' 
Supplement Facts
Serving Size: 4 Tablets
Amount Per Serving
%DV
Calories
10
Total Carbohydrate
1 g
<1%**
Dietary Fiber
1 g
4%**
Vitamin D (as cholecalciferol)
15 mcg (600 IU)
75%
Calcium (as calcium citrate)
1000 mg
77%
Sodium†
20 mg
<1%
The product is found useful for the following medical conditions
Osteoporosis
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.3
USERS' SCORE
Good
Based on 25 Reviews
8.4
8
Vitamin D's impact on osteoporosis
The Vitamin D-Sirt1/PGC1α Axis Regulates Bone Metabolism and Counteracts Osteoporosis.
Most Relevant Research
We aimed to understand how vitamin D influences bone health and helps combat osteoporosis, a condition that weakens bones. In our study, we used various mouse models, including those that mimic a deficiency in active vitamin D. Through a range of advanced methods, we assessed how changes in vitamin D levels affected bone structure and metabolism.
The research revealed that insufficient vitamin D led to a drop in Sirt1, a gene that plays a crucial role in maintaining bone density. This lack of Sirt1 resulted in increased bone loss. However, when we boosted Sirt1 levels in bone stem cells, we observed a reversal in bone loss. This improvement happened because higher Sirt1 levels reduced oxidative stress, slowed down aging processes in bone cells, and enhanced new bone formation while curbing bone resorption.
Additionally, our findings indicated that vitamin D directly stimulates Sirt1 expression in these stem cells, which is vital for bone health. We also explored the effects of resveratrol, a natural compound known for activating Sirt1, and found it helped alleviate osteoporosis symptoms linked to vitamin D deficiency by enhancing the relationship between Sirt1 and another protein called PGC1α, which supports bone formation and energy metabolism.
This research underscores the importance of the vitamin D-Sirt1/PGC1α axis in bone metabolism, providing insight into how vitamin D can serve as a target for osteoporosis prevention and treatment.
The research revealed that insufficient vitamin D led to a drop in Sirt1, a gene that plays a crucial role in maintaining bone density. This lack of Sirt1 resulted in increased bone loss. However, when we boosted Sirt1 levels in bone stem cells, we observed a reversal in bone loss. This improvement happened because higher Sirt1 levels reduced oxidative stress, slowed down aging processes in bone cells, and enhanced new bone formation while curbing bone resorption.
Additionally, our findings indicated that vitamin D directly stimulates Sirt1 expression in these stem cells, which is vital for bone health. We also explored the effects of resveratrol, a natural compound known for activating Sirt1, and found it helped alleviate osteoporosis symptoms linked to vitamin D deficiency by enhancing the relationship between Sirt1 and another protein called PGC1α, which supports bone formation and energy metabolism.
This research underscores the importance of the vitamin D-Sirt1/PGC1α axis in bone metabolism, providing insight into how vitamin D can serve as a target for osteoporosis prevention and treatment.
9.5
Effective for healing bones
Most Useful Review
At 58, after breaking an arm and leg, I began taking calcium citrate with vitamin D3. When my plaster was removed after 1.5 months, my bones had fused well, so I continued using it until the pack was complete. I've since ordered more and take it in intervals of 2 months for osteoporosis prevention. I am very pleased with its effectiveness for strengthening bones.
Heartburn
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8
USERS' SCORE
Moderately Good
Based on 1 Review
7.8
8
Calcium aids heartburn relief
Calcium supplementation during pregnancy and lactation: effects on the mother and the fetus.
Most Relevant Research
We explored the effectiveness of calcium in alleviating heartburn, especially in pregnant women. Our findings highlighted that many expectant mothers experience heartburn due to hormonal changes and the physical pressure of a growing fetus on the stomach.
Calcium-based antacids emerged as an excellent choice for providing relief. Not only do they help manage heartburn symptoms, but they also offer a source of calcium, which is vital for bone health in both mothers and their developing babies.
By ensuring adequate calcium intake through these antacids, we can support maternal health while addressing the discomforts of pregnancy. This dual benefit makes calcium supplementation a practical option for maintaining well-being during this critical time.
Calcium-based antacids emerged as an excellent choice for providing relief. Not only do they help manage heartburn symptoms, but they also offer a source of calcium, which is vital for bone health in both mothers and their developing babies.
By ensuring adequate calcium intake through these antacids, we can support maternal health while addressing the discomforts of pregnancy. This dual benefit makes calcium supplementation a practical option for maintaining well-being during this critical time.
1
Difficult to swallow
Most Useful Review
Huge and very hard to swallow; it was irritating. I wanted good calcium but these tablets are oversized, tough to digest, and cause heartburn and stomach discomfort. Unfortunately, the product cannot be returned, which is understandable, but I received no compensation for this unsatisfactory and expensive purchase.
