We focused on a case of pernicious anemia in a 51-year-old Ugandan man who presented with recurring lower limb weakness. After initial treatment for vitamin B12 deficiency years ago and further testing, we confirmed his diagnosis of pernicious anemia marked by low cobalamin levels. Thanks to timely parenteral methylcobalamin therapy, he showed improvement. This case underscores the importance of recognizing vitamin B12 deficiency, especially in rural and resource-limited settings, to address neurological symptoms quickly.
Read More
8
Pernicious anemia misdiagnosed as fibromyalgia
A long-standing undiagnosed case of vitamin B12 deficiency: a case report.
We explored a notable case of a woman suffering from pernicious anemia, an autoimmune condition that can be misdiagnosed due to its vague symptoms like fatigue and cognitive issues.
After years of struggling with these nonspecific symptoms, her low vitamin B12 levels were finally identified as the underlying cause.
Upon receiving treatment with vitamin B12, she experienced neurological improvements, highlighting the importance of recognizing this deficiency, even when traditional anemia indicators are absent.
Read More
8
Nicotinamide suppresses autoimmune activation
Nicotinamide Suppresses Hyperactivation of Dendritic Cells to Control Autoimmune Disease through PARP Dependent Signaling.
We explored the influence of Nicotinamide (NAM), a form of vitamin B3, on dendritic cells (DCs) in autoimmune diseases. Our research indicates that NAM can effectively reduce the overactivation of DCs, helping to ease symptoms in conditions like psoriasis.
Through detailed analysis of available studies, we found that NAM affects DCs via a specific signaling pathway, ultimately offering a potential new direction for treatment. Importantly, these findings highlight NAM’s significant role in managing autoimmune disorders related to immune response regulation.
Read More
Most Useful Reviews
9
Decreased psoriasis rashes
5 people found this helpful
We are delighted with this complex. My husband suffers from psoriasis, which flares up during autumn and spring. After consulting a dermatologist, we introduced B vitamins and decided to try this product. It helped reduce rashes, particularly those on his face. We will continue to order this.
Read More
9
Nervous system improvement
4 people found this helpful
I’ve ordered this vitamin for the third time. I’ve tried various B compounds, but this one stands out for its effectiveness on my nervous system. From the second capsule, I noticed improvement. The rich ingredients last over three months, making it safe for long-term use, although it's best taken in the morning to avoid insomnia.
Read More
9
Pain relief noted
2 people found this helpful
I order this B complex for the third time. It is beneficial for back pain, tension, and increasing my endurance and concentration. Initially, the high dosage worried me, but I recognised the necessity for such treatment. I take it in cycles during spring and autumn for about 1-1.5 months.
We explored three cases of biotinidase deficiency (BTD) that were misdiagnosed as neuromyelitis optica spectrum disorder (NMOSD) due to similar symptoms and neuroimaging results. Initially, two patients responded to immune therapy but later relapsed, while one showed no improvement. Interestingly, after timely diagnosis and biotin supplementation, two patients exhibited remarkable recoveries in both motor function and vision. This highlights the critical need for accurate diagnosis, as early treatment of BTD can lead to significant improvements.
Read More
8
Pernicious anemia misdiagnosed as fibromyalgia
A long-standing undiagnosed case of vitamin B12 deficiency: a case report.
We explored a notable case of a woman suffering from pernicious anemia, an autoimmune condition that can be misdiagnosed due to its vague symptoms like fatigue and cognitive issues.
After years of struggling with these nonspecific symptoms, her low vitamin B12 levels were finally identified as the underlying cause.
Upon receiving treatment with vitamin B12, she experienced neurological improvements, highlighting the importance of recognizing this deficiency, even when traditional anemia indicators are absent.
Read More
8
Pernicious anemia case in Uganda
Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report.
We focused on a case of pernicious anemia in a 51-year-old Ugandan man who presented with recurring lower limb weakness. After initial treatment for vitamin B12 deficiency years ago and further testing, we confirmed his diagnosis of pernicious anemia marked by low cobalamin levels. Thanks to timely parenteral methylcobalamin therapy, he showed improvement. This case underscores the importance of recognizing vitamin B12 deficiency, especially in rural and resource-limited settings, to address neurological symptoms quickly.
Read More
8
Nicotinamide suppresses autoimmune activation
Nicotinamide Suppresses Hyperactivation of Dendritic Cells to Control Autoimmune Disease through PARP Dependent Signaling.
We explored the influence of Nicotinamide (NAM), a form of vitamin B3, on dendritic cells (DCs) in autoimmune diseases. Our research indicates that NAM can effectively reduce the overactivation of DCs, helping to ease symptoms in conditions like psoriasis.
