' 
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.8
USERS' SCORE
Good
Based on 7 Reviews
8.2
Supplement Facts
Serving Size: 1 Vegetable Capsule
Amount Per Serving
%DV
Biotin
5,000 mcg
16,667%
Calcium (as dicalcium phosphate)
148 mg
11%
Phosphorous (as dicalcium phosphate)
115 mg
9%
Top Medical Research Studies
9.5
Biotin effectively improves rash symptoms
Dramatic Clinical Improvement With Biotin Mega-Dose Therapy in a Neonate With Holocarboxylase Synthetase Deficiency.
High relevance for clinical practice
We explored the effects of biotin therapy on a neonate suffering from a rare metabolic disorder known as holocarboxylase synthetase deficiency. After initiating a biotin mega-dose regimen, we observed impressive results, with the baby showing notable clinical improvement just one day later.
Within six days, mechanical ventilation was no longer necessary, and the child maintained stable health through follow-ups. This case underscores the importance of early genetic testing and how effective biotin can be in treating specific metabolic issues.
Within six days, mechanical ventilation was no longer necessary, and the child maintained stable health through follow-ups. This case underscores the importance of early genetic testing and how effective biotin can be in treating specific metabolic issues.
Read More
9.5
Biotin treatment showed significant effect
Holocarboxylase synthetase deficiency: report of one case.
Relevant case study on biotin deficiency
We examined a patient diagnosed with holocarboxylase synthetase (HCS) deficiency, who presented with a notable rash and other severe symptoms. This condition disrupts biotin's incorporation into enzymes, leading to serious health challenges.
After starting biotin treatment, we observed remarkable improvement in the patient’s condition, including normal growth and development over three years. This case highlights the importance of prompt diagnosis and treatment to avoid serious complications associated with biotin deficiency.
After starting biotin treatment, we observed remarkable improvement in the patient’s condition, including normal growth and development over three years. This case highlights the importance of prompt diagnosis and treatment to avoid serious complications associated with biotin deficiency.
Read More
8
Biotin treatment mitigates rash symptoms
Partial biotinidase deficiency: clinical and biochemical features.
Moderate relevance to biotin deficiency
This study looked at children with partial biotinidase deficiency to understand its effects and inheritance. While many were healthy at diagnosis, we found that one child developed skin rash, hair loss, and muscle weakness—symptoms that improved following biotin treatment.
Notably, other family members also displayed partial deficiency without symptoms, but one adult had minor issues that were alleviated with biotin. Overall, while most individuals are symptom-free at birth, this research suggests that biotin therapy could be beneficial for preventing future complications.
Notably, other family members also displayed partial deficiency without symptoms, but one adult had minor issues that were alleviated with biotin. Overall, while most individuals are symptom-free at birth, this research suggests that biotin therapy could be beneficial for preventing future complications.
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Most Useful Reviews
9.5
Cleared rashes
These vitamins are my favourite. After childbirth, my hair began to fall out, but upon starting these vitamins, everything appeared to restore itself; my skin is clearer, and the rashes have vanished. I cannot comment on nail growth, as I’ve had no issues in that area.
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9.5
Stopped rashes
These vitamins greatly benefit the skin of my face and scalp, as well as my nervous system. They help combat hair loss, especially if it's due to a lack of biotin. With regular use, I have noticed less hair loss and my nails are stronger. I have not experienced any side effects or unpleasant aftertaste. Although we might not require additional biotin if our diet is sufficient, I found that Solgar Biotin works effectively. The hair loss has decreased to a normal level, the nails have returned to health, and rashes on my face are less frequent.
Read More
9.5
Decreased rashes
Almost immediately, I noticed fewer skin problems, with a clear effect evident after two weeks. The rashes on my body have diminished, and new hair has begun to grow. I am eager to see further results.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.8
- All Researches
9.5
Biotin effectively improves rash symptoms
Dramatic Clinical Improvement With Biotin Mega-Dose Therapy in a Neonate With Holocarboxylase Synthetase Deficiency.
High relevance for clinical practice
We explored the effects of biotin therapy on a neonate suffering from a rare metabolic disorder known as holocarboxylase synthetase deficiency. After initiating a biotin mega-dose regimen, we observed impressive results, with the baby showing notable clinical improvement just one day later.
Within six days, mechanical ventilation was no longer necessary, and the child maintained stable health through follow-ups. This case underscores the importance of early genetic testing and how effective biotin can be in treating specific metabolic issues.
Within six days, mechanical ventilation was no longer necessary, and the child maintained stable health through follow-ups. This case underscores the importance of early genetic testing and how effective biotin can be in treating specific metabolic issues.
