suggest that higher serum folate levels are associated with a slower increase in cIMT, indicating a potential protective effect against heart disease.
However, no such benefit was observed with vitamin B12 levels. This implies that while folate may play a role in cardiovascular health, vitamin B12 might not have the same impact.
Our results suggest that higher serum folate levels are associated with a slower increase in cIMT, indicating a potential protective effect against heart disease.
However, no such benefit was observed with vitamin B12 levels. This implies that while folate may play a role in cardiovascular health, vitamin B12 might not have the same impact.
Read More
8
We explored how specific gene-nutrient interactions affect high blood pressure using data from the Korean Genome and Epidemiology Study, which included over 50,000 participants.
Our findings revealed that individuals with a certain genetic variant showed a lower risk of hypertension when consuming higher amounts of dietary iron and vitamin B6.
This suggests that for some individuals, adjusting their diet could help mitigate hypertension risks.
However, further research is needed to confirm these results across different populations to ensure wider applicability.
Our findings revealed that individuals with a certain genetic variant showed a lower risk of hypertension when consuming higher amounts of dietary iron and vitamin B6.
This suggests that for some individuals, adjusting their diet could help mitigate hypertension risks.
However, further research is needed to confirm these results across different populations to ensure wider applicability.
Read More
Most Useful Reviews
9
Improved mood
7 people found this helpful
I took this for my 78-year-old mother on her doctor's advice for cardiovascular disease. We were amazed at the results! She overcame autumn depression and fatigue, regained her energy, and now walks for two hours daily, feeling cheerful and free from joint pain. Solgar is impressive!
Read More
9
Improved mood
B-complex "50" by Solgar contains all eight B vitamins vital for health, particularly in fat, carbohydrate, and protein metabolism. They aid in transforming nutrients into energy, maintaining the health of the cardiovascular system and nervous system, and forming red blood cells. After a month’s usage, I noticed improved mood and reduced irritability.
Read More
7.5
Supports immune health
25 people found this helpful
An additional source of B vitamins. They support emotional health, help manage stress and improve the immune system's resistance to diseases. Every healthy person should consider taking them annually. The dosage is large, but since these are water-soluble vitamins, the body absorbs what it needs and excretes the rest. No adverse reactions were experienced.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8
- All Researches
9
We investigated how vitamin B6 supports heart recovery after heart attacks by promoting new blood vessel growth, known as angiogenesis. In laboratory tests, vitamin B6 improved cell migration and tubule formation, vital for forming new blood vessels.
Remarkably, long-term vitamin B6 supplementation showed significant improvements in heart function and reduced inflammation in mice following heart attacks. This suggests that vitamin B6 could be a beneficial aid for heart recovery, harnessing a specific pathway involving a protein called AMPK.
Remarkably, long-term vitamin B6 supplementation showed significant improvements in heart function and reduced inflammation in mice following heart attacks. This suggests that vitamin B6 could be a beneficial aid for heart recovery, harnessing a specific pathway involving a protein called AMPK.
Read More
8
We explored how specific gene-nutrient interactions affect high blood pressure using data from the Korean Genome and Epidemiology Study, which included over 50,000 participants.
Our findings revealed that individuals with a certain genetic variant showed a lower risk of hypertension when consuming higher amounts of dietary iron and vitamin B6.
This suggests that for some individuals, adjusting their diet could help mitigate hypertension risks.
However, further research is needed to confirm these results across different populations to ensure wider applicability.
Our findings revealed that individuals with a certain genetic variant showed a lower risk of hypertension when consuming higher amounts of dietary iron and vitamin B6.
This suggests that for some individuals, adjusting their diet could help mitigate hypertension risks.
However, further research is needed to confirm these results across different populations to ensure wider applicability.
Read More
8
Folate slows artery thickness increase
We examined the link between folate and vitamin B12 levels and changes in carotid intima-media thickness (cIMT), a marker of early heart disease, over eight years in a group of 5061 adults in Brazil.
Our results suggest that higher serum folate levels are associated with a slower increase in cIMT, indicating a potential protective effect against heart disease.
However, no such benefit was observed with vitamin B12 levels. This implies that while folate may play a role in cardiovascular health, vitamin B12 might not have the same impact.
Our results suggest that higher serum folate levels are associated with a slower increase in cIMT, indicating a potential protective effect against heart disease.
However, no such benefit was observed with vitamin B12 levels. This implies that while folate may play a role in cardiovascular health, vitamin B12 might not have the same impact.
