Supplement Facts
Serving Size: 1 Vegetable Capsule
Amount Per Serving
%DV
Iron (as iron bisglycinate chelate†)
25 mg
139%
The product is found useful for the following medical conditions
Anemia details
SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.6
USERS' SCORE
Excellent
Based on 318 Reviews
9.1
9.5
We examined how iron treatment specifically impacts anemia, particularly during pregnancy. Iron deficiency is a leading cause of anemia, and finding the right treatment is crucial for both mothers and their developing babies.
Our study focused on just the effects of iron without looking at other treatments. This clear approach allowed us to isolate the benefits of iron supplementation. The results were insightful, showing that iron treatment had measurable effects on reducing anemia.
However, we must be careful about overgeneralizing these findings. While our results indicate improvements, it's important to recognize that individual responses to iron may vary. Our findings highlight the importance of monitoring iron levels in pregnant women to effectively address anemia.
Our study focused on just the effects of iron without looking at other treatments. This clear approach allowed us to isolate the benefits of iron supplementation. The results were insightful, showing that iron treatment had measurable effects on reducing anemia.
However, we must be careful about overgeneralizing these findings. While our results indicate improvements, it's important to recognize that individual responses to iron may vary. Our findings highlight the importance of monitoring iron levels in pregnant women to effectively address anemia.
9.5
Saved from anemia
Most Useful Review
Solgar's iron supplement was a lifesaver for my severe anemia. I was barely able to function, feeling exhausted and memory impaired. After months of taking various iron pills, I finally overcame anemia. Doctors advised me to continue taking iron after each menstrual cycle due to my significant blood loss. I can't pinpoint any drawbacks to this supplement; it has solely beneficial effects.
High Cholesterol details
SCIENTIFIC SCORE
Questionable
Based on 6 Researches
6.3
USERS' SCORE
Excellent
Based on 33 Reviews
9
8
Iron's influence on cholesterol levels
We examined the relationship between essential and toxic elements in the plasma of institutionalized older adults and their cholesterol levels. Focusing on a group of 149 Brazilian seniors living in nursing homes, our goal was to understand how these elements influence lipid profiles and blood sugar levels.
Our findings indicated that lower concentrations of certain chemical elements, particularly iron, seemed to protect against increasing total cholesterol levels. We observed non-linear effects of iron, along with other elements like barium and copper, on triglyceride levels. Notably, when the concentration of these elements fell below a certain threshold, we found an associated decrease in total cholesterol.
These results suggest that monitoring the levels of these essential and toxic elements could be vital in preventing dyslipidemia—a condition characterized by abnormal lipid levels—and managing clinical interventions in older adults. The significant role of iron in influencing cholesterol levels emphasizes the need for continued research and screening in this population, to ensure that their health remains a top priority.
Our findings indicated that lower concentrations of certain chemical elements, particularly iron, seemed to protect against increasing total cholesterol levels. We observed non-linear effects of iron, along with other elements like barium and copper, on triglyceride levels. Notably, when the concentration of these elements fell below a certain threshold, we found an associated decrease in total cholesterol.
These results suggest that monitoring the levels of these essential and toxic elements could be vital in preventing dyslipidemia—a condition characterized by abnormal lipid levels—and managing clinical interventions in older adults. The significant role of iron in influencing cholesterol levels emphasizes the need for continued research and screening in this population, to ensure that their health remains a top priority.
10
Prevented hospitalisation
Most Useful Review
This iron saved me from needing hospital treatment! When my haemoglobin was critically low at 70, my gastroenterologist recommended this product. I took large dosages, and thankfully did not face any side effects. My haemoglobin improved to 125 in just three weeks, and my ferritin level also rose significantly. I’m immensely grateful for this iron and its quality!
Allergies details
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.8
USERS' SCORE
Good
Based on 15 Reviews
8.9
8
We examined the rise of hypersensitivity reactions (HRs) linked to iron agents, especially as their usage in treating iron deficiency has increased. In this study, we evaluated the clinical features of patients who experienced immediate hypersensitivity reactions (IHRs) to both oral and intravenous (IV) iron preparations.
Our analysis included the medical records of 96 patients with a history of these reactions. Among them, 47 had reactions to oral iron, while 49 reacted to IV iron. We conducted skin-prick tests with various iron salts, but found that these tests weren't very helpful for diagnosing IHRs. In fact, only a small percentage showed a positive reaction.
Interestingly, we noted that patients who were sensitive to IV iron experienced more severe reactions, including cases of anaphylaxis. Despite the challenges in diagnosing these allergies, we successfully conducted desensitization treatments for 15 patients needing iron, specifically using ferric carboxymaltose. This approach proved to be safe and effective, marking an important option for patients requiring iron therapy despite their hypersensitivity.
Our analysis included the medical records of 96 patients with a history of these reactions. Among them, 47 had reactions to oral iron, while 49 reacted to IV iron. We conducted skin-prick tests with various iron salts, but found that these tests weren't very helpful for diagnosing IHRs. In fact, only a small percentage showed a positive reaction.
Interestingly, we noted that patients who were sensitive to IV iron experienced more severe reactions, including cases of anaphylaxis. Despite the challenges in diagnosing these allergies, we successfully conducted desensitization treatments for 15 patients needing iron, specifically using ferric carboxymaltose. This approach proved to be safe and effective, marking an important option for patients requiring iron therapy despite their hypersensitivity.
9.5
No side effects
Most Useful Review
I took three large doses of two tablets daily for three months. My ferritin increased from 11 to 70. I experienced no issues with allergies or side effects, such as constipation. I've ordered another jar.
Chronic Cough details
SCIENTIFIC SCORE
Likely Very Effective
Based on 2 Researches
9
USERS' SCORE
Good
Based on 17 Reviews
8.9
9
We investigated whether low iron levels might be a factor in chronic cough among women. In our study, twenty-two non-smoking women with chronic unexplained cough and iron deficiency received iron supplementation for two months after initial treatments showed no improvement.
Remarkably, we found that iron therapy led to a significant reduction in cough severity and improved airway sensitivity. This suggests that checking for iron deficiency in women with chronic cough could be beneficial, as replenishing iron may help alleviate their symptoms.
Remarkably, we found that iron therapy led to a significant reduction in cough severity and improved airway sensitivity. This suggests that checking for iron deficiency in women with chronic cough could be beneficial, as replenishing iron may help alleviate their symptoms.
9.5
Improved energy levels
Most Useful Review
Works! I learned that I had anaemia almost a year ago, and lethargy, fatigue, and confusion became constant companions. Initially, I attributed this to chronic fatigue and lack of sleep until tests revealed my low ferritin and haemoglobin levels. I sought medical advice and was prescribed Totem, which proved ineffective. After researching, I chose a Solgar product that didn’t irritate my stomach due to my gastritis. Combined with vitamin C and other vitamins, I noticed improvements within a month. I became more energetic and my quality of life improved as my stomach tolerated the medication well. I recommend it for better health!
Chronic Fatigue Syndrome details
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 95 Reviews
8.9
We explored the effects of iron supplementation on individuals suffering from iron deficiency, specifically looking at its impact on symptoms like chronic fatigue syndrome (CFS). This was done through a well-structured study involving 176 blood donors who were iron deficient, with a randomized controlled trial design.
Participants were assigned to receive either intravenous iron or oral iron supplements. Over an 8-12 week period, we assessed changes in symptoms related to iron deficiency, including CFS, restless legs syndrome (RLS), sleeping disorders, and overall quality of life.
The results indicated that iron supplementation may significantly improve the symptoms associated with iron deficiency among blood donors. By addressing the iron deficiency, we noted improvements not only in fatigue but also in wellbeing, confirming that targeted iron treatment can be beneficial for those struggling with chronic fatigue linked to low iron levels. This is an exciting finding for both clinicians and patients, shedding light on a relatively simple intervention that can enhance quality of life.
Participants were assigned to receive either intravenous iron or oral iron supplements. Over an 8-12 week period, we assessed changes in symptoms related to iron deficiency, including CFS, restless legs syndrome (RLS), sleeping disorders, and overall quality of life.
The results indicated that iron supplementation may significantly improve the symptoms associated with iron deficiency among blood donors. By addressing the iron deficiency, we noted improvements not only in fatigue but also in wellbeing, confirming that targeted iron treatment can be beneficial for those struggling with chronic fatigue linked to low iron levels. This is an exciting finding for both clinicians and patients, shedding light on a relatively simple intervention that can enhance quality of life.
9.5
Fatigue alleviated
Most Useful Review
Iron in an easily digestible form helped me significantly. By the third day, my daytime fatigue and drowsiness vanished. I was diagnosed with low iron levels through tests. After my doctor prescribed this form, which is highly absorbable, I took one capsule daily along with other vitamins. I felt genuinely cheerful once I began this iron.
Dizziness details
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.8
USERS' SCORE
Good
Based on 96 Reviews
8.9
9
We studied the impact of iron treatment on dizziness experienced by a 42-year-old woman suffering from severe iron deficiency anemia due to menometrorrhagia. Throughout her hospital stay, she received blood transfusions and intravenous iron, which played a critical role in addressing her debilitating symptoms.
Remarkably, despite her initial critically low hemoglobin levels, she managed to remain hemodynamically stable. By the end of her treatment, her symptoms of fatigue and dizziness had resolved, allowing her to return to her normal activities before discharge. This case highlights an important connection between iron levels and dizziness, illustrating that replenishing iron can significantly alleviate dizzy spells linked to anemia.
Our findings underscore how crucial it is to address iron deficiency effectively, as it can prevent serious complications and improve overall quality of life for patients experiencing symptoms like dizziness.
Remarkably, despite her initial critically low hemoglobin levels, she managed to remain hemodynamically stable. By the end of her treatment, her symptoms of fatigue and dizziness had resolved, allowing her to return to her normal activities before discharge. This case highlights an important connection between iron levels and dizziness, illustrating that replenishing iron can significantly alleviate dizzy spells linked to anemia.
Our findings underscore how crucial it is to address iron deficiency effectively, as it can prevent serious complications and improve overall quality of life for patients experiencing symptoms like dizziness.
9.5
Dizziness subsided
Most Useful Review
This iron supplement is incredible! After suffering from anaemia and dizziness for years, I tried various treatments that only led to constipation. Following my doctor's recommendation, I took this easily digestible iron. Within a month, my haemoglobin levels rose, and the dizziness was gone. I'm continuing to take it.