Read More
9.5
Biotin treatment aids HLCS deficiency
Clinical, biochemical, and genetic analysis of 28 Chinese patients with holocarboxylase synthetase deficiency.
Highly relevant clinical findings
We reviewed the clinical and biochemical characteristics of 28 Chinese patients with holocarboxylase synthetase (HLCS) deficiency. Through this retrospective analysis, we observed that most patients exhibited symptoms like rash, seizures, and vomiting. However, after timely biotin supplementation, almost all showed remarkable improvement in their symptoms and overall health.
This suggests that biotin therapy plays a vital role in managing HLCS deficiency, leading to low mortality rates and encouraging long-term outcomes. Early diagnosis through newborn screening is highlighted as essential for effective treatment.
This suggests that biotin therapy plays a vital role in managing HLCS deficiency, leading to low mortality rates and encouraging long-term outcomes. Early diagnosis through newborn screening is highlighted as essential for effective treatment.
Read More
9.5
Biotin effectively treats skin rash
The first reported HLCS gene mutation causing holocarboxylase synthetase deficiency in a Vietnamese patient.
Significant clinical relevance noted
We explored a fascinating case involving a 6-year-old Vietnamese boy diagnosed with holocarboxylase synthetase deficiency, which is linked to biotin metabolism issues. The boy had a significant skin rash and metabolic acidosis, raising suspicion of multiple carboxylase deficiency. After confirming the diagnosis through urine and genetic tests, he began treatment with biotin.
Remarkably, he experienced a dramatic improvement in his condition within just days of starting the treatment. This strongly suggests that biotin can effectively address symptoms related to this deficiency, including skin rashes.
Remarkably, he experienced a dramatic improvement in his condition within just days of starting the treatment. This strongly suggests that biotin can effectively address symptoms related to this deficiency, including skin rashes.
Read More
9.5
Biotin treatment resolved skin rash
Biotinidase deficiency--clinching the diagnosis rapidly can make all the difference!
Highly relevant clinical case study
We explored a case involving a 2-month-old boy who presented with severe symptoms, including seizures and rash, and was quickly suspected of having biotinidase deficiency. After starting him on biotin supplements, we observed remarkable improvement within just 48 hours. His skin conditions, including perioral and perianal rashes, as well as overall health, significantly improved after regular biotin intake. At 10 months, the child is thriving and seizure-free, showcasing how effective timely biotin treatment can be in alleviating symptoms and resolving rash in such cases.
Read More
9.5
Biotin treatment showed significant effect
Holocarboxylase synthetase deficiency: report of one case.
Relevant case study on biotin deficiency
We examined a patient diagnosed with holocarboxylase synthetase (HCS) deficiency, who presented with a notable rash and other severe symptoms. This condition disrupts biotin's incorporation into enzymes, leading to serious health challenges.
After starting biotin treatment, we observed remarkable improvement in the patient’s condition, including normal growth and development over three years. This case highlights the importance of prompt diagnosis and treatment to avoid serious complications associated with biotin deficiency.
After starting biotin treatment, we observed remarkable improvement in the patient’s condition, including normal growth and development over three years. This case highlights the importance of prompt diagnosis and treatment to avoid serious complications associated with biotin deficiency.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Cleared rashes
These vitamins are my favourite. After childbirth, my hair began to fall out, but upon starting these vitamins, everything appeared to restore itself; my skin is clearer, and the rashes have vanished. I cannot comment on nail growth, as I’ve had no issues in that area.
9.5
Stopped rashes
These vitamins greatly benefit the skin of my face and scalp, as well as my nervous system. They help combat hair loss, especially if it's due to a lack of biotin. With regular use, I have noticed less hair loss and my nails are stronger. I have not experienced any side effects or unpleasant aftertaste. Although we might not require additional biotin if our diet is sufficient, I found that Solgar Biotin works effectively. The hair loss has decreased to a normal level, the nails have returned to health, and rashes on my face are less frequent.
Read More
9.5
Decreased rashes
Almost immediately, I noticed fewer skin problems, with a clear effect evident after two weeks. The rashes on my body have diminished, and new hair has begun to grow. I am eager to see further results.
8.8
Fewer rashes
My skin condition has significantly improved; there are fewer rashes and inflammation. Although the effect on my hair is not as apparent, I've noticed the emergence of many new strands.
8.8
Reduced rashes
Work it seems I have been taking for about a month. My hair grows rapidly everywhere except on my head, where only a few new strands have emerged. Having previously suffered from toenail problems, yellowing and cracking post-fungus, my nails are now healthy. The nails on my hands are strong but have not improved much in growth. My facial rashes occur less frequently, and the acne on my back and chest has disappeared.
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