We investigated how benfotiamine might impact stomach ulcers in male rats. The study involved dividing 30 rats into groups receiving different treatments, including benfotiamine at varying doses, following the induction of ulcers using indomethacin.
Our results showed that benfotiamine notably decreased gastric damage and lowered inflammation markers. Specifically, doses of 100 and 200 mg/kg appeared to enhance antioxidant levels and reduce tissue damage.
However, while these findings are promising, more research is needed to fully understand the mechanisms at play and assess benfotiamine's potential for human treatment.
Read More
8
ImproWin® aids gastric ulcer healing
ImproWin® in the treatment of gastric ulceration of the squamous mucosa in trotting racehorses.
We aimed to determine if ImproWin®, a feed additive, could help improve gastric ulcers in Standardbred and Coldblooded trotting racehorses. By conducting a randomized, double-blinded study, we assessed horses' ulcers before and after three weeks of treatment.
Our results showed a significant reduction in ulcer scores for horses treated with ImproWin®, with 78% classified as responders compared to only 54.8% in the placebo group. This indicates that ImproWin® may be beneficial for aiding the healing of gastric ulcers in affected racehorses.
Read More
8
Folic acid has mixed effects
The dual modulatory effect of folic acid supplementation on indomethacin-induced gastropathy in the rat.
We examined how different doses of folic acid supplementation affect ulcer formation in rats. Male Wistar rats were treated with varying doses for 21 days while gastric ulcers were induced with indomethacin.
We found that a dose of 2 mg/kg significantly reduced gastric lesions, while a higher dose of 3 mg/kg unexpectedly worsened damage. Our results suggest that low doses of folic acid can be protective for the stomach, but high doses could pose risks.
Thus, it appears that moderation is key when considering folic acid for ulcer treatment.
Read More
Most Useful Reviews
9
Effectively treats ulcer
3 people found this helpful
Those suffering from stomach ulcers, mouth ulcers, and daily fatigue should consider this product. I was sceptical initially, but after using the socio-vitamin-non-complex along with Ginga Minggae's herbal supplements, it significantly improved my husband's mouth ulcers. The B vitamins here are especially effective; I highly recommend this, but be cautious as the pills are quite large!
Read More
9
Reduces oral ulcers
1 people found this helpful
Human metabolism requires the B vitamins. After taking them for a while, I no longer experience oral ulcers. The effect is impressive, and I plan to keep taking them.
Read More
9
No more ulcers
1 people found this helpful
I feel great! I've tried various supplements to prevent mouth ulcers with little success. Unexpectedly, I haven't had any since using this product, likely due to its abundant B vitamins. My trust in "Solgar" has definitely grown.
We analyzed the potential connection between folic acid supplementation and gastric ulcers using data from the UK Biobank and advanced statistical methods.
Our findings suggest that folic acid may significantly lower the risk of developing gastric ulcers.
Various robust models reinforced this result, showing consistent outcomes across different analyses.
Ultimately, this research provides genetic evidence supporting the idea that receiving folic acid therapy can be beneficial in reducing gastric ulcer risk.
Read More
9
Benfotiamine improves ulcer healing
The protective effect of benfotiamine on gastric ulcers in male rats: an experimental study.
We investigated how benfotiamine might impact stomach ulcers in male rats. The study involved dividing 30 rats into groups receiving different treatments, including benfotiamine at varying doses, following the induction of ulcers using indomethacin.
Our results showed that benfotiamine notably decreased gastric damage and lowered inflammation markers. Specifically, doses of 100 and 200 mg/kg appeared to enhance antioxidant levels and reduce tissue damage.
However, while these findings are promising, more research is needed to fully understand the mechanisms at play and assess benfotiamine's potential for human treatment.
Read More
9
Effective ulcer treatment in diabetes
Protective effect of Luffa acutangula extracts on gastric ulceration in NIDDM rats: role of gastric mucosal glycoproteins and antioxidants.