Anxiety details
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 7 Reviews
8.8
7
We examined how changes in iron levels during pregnancy relate to anxiety and overall wellbeing. The study followed pregnant women in Cape Coast, Ghana, tracking their iron status and psychological health throughout the first, second, and third trimesters.
Our findings indicate that improvements in iron levels from the first to the second trimester significantly reduced anxiety, especially concerning fearful feelings. The numbers showed that women who enjoyed better iron status experienced less anxiety, which suggests iron supplementation might play a helpful role in enhancing mental health during early pregnancy.
However, we also noted that as iron levels changed from the second to the third trimester, there was a surprising rise in anxiety. Despite initial improvements, some aspects of quality of life declined, indicating the complex relationship between iron status and mental wellbeing.
Overall, this study sheds light on the importance of monitoring and managing iron levels in expecting mothers, as it may impact not only physical health but also emotional wellbeing.
Our findings indicate that improvements in iron levels from the first to the second trimester significantly reduced anxiety, especially concerning fearful feelings. The numbers showed that women who enjoyed better iron status experienced less anxiety, which suggests iron supplementation might play a helpful role in enhancing mental health during early pregnancy.
However, we also noted that as iron levels changed from the second to the third trimester, there was a surprising rise in anxiety. Despite initial improvements, some aspects of quality of life declined, indicating the complex relationship between iron status and mental wellbeing.
Overall, this study sheds light on the importance of monitoring and managing iron levels in expecting mothers, as it may impact not only physical health but also emotional wellbeing.
9.5
Resolved emotional anxiety
Most Useful Review
Sleeping pills have decreased since I started this iron supplement, which I suspect improved my sleep due to a previous iron deficiency. After three months, my iron value rose from 5 to 20, surprising my doctor. Importantly, my emotional anxiety has resolved, and the price has been reasonable, offering great value.
Autoimmune Disorder details
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
USERS' SCORE
Good
Based on 125 Reviews
8.8
8
We examined how curcumin-mediated photodynamic therapy (CUR-PDT) induces a specific type of cell death called ferroptosis in fibroblast-like synoviocytes from rheumatoid arthritis patients.
Using a rat model, we monitored joint swelling and inflammation while analyzing key proteins involved in this process. The results indicated that CUR-PDT successfully reduces harmful cell growth and inflammation in RA cells by targeting the Nrf2-xCT-GPX4 pathway.
This finding emphasizes the potential of CUR-PDT as a treatment strategy in managing rheumatoid arthritis.
Using a rat model, we monitored joint swelling and inflammation while analyzing key proteins involved in this process. The results indicated that CUR-PDT successfully reduces harmful cell growth and inflammation in RA cells by targeting the Nrf2-xCT-GPX4 pathway.
This finding emphasizes the potential of CUR-PDT as a treatment strategy in managing rheumatoid arthritis.
9.5
Improved health
Most Useful Review
I am alive! I have chronic anaemia and have tried various forms of iron. Oral iron often causes digestive issues, especially at high doses. Solgar is gentle and has had no side effects for me; I noticed a positive effect within three days. Remember: iron absorbs poorly with tea, coffee, and dairy. It’s best taken with vegetables, fruits, or protein. Health to you, Russians!
Blurred Vision details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 6 Reviews
8.8
9.5
Improved vision
Most Useful Review
We drink Magic Vitamins with the whole family and are extremely pleased! I stopped frequently getting ill; my hemoglobin was at 65 for 20 years! It only reached 97 at its highest. Since starting the vitamins, my hemoglobin is now between 120-130! I’m astounded; the doctors are amazed! I'm also very pleased as my bad mood has vanished, and my vision, which was -2.6, is now back to normal! I wake and sleep without issues! A year ago, I weighed 87 kg, and now only 59 kg at 37 years old! All the crunching in my bones has stopped, allowing me to sit comfortably—all health to you all; take care of yourselves!
Constipation details
SCIENTIFIC SCORE
Questionable
Based on 11 Researches
6
USERS' SCORE
Good
Based on 361 Reviews
8.8
9
We assessed how iron supplementation impacts blood donors who may suffer from low iron levels. Our analysis included thirty studies with nearly 4,700 participants, focusing on the differences between those receiving iron and those who didn’t.
We found that iron supplements reduced the chances of donors being deferred due to low hemoglobin levels and helped elevate their hemoglobin and iron stores. However, we also noted more side effects, like constipation and nausea, among those taking iron.
These side effects hinder its widespread use, suggesting iron supplements should be targeted to at-risk individuals only.
We found that iron supplements reduced the chances of donors being deferred due to low hemoglobin levels and helped elevate their hemoglobin and iron stores. However, we also noted more side effects, like constipation and nausea, among those taking iron.
These side effects hinder its widespread use, suggesting iron supplements should be targeted to at-risk individuals only.
9.5
No constipation
Most Useful Review
I started taking it with vitamin C on an empty stomach and in the evening with lactoferrin before bed. It seems to positively impact my digestion and iron absorption. I feel cheery, with no fatigue, and my hair stopped falling out. There’s no metallic taste, no stomach pains, and importantly, no constipation. I find the capsules easy to swallow; just one a day has noticeable effects. I highly recommend it for health.
Depression details
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.7
USERS' SCORE
Good
Based on 21 Reviews
8.8
8
We explored how iron levels impact depression and hippocampal health. By studying mice under chronic mild stress and using an iron chelator, we observed that excessive iron leads to synaptic damage in the brain. This harmful effect was linked to the downregulation of crucial proteins involved in brain health.
Interestingly, when we activated a protein called Nrf2, we saw improvements in iron balance and a reduction in depression symptoms. Our findings suggest that focusing on Nrf2 and managing iron levels could be key in developing better treatments for depression.
Interestingly, when we activated a protein called Nrf2, we saw improvements in iron balance and a reduction in depression symptoms. Our findings suggest that focusing on Nrf2 and managing iron levels could be key in developing better treatments for depression.
9.3
Improved mood
Most Useful Review
Iron bisglycinate is the best form for absorption. After months of use due to low ferritin levels, I haven't yet retested my blood but did notice an initial excitement followed by stability in mood. My menstrual blood loss has decreased. A reasonable psychiatrist will check ferritin levels in those with depression, as low ferritin can be a contributing factor.
Migraine details
SCIENTIFIC SCORE
Questionable
Based on 4 Researches
6.8
USERS' SCORE
Good
Based on 9 Reviews
8.8
8
We examined the link between iron deficiency anemia and migraines to understand how iron levels affect migraine symptoms. Our research confirmed that individuals suffering from migraines, especially women, tend to have lower iron levels. This suggests a significant relationship where low iron may worsen migraine frequency and intensity.
Through our literature review, we discovered that iron supplementation has been beneficial for some migraine sufferers, particularly those with diagnosed iron deficiency anemia. By increasing iron levels, we noted improvements in migraine symptoms, making it a potential treatment strategy worth considering.
However, we also highlighted that while iron supplementation shows promise, it’s essential to approach treatment carefully. Further research is necessary to determine the long-term effects and to establish guidelines on its use, minimizing any risks of iron overload. Overall, we advocate for incorporating nutritional evaluations into migraine management strategies to enhance patient outcomes effectively.
Through our literature review, we discovered that iron supplementation has been beneficial for some migraine sufferers, particularly those with diagnosed iron deficiency anemia. By increasing iron levels, we noted improvements in migraine symptoms, making it a potential treatment strategy worth considering.
However, we also highlighted that while iron supplementation shows promise, it’s essential to approach treatment carefully. Further research is necessary to determine the long-term effects and to establish guidelines on its use, minimizing any risks of iron overload. Overall, we advocate for incorporating nutritional evaluations into migraine management strategies to enhance patient outcomes effectively.
10
Eliminated migraines completely
Most Useful Review
Before starting these capsules, I had my ferritin level checked, which was at 11.2 ng/ml. Two months later, after taking one pill a day with 500mg of Vitamin C, I've noticed a significant improvement and my migraines have completely disappeared!
Urinary Tract Infection details
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7
USERS' SCORE
Good
Based on 50 Reviews
8.8
8
Iron nanoparticles show promising antibacterial effects
We investigated how iron oxide nanoparticles can combat bacterial infections in the urinary tract. During our study, we analyzed urine samples from elderly patients and identified various bacterial strains causing infections. By synthesizing iron oxide nanoparticles, we tested their effectiveness against these bacteria.
We found that these nanoparticles displayed strong antibacterial activity, particularly against gram-negative bacteria. The minimum inhibitory concentration demonstrated significant results compared to controls, indicating their potential as a novel treatment option. However, results suggested that while effective, iron oxide nanoparticles’ advantages may not be uniform across all bacteria types.
We found that these nanoparticles displayed strong antibacterial activity, particularly against gram-negative bacteria. The minimum inhibitory concentration demonstrated significant results compared to controls, indicating their potential as a novel treatment option. However, results suggested that while effective, iron oxide nanoparticles’ advantages may not be uniform across all bacteria types.
9.5
Fatigue resolved
Most Useful Review
I am now past the symptoms of low ferritin, which I strongly recommend checking with your doctor. I take iron in the evening with probiotics. The cold hands, mood swings, and fatigue are behind me, which is a relief!
Frozen Shoulder details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 6 Reviews
8.7
9
Improved symptoms
Most Useful Review
I was diagnosed with anemia before a blood transfusion and began taking this supplement. I had been experiencing anaemia during pregnancy, and while I was on medication, the iron preparations caused constipation and stomach pain. Consulting a doctor led me to try supplements. By the third month, my anaemia symptoms improved. The cause in my case was uterine fibroids, so I plan to continue this supplement until menopause. My terribly stiff shoulders have improved, and I'm very grateful for this supplement. I only took one tablet daily, making it quite cost-effective.
Kidney Stones details
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
6.5
USERS' SCORE
Good
Based on 5 Reviews
8.7
9
We explored the potential of an innovative treatment for calcium oxalate (CaOx) nephropathies using ultrasmall iron-gallic acid (Fe-Ga) metal-phenolic networks. These nanonetworks showcase the unique ability to attach themselves to certain crystal surfaces, specifically targeting the high-energy faces of calcium oxalate crystals. By doing so, they inhibit the growth of these harmful crystals and encourage a transition to a less dangerous form.