Through detailed analysis of available studies, we found that NAM affects DCs via a specific signaling pathway, ultimately offering a potential new direction for treatment. Importantly, these findings highlight NAM’s significant role in managing autoimmune disorders related to immune response regulation.
Read More
7
Vitamin B may indicate GBS severity
Correlation of Serum Vitamin B and Muscle Enzyme (CK-NAC) Level with Severity of Guillain-Barre Syndrome and Its Prediction in Respiratory Failure.
We aimed to see if vitamin B levels could signal the severity of Guillain-Barré syndrome (GBS) and its potential for complications like respiratory failure. Our study involved 50 GBS patients, where we examined their vitamin B and creatine kinase levels alongside their motor abilities.
Interestingly, we found that 44% of patients had low vitamin B levels, which linked strongly to GBS severity. However, while vitamin B showed predictive value, the creatine kinase levels did not relate to GBS severity.
Read More
User Reviews
USERS' SCORE
Good
Based on 11 Reviews
8.2
All Reviews
Positive Reviews
Negative Reviews
9
Decreased psoriasis rashes
5 people found this helpful
We are delighted with this complex. My husband suffers from psoriasis, which flares up during autumn and spring. After consulting a dermatologist, we introduced B vitamins and decided to try this product. It helped reduce rashes, particularly those on his face. We will continue to order this.
Read More
9
Nervous system improvement
4 people found this helpful
I’ve ordered this vitamin for the third time. I’ve tried various B compounds, but this one stands out for its effectiveness on my nervous system. From the second capsule, I noticed improvement. The rich ingredients last over three months, making it safe for long-term use, although it's best taken in the morning to avoid insomnia.
Read More
9
Pain relief noted
2 people found this helpful
I order this B complex for the third time. It is beneficial for back pain, tension, and increasing my endurance and concentration. Initially, the high dosage worried me, but I recognised the necessity for such treatment. I take it in cycles during spring and autumn for about 1-1.5 months.
Read More
7.5
Reduced panic attacks
136 people found this helpful
Excellent vitamins. No injections needed. After using Berocca, which was expensive and ineffective, I experienced anxiety and eye twitching. After a week on these vitamins, my symptoms disappeared. They also helped alleviate panic attacks and discomfort from my autoimmune disorder related to osteochondrosis. Taken with chelated magnesium, my breathing issues resolved. If you found this helpful, please like it :)
Read More
9
Highly recommend B complex
120 people found this helpful
Excellent! The B complex is superb. My sister saw it and requested that I order it for her as well. I recommend everyone purchase it. The delivery was very quick.
An autoimmune disorder occurs when the body's immune system mistakenly attacks its own healthy cells and tissues, believing them to be foreign invaders, such as bacteria or viruses. This reaction can lead to inflammation, tissue damage, and impaired function of the affected organs. There are over 80 known autoimmune diseases, including rheumatoid arthritis, lupus, multiple sclerosis, and type 1 diabetes, each with its own specific symptoms and treatment options. The exact cause of these disorders is still unclear, but a combination of genetic, environmental, and hormonal factors is believed to play a role in their development.
Diagnosis of autoimmune disorders often involves a combination of physical examinations, assessment of symptoms, blood tests, and imaging studies to evaluate organ involvement. Treatment typically focuses on managing symptoms and controlling the immune response using medications such as corticosteroids, immunosuppressants, and biologics. In addition to medication, lifestyle modifications, such as stress management and a balanced diet, can be beneficial in managing symptoms. If you suspect you have an autoimmune condition, it's important to consult a healthcare professional for proper evaluation and tailored treatment options.
Vitamin B Complex refers to a group of water-soluble vitamins that play important roles in cell metabolism and overall health. This group typically includes eight essential vitamins: B1 (thiamine), B2 (riboflavin), B3 (niacin), B5 (pantothenic acid), B6 (pyridoxine), B7 (biotin), B9 (folate), and B12 (cobalamin). Each of these vitamins contributes uniquely to various bodily functions, such as energy production, red blood cell formation, and nervous system function. For instance, B12 and folate are crucial in preventing anemia, while B6 is vital for brain development and function.
Many people can obtain their daily requirements of B vitamins through a balanced diet that includes whole grains, meats, eggs, nuts, leafy greens, and dairy products. However, certain groups—like vegetarians, pregnant women, and older adults—may benefit from supplementation to meet their nutritional needs. It's important to consult with a healthcare professional before starting any supplement regimen, as excessive intake of certain B vitamins can lead to adverse effects. Overall, ensuring adequate intake of Vitamin B Complex is vital for maintaining energy levels and supporting overall health.
