Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.8
USERS' SCORE
Good
Based on 3 Reviews
8
Supplement Facts
Serving Size: 1 Vegetable Capsule
Amount Per Serving
%DV
Iron (as iron bisglycinate chelate†)
25 mg
139%
Top Medical Research Studies
9
We explored how ageing affects lung cancer development, focusing on the role of iron homeostasis. Our research used aged mouse models and primary cells to demonstrate that ageing actually suppresses the initiation and growth of lung cancer. This happens because the cells that could potentially give rise to tumors lose their "stemness," or ability to self-renew and form new cells, over time.
A key finding was the role of the NUPR1 transcription factor and its target, lipocalin-2. Both of these proteins increase with ageing, leading to functional iron insufficiency in the cells. We discovered that by either disabling the NUPR1-lipocalin-2 pathway or adding iron back into aged cells, we could restore their stemness and boost their potential to cause tumors. Interestingly, in younger cells, disrupting this pathway could lead to harmful effects like ferroptosis, a form of cell death.
Our research also revealed that specific changes in DNA methylation related to ageing contribute to higher NUPR1 levels. This underscores a complex relationship where ageing facilitates a protective environment against certain types of cell death while promoting traits that suppress cancer. The findings have important implications for cancer prevention strategies, suggesting that efforts should be focused on younger individuals where most cancers begin.
A key finding was the role of the NUPR1 transcription factor and its target, lipocalin-2. Both of these proteins increase with ageing, leading to functional iron insufficiency in the cells. We discovered that by either disabling the NUPR1-lipocalin-2 pathway or adding iron back into aged cells, we could restore their stemness and boost their potential to cause tumors. Interestingly, in younger cells, disrupting this pathway could lead to harmful effects like ferroptosis, a form of cell death.
Our research also revealed that specific changes in DNA methylation related to ageing contribute to higher NUPR1 levels. This underscores a complex relationship where ageing facilitates a protective environment against certain types of cell death while promoting traits that suppress cancer. The findings have important implications for cancer prevention strategies, suggesting that efforts should be focused on younger individuals where most cancers begin.
8
Iron complexes show anticancer promise
We sought to understand how iron interacts with lung cancer through the study of two novel anthraquinone (AQ) derivatives. Our focus was on investigating their potential as anticancer agents and how they could help reduce the harmful effects typically associated with traditional treatments.
In this study, we observed that one of the AQs, called 3-(hydroxymethyl)naphto[2,3-]cinnoline-4,7,12(1)-trione (Q3), effectively formed complexes with iron ions, while the other derivative, 4-hydroxynaphto[2,3-]cinnoline-7,12-dione (Q2), did not show any chelating properties. Chasing deeper insights, we evaluated the cytotoxic effects of these complexes on A549 lung cancer cells. Our findings indicated that the iron complex of Q3 displayed a notable decrease in cell viability, making it a strong candidate for further exploration in cancer therapy.
Surprisingly, Q3 and its copper complex did not show significant toxicity against the cancer cells. Furthermore, while Q3 helped to reduce the rate of iron-induced lipid peroxidation, Q2 did not have any effect. This suggests that Q3, particularly in its iron complex form, could have promising potential as a new treatment strategy, warranting further investigation as a chemotherapeutic agent in fighting lung cancer.
In this study, we observed that one of the AQs, called 3-(hydroxymethyl)naphto[2,3-]cinnoline-4,7,12(1)-trione (Q3), effectively formed complexes with iron ions, while the other derivative, 4-hydroxynaphto[2,3-]cinnoline-7,12-dione (Q2), did not show any chelating properties. Chasing deeper insights, we evaluated the cytotoxic effects of these complexes on A549 lung cancer cells. Our findings indicated that the iron complex of Q3 displayed a notable decrease in cell viability, making it a strong candidate for further exploration in cancer therapy.