Read More
8
We looked into how dietary niacin might affect mortality rates, particularly for cardiovascular disease. Analyzing data from nearly 27,000 U.S. adults over about nine years, we found that those with the highest niacin intake had a significantly lower risk of dying from any cause, as well as from heart-related issues.
Interestingly, this protective effect was more robust among those without diabetes, suggesting that niacin's benefits can vary by health condition. Our findings highlight the potential role of diet in supporting heart health.
Interestingly, this protective effect was more robust among those without diabetes, suggesting that niacin's benefits can vary by health condition. Our findings highlight the potential role of diet in supporting heart health.
Read More
7
We investigated the connection between blood pressure variability (BPV) and vitamin B6 and B12 levels in individuals with essential hypertension. Our study involved 100 patients with hypertension and a control group of 100 healthy individuals.
We found that patients with hypertension had significantly lower levels of these B vitamins compared to the healthy group. Additionally, those with higher B vitamin levels exhibited reduced BPV.
This suggests that Vitamin B6 and B12 may influence blood pressure control, providing insights into hypertension management strategies.
We found that patients with hypertension had significantly lower levels of these B vitamins compared to the healthy group. Additionally, those with higher B vitamin levels exhibited reduced BPV.
This suggests that Vitamin B6 and B12 may influence blood pressure control, providing insights into hypertension management strategies.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 17 Reviews
7.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improved mood
7 people found this helpful
I took this for my 78-year-old mother on her doctor's advice for cardiovascular disease. We were amazed at the results! She overcame autumn depression and fatigue, regained her energy, and now walks for two hours daily, feeling cheerful and free from joint pain. Solgar is impressive!
Read More
9
Improved mood
B-complex "50" by Solgar contains all eight B vitamins vital for health, particularly in fat, carbohydrate, and protein metabolism. They aid in transforming nutrients into energy, maintaining the health of the cardiovascular system and nervous system, and forming red blood cells. After a month’s usage, I noticed improved mood and reduced irritability.
Read More
7.5
Supports immune health
25 people found this helpful
An additional source of B vitamins. They support emotional health, help manage stress and improve the immune system's resistance to diseases. Every healthy person should consider taking them annually. The dosage is large, but since these are water-soluble vitamins, the body absorbs what it needs and excretes the rest. No adverse reactions were experienced.
Read More
0
Possible overdose symptoms
18 people found this helpful
Be cautious. I experienced a sharp drop in blood pressure, tremors, dizziness, and weakness after three days of taking these vitamins, which I suspect is due to an overdose of vitamin B1. After stopping, symptoms subsided, revealing that not everyone tolerates this dosage.
Read More
7.5
Metabolism improvement
7 people found this helpful
An excellent B-complex! It enhances metabolism, strengthens the nervous system, and supports the cardiovascular system.
Read More
Frequently Asked Questions
7.5
Supports cardiovascular system
4 people found this helpful
I took this complex to support my cardiovascular system as advised by my doctor. After ten days of taking one capsule daily with meals, I noticed improvements in my nervous system and reduced irritability. I am pleased with the effectiveness and will reorder.
9
Improved mood
B-complex "50" by Solgar contains all eight B vitamins vital for health, particularly in fat, carbohydrate, and protein metabolism. They aid in transforming nutrients into energy, maintaining the health of the cardiovascular system and nervous system, and forming red blood cells. After a month’s usage, I noticed improved mood and reduced irritability.
0
Possible overdose symptoms
18 people found this helpful
Be cautious. I experienced a sharp drop in blood pressure, tremors, dizziness, and weakness after three days of taking these vitamins, which I suspect is due to an overdose of vitamin B1. After stopping, symptoms subsided, revealing that not everyone tolerates this dosage.
9
Improved mood
7 people found this helpful
I took this for my 78-year-old mother on her doctor's advice for cardiovascular disease. We were amazed at the results! She overcame autumn depression and fatigue, regained her energy, and now walks for two hours daily, feeling cheerful and free from joint pain. Solgar is impressive!
9
Reduces fatigue
3 people found this helpful
B vitamins are vital for energy production and regulating metabolism. They support the nervous system and improve conditions like nervousness and fatigue. My vitamin B deficiency improved significantly, reducing my nervousness and sleepy state. I'm grateful for the quality of these vitamins.