Based on user reviews, the time it typically takes to see results from this B complex supplement can vary, but many users report experiencing improvements within a week to a month. For instance, one user mentioned feeling energized and less irritable just a week after starting the supplement, attributing the improvement to the B vitamins addressing their autoimmune disorder symptoms Read Review. Another user noticed benefits for anxiety and panic attacks after only a week of use Read Review.
Others, however, recommend a longer duration of continuous use, around one to one-and-a-half months, to achieve the best results, particularly when dealing with more chronic issues or when cycling the use of the vitamins Read Review. Overall, while some users feel immediate benefits, a sustained intake may provide optimal outcomes for managing symptoms associated with autoimmune disorders.
Scientific research provides a nuanced view on the potential benefits of various forms of vitamin B for individuals with autoimmune disorders. For instance, a study focused on pernicious anemia—a condition that results from vitamin B12 deficiency—illustrated the importance of identifying and treating this deficiency. The patient in question experienced significant neurological improvements after receiving vitamin B12 treatment, underscoring the vital role this vitamin plays in managing symptoms associated with autoimmune conditions [2]. Additionally, another case study corroborated this by demonstrating the effectiveness of methylcobalamin therapy in a patient diagnosed with pernicious anemia, further establishing the connection between vitamin B12 and neurological function in autoimmune contexts [3].
Moreover, vitamin B3 (Nicotinamide) has shown promise in controlling autoimmune diseases by reducing the overactivation of dendritic cells, which are implicated in various conditions such as psoriasis. This research suggests that Nicotinamide may offer new therapeutic avenues for managing autoimmune disorders based on its regulatory effects on immune response [4]. Collectively, these findings indicate that particular B vitamins could play a significant role in supporting individuals with autoimmune disorders, although the need for accurate diagnosis and targeted treatment remains paramount.
Based on user reviews, many individuals have reported significant improvements in various symptoms after incorporating this B complex supplement into their routines. Notably, one user described a marked reduction in psoriasis flare-ups and facial rashes after starting the supplement, saying it helped manage their husband’s skin conditions during seasonal changes Read Review. Other users have experienced enhancements in their nervous system health, with one reviewer noting improvements in mood and energy levels almost immediately after beginning use Read Review.
Additionally, a number of users have noted relief from anxiety symptoms, with one individual reporting that panic attacks subsided within a week of taking the vitamins Read Review. Some have also shared overall well-being improvements, mentioning benefits like increased focus, reduced back pain, and the alleviation of chronic fatigue Read Review. Despite varied experiences, many affirm that consistent use often yields the best results, and individual responses may vary based on personal health situations.
Based on user reviews, many individuals with autoimmune disorders have reported positive experiences when combining this B complex supplement with other supplements. For example, one user experienced an alleviation of breathing issues after taking the B vitamins alongside chelated magnesium, essentially managing their discomfort related to an autoimmune disorder Read Review. This suggests that layering supplements might enhance overall effectiveness, particularly for those dealing with multifaceted health challenges.
Additionally, while specific combinations were not extensively detailed, users mentioned that integrating this B complex with their existing supplement routines yielded beneficial results. One reviewer noted that they had improved their concentration and endurance while using the B complex in cycles during specific seasons Read Review. This cyclical approach implies that users are finding efficacy not only in the B vitamins alone but also in their strategic use in conjunction with other supplemental aids to better manage their autoimmune symptoms.
Users have reported varying experiences with the appropriate dosage of Vitamin B Complex for managing symptoms associated with autoimmune disorders. One user noted their husband's improvement from psoriasis after incorporating a B vitamin complex, citing a noticeable reduction in facial rashes after starting the product Read Review. Another user addressed their concerns about the high dosage but acknowledged its necessity, taking the vitamins in cycles of 1 to 1.5 months during the change of seasons Read Review.
Additionally, users found that consistent use led to alleviated symptoms related to their autoimmune conditions; for instance, one user experienced a reduction in anxiety and panic attacks due to their autoimmune disorder, indicating a beneficial response to the B vitamins Read Review. Another user reported feeling significantly better after identifying their B vitamin deficiency and adjusting their dosage accordingly Read Review. Overall, while there is no one-size-fits-all dose, many users recommend regular, high-quality B Complex supplements taken as necessary for symptom management.
7.5
Increased energy levels
4 people found this helpful
For a long time, I suffered from lethargy and muscle pain, not understanding the cause. After researching, I discovered I had a lack of B vitamins. I ordered Solgar B vitamins, which are high quality and contain all B vitamins. A week later, I felt energised and less irritable, and my autoimmune disorder symptoms improved.