We explored the effects of Luffa acutangula extracts on gastric ulcers in diabetic rats. By inducing non-insulin dependent diabetes mellitus (NIDDM) and then creating gastric ulcers, we evaluated the extracts' potential for healing.
The results showed that the methanolic extract significantly boosted healing, improving protective mucosal glycoproteins and antioxidant levels. This was better than the aqueous extract and standard treatments.
Overall, Luffa acutangula appears to offer promising support for treating gastric ulcers in diabetes, highlighting its dual action in managing both conditions.
Read More
9
Effective treatment for oral ulcers
Clinical Evaluation and Therapeutic Effects of Combination Treatment with Mecobalamin + Vitamin E in Recurrent Oral Ulcer.
We explored the effectiveness of mecobalamin and vitamin E in treating recurrent oral ulcers. In a study with 58 patients, those receiving both treatments showed significantly improved healing times and reduced symptoms compared to the control group. They experienced longer periods without ulcer flare-ups and better quality of life scores. Both groups felt pain relief, but the test group had more noticeable benefits. This finding suggests that mecobalamin and vitamin E can be a valuable addition to ulcer treatment, enhancing both comfort and recovery.
Read More
8
ImproWin® aids gastric ulcer healing
ImproWin® in the treatment of gastric ulceration of the squamous mucosa in trotting racehorses.
We aimed to determine if ImproWin®, a feed additive, could help improve gastric ulcers in Standardbred and Coldblooded trotting racehorses. By conducting a randomized, double-blinded study, we assessed horses' ulcers before and after three weeks of treatment.
Our results showed a significant reduction in ulcer scores for horses treated with ImproWin®, with 78% classified as responders compared to only 54.8% in the placebo group. This indicates that ImproWin® may be beneficial for aiding the healing of gastric ulcers in affected racehorses.
Those suffering from stomach ulcers, mouth ulcers, and daily fatigue should consider this product. I was sceptical initially, but after using the socio-vitamin-non-complex along with Ginga Minggae's herbal supplements, it significantly improved my husband's mouth ulcers. The B vitamins here are especially effective; I highly recommend this, but be cautious as the pills are quite large!
Read More
9
Reduces oral ulcers
1 people found this helpful
Human metabolism requires the B vitamins. After taking them for a while, I no longer experience oral ulcers. The effect is impressive, and I plan to keep taking them.
Read More
9
No more ulcers
1 people found this helpful
I feel great! I've tried various supplements to prevent mouth ulcers with little success. Unexpectedly, I haven't had any since using this product, likely due to its abundant B vitamins. My trust in "Solgar" has definitely grown.
Read More
9
Less frequent ulcers
Vitamin B helps reduce mouth ulcers! I tended to get them easily and often felt fatigued. Since starting this, I'm getting fewer ulcers and have come to realise the importance of vitamin B. The ingredients are excellent!
Read More
9
Immediate effect
This B complex product delivered immediate results. I frequently suffered from mouth ulcers. The high-quality ingredients made a noticeable difference. I consider it essential to my supplements.
An ulcer is a sore that develops on the lining of the stomach, small intestine, or colon. It occurs when the digestive tract is damaged or inflamed, often due to an imbalance between stomach acid and the protective factors in the digestive system. The most common types of ulcers include peptic ulcers, which can be further categorized into gastric ulcers (located in the stomach) and duodenal ulcers (found in the first part of the small intestine). Symptoms may include burning stomach pain, bloating, and nausea, which can vary in intensity based on the severity of the condition.
Vitamin B Complex refers to a group of water-soluble vitamins that play important roles in cell metabolism and overall health. This group typically includes eight essential vitamins: B1 (thiamine), B2 (riboflavin), B3 (niacin), B5 (pantothenic acid), B6 (pyridoxine), B7 (biotin), B9 (folate), and B12 (cobalamin). Each of these vitamins contributes uniquely to various bodily functions, such as energy production, red blood cell formation, and nervous system function. For instance, B12 and folate are crucial in preventing anemia, while B6 is vital for brain development and function.