Additionally, Fe-Ga MPNs have shown promise as powerful antioxidants, reducing oxidative damage and inflammation within the kidneys. This treatment seems to be particularly effective at accumulating where kidney injury occurs, subsequently aiding in tubule function and reducing overall kidney inflammation. The result is a multi-faceted approach to kidney stone treatment, combining crystallization inhibition with anti-inflammatory and antioxidant effects.
Our analysis points to a shift in immune responses as a result of Fe-Ga MPNs, showing potential benefits in preventing future complications from kidney stones. Overall, this multifunctional treatment approach presents exciting opportunities for addressing kidney stones while also providing protective effects against oxidative stress and inflammation.
Additionally, Fe-Ga MPNs have shown promise as powerful antioxidants, reducing oxidative damage and inflammation within the kidneys. This treatment seems to be particularly effective at accumulating where kidney injury occurs, subsequently aiding in tubule function and reducing overall kidney inflammation. The result is a multi-faceted approach to kidney stone treatment, combining crystallization inhibition with anti-inflammatory and antioxidant effects.
Our analysis points to a shift in immune responses as a result of Fe-Ga MPNs, showing potential benefits in preventing future complications from kidney stones. Overall, this multifunctional treatment approach presents exciting opportunities for addressing kidney stones while also providing protective effects against oxidative stress and inflammation.
9.5
Effective for absorption
Most Useful Review
I ordered this for my child after a kidney transplant. The iron is perfectly absorbed with no negative effects on the intestines, and it doesn’t stain stools black. Over the month of use, iron levels increased significantly, and haemoglobin returned to normal.
Swollen Lymph Nodes details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 10 Reviews
8.7
9.5
Edema reduced
Most Useful Review
After starting this medication, I noticed my tongue swelling disappeared within about a week. I recommend it, especially for its rapid effectiveness. I took two capsules each evening.
Tinnitus details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.7
9.5
Tinnitus improvement
Most Useful Review
I liked it! After passing my tests, I began taking this supplement as my iron levels were low. These vitamins are effective and gentle, with no side effects like the taste of iron. Within a week, I felt much better, and my tinnitus reduced significantly. Subsequent tests confirmed my iron levels had normalised, and I continued to feel well.
Ulcer details
SCIENTIFIC SCORE
Likely Very Effective
Based on 3 Researches
9
USERS' SCORE
Good
Based on 3 Reviews
8.7
9
We explored a case involving a 66-year-old woman who developed a gastric ulcer after using oral iron supplements for an extended period. Iron therapy is commonly prescribed for treating iron deficiency anemia, but it often comes with gastrointestinal side effects.
In this instance, the patient had a history of GI bleeding and other medical conditions, which might have contributed to her increased risk. While gastrointestinal issues with iron supplements are not unusual, having a gastric ulcer as a direct result is rare, and only a handful of similar cases have been reported in medical literature.
Upon conducting endoscopic and histopathological evaluations, we identified iron deposits in the ulcer bed, confirming that the iron therapy was indeed linked to her gastric ulcer. After stopping the oral iron supplements, her symptoms resolved, highlighting the need for careful patient monitoring during iron therapy to prevent serious complications like ulcers.
Our findings emphasize the importance of recognizing and managing the potential adverse effects of oral iron to maintain a safe and effective treatment regimen for iron deficiency anemia.
In this instance, the patient had a history of GI bleeding and other medical conditions, which might have contributed to her increased risk. While gastrointestinal issues with iron supplements are not unusual, having a gastric ulcer as a direct result is rare, and only a handful of similar cases have been reported in medical literature.
Upon conducting endoscopic and histopathological evaluations, we identified iron deposits in the ulcer bed, confirming that the iron therapy was indeed linked to her gastric ulcer. After stopping the oral iron supplements, her symptoms resolved, highlighting the need for careful patient monitoring during iron therapy to prevent serious complications like ulcers.
Our findings emphasize the importance of recognizing and managing the potential adverse effects of oral iron to maintain a safe and effective treatment regimen for iron deficiency anemia.
9.5
Suitable for ulcers
Most Useful Review
This Gentle Iron is appropriate for individuals with ulcers and anaemia like myself.
Yeast Infection details
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.5
USERS' SCORE
Good
Based on 4 Reviews
8.7
8
We explored the potential of iron chelation in combating yeast infections caused by the common fungus Candida, which can lead to serious systemic diseases. Our research involved screening over 3,000 unique compounds from a specialized chemical library to identify those that effectively inhibited the growth of a clinical isolate of Candida.
Through this extensive screening, we discovered 17 promising compounds, with three—CMLD013360, CMLD012661, and CMLD012693—showing particularly strong antifungal effects. These compounds belong to two different chemical families and are believed to combat fungal growth by binding to essential metal nutrients like iron.
Interestingly, when we supplemented the growth media with iron, we observed a recovery in the fungus’s growth. This confirmed that the antifungal activity of our compounds was indeed due to their capacity to chelate iron. Importantly, our findings also revealed that these compounds were effective against a variety of other pathogenic fungi, thus underscoring their potential as new treatments in an era where antifungal resistance is becoming increasingly common.
Overall, this study highlights the critical role that iron chelation can play in tackling yeast infections and opens up exciting avenues for the development of novel antifungal therapies.
Through this extensive screening, we discovered 17 promising compounds, with three—CMLD013360, CMLD012661, and CMLD012693—showing particularly strong antifungal effects. These compounds belong to two different chemical families and are believed to combat fungal growth by binding to essential metal nutrients like iron.
Interestingly, when we supplemented the growth media with iron, we observed a recovery in the fungus’s growth. This confirmed that the antifungal activity of our compounds was indeed due to their capacity to chelate iron. Importantly, our findings also revealed that these compounds were effective against a variety of other pathogenic fungi, thus underscoring their potential as new treatments in an era where antifungal resistance is becoming increasingly common.
Overall, this study highlights the critical role that iron chelation can play in tackling yeast infections and opens up exciting avenues for the development of novel antifungal therapies.
9.5
Increased energy levels
Most Useful Review
HEMOGLOBIN IS GOING UP IMMEDIATELY! Excellent drug. Iron in the chelated form of bisglycinate. A trusted company, a highly bioavailable form of iron that is easily digestible. It does not cause constipation and works gently, with no side effects. It helped me restore my ferritin levels and normalise my haemoglobin levels. The effects make me feel more energetic and less lethargic. My mother also took it and was satisfied. Iron is vital for transporting oxygen to tissues, metabolic processes, and maintaining immune function. Iron deficiency results in extreme fatigue and other issues. If my review was useful to you, please put YES 👍
Athlete’s Foot details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 4 Reviews
8.6
8.3
Increased energy levels
Most Useful Review
Great for an athlete with low iron levels. I've consistently had low iron levels, but I enjoy challenging myself with long-distance cycling. Unfortunately, my energy tends to drop significantly towards the end of rides, causing poor concentration, fatigue, and slow healing of minor grazes. After an iron infusion in February, I felt much better for a couple of months, but when symptoms returned, I decided to try this product. I appreciate it doesn't contain additional B vitamins, as those can affect my sleep. I take it every morning and in the evening before long rides. It has been tremendous—highly recommended.
Bone Pain details
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.3
USERS' SCORE
Good
Based on 4 Reviews
8.6
9
Alendronate reduces pain and improves BMD
We explored the effectiveness of alendronate, a common drug for osteoporosis, in treating bone pain and improving bone health in patients with thalassemia. This randomized controlled trial involved men and premenopausal women, who were given either alendronate or a placebo for 12 months.
We found that alendronate significantly improved bone mineral density and reduced back pain. Even better, the treatment was well tolerated with a good safety profile. Overall, our findings suggest that alendronate can be beneficial for those struggling with osteoporosis linked to thalassemia.
We found that alendronate significantly improved bone mineral density and reduced back pain. Even better, the treatment was well tolerated with a good safety profile. Overall, our findings suggest that alendronate can be beneficial for those struggling with osteoporosis linked to thalassemia.
9.5
Improved health
Most Useful Review
The best hardware! I discovered this iron supplement during my pregnancy due to my anaemia. After two months, my iron deficiency was rectified, and my health improved significantly, with bone pain and dizziness disappearing. It is a mild form of iron that does not cause diarrhoea or stomach pain. If this was helpful, please like it!
Food Poisoning details
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 36 Reviews
8.6
8
We explored how iron influences food poisoning, particularly in the context of campylobacteriosis, a common foodborne illness. Our focus was on the effects of deferoxamine (DESF), an iron-chelating compound, when administered orally to mice before they were infected.
In our study, we included microbiota-depleted IL-10 mice that received DESF through their drinking water starting a week ahead of being exposed to the Campylobacter strain known as 81-176. While we did not observe any significant reduction in the levels of the bacteria in the gastrointestinal tract, we did identify some noteworthy improvements in the overall health status of the infected mice by the sixth day post-infection.
These findings suggested that DESF treatment seemed to alleviate the disease's impact, manifesting as reduced cell death in the colon, lower numbers of immune cells like neutrophils accumulating in the large intestines, and decreased levels of inflammatory markers, including IFN-γ and MCP-1, in both the intestines and systemically.
Overall, our research illustrates the potential for iron-targeting strategies to positively affect the progression and severity of campylobacteriosis, offering a new outlook for treatment approaches when conventional antibiotic methods are not recommended.
In our study, we included microbiota-depleted IL-10 mice that received DESF through their drinking water starting a week ahead of being exposed to the Campylobacter strain known as 81-176. While we did not observe any significant reduction in the levels of the bacteria in the gastrointestinal tract, we did identify some noteworthy improvements in the overall health status of the infected mice by the sixth day post-infection.
These findings suggested that DESF treatment seemed to alleviate the disease's impact, manifesting as reduced cell death in the colon, lower numbers of immune cells like neutrophils accumulating in the large intestines, and decreased levels of inflammatory markers, including IFN-γ and MCP-1, in both the intestines and systemically.
Overall, our research illustrates the potential for iron-targeting strategies to positively affect the progression and severity of campylobacteriosis, offering a new outlook for treatment approaches when conventional antibiotic methods are not recommended.
9.5
No constipation noted
Most Useful Review
This is the best iron! I battled anaemia and dizziness for ages and suffered from severe constipation with other medications. A doctor recommended this easily digestible iron from Solgar, which has been my salvation! No side effects or constipation, just one capsule daily with food. Within a month, my hemoglobin rose above average and my ferritin improved as well. I continue to take it.