Surprisingly, Q3 and its copper complex did not show significant toxicity against the cancer cells. Furthermore, while Q3 helped to reduce the rate of iron-induced lipid peroxidation, Q2 did not have any effect. This suggests that Q3, particularly in its iron complex form, could have promising potential as a new treatment strategy, warranting further investigation as a chemotherapeutic agent in fighting lung cancer.
9.5
Iron-based multifunctional therapy evaluated
We explored a unique approach to treat lung cancer by developing a multifunctional nanodelivery system that combines several therapeutic methods. This system uses polydopamine as a foundation, with iron ions incorporated into its structure to enhance the therapy's effectiveness.
A notable aspect of our study is that the addition of iron was not just for its own potential benefits. It functioned alongside glucose oxidase and gambogic acid to lead a comprehensive assault on tumor cells. While gambogic acid alone has shown promise, the integration of iron is designed to improve the delivery and efficacy of this treatment.
Under controlled conditions, our system managed to release the therapeutic agents effectively, particularly when stimulated by certain environmental factors like pH changes and near-infrared light. As a result, we observed significant inhibition of tumor proliferation and increased levels of cell death, indicating a potential multi-modal strategy for lung cancer treatment.
Although the study highlights the ability of the iron-enhanced system to contribute to therapy, it's important to recognize that isolating iron's specific effect on lung cancer treatment remains challenging due to the complex interactions involved in this multifunctional approach.
A notable aspect of our study is that the addition of iron was not just for its own potential benefits. It functioned alongside glucose oxidase and gambogic acid to lead a comprehensive assault on tumor cells. While gambogic acid alone has shown promise, the integration of iron is designed to improve the delivery and efficacy of this treatment.
Under controlled conditions, our system managed to release the therapeutic agents effectively, particularly when stimulated by certain environmental factors like pH changes and near-infrared light. As a result, we observed significant inhibition of tumor proliferation and increased levels of cell death, indicating a potential multi-modal strategy for lung cancer treatment.
Although the study highlights the ability of the iron-enhanced system to contribute to therapy, it's important to recognize that isolating iron's specific effect on lung cancer treatment remains challenging due to the complex interactions involved in this multifunctional approach.
Most Useful Reviews
7.5
Anemia improvement
6 people found this helpful
Anemia improved after my mother, who had her oesophagus removed due to lung cancer, struggled for over three years. Despite trying domestic supplements and iron medications, nothing worked until I started this treatment. Following several months of regular health check-ups, her blood test results showed improvement. I advised others to drink it after meals to avoid stomach ache, and I've noticed a reduction in dizziness. I'm just disappointed it's out of stock now.
2
Ineffective treatment
My mother-in-law, who had lung cancer, suffered from very low haemoglobin and iron levels. Despite faithfully taking these vitamins and following all guidelines, they did not help to raise her blood iron or haemoglobin. While there were no side effects, this medication is ineffective for serious health issues.
7.5
Significant relief achieved
2 people found this helpful
After just three days of taking the iron supplement, I felt a remarkable relief, as though a weight had been lifted from my lungs and heart. For four years, I had struggled with a sensation of lacking oxygen, which medical tests could not resolve. I recommend getting iron levels checked and trying this specific form of iron if needed.
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.8
- All Researches
9.5
Iron-based multifunctional therapy evaluated
We explored a unique approach to treat lung cancer by developing a multifunctional nanodelivery system that combines several therapeutic methods. This system uses polydopamine as a foundation, with iron ions incorporated into its structure to enhance the therapy's effectiveness.
A notable aspect of our study is that the addition of iron was not just for its own potential benefits. It functioned alongside glucose oxidase and gambogic acid to lead a comprehensive assault on tumor cells. While gambogic acid alone has shown promise, the integration of iron is designed to improve the delivery and efficacy of this treatment.
Under controlled conditions, our system managed to release the therapeutic agents effectively, particularly when stimulated by certain environmental factors like pH changes and near-infrared light. As a result, we observed significant inhibition of tumor proliferation and increased levels of cell death, indicating a potential multi-modal strategy for lung cancer treatment.