Many people can obtain their daily requirements of B vitamins through a balanced diet that includes whole grains, meats, eggs, nuts, leafy greens, and dairy products. However, certain groups—like vegetarians, pregnant women, and older adults—may benefit from supplementation to meet their nutritional needs. It's important to consult with a healthcare professional before starting any supplement regimen, as excessive intake of certain B vitamins can lead to adverse effects. Overall, ensuring adequate intake of Vitamin B Complex is vital for maintaining energy levels and supporting overall health.
Based on user reviews, individuals taking B vitamin complexes for relief from ulcers often notice results relatively quickly. Many users have reported improvements in their condition after just a few doses, indicating a rapid response to the supplement. For instance, one reviewer mentioned their mouth ulcer pain was soothed after only two doses of the product Read Review. Additionally, another user remarked that since starting the supplement, they have encountered fewer mouth ulcers, highlighting a direct correlation with the product’s efficacy Read Review.
However, while many users experience improvements in a matter of days, some reports suggest ongoing use may be necessary for optimal results. A recurrent theme seen in user feedback is the continued commitment to the supplement, with users planning to keep taking it due to its effectiveness in reducing ulcer frequency Read Review. Overall, while the initial effects might be felt quite rapidly, achieving consistent long-term relief may require sustained usage.
Based on recent scientific research, there is evidence to suggest that certain supplements may support the management of gastric ulcers. Notably, folic acid has been shown to potentially lower the risk of developing these ulcers. A study utilizing data from the UK Biobank found that folic acid supplementation could significantly reduce gastric ulcer risk, highlighting the benefits of therapeutic folic acid [1]. Additionally, another study on rats indicated that low doses of folic acid could protect against ulcer formation, while excessively high doses could be harmful, suggesting an important balance in its therapeutic use [4].
Furthermore, other supplements have shown promise in ulcer treatment. Nicotinamide, for instance, was effective in reducing gastric lesions and restoring affected biochemical parameters in experimental models [6]. Likewise, benfotiamine demonstrated a notable reduction in gastric damage and inflammation markers in rat studies, although further research is necessary to determine its efficacy in humans [2]. Overall, while a growing body of research supports the potential of specific supplements in treating gastric ulcers, their applications may vary, and more extensive human trials would be essential to confirm these findings.
Users report a notable improvement in symptoms related to mouth ulcers after taking the B vitamin complex. Many individuals have experienced a significant reduction in the frequency and severity of their mouth ulcers. For instance, one reviewer mentioned that their husband saw a marked improvement in mouth ulcers after using the product alongside herbal supplements Read Review. Another user stated that they have not had any oral ulcers since starting the regimen, attributing this success to the abundance of B vitamins Read Review. Additionally, reports indicate that users feel less prone to developing ulcers, with some highlighting a connection between B vitamin intake and reduced fatigue Read Review.
While positive results are experienced by many, individual outcomes can vary. Some users plan to continue taking the supplement due to its efficacy in reducing their symptoms, reflecting a general satisfaction with the product's effects on their mouth ulcer occurrences Read Review. Others have reported immediate benefits, stating that noticeable differences appeared shortly after starting the B complex Read Review. Overall, while anecdotal evidence suggests promising results, it's essential for users to monitor their experiences, as responses to supplementation can differ.
Users have reported positive outcomes when combining the B vitamin complex with other supplements to manage their ulcer symptoms. For instance, one reviewer indicated that their husband's mouth ulcers improved significantly after using this product in conjunction with herbal supplements Read Review. Similarly, another user mentioned that they experienced soothing effects on their mouth ulcer pain after just two doses when taken alongside an "immune 4" supplement Read Review. This suggests that the B vitamin complex can enhance the effectiveness of other treatments.
