Overview
SCIENTIFIC SCORE
Likely Very Effective
Based on 2 Researches
9
USERS' SCORE
Good
Based on 6 Reviews
8.3
Supplement Facts
Serving Size: 1 Vegetable Capsule
Amount Per Serving
%DV
Iron (as iron bisglycinate chelate†)
25 mg
139%
Top Medical Research Studies
9
Macrophage EVs combat iron overload
We delved into the connection between iron overload and its effects on heart function after a heart attack, also known as myocardial infarction (MI). Our research focused on utilizing macrophage-derived extracellular vesicles (EVs) as a natural therapy to help with excessive iron levels in the heart.
The downside of existing chemical iron chelators is that they often come with side effects, so we sought a safer and more effective solution. By isolating EVs from macrophages, we found that they serve as a biological chelator for iron. When we introduced these EVs to heart cells affected by low oxygen levels, they significantly reduced iron overload and minimized the oxidative stress linked to this excess iron.
Notably, these EVs work by harnessing a receptor called transferrin receptor (TfR), which helps them grab onto and remove the surplus protein-bound iron. In our observations, when the EVs lacked TfR, they were ineffective in protecting heart tissue. This shows that leveraging macrophage-derived EVs could offer a new approach in treating heart damage due to iron overload, especially after myocardial infarction.
The downside of existing chemical iron chelators is that they often come with side effects, so we sought a safer and more effective solution. By isolating EVs from macrophages, we found that they serve as a biological chelator for iron. When we introduced these EVs to heart cells affected by low oxygen levels, they significantly reduced iron overload and minimized the oxidative stress linked to this excess iron.
Notably, these EVs work by harnessing a receptor called transferrin receptor (TfR), which helps them grab onto and remove the surplus protein-bound iron. In our observations, when the EVs lacked TfR, they were ineffective in protecting heart tissue. This shows that leveraging macrophage-derived EVs could offer a new approach in treating heart damage due to iron overload, especially after myocardial infarction.
9
We explored the role of iron therapy in patients suffering from acute myocardial infarction (AMI), particularly those with iron deficiency. This interesting study analyzed data from the Medical Information Mart in Intensive Care-IV database, focusing on patients admitted to an intensive care unit between 2008 and 2019.
After carefully categorizing patients based on their exposure to iron treatment, we performed a thorough statistical analysis to highlight any differences in outcomes. The primary focus was on 28-day mortality rates, and the results were telling. In a group of 208 patients who received either iron treatment or no treatment, those receiving iron had significantly lower death rates—8.65% compared to 20.19% in the untreated group.
This finding suggests that iron therapy could play a crucial role in improving survival in AMI patients with iron deficiency. While it did not affect how long patients stayed in the hospital or the ICU, the potential for reduced mortality is promising. However, we recognize that more prospective studies are needed to fully verify these conclusions and understand the broader implications for treatment.
After carefully categorizing patients based on their exposure to iron treatment, we performed a thorough statistical analysis to highlight any differences in outcomes. The primary focus was on 28-day mortality rates, and the results were telling. In a group of 208 patients who received either iron treatment or no treatment, those receiving iron had significantly lower death rates—8.65% compared to 20.19% in the untreated group.
This finding suggests that iron therapy could play a crucial role in improving survival in AMI patients with iron deficiency. While it did not affect how long patients stayed in the hospital or the ICU, the potential for reduced mortality is promising. However, we recognize that more prospective studies are needed to fully verify these conclusions and understand the broader implications for treatment.
Most Useful Reviews
9.5
Significant relief
After three days of taking this iron supplement, I felt a remarkable improvement. I've struggled with a lack of oxygen sensation for four years, which visits to specialists could not resolve. I luckily discovered that iron deficiency could cause this feeling. Since starting the supplement, I’ve experienced a significant sense of relief, as if a weight has been lifted from my lungs and heart. I highly recommend checking iron levels for anyone feeling similarly.
7.8
Gentle on digestion
This is the best iron supplement I've taken—previous ones caused fatigue and constipation. This one is easy on my stomach and intestines, and I’ve maintained a good iron level. After four months, my ferritin has increased significantly, which is a relief. The capsules are small, easy to swallow, and have a pleasant smell.
9.5
Effective iron solution
This iron supplement is now a staple for me. After dealing with hormonal issues and critically low haemoglobin, I've managed to maintain stable levels with this product. My doctor recommended it, and I’m grateful for the improvement. I also bought it for my father, whose iron absorption was previously poor. After using this, his haemoglobin returned to normal levels, which is a tremendous relief.
Medical Researches
SCIENTIFIC SCORE
Likely Very Effective
Based on 2 Researches
9
- All Researches
9
Macrophage EVs combat iron overload
We delved into the connection between iron overload and its effects on heart function after a heart attack, also known as myocardial infarction (MI). Our research focused on utilizing macrophage-derived extracellular vesicles (EVs) as a natural therapy to help with excessive iron levels in the heart.