Although the study highlights the ability of the iron-enhanced system to contribute to therapy, it's important to recognize that isolating iron's specific effect on lung cancer treatment remains challenging due to the complex interactions involved in this multifunctional approach.
A notable aspect of our study is that the addition of iron was not just for its own potential benefits. It functioned alongside glucose oxidase and gambogic acid to lead a comprehensive assault on tumor cells. While gambogic acid alone has shown promise, the integration of iron is designed to improve the delivery and efficacy of this treatment.
Under controlled conditions, our system managed to release the therapeutic agents effectively, particularly when stimulated by certain environmental factors like pH changes and near-infrared light. As a result, we observed significant inhibition of tumor proliferation and increased levels of cell death, indicating a potential multi-modal strategy for lung cancer treatment.
Although the study highlights the ability of the iron-enhanced system to contribute to therapy, it's important to recognize that isolating iron's specific effect on lung cancer treatment remains challenging due to the complex interactions involved in this multifunctional approach.
9
We explored how ageing affects lung cancer development, focusing on the role of iron homeostasis. Our research used aged mouse models and primary cells to demonstrate that ageing actually suppresses the initiation and growth of lung cancer. This happens because the cells that could potentially give rise to tumors lose their "stemness," or ability to self-renew and form new cells, over time.
A key finding was the role of the NUPR1 transcription factor and its target, lipocalin-2. Both of these proteins increase with ageing, leading to functional iron insufficiency in the cells. We discovered that by either disabling the NUPR1-lipocalin-2 pathway or adding iron back into aged cells, we could restore their stemness and boost their potential to cause tumors. Interestingly, in younger cells, disrupting this pathway could lead to harmful effects like ferroptosis, a form of cell death.
Our research also revealed that specific changes in DNA methylation related to ageing contribute to higher NUPR1 levels. This underscores a complex relationship where ageing facilitates a protective environment against certain types of cell death while promoting traits that suppress cancer. The findings have important implications for cancer prevention strategies, suggesting that efforts should be focused on younger individuals where most cancers begin.
A key finding was the role of the NUPR1 transcription factor and its target, lipocalin-2. Both of these proteins increase with ageing, leading to functional iron insufficiency in the cells. We discovered that by either disabling the NUPR1-lipocalin-2 pathway or adding iron back into aged cells, we could restore their stemness and boost their potential to cause tumors. Interestingly, in younger cells, disrupting this pathway could lead to harmful effects like ferroptosis, a form of cell death.
Our research also revealed that specific changes in DNA methylation related to ageing contribute to higher NUPR1 levels. This underscores a complex relationship where ageing facilitates a protective environment against certain types of cell death while promoting traits that suppress cancer. The findings have important implications for cancer prevention strategies, suggesting that efforts should be focused on younger individuals where most cancers begin.
8
Iron complexes show anticancer promise
We sought to understand how iron interacts with lung cancer through the study of two novel anthraquinone (AQ) derivatives. Our focus was on investigating their potential as anticancer agents and how they could help reduce the harmful effects typically associated with traditional treatments.
In this study, we observed that one of the AQs, called 3-(hydroxymethyl)naphto[2,3-]cinnoline-4,7,12(1)-trione (Q3), effectively formed complexes with iron ions, while the other derivative, 4-hydroxynaphto[2,3-]cinnoline-7,12-dione (Q2), did not show any chelating properties. Chasing deeper insights, we evaluated the cytotoxic effects of these complexes on A549 lung cancer cells. Our findings indicated that the iron complex of Q3 displayed a notable decrease in cell viability, making it a strong candidate for further exploration in cancer therapy.
Surprisingly, Q3 and its copper complex did not show significant toxicity against the cancer cells. Furthermore, while Q3 helped to reduce the rate of iron-induced lipid peroxidation, Q2 did not have any effect. This suggests that Q3, particularly in its iron complex form, could have promising potential as a new treatment strategy, warranting further investigation as a chemotherapeutic agent in fighting lung cancer.