Heart Disease details
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.5
USERS' SCORE
Good
Based on 4 Reviews
8.6
9
We investigated the role of iron treatment in managing heart disease, particularly its isolated effects. The research closely looked at how iron supplementation interacts with other therapies in patients with heart conditions.
Heart disease can often be complicated by iron deficiency, leading to questions about the potential benefits of treating this deficiency. Our findings revealed that while iron treatment showed some promise, its overall effectiveness on improving heart disease symptoms or outcomes appeared limited when considered in isolation.
Additionally, the study emphasized the importance of viewing iron treatment not as a standalone solution, but as part of a broader approach that includes other therapies. This nuanced understanding can help guide healthcare practices in treating heart disease patients more effectively.
Heart disease can often be complicated by iron deficiency, leading to questions about the potential benefits of treating this deficiency. Our findings revealed that while iron treatment showed some promise, its overall effectiveness on improving heart disease symptoms or outcomes appeared limited when considered in isolation.
Additionally, the study emphasized the importance of viewing iron treatment not as a standalone solution, but as part of a broader approach that includes other therapies. This nuanced understanding can help guide healthcare practices in treating heart disease patients more effectively.
9.5
Significant relief
Most Useful Review
After three days of taking this iron supplement, I felt a remarkable difference. For four years, I’ve struggled with a lack of oxygen, which traditional visits to cardiologists failed to address. Discovering this product provided such relief, like a weight was lifted from my lungs and heart! If you have similar symptoms, I recommend getting an iron test and considering this supplement, as it genuinely works.
Insomnia details
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 3 Reviews
8.6
7
We observed a strong connection between iron deficiency (ID) and restlessness impacting sleep in children with neurodevelopmental disorders such as ADHD and autism spectrum disorders (ASD). In a clinic focused on sleep/wake behaviors, we found that a staggering 94% of the 199 patients evaluated had ID, and many struggled with insomnia and sleep disorders.
Notably, patients with a family history of ID faced heightened risks of experiencing sleep disturbances, including restless legs syndrome (RLS) and chronic insomnia. For instance, in children with ADHD, the odds of insomnia increased significantly with a family background of ID. Similarly, those with ASD also showed increased odds for various sleep issues tied to a familial history of ID.
These insights highlight an urgent need for integrating comprehensive evaluations that address both iron levels and family sleep history. By doing so, we can better understand and address the sleep challenges faced by these children and adolescents, and potentially improve their quality of life.
Notably, patients with a family history of ID faced heightened risks of experiencing sleep disturbances, including restless legs syndrome (RLS) and chronic insomnia. For instance, in children with ADHD, the odds of insomnia increased significantly with a family background of ID. Similarly, those with ASD also showed increased odds for various sleep issues tied to a familial history of ID.
These insights highlight an urgent need for integrating comprehensive evaluations that address both iron levels and family sleep history. By doing so, we can better understand and address the sleep challenges faced by these children and adolescents, and potentially improve their quality of life.
9.5
Improved sleep
Most Useful Review
Great sleep improved; I had insomnia for seven months.
Knee Pain details
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 59 Reviews
8.6
8
We focused on the effects of iron treatment as part of a broader strategy for managing blood loss and pain in patients undergoing staged bilateral total knee arthroplasty (TKA) within a single hospital stay. In our study, we compared two groups of patients: one receiving a newly introduced multimodal blood management (MBM) approach that included preoperative oral iron treatment, and a control group that only received standard care.
Our findings were promising. The group treated with the MBM protocol experienced significantly lower rates of blood transfusion—only 9% of patients required one—compared to 32.4% in the control group. This approach not only reduced the need for additional blood transfusions but also led to improvements in postoperative hemoglobin levels and reduced pain and swelling in the knees after surgery.
The results suggest that incorporating iron treatment in a comprehensive management program can effectively help alleviate knee pain and enhance recovery from surgery. Best of all, this was achieved without leading to any significant complications, indicating a safe and economical option for improving outcomes in TKA patients.
Our findings were promising. The group treated with the MBM protocol experienced significantly lower rates of blood transfusion—only 9% of patients required one—compared to 32.4% in the control group. This approach not only reduced the need for additional blood transfusions but also led to improvements in postoperative hemoglobin levels and reduced pain and swelling in the knees after surgery.
The results suggest that incorporating iron treatment in a comprehensive management program can effectively help alleviate knee pain and enhance recovery from surgery. Best of all, this was achieved without leading to any significant complications, indicating a safe and economical option for improving outcomes in TKA patients.
9.5
Great for anaemia
Most Useful Review
This product is wonderful for those suffering from anaemia and low iron levels, which can cause constipation and stomach issues. I particularly recommend taking it alongside orange juice for better absorption.
Nausea details
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8
USERS' SCORE
Good
Based on 109 Reviews
8.6
9
We evaluated how switching to ferric citrate hydrate (FCH) impacts nausea in women with iron deficiency anemia (IDA) who struggled with oral iron. In a multicenter study of 30 patients, those on FCH experienced significant improvements. Nausea scores dropped from 5.7 to 1.7, and the overall incidence of nausea decreased notably. Also, 80% reported better experiences compared to previous treatments.
Overall, our findings suggest that FCH not only enhances medication adherence but also effectively reduces nausea and improves quality of life in these patients.
Overall, our findings suggest that FCH not only enhances medication adherence but also effectively reduces nausea and improves quality of life in these patients.
9.5
No nausea noted
Most Useful Review
A gentle and effective product. I've been using it every other day without any nausea, even on an empty stomach, and my iron levels improved!
Osteoporosis details
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8
USERS' SCORE
Good
Based on 2 Reviews
8.6
8
We investigated how excess iron in the body affects osteoporosis and how a compound called Cardamonin could help combat this issue. The study involved creating a mouse model with iron overload and assessing the severity of osteoporosis using advanced imaging and staining techniques.
We focused on understanding the cellular effects of high iron levels on osteoblasts, the cells responsible for bone formation. We discovered that iron overload triggers oxidative stress in these cells, which can impede their function and lead to weaker bones. Our findings showed that Cardamonin can mitigate these adverse effects by reducing the buildup of reactive oxygen species (ROS) and promoting healthier bone formation.
Ultimately, we found that by targeting specific pathways related to oxidative stress, Cardamonin offers a promising therapeutic option for addressing osteoporosis exacerbated by iron overload. This research highlights the importance of maintaining proper iron balance for bone health.
We focused on understanding the cellular effects of high iron levels on osteoblasts, the cells responsible for bone formation. We discovered that iron overload triggers oxidative stress in these cells, which can impede their function and lead to weaker bones. Our findings showed that Cardamonin can mitigate these adverse effects by reducing the buildup of reactive oxygen species (ROS) and promoting healthier bone formation.
Ultimately, we found that by targeting specific pathways related to oxidative stress, Cardamonin offers a promising therapeutic option for addressing osteoporosis exacerbated by iron overload. This research highlights the importance of maintaining proper iron balance for bone health.
9.5
Effective treatment
Most Useful Review
The medication was prescribed for low ferritin and indications of osteoporosis. It works effectively with no side effects. I took it as directed by my doctor—one capsule each evening.
Stroke details
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.3
USERS' SCORE
Good
Based on 2 Reviews
8.6
9
We aimed to understand how Lycium barbarum glycopeptide could help reduce the harmful effects of iron overload in stroke-affected neurons. Through a controlled study involving rats, we examined the substance's ability to alleviate damage following a stroke induced by middle cerebral artery occlusion.
Over the course of seven days, beginning 24 hours after the stroke event, we treated these rats with Lycium barbarum glycopeptide. We observed significant improvements in brain health, including reduced infarct volume and neuronal death, which were verified through various medical imaging techniques.
More importantly, we noted improvements in sensory and motor functions, as well as reductions in anxiety and depression-like behaviors. The research also showed that this glycopeptide effectively decreased iron levels in the ischemic tissue while promoting protective proteins in the brain.
These findings suggest that Lycium barbarum glycopeptide could be a valuable neuroprotective agent for stroke patients by targeting iron overload and oxidation, ultimately enhancing recovery. The positive effects we found were compromised when a ferroptosis activator was introduced, highlighting the importance of the mechanisms that this treatment influences.
Over the course of seven days, beginning 24 hours after the stroke event, we treated these rats with Lycium barbarum glycopeptide. We observed significant improvements in brain health, including reduced infarct volume and neuronal death, which were verified through various medical imaging techniques.
More importantly, we noted improvements in sensory and motor functions, as well as reductions in anxiety and depression-like behaviors. The research also showed that this glycopeptide effectively decreased iron levels in the ischemic tissue while promoting protective proteins in the brain.
These findings suggest that Lycium barbarum glycopeptide could be a valuable neuroprotective agent for stroke patients by targeting iron overload and oxidation, ultimately enhancing recovery. The positive effects we found were compromised when a ferroptosis activator was introduced, highlighting the importance of the mechanisms that this treatment influences.
8.8
Improved dizziness
Most Useful Review
I purchased this for my elderly mother, who was very dizzy following her stroke. The doctor mentioned she might require iron supplements, so I decided to get this one. I am pleased with the results; the quality is excellent, the size is convenient, and the benefits are significant. Many older adults suffer from iron deficiency, making this supplement essential. Dizziness is the primary symptom. The taste is reasonable, and I use it twice daily. The ingredients include iron.
Vertigo details
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 2 Reviews
8.6
9
Iron treatment alleviates vertigo symptoms
Our study aimed to understand how iron deficiency impacts students' experiences, particularly focusing on symptoms like vertigo and dizziness. We set out to identify undiagnosed iron deficiency among first-grade students at an upper secondary school and evaluated changes in their symptoms and lab results after three months of iron supplementation.
Through our research, we found that 12% of the students had iron deficiency, and 61% exhibited some abnormal test results related to iron levels. Notably, we observed that symptoms of vertigo and dizziness were significantly more common in those with iron deficiency. After the students received iron supplementation, we recorded notable improvements: iron levels increased, transferrin levels decreased, and importantly, there was a marked reduction in symptoms, including vertigo, irritability, and depressive feelings.
Our findings convincingly highlight that iron supplementation can be beneficial in alleviating certain symptoms, specifically vertigo and dizziness, among students struggling with iron deficiency. This connection opens doors to addressing quality of life issues tied to iron levels among young individuals.
Through our research, we found that 12% of the students had iron deficiency, and 61% exhibited some abnormal test results related to iron levels. Notably, we observed that symptoms of vertigo and dizziness were significantly more common in those with iron deficiency. After the students received iron supplementation, we recorded notable improvements: iron levels increased, transferrin levels decreased, and importantly, there was a marked reduction in symptoms, including vertigo, irritability, and depressive feelings.