The downside of existing chemical iron chelators is that they often come with side effects, so we sought a safer and more effective solution. By isolating EVs from macrophages, we found that they serve as a biological chelator for iron. When we introduced these EVs to heart cells affected by low oxygen levels, they significantly reduced iron overload and minimized the oxidative stress linked to this excess iron.
Notably, these EVs work by harnessing a receptor called transferrin receptor (TfR), which helps them grab onto and remove the surplus protein-bound iron. In our observations, when the EVs lacked TfR, they were ineffective in protecting heart tissue. This shows that leveraging macrophage-derived EVs could offer a new approach in treating heart damage due to iron overload, especially after myocardial infarction.
The downside of existing chemical iron chelators is that they often come with side effects, so we sought a safer and more effective solution. By isolating EVs from macrophages, we found that they serve as a biological chelator for iron. When we introduced these EVs to heart cells affected by low oxygen levels, they significantly reduced iron overload and minimized the oxidative stress linked to this excess iron.
Notably, these EVs work by harnessing a receptor called transferrin receptor (TfR), which helps them grab onto and remove the surplus protein-bound iron. In our observations, when the EVs lacked TfR, they were ineffective in protecting heart tissue. This shows that leveraging macrophage-derived EVs could offer a new approach in treating heart damage due to iron overload, especially after myocardial infarction.
9
We explored the role of iron therapy in patients suffering from acute myocardial infarction (AMI), particularly those with iron deficiency. This interesting study analyzed data from the Medical Information Mart in Intensive Care-IV database, focusing on patients admitted to an intensive care unit between 2008 and 2019.
After carefully categorizing patients based on their exposure to iron treatment, we performed a thorough statistical analysis to highlight any differences in outcomes. The primary focus was on 28-day mortality rates, and the results were telling. In a group of 208 patients who received either iron treatment or no treatment, those receiving iron had significantly lower death rates—8.65% compared to 20.19% in the untreated group.
This finding suggests that iron therapy could play a crucial role in improving survival in AMI patients with iron deficiency. While it did not affect how long patients stayed in the hospital or the ICU, the potential for reduced mortality is promising. However, we recognize that more prospective studies are needed to fully verify these conclusions and understand the broader implications for treatment.
After carefully categorizing patients based on their exposure to iron treatment, we performed a thorough statistical analysis to highlight any differences in outcomes. The primary focus was on 28-day mortality rates, and the results were telling. In a group of 208 patients who received either iron treatment or no treatment, those receiving iron had significantly lower death rates—8.65% compared to 20.19% in the untreated group.
This finding suggests that iron therapy could play a crucial role in improving survival in AMI patients with iron deficiency. While it did not affect how long patients stayed in the hospital or the ICU, the potential for reduced mortality is promising. However, we recognize that more prospective studies are needed to fully verify these conclusions and understand the broader implications for treatment.
User Reviews
USERS' SCORE
Good
Based on 6 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Significant relief
After three days of taking this iron supplement, I felt a remarkable improvement. I've struggled with a lack of oxygen sensation for four years, which visits to specialists could not resolve. I luckily discovered that iron deficiency could cause this feeling. Since starting the supplement, I’ve experienced a significant sense of relief, as if a weight has been lifted from my lungs and heart. I highly recommend checking iron levels for anyone feeling similarly.
7.8
Gentle on digestion
This is the best iron supplement I've taken—previous ones caused fatigue and constipation. This one is easy on my stomach and intestines, and I’ve maintained a good iron level. After four months, my ferritin has increased significantly, which is a relief. The capsules are small, easy to swallow, and have a pleasant smell.
9.5
Effective iron solution
This iron supplement is now a staple for me. After dealing with hormonal issues and critically low haemoglobin, I've managed to maintain stable levels with this product. My doctor recommended it, and I’m grateful for the improvement. I also bought it for my father, whose iron absorption was previously poor. After using this, his haemoglobin returned to normal levels, which is a tremendous relief.
9
Positive health change
I routinely take iron for my anaemia. This supplement has not upset my gastrointestinal tract, and my health has notably improved. I'm free from the symptoms I previously experienced like dizziness, fatigue, and leg cramps. It's a truly effective product with no apparent side effects, especially for avoiding heart attack symptoms during workouts. I pair it with folic acid and vitamin C for better results.
2.5
Heart reaction issue
Unfortunately, this iron didn’t suit me as it caused noticeable heart palpitations. I had to switch to another preparation. However, my mother experienced no side effects and successfully increased her ferritin levels to normal. I rate it as good based on her experience, but be cautious if you have cardiovascular concerns.
Frequently Asked Questions
9.5
Significant relief
After three days of taking this iron supplement, I felt a remarkable improvement. I've struggled with a lack of oxygen sensation for four years, which visits to specialists could not resolve. I luckily discovered that iron deficiency could cause this feeling. Since starting the supplement, I’ve experienced a significant sense of relief, as if a weight has been lifted from my lungs and heart. I highly recommend checking iron levels for anyone feeling similarly.
7.8
Gentle on digestion
This is the best iron supplement I've taken—previous ones caused fatigue and constipation. This one is easy on my stomach and intestines, and I’ve maintained a good iron level. After four months, my ferritin has increased significantly, which is a relief. The capsules are small, easy to swallow, and have a pleasant smell.