7.5
Reduced panic attacks
136 people found this helpful
Excellent vitamins. No injections needed. After using Berocca, which was expensive and ineffective, I experienced anxiety and eye twitching. After a week on these vitamins, my symptoms disappeared. They also helped alleviate panic attacks and discomfort from my autoimmune disorder related to osteochondrosis. Taken with chelated magnesium, my breathing issues resolved. If you found this helpful, please like it :)
9
Pain relief noted
2 people found this helpful
I order this B complex for the third time. It is beneficial for back pain, tension, and increasing my endurance and concentration. Initially, the high dosage worried me, but I recognised the necessity for such treatment. I take it in cycles during spring and autumn for about 1-1.5 months.
9
Decreased psoriasis rashes
5 people found this helpful
We are delighted with this complex. My husband suffers from psoriasis, which flares up during autumn and spring. After consulting a dermatologist, we introduced B vitamins and decided to try this product. It helped reduce rashes, particularly those on his face. We will continue to order this.
9
Nervous system improvement
4 people found this helpful
I’ve ordered this vitamin for the third time. I’ve tried various B compounds, but this one stands out for its effectiveness on my nervous system. From the second capsule, I noticed improvement. The rich ingredients last over three months, making it safe for long-term use, although it's best taken in the morning to avoid insomnia.
6
Vitamins improved health
41 people found this helpful
I ordered these vitamins Realising my body was exhausted. I experienced lethargy and irritability, knowing I lacked B vitamins. I took a higher dosage and felt significantly better on gloomy days, but reduced my intake when I felt good. My test results showed elevated B12 levels, indicating the necessity for a break. These vitamins work!
8
Pernicious anemia misdiagnosed as fibromyalgia
A long-standing undiagnosed case of vitamin B12 deficiency: a case report.
We explored a notable case of a woman suffering from pernicious anemia, an autoimmune condition that can be misdiagnosed due to its vague symptoms like fatigue and cognitive issues.
After years of struggling with these nonspecific symptoms, her low vitamin B12 levels were finally identified as the underlying cause.
Upon receiving treatment with vitamin B12, she experienced neurological improvements, highlighting the importance of recognizing this deficiency, even when traditional anemia indicators are absent.
8
Pernicious anemia case in Uganda
Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report.
We focused on a case of pernicious anemia in a 51-year-old Ugandan man who presented with recurring lower limb weakness. After initial treatment for vitamin B12 deficiency years ago and further testing, we confirmed his diagnosis of pernicious anemia marked by low cobalamin levels. Thanks to timely parenteral methylcobalamin therapy, he showed improvement. This case underscores the importance of recognizing vitamin B12 deficiency, especially in rural and resource-limited settings, to address neurological symptoms quickly.
8
Nicotinamide suppresses autoimmune activation
Nicotinamide Suppresses Hyperactivation of Dendritic Cells to Control Autoimmune Disease through PARP Dependent Signaling.
We explored the influence of Nicotinamide (NAM), a form of vitamin B3, on dendritic cells (DCs) in autoimmune diseases. Our research indicates that NAM can effectively reduce the overactivation of DCs, helping to ease symptoms in conditions like psoriasis.
Through detailed analysis of available studies, we found that NAM affects DCs via a specific signaling pathway, ultimately offering a potential new direction for treatment. Importantly, these findings highlight NAM’s significant role in managing autoimmune disorders related to immune response regulation.
References
Jatav VS, Sardana V, Bhushan B, Maheshwari D, Garg S, et al. Correlation of Serum Vitamin B and Muscle Enzyme (CK-NAC) Level with Severity of Guillain-Barre Syndrome and Its Prediction in Respiratory Failure. J Assoc Physicians India. 2025;73:48. 10.59556/japi.73.0892
Mesgarankarimi A, Rezapour M, Tabrizi N. A long-standing undiagnosed case of vitamin B12 deficiency: a case report. J Med Case Rep. 2025;19:151. 10.1186/s13256-025-05149-7
Mswelo VE, David MM, Banturaki A, Munyambalu DK, Hassan HA, et al. Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report. J Med Case Rep. 2025;19:60. 10.1186/s13256-025-05095-4
Cao AP, Wang YY, Shen YY, Liu YH, Liu JY, et al. Nicotinamide Suppresses Hyperactivation of Dendritic Cells to Control Autoimmune Disease through PARP Dependent Signaling. Nutrients. 2024;16. 10.3390/nu16162665
Ali F, Mukhtiar K, Raza M, Ibrahim S. Atypical presentation of biotinidase deficiency: masquerading neuromyelitis optica spectrum disorder. BMJ Case Rep. 2024;17. 10.1136/bcr-2023-258703