Our findings convincingly highlight that iron supplementation can be beneficial in alleviating certain symptoms, specifically vertigo and dizziness, among students struggling with iron deficiency. This connection opens doors to addressing quality of life issues tied to iron levels among young individuals.
8.3
Menstruation normalised
Most Useful Review
The first joy of taking dietary supplements was the normalisation of my menstruation. My blood pressure stabilised, my head stopped hurting, and I regained normal sleep patterns. I acted quickly, so my vertigo also ceased. There were no issues with brown teeth or gastrointestinal problems after starting this supplement.
Common Cold details
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 13 Reviews
8.5
9
We explored whether home fortification of foods with multiple micronutrient powders (MNPs) impacts nutrition and health in children under two years. Analyzing 29 studies, we discovered that using MNPs significantly lowered anaemia rates by 18% and iron deficiency by 53%. Moreover, MNPs improved haemoglobin levels compared to no intervention. However, there was no notable influence on weight. While the intervention showed promise for anaemia, its direct effects on other health areas remain unclear, indicating a need for more research in this area.
9.5
Increased energy
Most Useful Review
HEMOGLOBIN IS GOING UP IMMEDIATELY! This excellent drug, iron in the chelated form of bisglycinate, has effectively restored my ferritin and normalised my haemoglobin levels. I feel more energetic and no longer sluggish. It has no side effects, such as constipation. My mother was also satisfied with it.
Hypothyroidism details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.5
9.5
Significant improvement
Most Useful Review
After struggling with anaemia for many years, I finally discovered my hemoglobin was 80 when it should be 120. I had attributed my weakness and hair loss to my mild hypothyroidism. Since taking Solgar iron supplements for 2.5 months, my hemoglobin has risen to 122, which is normal. My overall well-being has greatly improved, and my hair hardly falls out anymore. Although my ferritin levels are still low, I understand that it takes about six months of iron preparation to raise them. I am VERY SATISFIED.
Cancer details
SCIENTIFIC SCORE
Likely Very Effective
Based on 10 Researches
9
USERS' SCORE
Good
Based on 4 Reviews
8.4
9
SPIO improves lymph node detection
We explored the effectiveness of superparamagnetic iron oxide (SPIO) in detecting sentinel lymph nodes in breast cancer patients who had undergone neoadjuvant systemic therapy before surgery. This study included a systematic review of multiple databases and focused on comparing SPIO to the standard methods involving radioisotope and blue dye.
Our findings highlight that SPIO successfully identified sentinel lymph nodes in about 98.1% of cases, while the standard method achieved a detection rate of 94.6%. When examining the number of lymph nodes retrieved, SPIO demonstrated superior performance, with an average of 2.26 nodes detected compared to 1.86 with the conventional approach.
The overall quality of the studies reviewed was considered good, indicating that we can reliably say SPIO can be safely and effectively adopted in clinical practice for these patients. This suggests a promising alternative in medical settings, where identifying lymph nodes accurately is crucial for treatment planning.
Our findings highlight that SPIO successfully identified sentinel lymph nodes in about 98.1% of cases, while the standard method achieved a detection rate of 94.6%. When examining the number of lymph nodes retrieved, SPIO demonstrated superior performance, with an average of 2.26 nodes detected compared to 1.86 with the conventional approach.
The overall quality of the studies reviewed was considered good, indicating that we can reliably say SPIO can be safely and effectively adopted in clinical practice for these patients. This suggests a promising alternative in medical settings, where identifying lymph nodes accurately is crucial for treatment planning.
9.5
Significant improvement
Most Useful Review
These pills are excellent. My father is a cancer patient and was incredibly weak with a hemoglobin level of just 50 in August. After two months of taking these pills, his hemoglobin rose to 106. I’m really pleased with the results.
Cardiovascular Disease details
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 6 Reviews
8.4
7
Iron deficiency impacts heart failure
Our investigation focused on the impact of iron deficiency in patients with worsening chronic heart failure, seeking clarity on how it affects their condition and recovery. We enrolled 163 patients from multiple centers who were hospitalized for this serious health issue. By evaluating iron deficiency at discharge, we distinguished those affected by low iron levels and compared various health indicators between groups.
We discovered that over half of the patients, 54.6%, had iron deficiency. Those with lower iron were more likely to exhibit signs of congestion and were categorized into more advanced heart failure classes. Interestingly, their levels of NT-proBNP, a crucial marker associated with heart failure, were significantly higher upon admission and didn’t improve much during their hospital stay.
While we found that mortality rates within 30 days had no significant difference between patients with and without iron deficiency, a notable increase in deaths was observed at 90 days post-discharge for those with iron deficiency. This suggests that iron levels could potentially influence recovery, especially in the longer term.
In conclusion, patients dealing with both chronic heart failure and iron deficiency showed more unresolved symptoms and poorer outcomes post-discharge. These findings highlight the importance of monitoring iron levels in patients facing heart issues, paving the way for future studies into treatment effectiveness and potential benefits of iron therapies.
We discovered that over half of the patients, 54.6%, had iron deficiency. Those with lower iron were more likely to exhibit signs of congestion and were categorized into more advanced heart failure classes. Interestingly, their levels of NT-proBNP, a crucial marker associated with heart failure, were significantly higher upon admission and didn’t improve much during their hospital stay.
While we found that mortality rates within 30 days had no significant difference between patients with and without iron deficiency, a notable increase in deaths was observed at 90 days post-discharge for those with iron deficiency. This suggests that iron levels could potentially influence recovery, especially in the longer term.
In conclusion, patients dealing with both chronic heart failure and iron deficiency showed more unresolved symptoms and poorer outcomes post-discharge. These findings highlight the importance of monitoring iron levels in patients facing heart issues, paving the way for future studies into treatment effectiveness and potential benefits of iron therapies.
9.5
Gentle iron absorption
Most Useful Review
A friend's iron level fell significantly, but after three months of using this supplement, it improved from 85 to 125. We started with two capsules daily, then reduced the dose gradually. However, always investigate the reason behind low iron levels before treatment, as sometimes the body lowers iron intentionally due to health issues.
Lung Cancer details
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.8
USERS' SCORE
Good
Based on 3 Reviews
8.4
9
We explored how ageing affects lung cancer development, focusing on the role of iron homeostasis. Our research used aged mouse models and primary cells to demonstrate that ageing actually suppresses the initiation and growth of lung cancer. This happens because the cells that could potentially give rise to tumors lose their "stemness," or ability to self-renew and form new cells, over time.
A key finding was the role of the NUPR1 transcription factor and its target, lipocalin-2. Both of these proteins increase with ageing, leading to functional iron insufficiency in the cells. We discovered that by either disabling the NUPR1-lipocalin-2 pathway or adding iron back into aged cells, we could restore their stemness and boost their potential to cause tumors. Interestingly, in younger cells, disrupting this pathway could lead to harmful effects like ferroptosis, a form of cell death.
Our research also revealed that specific changes in DNA methylation related to ageing contribute to higher NUPR1 levels. This underscores a complex relationship where ageing facilitates a protective environment against certain types of cell death while promoting traits that suppress cancer. The findings have important implications for cancer prevention strategies, suggesting that efforts should be focused on younger individuals where most cancers begin.
A key finding was the role of the NUPR1 transcription factor and its target, lipocalin-2. Both of these proteins increase with ageing, leading to functional iron insufficiency in the cells. We discovered that by either disabling the NUPR1-lipocalin-2 pathway or adding iron back into aged cells, we could restore their stemness and boost their potential to cause tumors. Interestingly, in younger cells, disrupting this pathway could lead to harmful effects like ferroptosis, a form of cell death.
Our research also revealed that specific changes in DNA methylation related to ageing contribute to higher NUPR1 levels. This underscores a complex relationship where ageing facilitates a protective environment against certain types of cell death while promoting traits that suppress cancer. The findings have important implications for cancer prevention strategies, suggesting that efforts should be focused on younger individuals where most cancers begin.
8.8
Anemia improvement
Most Useful Review
Anemia improved after my mother, who had her oesophagus removed due to lung cancer, struggled for over three years. Despite trying domestic supplements and iron medications, nothing worked until I started this treatment. Following several months of regular health check-ups, her blood test results showed improvement. I advised others to drink it after meals to avoid stomach ache, and I've noticed a reduction in dizziness. I'm just disappointed it's out of stock now.
Menopause details
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.1
USERS' SCORE
Good
Based on 4 Reviews
8.4
9
We investigated how iron treatment affects iron levels and blood production in rats that underwent ovariectomy, a procedure mimicking menopause. By using Deferasirox, a medication often prescribed for iron overload conditions, we aimed to understand its role in managing iron levels and supporting blood health in this context.
Our study involved sixty-four female Wistar rats divided into several groups. After undergoing surgery to simulate menopause, we induced iron accumulation in them. We then treated some groups with Deferasirox at varying doses and looked into its effects on their health.
We observed that the treatment with Deferasirox led to improved conditions in several key areas. There were noticeable positive changes in the uterine tissue, an increase in white blood cells, and a decrease in harmful iron levels. Moreover, the treatment increased the body’s antioxidant capacity, helping fight oxidative stress commonly seen in menopausal conditions.
Deferasirox also had beneficial effects on bone health and the overall functioning of blood-producing cells. Additionally, it influenced gene expressions related to iron metabolism and blood production. Overall, we found that Deferasirox plays an important role in managing iron and enhancing blood health in rats experiencing conditions similar to menopause.
Our study involved sixty-four female Wistar rats divided into several groups. After undergoing surgery to simulate menopause, we induced iron accumulation in them. We then treated some groups with Deferasirox at varying doses and looked into its effects on their health.
We observed that the treatment with Deferasirox led to improved conditions in several key areas. There were noticeable positive changes in the uterine tissue, an increase in white blood cells, and a decrease in harmful iron levels. Moreover, the treatment increased the body’s antioxidant capacity, helping fight oxidative stress commonly seen in menopausal conditions.
Deferasirox also had beneficial effects on bone health and the overall functioning of blood-producing cells. Additionally, it influenced gene expressions related to iron metabolism and blood production. Overall, we found that Deferasirox plays an important role in managing iron and enhancing blood health in rats experiencing conditions similar to menopause.