8.5
Reduced symptoms noticed
I frequently use this type of iron and have always found it satisfactory. The price is fair, and I’ve noticed my symptoms linked to severe iron deficiency—such as an increased heart rate—have eased with regular use. It's crucial to take it with or after meals to avoid constipation. I continue to take it daily for optimal health management.
9.5
Effective iron solution
This iron supplement is now a staple for me. After dealing with hormonal issues and critically low haemoglobin, I've managed to maintain stable levels with this product. My doctor recommended it, and I’m grateful for the improvement. I also bought it for my father, whose iron absorption was previously poor. After using this, his haemoglobin returned to normal levels, which is a tremendous relief.
9
Positive health change
I routinely take iron for my anaemia. This supplement has not upset my gastrointestinal tract, and my health has notably improved. I'm free from the symptoms I previously experienced like dizziness, fatigue, and leg cramps. It's a truly effective product with no apparent side effects, especially for avoiding heart attack symptoms during workouts. I pair it with folic acid and vitamin C for better results.
2.5
Heart reaction issue
Unfortunately, this iron didn’t suit me as it caused noticeable heart palpitations. I had to switch to another preparation. However, my mother experienced no side effects and successfully increased her ferritin levels to normal. I rate it as good based on her experience, but be cautious if you have cardiovascular concerns.
9
Macrophage EVs combat iron overload
We delved into the connection between iron overload and its effects on heart function after a heart attack, also known as myocardial infarction (MI). Our research focused on utilizing macrophage-derived extracellular vesicles (EVs) as a natural therapy to help with excessive iron levels in the heart.
The downside of existing chemical iron chelators is that they often come with side effects, so we sought a safer and more effective solution. By isolating EVs from macrophages, we found that they serve as a biological chelator for iron. When we introduced these EVs to heart cells affected by low oxygen levels, they significantly reduced iron overload and minimized the oxidative stress linked to this excess iron.
Notably, these EVs work by harnessing a receptor called transferrin receptor (TfR), which helps them grab onto and remove the surplus protein-bound iron. In our observations, when the EVs lacked TfR, they were ineffective in protecting heart tissue. This shows that leveraging macrophage-derived EVs could offer a new approach in treating heart damage due to iron overload, especially after myocardial infarction.
The downside of existing chemical iron chelators is that they often come with side effects, so we sought a safer and more effective solution. By isolating EVs from macrophages, we found that they serve as a biological chelator for iron. When we introduced these EVs to heart cells affected by low oxygen levels, they significantly reduced iron overload and minimized the oxidative stress linked to this excess iron.
Notably, these EVs work by harnessing a receptor called transferrin receptor (TfR), which helps them grab onto and remove the surplus protein-bound iron. In our observations, when the EVs lacked TfR, they were ineffective in protecting heart tissue. This shows that leveraging macrophage-derived EVs could offer a new approach in treating heart damage due to iron overload, especially after myocardial infarction.
9
We explored the role of iron therapy in patients suffering from acute myocardial infarction (AMI), particularly those with iron deficiency. This interesting study analyzed data from the Medical Information Mart in Intensive Care-IV database, focusing on patients admitted to an intensive care unit between 2008 and 2019.
After carefully categorizing patients based on their exposure to iron treatment, we performed a thorough statistical analysis to highlight any differences in outcomes. The primary focus was on 28-day mortality rates, and the results were telling. In a group of 208 patients who received either iron treatment or no treatment, those receiving iron had significantly lower death rates—8.65% compared to 20.19% in the untreated group.
This finding suggests that iron therapy could play a crucial role in improving survival in AMI patients with iron deficiency. While it did not affect how long patients stayed in the hospital or the ICU, the potential for reduced mortality is promising. However, we recognize that more prospective studies are needed to fully verify these conclusions and understand the broader implications for treatment.
After carefully categorizing patients based on their exposure to iron treatment, we performed a thorough statistical analysis to highlight any differences in outcomes. The primary focus was on 28-day mortality rates, and the results were telling. In a group of 208 patients who received either iron treatment or no treatment, those receiving iron had significantly lower death rates—8.65% compared to 20.19% in the untreated group.
This finding suggests that iron therapy could play a crucial role in improving survival in AMI patients with iron deficiency. While it did not affect how long patients stayed in the hospital or the ICU, the potential for reduced mortality is promising. However, we recognize that more prospective studies are needed to fully verify these conclusions and understand the broader implications for treatment.
References
- Guo D, Yang X, Yu R, Geng J, Zhang X, et al. Macrophage-derived extracellular vesicles represent a promising endogenous iron-chelating therapy for iron overload and cardiac injury in myocardial infarction. J Nanobiotechnology. 2024;22:527. doi:10.1186/s12951-024-02800-1
- Ding Y, Zhang Y, Gao X, Hua C, Liu L, et al. Association of Iron Therapy with Mortality in Patients with Acute Myocardial Infarction and Iron Deficiency. Cardiovasc Toxicol. 2024;24:1018. doi:10.1007/s12012-024-09905-x