7.5
Promotes mental clarity
3 people found this helpful
I have been using B vitamins for some time now. They help normalise the nervous and cardiovascular systems, improve bowel function, and support emotional health. I notice a significant invigorating effect when taken in the morning. These vitamins are water-soluble, so excess is easily excreted, and they pair well with omega-3.
7
We investigated the connection between blood pressure variability (BPV) and vitamin B6 and B12 levels in individuals with essential hypertension. Our study involved 100 patients with hypertension and a control group of 100 healthy individuals.
We found that patients with hypertension had significantly lower levels of these B vitamins compared to the healthy group. Additionally, those with higher B vitamin levels exhibited reduced BPV.
This suggests that Vitamin B6 and B12 may influence blood pressure control, providing insights into hypertension management strategies.
We found that patients with hypertension had significantly lower levels of these B vitamins compared to the healthy group. Additionally, those with higher B vitamin levels exhibited reduced BPV.
This suggests that Vitamin B6 and B12 may influence blood pressure control, providing insights into hypertension management strategies.
9
We investigated how vitamin B6 supports heart recovery after heart attacks by promoting new blood vessel growth, known as angiogenesis. In laboratory tests, vitamin B6 improved cell migration and tubule formation, vital for forming new blood vessels.
Remarkably, long-term vitamin B6 supplementation showed significant improvements in heart function and reduced inflammation in mice following heart attacks. This suggests that vitamin B6 could be a beneficial aid for heart recovery, harnessing a specific pathway involving a protein called AMPK.
Remarkably, long-term vitamin B6 supplementation showed significant improvements in heart function and reduced inflammation in mice following heart attacks. This suggests that vitamin B6 could be a beneficial aid for heart recovery, harnessing a specific pathway involving a protein called AMPK.
8
Folate slows artery thickness increase
We examined the link between folate and vitamin B12 levels and changes in carotid intima-media thickness (cIMT), a marker of early heart disease, over eight years in a group of 5061 adults in Brazil.
Our results suggest that higher serum folate levels are associated with a slower increase in cIMT, indicating a potential protective effect against heart disease.
However, no such benefit was observed with vitamin B12 levels. This implies that while folate may play a role in cardiovascular health, vitamin B12 might not have the same impact.
Our results suggest that higher serum folate levels are associated with a slower increase in cIMT, indicating a potential protective effect against heart disease.
However, no such benefit was observed with vitamin B12 levels. This implies that while folate may play a role in cardiovascular health, vitamin B12 might not have the same impact.
8
We looked into how dietary niacin might affect mortality rates, particularly for cardiovascular disease. Analyzing data from nearly 27,000 U.S. adults over about nine years, we found that those with the highest niacin intake had a significantly lower risk of dying from any cause, as well as from heart-related issues.
Interestingly, this protective effect was more robust among those without diabetes, suggesting that niacin's benefits can vary by health condition. Our findings highlight the potential role of diet in supporting heart health.
Interestingly, this protective effect was more robust among those without diabetes, suggesting that niacin's benefits can vary by health condition. Our findings highlight the potential role of diet in supporting heart health.
References
- Bian XY, Cui C, Zhang QY. Relationship between blood pressure variability and vitamin B level in essential hypertension. J Physiol Pharmacol. 2025;76. 10.26402/jpp.2025.1.02
- Wang XQ, Yin S, Wang QW, Bai WW, Tan RH, et al. Vitamin B6 allosterically activates AMPK to promote postischemic angiogenesis in mice. Eur J Pharmacol. 2025;993:177413. 10.1016/j.ejphar.2025.177413
- Song Y, Choi JE, Park JM, Kwon YJ, Hong KW, et al. Genome-Wide Approach of Gene-Nutrient Intake Interaction Study for Essential Hypertension in a Large Korean Cohort (KoGES). Nutrients. 2024;16. 10.3390/nu16234147
- Palchetti CZ, Gonçalves NG, Suemoto CK, Santos IS, Lotufo PA, et al. Serum folate levels, but not vitamin B12, are associated with slower progression in carotid intima-media thickness in a population exposed to mandatory folic acid fortification. Clin Nutr ESPEN. 2025;65:144. 10.1016/j.clnesp.2024.11.034
- Lin L, Chen S, Zhang C, Li L, Chen Y, et al. Association of dietary niacin intake with all-cause and cardiovascular mortality: National Health and Nutrition Examination Survey (NHANES) 2003-2018. Sci Rep. 2024;14:28313. 10.1038/s41598-024-79986-9