Additionally, some users highlighted the importance of a comprehensive approach to managing their symptoms. One user noted they take a mix of vitamin C, iron, and other supplements from the same manufacturer, which has helped them remain free from mouth ulcers Read Review. Reports indicate that supplement combinations can yield noticeable improvements in ulcer frequency and severity, which may speak to the synergistic effects of diverse nutrients in supporting overall health Read Review. Overall, combining this B vitamin complex with other supplements appears to be a strategy favored by users seeking better management of their ulcer symptoms.
Based on user reviews, many individuals have reported significant improvements in their mouth ulcer conditions after taking Vitamin B Complex supplements. Users highlighted that the B vitamins within these products were particularly effective in reducing the occurrence of mouth ulcers and alleviating associated symptoms. For instance, one user noted that after taking the vitamin complex, they no longer experienced oral ulcers, demonstrating the product's positive impact Read Review. Another user remarked on the immediate positive results, specifically emphasizing a decrease in the frequency of their mouth ulcers after consistent use Read Review.
Though users did not specify a universal "right dose," their experiences indicate that incorporating Vitamin B Complex into daily routines has led to noticeable improvements in their oral health. Several users expressed their commitment to continuing the supplement due to its effectiveness in managing their conditions, suggesting that a sustained intake could enhance results Read ReviewRead Review. Additionally, the emphasis on high-quality ingredients and fulfilling the body's vitamin needs is a common theme among the reviews, pointing to the importance of selecting a reputable product for optimal benefits Read Review.
7.5
Soothes ulcer pain
This product helped soothe my mouth ulcer pain after just two doses, especially when combined with “immune 4”.
7.5
Prevents mouth ulcers
Since I started this supplement, I'm less prone to mouth ulcers. It's effective for skin issues too. I believe it's a valuable addition to my regimen.
9
Effective prevention
I find this product beneficial. I previously took Solgar B Complex 50 for my frequent stomatitis, but this seems more effective, reducing the number of mouth ulcers. I intend to keep using it.
9
Effectively treats ulcer
3 people found this helpful
Those suffering from stomach ulcers, mouth ulcers, and daily fatigue should consider this product. I was sceptical initially, but after using the socio-vitamin-non-complex along with Ginga Minggae's herbal supplements, it significantly improved my husband's mouth ulcers. The B vitamins here are especially effective; I highly recommend this, but be cautious as the pills are quite large!
9
No more ulcers
1 people found this helpful
I feel great! I've tried various supplements to prevent mouth ulcers with little success. Unexpectedly, I haven't had any since using this product, likely due to its abundant B vitamins. My trust in "Solgar" has definitely grown.
9
Less frequent ulcers
Vitamin B helps reduce mouth ulcers! I tended to get them easily and often felt fatigued. Since starting this, I'm getting fewer ulcers and have come to realise the importance of vitamin B. The ingredients are excellent!
9
Immediate effect
This B complex product delivered immediate results. I frequently suffered from mouth ulcers. The high-quality ingredients made a noticeable difference. I consider it essential to my supplements.
9
No more ulcers
I take a mix of vitamin C, iron, and other supplements from the same manufacturer. The capsules are quite large and initially difficult to swallow, but I've grown accustomed to it. Since beginning this regimen, I've been free from the cracked corners of my mouth and ulcers I often experienced in autumn and winter. Vitamin B complex is truly important!
9
Reduces oral ulcers
1 people found this helpful
Human metabolism requires the B vitamins. After taking them for a while, I no longer experience oral ulcers. The effect is impressive, and I plan to keep taking them.
7.5
Decreased ulcer frequency
I feel that the frequency of my mouth ulcers has decreased since using this product.
9.5
Folic acid may reduce ulcers
Causal association of folic acid supplementary therapy and gastric ulcer: a Mendelian randomisation study.