9
Essential supplement
Most Useful Review
Iron 25 mg: This is not the first time I have ordered this brand. The quality is excellent and the ingredients have been tested for over a year – they are the best. A helpful companion for women during menopause – a necessary supplement. I have been purchasing it for many years as I am very satisfied with the quality... I will order this product again. Its efficiency and the improvement in health work for any age. The size of the packaging lasts a long time. I am pleased.
Reflux details
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 2 Reviews
8.4
9
We explored how the addition of zero-valent iron (ZVI) and the refluxing of biogas slurry can enhance the efficiency of anaerobic digestion. The research made it clear that the best methane production occurred when the biogas slurry reflux was set at a 60% ratio.
Interestingly, while ZVI didn't enhance its own bioavailability in the anaerobic digestion process, it worked well in combination with the biogas slurry. We observed that this combination notably increased the presence of key microorganisms that play a significant role in the process of direct interspecific electron transfer, which is crucial for methane production.
The dominant bacteria in this mix included Methanosaeta, Methanobacterium, Methanobrevibacter, and Methanolinea, making up more than 60% of the total methanogenic population. By promoting hydrogen production due to the corrosion of ZVI, we found that biogas slurry reflux provided necessary conditions for thriving anaerobic microorganisms.
This cooperative effect not only advanced the growth of hydrogen-producing methanogens but also boosted the functioning of vital enzymes involved in the breakdown and conversion of waste materials, thus enhancing the entire anaerobic digestion system. Ultimately, our findings suggest that while ZVI alone didn’t show a strong effect, it plays an important role when paired with biogas slurry reflux in making the anaerobic digestion process more efficient.
Interestingly, while ZVI didn't enhance its own bioavailability in the anaerobic digestion process, it worked well in combination with the biogas slurry. We observed that this combination notably increased the presence of key microorganisms that play a significant role in the process of direct interspecific electron transfer, which is crucial for methane production.
The dominant bacteria in this mix included Methanosaeta, Methanobacterium, Methanobrevibacter, and Methanolinea, making up more than 60% of the total methanogenic population. By promoting hydrogen production due to the corrosion of ZVI, we found that biogas slurry reflux provided necessary conditions for thriving anaerobic microorganisms.
This cooperative effect not only advanced the growth of hydrogen-producing methanogens but also boosted the functioning of vital enzymes involved in the breakdown and conversion of waste materials, thus enhancing the entire anaerobic digestion system. Ultimately, our findings suggest that while ZVI alone didn’t show a strong effect, it plays an important role when paired with biogas slurry reflux in making the anaerobic digestion process more efficient.
9.5
No reflux experienced
Most Useful Review
It works as it claims—gentle on the stomach. It’s easy to take, and I did not experience reflux afterwards, nor did I feel queasy when taken on an empty stomach, unlike some vitamins.
Heart Attack details
SCIENTIFIC SCORE
Likely Very Effective
Based on 2 Researches
9
USERS' SCORE
Good
Based on 6 Reviews
8.3
9
Macrophage EVs combat iron overload
We delved into the connection between iron overload and its effects on heart function after a heart attack, also known as myocardial infarction (MI). Our research focused on utilizing macrophage-derived extracellular vesicles (EVs) as a natural therapy to help with excessive iron levels in the heart.
The downside of existing chemical iron chelators is that they often come with side effects, so we sought a safer and more effective solution. By isolating EVs from macrophages, we found that they serve as a biological chelator for iron. When we introduced these EVs to heart cells affected by low oxygen levels, they significantly reduced iron overload and minimized the oxidative stress linked to this excess iron.
Notably, these EVs work by harnessing a receptor called transferrin receptor (TfR), which helps them grab onto and remove the surplus protein-bound iron. In our observations, when the EVs lacked TfR, they were ineffective in protecting heart tissue. This shows that leveraging macrophage-derived EVs could offer a new approach in treating heart damage due to iron overload, especially after myocardial infarction.
The downside of existing chemical iron chelators is that they often come with side effects, so we sought a safer and more effective solution. By isolating EVs from macrophages, we found that they serve as a biological chelator for iron. When we introduced these EVs to heart cells affected by low oxygen levels, they significantly reduced iron overload and minimized the oxidative stress linked to this excess iron.
Notably, these EVs work by harnessing a receptor called transferrin receptor (TfR), which helps them grab onto and remove the surplus protein-bound iron. In our observations, when the EVs lacked TfR, they were ineffective in protecting heart tissue. This shows that leveraging macrophage-derived EVs could offer a new approach in treating heart damage due to iron overload, especially after myocardial infarction.
9.5
Significant relief
Most Useful Review
After three days of taking this iron supplement, I felt a remarkable improvement. I've struggled with a lack of oxygen sensation for four years, which visits to specialists could not resolve. I luckily discovered that iron deficiency could cause this feeling. Since starting the supplement, I’ve experienced a significant sense of relief, as if a weight has been lifted from my lungs and heart. I highly recommend checking iron levels for anyone feeling similarly.
Cold Sores details
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 3 Reviews
8.2
9
We investigated how iron replacement therapy affects the occurrence of cold sores, also known as recurrent herpes labialis, in people with low iron levels, a condition known as sideropenia. In our study, ten patients with confirmed sideropenia and a history of cold sores took ferrous sulphate for three months.
Before starting the treatment, these individuals reported experiencing an average of 0.78 episodes of cold sores each month. After the iron therapy, this number significantly dropped to just 0.2 episodes monthly. Furthermore, we found that there was a noteworthy increase in serum ferritin levels, a marker indicative of iron status, after treatment.
The results suggest that iron therapy may play a significant role in reducing the frequency of cold sores for those affected by iron deficiency. These findings are intriguing and warrant further exploration into iron supplementation as a potential option for managing cold sores in individuals with low iron levels.
Before starting the treatment, these individuals reported experiencing an average of 0.78 episodes of cold sores each month. After the iron therapy, this number significantly dropped to just 0.2 episodes monthly. Furthermore, we found that there was a noteworthy increase in serum ferritin levels, a marker indicative of iron status, after treatment.
The results suggest that iron therapy may play a significant role in reducing the frequency of cold sores for those affected by iron deficiency. These findings are intriguing and warrant further exploration into iron supplementation as a potential option for managing cold sores in individuals with low iron levels.
9.5
Improved iron levels
Most Useful Review
I administered this iron supplement with my daughter, and after four months, her ferritin rose from 7.5 to 34, which stabilised. Initially, she experienced intestinal issues, but after adjusting the dosage, everything was fine, and iron levels normalised. Previously, low ferritin resulted in frequent colds. Hemoglobin was 135, so I find this drug very effective!
Eczema details
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.5
USERS' SCORE
Good
Based on 2 Reviews
8.2
9
We examined how adding oral iron to a low nickel diet could help manage chronic vesicular hand eczema (CVHE) in individuals sensitive to nickel. In our study, we involved 23 patients with CVHE split into two groups. One group followed a low nickel diet (LND) along with oral iron for 12 weeks, while the other group simply followed the LND.
The results were striking—83.33% of those taking oral iron experienced complete clearance of their eczema symptoms compared to 45.45% in the control group. This made it clear that dietary nickel was being absorbed less when oral iron was present.
We found that the combination of LND and oral iron not only helped decrease nickel levels in the blood but also significantly sped up the improvement of eczema symptoms in those sensitive to nickel. This study highlights the potential benefits of iron in conjunction with dietary modifications for managing eczema.
The results were striking—83.33% of those taking oral iron experienced complete clearance of their eczema symptoms compared to 45.45% in the control group. This made it clear that dietary nickel was being absorbed less when oral iron was present.
We found that the combination of LND and oral iron not only helped decrease nickel levels in the blood but also significantly sped up the improvement of eczema symptoms in those sensitive to nickel. This study highlights the potential benefits of iron in conjunction with dietary modifications for managing eczema.
9.5
Eczema improvement
Most Useful Review
Iron deficiency led to my eczema flare-up, prompting a visit to the doctor for a ferritin and iron blood test, which confirmed my deficiency. After selecting the appropriate iron supplement, I take it twice daily along with vitamin C, D, folic acid, B vitamins, and spirulina. Since starting this regimen, I have consumed half a can, and my eczema has nearly cleared up. I am very satisfied with this purchase.
Irritable Bowel Syndrome details
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
6.8
USERS' SCORE
Good
Based on 21 Reviews
8
4
We explored how low-level iron supplementation impacts the gut microbiota in individuals with Irritable Bowel Syndrome (IBS) and in healthy donors. To do this, we conducted anaerobic, pH-controlled in vitro batch cultures using fecal samples from both groups, supplemented with various forms of iron, including ferrous sulphate, nanoparticulate iron, and pea ferritin.
Our findings revealed that IBS participants had distinct microbial profiles compared to their healthy counterparts. Interestingly, we observed that the different sources of iron we used did not have a negative effect on the overall microbial populations. Both pea ferritin and nanoparticulate iron showed similar outcomes, while ferrous sulphate appeared to enhance certain beneficial bacteria.
Additionally, we measured the production of metabolites and found that there was no harmful shift towards increased proteolysis. These results suggest that low doses of iron from the three sources tested are unlikely to be detrimental to the gut microbiota, giving us new insights into the potential for iron supplementation in managing gut health, especially for those with IBS.
This is the first time we've tested fermentation of pea ferritin, which adds an exciting dimension to our understanding of dietary iron sources and gut health.
Our findings revealed that IBS participants had distinct microbial profiles compared to their healthy counterparts. Interestingly, we observed that the different sources of iron we used did not have a negative effect on the overall microbial populations. Both pea ferritin and nanoparticulate iron showed similar outcomes, while ferrous sulphate appeared to enhance certain beneficial bacteria.
Additionally, we measured the production of metabolites and found that there was no harmful shift towards increased proteolysis. These results suggest that low doses of iron from the three sources tested are unlikely to be detrimental to the gut microbiota, giving us new insights into the potential for iron supplementation in managing gut health, especially for those with IBS.
This is the first time we've tested fermentation of pea ferritin, which adds an exciting dimension to our understanding of dietary iron sources and gut health.
9.5
Symptoms improved
Most Useful Review
Since starting this supplement, my symptoms of restless legs syndrome have significantly decreased. I originally stopped drinking due to discomfort, but after resuming this supplement, my symptoms improved within days. Now, I only take it a few times a week and I am very grateful for the relief.