In this study, we observed that one of the AQs, called 3-(hydroxymethyl)naphto[2,3-]cinnoline-4,7,12(1)-trione (Q3), effectively formed complexes with iron ions, while the other derivative, 4-hydroxynaphto[2,3-]cinnoline-7,12-dione (Q2), did not show any chelating properties. Chasing deeper insights, we evaluated the cytotoxic effects of these complexes on A549 lung cancer cells. Our findings indicated that the iron complex of Q3 displayed a notable decrease in cell viability, making it a strong candidate for further exploration in cancer therapy.
Surprisingly, Q3 and its copper complex did not show significant toxicity against the cancer cells. Furthermore, while Q3 helped to reduce the rate of iron-induced lipid peroxidation, Q2 did not have any effect. This suggests that Q3, particularly in its iron complex form, could have promising potential as a new treatment strategy, warranting further investigation as a chemotherapeutic agent in fighting lung cancer.
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Anemia improvement
6 people found this helpful
Anemia improved after my mother, who had her oesophagus removed due to lung cancer, struggled for over three years. Despite trying domestic supplements and iron medications, nothing worked until I started this treatment. Following several months of regular health check-ups, her blood test results showed improvement. I advised others to drink it after meals to avoid stomach ache, and I've noticed a reduction in dizziness. I'm just disappointed it's out of stock now.
2
Ineffective treatment
My mother-in-law, who had lung cancer, suffered from very low haemoglobin and iron levels. Despite faithfully taking these vitamins and following all guidelines, they did not help to raise her blood iron or haemoglobin. While there were no side effects, this medication is ineffective for serious health issues.
7.5
Significant relief achieved
2 people found this helpful
After just three days of taking the iron supplement, I felt a remarkable relief, as though a weight had been lifted from my lungs and heart. For four years, I had struggled with a sensation of lacking oxygen, which medical tests could not resolve. I recommend getting iron levels checked and trying this specific form of iron if needed.
Frequently Asked Questions
7.5
Anemia improvement
6 people found this helpful
Anemia improved after my mother, who had her oesophagus removed due to lung cancer, struggled for over three years. Despite trying domestic supplements and iron medications, nothing worked until I started this treatment. Following several months of regular health check-ups, her blood test results showed improvement. I advised others to drink it after meals to avoid stomach ache, and I've noticed a reduction in dizziness. I'm just disappointed it's out of stock now.
2
Ineffective treatment
My mother-in-law, who had lung cancer, suffered from very low haemoglobin and iron levels. Despite faithfully taking these vitamins and following all guidelines, they did not help to raise her blood iron or haemoglobin. While there were no side effects, this medication is ineffective for serious health issues.
7.5
Significant relief achieved
2 people found this helpful
After just three days of taking the iron supplement, I felt a remarkable relief, as though a weight had been lifted from my lungs and heart. For four years, I had struggled with a sensation of lacking oxygen, which medical tests could not resolve. I recommend getting iron levels checked and trying this specific form of iron if needed.
9.5
Iron-based multifunctional therapy evaluated
We explored a unique approach to treat lung cancer by developing a multifunctional nanodelivery system that combines several therapeutic methods. This system uses polydopamine as a foundation, with iron ions incorporated into its structure to enhance the therapy's effectiveness.
A notable aspect of our study is that the addition of iron was not just for its own potential benefits. It functioned alongside glucose oxidase and gambogic acid to lead a comprehensive assault on tumor cells. While gambogic acid alone has shown promise, the integration of iron is designed to improve the delivery and efficacy of this treatment.
Under controlled conditions, our system managed to release the therapeutic agents effectively, particularly when stimulated by certain environmental factors like pH changes and near-infrared light. As a result, we observed significant inhibition of tumor proliferation and increased levels of cell death, indicating a potential multi-modal strategy for lung cancer treatment.
Although the study highlights the ability of the iron-enhanced system to contribute to therapy, it's important to recognize that isolating iron's specific effect on lung cancer treatment remains challenging due to the complex interactions involved in this multifunctional approach.