We analyzed the potential connection between folic acid supplementation and gastric ulcers using data from the UK Biobank and advanced statistical methods.
Our findings suggest that folic acid may significantly lower the risk of developing gastric ulcers.
Various robust models reinforced this result, showing consistent outcomes across different analyses.
Ultimately, this research provides genetic evidence supporting the idea that receiving folic acid therapy can be beneficial in reducing gastric ulcer risk.
8
Folic acid has mixed effects
The dual modulatory effect of folic acid supplementation on indomethacin-induced gastropathy in the rat.
We examined how different doses of folic acid supplementation affect ulcer formation in rats. Male Wistar rats were treated with varying doses for 21 days while gastric ulcers were induced with indomethacin.
We found that a dose of 2 mg/kg significantly reduced gastric lesions, while a higher dose of 3 mg/kg unexpectedly worsened damage. Our results suggest that low doses of folic acid can be protective for the stomach, but high doses could pose risks.
Thus, it appears that moderation is key when considering folic acid for ulcer treatment.
8
Nicotinamide shows ulcer protection
Nicotinamide alleviates indomethacin-induced gastric ulcers: a novel antiulcer agent.
We explored the effects of nicotinamide on gastric ulcers caused by indomethacin in a laboratory setting. Using a well-established model, we compared the treatment of nicotinamide with sucralfate, a known antiulcer drug.
Our findings revealed that nicotinamide significantly reduced the severity of gastric lesions. It also helped restore vital biochemical parameters affected by the ulcer-inducing drug.
The protective effect of nicotinamide appears to stem from its ability to conserve gastric mucus and nitric oxide, improve gastric microvascular permeability, and exert antioxidant actions.
9
Benfotiamine improves ulcer healing
The protective effect of benfotiamine on gastric ulcers in male rats: an experimental study.
We investigated how benfotiamine might impact stomach ulcers in male rats. The study involved dividing 30 rats into groups receiving different treatments, including benfotiamine at varying doses, following the induction of ulcers using indomethacin.
Our results showed that benfotiamine notably decreased gastric damage and lowered inflammation markers. Specifically, doses of 100 and 200 mg/kg appeared to enhance antioxidant levels and reduce tissue damage.
However, while these findings are promising, more research is needed to fully understand the mechanisms at play and assess benfotiamine's potential for human treatment.
References
Li F, Huang F, Tang Y, Zhang F, Jiang H, et al. Causal association of folic acid supplementary therapy and gastric ulcer: a Mendelian randomisation study. Br J Nutr. 2024;132:1348. doi:10.1017/S0007114524002368
Shokati Sayyad M, Khanjani MH, Amirbeik M, Seyedabadi M, Talebpour Amiri F, et al. The protective effect of benfotiamine on gastric ulcers in male rats: an experimental study. J Mol Histol. 2024;55:863. doi:10.1007/s10735-024-10237-x
Hellings IR, Larsen S. ImproWin® in the treatment of gastric ulceration of the squamous mucosa in trotting racehorses. Acta Vet Scand. 2014;56:13. doi:10.1186/1751-0147-56-13
Ajeigbe K, Oladejo E, Emikpe B, Asuk A, Olaleye S. The dual modulatory effect of folic acid supplementation on indomethacin-induced gastropathy in the rat. Turk J Gastroenterol. 2012;23:639.
Pimple BP, Kadam PV, Patil MJ. Protective effect of Luffa acutangula extracts on gastric ulceration in NIDDM rats: role of gastric mucosal glycoproteins and antioxidants. Asian Pac J Trop Med. 2012;5:610. doi:10.1016/S1995-7645(12)60126-6
Cui J, Lin W, Ma X, Wang J. Clinical Evaluation and Therapeutic Effects of Combination Treatment with Mecobalamin + Vitamin E in Recurrent Oral Ulcer. Clin Ther. 2022;44:123. doi:10.1016/j.clinthera.2021.10.015