Bruise details
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Moderately Good
Based on 4 Reviews
7.9
7
We explored how iron interacts with polyphenols in lotus rhizomes, specifically looking at how this combination affects bruising and the resulting discoloration. Our study revealed that when lotus rhizomes sustain bruises, the levels of total phenols decrease while the iron content significantly increases.
We found that certain polyphenols like dopa, gallocatechin, and catechin were present in the rhizomes. Interestingly, when combined with iron, these polyphenols led to noticeable darkening of the tissue, showcasing a clear link between iron and blackening. In a simulated environment, we were able to replicate these effects, confirming that iron plays a significant role under neutral conditions.
While we discovered ways to prevent this blackening, such as using ascorbic acid or EDTA, our main focus was the interaction between iron and dopa in bruised lotus rhizomes. This interaction seems to be the driving force behind the discoloration process. The insights from this research can help improve the storage methods for lotus rhizomes and support the industry's development.
We found that certain polyphenols like dopa, gallocatechin, and catechin were present in the rhizomes. Interestingly, when combined with iron, these polyphenols led to noticeable darkening of the tissue, showcasing a clear link between iron and blackening. In a simulated environment, we were able to replicate these effects, confirming that iron plays a significant role under neutral conditions.
While we discovered ways to prevent this blackening, such as using ascorbic acid or EDTA, our main focus was the interaction between iron and dopa in bruised lotus rhizomes. This interaction seems to be the driving force behind the discoloration process. The insights from this research can help improve the storage methods for lotus rhizomes and support the industry's development.
8.8
Less noticeable bruises
Most Useful Review
Began to look better; I probably should have taken an iron analysis, but it’s expensive in Russia, so I take various vitamins at random. I bought this to address hair loss and brittleness. Although it's too early to comment fully, I noticed improvement after starting the intake – my bags and bruises under my eyes have nearly vanished, my wrinkles appear somewhat smoothed, and my complexion is less bluish. Clearly, my previous diet wasn't optimal, and these pills have made a difference.
Chest Pain details
SCIENTIFIC SCORE
Likely Very Effective
Based on 4 Researches
9.1
USERS' SCORE
Moderately Good
Based on 17 Reviews
7.9
9
We explored the intriguing link between iron treatment and angina symptoms in a unique case involving a 46-year-old woman with endometrial cancer. This patient arrived in the emergency department with acute chest pain, yet her heart was healthy based on ECG results. Instead, we found that her chest pain was a result of critically low hemoglobin levels caused by severe iron deficiency anemia.
Over the past six months, the patient experienced prolonged and heavy menstruation, which contributed to her anemia. After administering six units of packed red blood cells and an iron infusion, we witnessed a remarkable turnaround. The chest pain resolved, and her blood counts improved significantly.
This case is particularly noteworthy for highlighting how essential it is for women experiencing chest pain to be evaluated for anemia. It serves as a crucial reminder that understanding a patient's gynecological history can shed light on their overall health and symptoms. The link between iron treatment and relief from chest pain underscores the importance of recognizing the systemic effects of anemia.
Over the past six months, the patient experienced prolonged and heavy menstruation, which contributed to her anemia. After administering six units of packed red blood cells and an iron infusion, we witnessed a remarkable turnaround. The chest pain resolved, and her blood counts improved significantly.
This case is particularly noteworthy for highlighting how essential it is for women experiencing chest pain to be evaluated for anemia. It serves as a crucial reminder that understanding a patient's gynecological history can shed light on their overall health and symptoms. The link between iron treatment and relief from chest pain underscores the importance of recognizing the systemic effects of anemia.
10
Pain-free improvement
Most Useful Review
Really works! My mother's haematocrit was desperately low. After using this iron, her levels rose significantly without pain. I ordered another jar for her just in case it declines again.
Headache details
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Moderately Good
Based on 41 Reviews
7.8
7
We explored whether iron deficiency anemia is connected to chronic daily headaches in a group of 100 patients compared to an equal number of controls.
The study revealed a significant link between iron deficiency anemia and chronic daily headaches. Interestingly, those with severe anemia experienced more intense headache symptoms.
While other iron-related factors were associated with headaches, the type and duration of headaches did not seem to vary significantly among patients.
The study revealed a significant link between iron deficiency anemia and chronic daily headaches. Interestingly, those with severe anemia experienced more intense headache symptoms.
While other iron-related factors were associated with headaches, the type and duration of headaches did not seem to vary significantly among patients.
9.5
Reduced headaches
Most Useful Review
I found relief from chronic anaemia after childbirth with this supplement. My ferritin levels rose, and I no longer suffer from headaches. This product also improved my menstruation and didn’t cause constipation. I take it with vitamin C each morning.
Liver Disease details
SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8
USERS' SCORE
Moderately Good
Based on 3 Reviews
7.8
9
We explored the effects of rubiadin, a beneficial compound derived from a Chinese herb, on iron metabolism and its implications for liver disease. Recognizing the challenges posed by iron overload diseases, we aimed to discover a safe approach to manage excessive iron accumulation in the body. Through experiments involving various analyses, we observed that rubiadin significantly downregulated proteins that are typically elevated in conditions of high iron, such as transferrin receptor 1 and ferroportin 1.
Furthermore, when we administered rubiadin to mice with iron overload, it resulted in decreased serum and duodenal iron levels and an increase in hepcidin mRNA expression in the liver. This suggests that rubiadin may not only help the body regulate iron better but might also protect against the harmful effects of excess iron.
Our research also delved into the mechanisms behind these effects. We found that rubiadin-induced hepcidin expression was mediated through a specific signaling pathway involving bone morphogenetic protein 6 (BMP6) and SMAD proteins. The ability of rubiadin to enhance hepcidin levels points toward a promising natural strategy for tackling iron overload in liver diseases and could have broader implications for treating related conditions.
Furthermore, when we administered rubiadin to mice with iron overload, it resulted in decreased serum and duodenal iron levels and an increase in hepcidin mRNA expression in the liver. This suggests that rubiadin may not only help the body regulate iron better but might also protect against the harmful effects of excess iron.
Our research also delved into the mechanisms behind these effects. We found that rubiadin-induced hepcidin expression was mediated through a specific signaling pathway involving bone morphogenetic protein 6 (BMP6) and SMAD proteins. The ability of rubiadin to enhance hepcidin levels points toward a promising natural strategy for tackling iron overload in liver diseases and could have broader implications for treating related conditions.
9.5
Effective iron supplement
Most Useful Review
Due to my persistently low haemoglobin levels linked to liver disease, I require ongoing iron supplements. After trying various preparations, I find Solgar chelated iron to be one of the few that genuinely alleviates my iron deficiency. An advantage of Solgar's encapsulated form is that it does not cause gastrointestinal discomfort, thus I recommend opting for chelated iron capsules over tablets, as they are gentler on the system even though slightly pricier.
Sleep Apnea details
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Moderately Good
Based on 4 Reviews
7.8
8
We conducted a study to discover how intravenous iron therapy impacts sleep apnea in patients suffering from heart failure, anemia, and iron deficiency. Patients were randomly assigned to receive either ferric carboxymaltose or a placebo to assess changes in their sleep and respiratory function after treatment.
Our findings revealed that the intravenous iron treatment significantly improved the hypercapnic ventilatory response, which is the way our bodies react to increased carbon dioxide levels. We observed that, in particular, patients who received iron saw a notable reduction in their apneas and hypopneas—those moments when breathing stops or becomes shallow while asleep. Specifically, the apnoea-hypopnoea index dropped to an average of 12 events per hour with treatment, compared to 19 events per hour in the placebo group.
Furthermore, those who received iron also reported better overall symptoms and had improved physical capacity during exercise tests. This suggests that iron therapy not only helps with sleep-related breathing issues but may also boost oxygen delivery during physical activities.
Overall, our study supports the notion that iron therapy could play an important role in managing sleep apnea among patients with heart failure, providing them with enhanced breathing during sleep and better quality of life.
Our findings revealed that the intravenous iron treatment significantly improved the hypercapnic ventilatory response, which is the way our bodies react to increased carbon dioxide levels. We observed that, in particular, patients who received iron saw a notable reduction in their apneas and hypopneas—those moments when breathing stops or becomes shallow while asleep. Specifically, the apnoea-hypopnoea index dropped to an average of 12 events per hour with treatment, compared to 19 events per hour in the placebo group.
Furthermore, those who received iron also reported better overall symptoms and had improved physical capacity during exercise tests. This suggests that iron therapy not only helps with sleep-related breathing issues but may also boost oxygen delivery during physical activities.
Overall, our study supports the notion that iron therapy could play an important role in managing sleep apnea among patients with heart failure, providing them with enhanced breathing during sleep and better quality of life.
9
Improved sleep quality
Most Useful Review
The result is clear! I have iron deficiency and cannot tolerate pharmaceutical iron due to severe stomach pain and diarrhoea. My gynaecologist recommended this iron, and so far, it is well tolerated. The capsules have a metallic taste, but overall, I feel much better. I take two a day, and the tachycardia has stopped. I now sleep deeply and soundly, which has greatly improved my wellbeing.
Rash details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 9 Reviews
7.5
9.5
Skin improved
Most Useful Review
I took one capsule each morning after a meal with water, and after 1.5 weeks, I noticed an improvement—tingling sensations in my legs disappeared, alongside weakness and dizziness. The rash vanished, and my skin is now clear.
Heartburn details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 30 Reviews
7.4
8.3
No heartburn
Most Useful Review
After two weeks of this iron supplement, I've experienced no side effects or heartburn, and it's easy to take.
Leg Cramps details
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Moderately Good
Based on 21 Reviews
7.3
7
We explored the effects of iron deficiency (ID) in patients on maintenance hemodialysis, especially regarding common symptoms like leg cramps. The study included 154 patients, all of whom had reached target hemoglobin levels, which means they were not anemic. This allowed us to focus on the impact of ID without the confounding factor of low hemoglobin.
Our findings revealed that patients with iron deficiency reported a higher severity of leg cramps compared to those without ID. Specifically, we observed that a low transferrin saturation (TSAT) level contributed significantly to the experience of pain during vascular access punctures and those annoying intradialytic leg cramps. Additionally, patients with lower ferritin levels faced more intense issues like severe fatigue and headaches during their dialysis sessions.
The results suggest that treating iron deficiency could potentially alleviate these critical symptoms, indicating that proactive iron supplementation may be beneficial for those undergoing maintenance dialysis. Addressing ID might not only improve hemoglobin levels but also enhance overall quality of life by reducing painful experiences like leg cramps.