A notable aspect of our study is that the addition of iron was not just for its own potential benefits. It functioned alongside glucose oxidase and gambogic acid to lead a comprehensive assault on tumor cells. While gambogic acid alone has shown promise, the integration of iron is designed to improve the delivery and efficacy of this treatment.
Under controlled conditions, our system managed to release the therapeutic agents effectively, particularly when stimulated by certain environmental factors like pH changes and near-infrared light. As a result, we observed significant inhibition of tumor proliferation and increased levels of cell death, indicating a potential multi-modal strategy for lung cancer treatment.
Although the study highlights the ability of the iron-enhanced system to contribute to therapy, it's important to recognize that isolating iron's specific effect on lung cancer treatment remains challenging due to the complex interactions involved in this multifunctional approach.
8
Iron complexes show anticancer promise
We sought to understand how iron interacts with lung cancer through the study of two novel anthraquinone (AQ) derivatives. Our focus was on investigating their potential as anticancer agents and how they could help reduce the harmful effects typically associated with traditional treatments.
In this study, we observed that one of the AQs, called 3-(hydroxymethyl)naphto[2,3-]cinnoline-4,7,12(1)-trione (Q3), effectively formed complexes with iron ions, while the other derivative, 4-hydroxynaphto[2,3-]cinnoline-7,12-dione (Q2), did not show any chelating properties. Chasing deeper insights, we evaluated the cytotoxic effects of these complexes on A549 lung cancer cells. Our findings indicated that the iron complex of Q3 displayed a notable decrease in cell viability, making it a strong candidate for further exploration in cancer therapy.
Surprisingly, Q3 and its copper complex did not show significant toxicity against the cancer cells. Furthermore, while Q3 helped to reduce the rate of iron-induced lipid peroxidation, Q2 did not have any effect. This suggests that Q3, particularly in its iron complex form, could have promising potential as a new treatment strategy, warranting further investigation as a chemotherapeutic agent in fighting lung cancer.
In this study, we observed that one of the AQs, called 3-(hydroxymethyl)naphto[2,3-]cinnoline-4,7,12(1)-trione (Q3), effectively formed complexes with iron ions, while the other derivative, 4-hydroxynaphto[2,3-]cinnoline-7,12-dione (Q2), did not show any chelating properties. Chasing deeper insights, we evaluated the cytotoxic effects of these complexes on A549 lung cancer cells. Our findings indicated that the iron complex of Q3 displayed a notable decrease in cell viability, making it a strong candidate for further exploration in cancer therapy.
Surprisingly, Q3 and its copper complex did not show significant toxicity against the cancer cells. Furthermore, while Q3 helped to reduce the rate of iron-induced lipid peroxidation, Q2 did not have any effect. This suggests that Q3, particularly in its iron complex form, could have promising potential as a new treatment strategy, warranting further investigation as a chemotherapeutic agent in fighting lung cancer.
References
- Liu J, Chen ZH, Wei XQ, Lin LT, Xu W. [Construction and in vitro pharmacodynamic evaluation of a polydopamine nanodelivery system co-loaded with gambogic acid, Fe(Ⅲ), and glucose oxidase]. Zhongguo Zhong Yao Za Zhi. 2025;50:111. doi:10.19540/j.cnki.cjcmm.20240919.301
- Selyutina OY, Ul'yanova MA, Chinak OA, Timoshnikov VA, Fedenok LG, et al. Novel Anthraquinone Derivatives and Their Complexes with Metal Ions with Anticancer Activity: Structure/Redox and Chelation Activity Correlations. Pharmaceuticals (Basel). 2024;17. doi:10.3390/ph17121717
- Zhuang X, Wang Q, Joost S, Ferrena A, Humphreys DT, et al. Ageing limits stemness and tumorigenesis by reprogramming iron homeostasis. Nature. 2025;637:184. doi:10.1038/s41586-024-08285-0