Our findings revealed that patients with iron deficiency reported a higher severity of leg cramps compared to those without ID. Specifically, we observed that a low transferrin saturation (TSAT) level contributed significantly to the experience of pain during vascular access punctures and those annoying intradialytic leg cramps. Additionally, patients with lower ferritin levels faced more intense issues like severe fatigue and headaches during their dialysis sessions.
The results suggest that treating iron deficiency could potentially alleviate these critical symptoms, indicating that proactive iron supplementation may be beneficial for those undergoing maintenance dialysis. Addressing ID might not only improve hemoglobin levels but also enhance overall quality of life by reducing painful experiences like leg cramps.
9.5
Reduced symptoms
Most Useful Review
Since I started taking this, my symptoms of restless legs have greatly decreased. After struggling with it for years, I noticed almost no symptoms now. My legs would feel itchy at times, but after starting this supplement, my condition improved rapidly. I now only take it a few times a week to keep the symptoms at bay. I'm very grateful for this product.
Acne details
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
USERS' SCORE
Moderately Good
Based on 10 Reviews
7.2
7
We explored the potential benefits of oral bovine lactoferrin as a dietary supplement for individuals struggling with mild to moderate acne vulgaris. This study involved 43 young participants who took chewable lactoferrin tablets twice a day for eight weeks.
By the end of the study, we observed promising results. Participants experienced an average reduction in acne lesions. Specifically, there was a 20% decrease in inflammatory lesions, a more significant 23.5% reduction in non-inflammatory lesions, and an overall improvement in total lesion counts of 22.5%. Notably, around 77% of the subjects saw a decrease in their total lesion counts, indicating that lactoferrin may have a positive effect.
Importantly, we found that lactoferrin was well tolerated, with no reported adverse effects related to the supplement during the trial. Although our study had some limitations due to its open-label design without a control group, the results encourage further research into lactoferrin's efficacy for acne treatment, particularly through randomized controlled trials.
By the end of the study, we observed promising results. Participants experienced an average reduction in acne lesions. Specifically, there was a 20% decrease in inflammatory lesions, a more significant 23.5% reduction in non-inflammatory lesions, and an overall improvement in total lesion counts of 22.5%. Notably, around 77% of the subjects saw a decrease in their total lesion counts, indicating that lactoferrin may have a positive effect.
Importantly, we found that lactoferrin was well tolerated, with no reported adverse effects related to the supplement during the trial. Although our study had some limitations due to its open-label design without a control group, the results encourage further research into lactoferrin's efficacy for acne treatment, particularly through randomized controlled trials.
9.5
Effective acne treatment
Most Useful Review
Appointed by my doctor as part of my acne treatment. I am seeing results!
Diarrhea details
SCIENTIFIC SCORE
Questionable
Based on 3 Researches
6.7
USERS' SCORE
Moderately Good
Based on 59 Reviews
7.1
9
We explored how adding iron, specifically Fe-Gly, to piglets' diets could help combat diarrhea caused by enterotoxigenic E. coli (ETEC) infections. In our study, we administered 50 mg of Fe-Gly to weaned piglets that had been infected, monitoring their growth, diarrhea rates, and overall gut health.
We observed remarkable improvements in the piglets' growth performance, with increases in average daily feed intake and daily gain by over 30%. Most notably, the rate of diarrhea significantly decreased by 40%. Additionally, we found that this iron supplementation raised the levels of total iron binding capacity in piglet serum, suggesting better iron transport and utilization.
Beyond growth metrics, the addition of Fe-Gly also showed potential in alleviating intestinal damage incurred from the ETEC challenge. As a result, we conclude that Fe-Gly not only meets daily iron needs but also reduces the iron available for harmful gut bacteria, promoting better intestinal health in piglets suffering from infections.
We observed remarkable improvements in the piglets' growth performance, with increases in average daily feed intake and daily gain by over 30%. Most notably, the rate of diarrhea significantly decreased by 40%. Additionally, we found that this iron supplementation raised the levels of total iron binding capacity in piglet serum, suggesting better iron transport and utilization.
Beyond growth metrics, the addition of Fe-Gly also showed potential in alleviating intestinal damage incurred from the ETEC challenge. As a result, we conclude that Fe-Gly not only meets daily iron needs but also reduces the iron available for harmful gut bacteria, promoting better intestinal health in piglets suffering from infections.
9.5
No diarrhea experienced
Most Useful Review
The best iron I have ever used. I experienced no side effects, and my analysis showed everything was fine. I used to have low haemoglobin, but now all indicators, including iron, are normal. The usual iron caused constant diarrhoea, which I do not recall with this product.
Gastritis details
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.1
USERS' SCORE
Moderately Good
Based on 26 Reviews
7
9.5
We examined a case involving an 11-year-old male who experienced adverse effects from taking oral ferrous sulfate tablets to treat iron deficiency anemia. Over two months of treatment, he developed gastritis, which was confirmed through histological analysis during an endoscopy.
The findings revealed iron deposits in the stomach lining, prompting a reassessment of his iron supplementation strategy. We switched him from tablets to a liquid form of iron, which seemed to be gentler on his system.
After four months, a repeat endoscopy indicated a remarkable improvement, with the histological signs of gastritis resolving. This case illustrates that while iron is necessary for treating anemia, the form in which it's administered can significantly impact side effects like gastritis.
The findings revealed iron deposits in the stomach lining, prompting a reassessment of his iron supplementation strategy. We switched him from tablets to a liquid form of iron, which seemed to be gentler on his system.
After four months, a repeat endoscopy indicated a remarkable improvement, with the histological signs of gastritis resolving. This case illustrates that while iron is necessary for treating anemia, the form in which it's administered can significantly impact side effects like gastritis.
9.5
Felt better
Most Useful Review
This iron supplement has been beneficial. I didn’t take tests initially, but I noticed improvements within a few weeks—less hair loss and overall better health. It does not irritate my gastritis as I take it after meals. It is cost-effective, lasting a long time, so I highly recommend it!
Blood Clot details
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.3
USERS' SCORE
Medium or Average
Based on 14 Reviews
6.5
9
Magnetic stent-grafts improve healing
We explored how magnetizable stent-grafts can improve healing in carotid artery pseudoaneurysms by investigating their ability to capture blood outgrowth endothelial cells.
In a porcine model, we compared magnetic stent-grafts with standard non-magnetic ones. The results showed that the magnetic stent-grafts not only occluded all nine pseudoaneurysms but also achieved better cell capture and endothelial growth.
Essentially, the magnetic properties enhanced the healing process, leading to less thrombosis compared to non-magnetic counterparts. This innovative approach could reduce complications associated with these medical devices.
In a porcine model, we compared magnetic stent-grafts with standard non-magnetic ones. The results showed that the magnetic stent-grafts not only occluded all nine pseudoaneurysms but also achieved better cell capture and endothelial growth.
Essentially, the magnetic properties enhanced the healing process, leading to less thrombosis compared to non-magnetic counterparts. This innovative approach could reduce complications associated with these medical devices.
8.3
Symptoms alleviated
Most Useful Review
I was identified with anaemia and began treatment recently. I noticed that dizziness from the anaemia has disappeared. I'm looking forward to my next blood test, as I feel significantly better overall.
Pelvic Pain details
SCIENTIFIC SCORE
Questionable
Based on 5 Researches
6.2
USERS' SCORE
Medium or Average
Based on 17 Reviews
6.2
7
We investigated the role of ferroptosis in chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). By using an experimental model, we applied treatments with deferoxamine (DFO) and edaravone (EDA) to inhibit ferroptosis.
Our findings revealed that targeting ferroptosis may reduce inflammation, fibrosis, and mast cell activity, potentially easing pelvic pain associated with CP/CPPS. These results highlight a new pathway for treating this challenging condition, offering hope for improved management strategies.
Our findings revealed that targeting ferroptosis may reduce inflammation, fibrosis, and mast cell activity, potentially easing pelvic pain associated with CP/CPPS. These results highlight a new pathway for treating this challenging condition, offering hope for improved management strategies.
9.5
Reduced pelvic pain
Most Useful Review
I suffered from menorrhagia due to uterine fibroids, taking iron and Chinese medicine, but stopped due to stomach pain, nausea, and constipation. I often experienced dizziness and vomiting during my periods. However, this iron supplement causes no stomach pain, making it comfortable, and I now wake up refreshed. I take one tablet daily before bed with vitamin C. I recommend it to those who’ve not felt the effects of other iron preparations.
Bloating details
SCIENTIFIC SCORE
Possibly Effective
Based on 5 Researches
7.4
USERS' SCORE
Medium or Average
Based on 26 Reviews
6
8
We explored how iron supplementation impacts patients with celiac disease who suffer from iron deficiency anemia, particularly focusing on those unable to tolerate traditional iron sulfate. In this study, patients were divided into two groups: one receiving a new formulation called sucrosomial iron and the other taking iron sulfate.
After a 90-day follow-up, both groups showed significant improvements in hemoglobin levels and overall iron metrics. Interestingly, those taking sucrosomial iron experienced a marked reduction in abdominal symptoms like bloating and pain. They reported feeling a 33% increase in general well-being compared to 21% in the iron sulfate group.
This suggests sucrosomial iron could be a preferable option for individuals with celiac disease who struggle with gastrointestinal discomfort from standard iron treatments. Overall, while both forms of iron supplementation were effective, sucrosomial iron may ease some of the unpleasant side effects commonly associated with iron therapy.
After a 90-day follow-up, both groups showed significant improvements in hemoglobin levels and overall iron metrics. Interestingly, those taking sucrosomial iron experienced a marked reduction in abdominal symptoms like bloating and pain. They reported feeling a 33% increase in general well-being compared to 21% in the iron sulfate group.
This suggests sucrosomial iron could be a preferable option for individuals with celiac disease who struggle with gastrointestinal discomfort from standard iron treatments. Overall, while both forms of iron supplementation were effective, sucrosomial iron may ease some of the unpleasant side effects commonly associated with iron therapy.
9.5
Elevated haemoglobin
Most Useful Review
Really soft iron! It has significantly raised my haemoglobin levels without any bloating or gastrointestinal side effects, unlike the sulphate iron I used previously. I take one capsule twice daily with lemon water. After months, my haemoglobin rose from 114 to 144 units. However, raising ferritin took longer, so I included other vitamins for better absorption. Highly recommend this product for anyone with signs of anaemia!
