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Supplement Facts
Serving Size: 3 tablets
Serving Per Container: 83
Amount Per Serving
%DV
Calcium (as calcium carbonate, calcium gluconate, calcium citrate)
1,000 mg
77%
Magnesium (as magnesium oxide, magnesium gluconate, magnesium citrate)
400 mg
95%
Zinc (as zinc gluconate)
15 mg
136%
Sodium†
15 mg
<1%
The product is found useful for the following medical conditions
Bone Pain details
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Excellent
Based on 39 Reviews
9
8
Calcium's role in bone pain unclear
In-depth clinical characterization of intravenous iron infusion-induced hypophosphatemic osteomalacia and its resolution.
Most Relevant Research
We explored the impact of calcium treatment on bone pain in patients who developed osteomalacia, a condition linked to intravenous iron infusions. Our focus was on a group of 13 patients diagnosed with this condition, who experienced low phosphate levels due to excess fibroblast growth factor 23 (iFGF23) after receiving ferric carboxymaltose (FCM) infusions.
After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.
Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.
After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.
Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.
9.5
Enhances bone strength
Most Useful Review
FOR IMMUNITY AND HEART HEALTH! A reliable brand that truly works. Magnesium and calcium are vital for maintaining many biological processes. With high physical and mental stress, these trace elements are indispensable for my heart and skeletal muscles, compensating for deficiencies in bone and dental tissues. Calcium is involved in blood coagulation and muscle contractions. Magnesium supports heart muscle functioning and energy processes, while zinc is essential for intestinal cell function, bone growth, and my immune system.
Leg Cramps details
SCIENTIFIC SCORE
Questionable
Based on 24 Researches
5.1
USERS' SCORE
Excellent
Based on 33 Reviews
9
9
Magnesium oxide treats leg cramps
A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps.
Most Relevant Research
We conducted a study to evaluate how effective magnesium oxide monohydrate (MOMH) is in treating nocturnal leg cramps (NLC). This was a randomized, double-blind, placebo-controlled trial involving multiple centers in Ukraine, where participants took either MOMH or a placebo nightly for 60 days.
Our focus was on measuring the frequency and duration of cramps, the pain they caused, and how they affected sleep quality and overall life satisfaction. We used thorough statistical methods to compare the results between the two groups.
The findings indicated that MOMH is both effective and safe for individuals dealing with NLC. Participants reported improvements in their symptoms, demonstrating that this magnesium supplement can play a helpful role in managing nocturnal leg cramps.
Our focus was on measuring the frequency and duration of cramps, the pain they caused, and how they affected sleep quality and overall life satisfaction. We used thorough statistical methods to compare the results between the two groups.
The findings indicated that MOMH is both effective and safe for individuals dealing with NLC. Participants reported improvements in their symptoms, demonstrating that this magnesium supplement can play a helpful role in managing nocturnal leg cramps.
10
Immediate cramp relief
Most Useful Review
I adore this vitamin complex; the effects are felt almost immediately. My leg cramps have disappeared, and I feel upbeat in the morning. Zinc has truly made a difference!
Anxiety details
SCIENTIFIC SCORE
Possibly Effective
Based on 21 Researches
7.4
USERS' SCORE
Good
Based on 8 Reviews
8.9
8
Zinc may alleviate anxiety symptoms
A systematic review of the association between zinc and anxiety.
Most Relevant Research
We explored the connection between zinc intake and anxiety in adults through a systematic review of nine original studies. Two of these studies looked at how zinc consumption impacts anxiety, while the other seven focused on the relationship between serum zinc levels and anxiety symptoms. Our analysis included studies published in English within peer-reviewed journals, ensuring a solid foundation for understanding this potential link.
What we discovered was quite illuminating. The data indicated that individuals experiencing anxiety often had lower levels of zinc in their serum compared to those who did not suffer from anxiety. Additionally, we observed an inverse association between zinc intake and anxiety levels. This suggests that higher consumption of zinc may contribute to reduced anxiety symptoms.
In conclusion, the evidence points towards zinc playing a positive role in treating anxiety, although we acknowledge some limitations in the available studies. This means zinc supplementation could be a beneficial strategy for those looking to manage their anxiety, but more research is needed to confirm these findings and understand the underlying mechanisms better.
What we discovered was quite illuminating. The data indicated that individuals experiencing anxiety often had lower levels of zinc in their serum compared to those who did not suffer from anxiety. Additionally, we observed an inverse association between zinc intake and anxiety levels. This suggests that higher consumption of zinc may contribute to reduced anxiety symptoms.
In conclusion, the evidence points towards zinc playing a positive role in treating anxiety, although we acknowledge some limitations in the available studies. This means zinc supplementation could be a beneficial strategy for those looking to manage their anxiety, but more research is needed to confirm these findings and understand the underlying mechanisms better.
10
Feeling happier
Most Useful Review
Absolutely amazing. I ordered this product for anxiety, and it is simply remarkable. I've been using it for two weeks now and couldn't be happier.
Autoimmune Disorder details
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.8
USERS' SCORE
Good
Based on 16 Reviews
8.9
9
Zinc supplementation benefits MS models
Dietary zinc status is associated with ZnT3 (SLC30A3), IL-6 gene expressions and spinal cord tissue damage in spinal cord tissue in a cuprizone-induced rat Multiple Sclerosis model.
Most Relevant Research
We explored how dietary zinc levels influence spinal cord damage and gene expressions associated with Multiple Sclerosis (MS) using a cuprizone-induced rat model. The study included 46 adult male Wistar rats divided into five groups, with some receiving zinc supplementation while others followed a zinc-deficient diet.
After eight weeks of treatment, we found that the rats with MS symptoms showed elevated markers of tissue damage and inflammation, particularly in the groups that lacked zinc. Notably, those receiving zinc supplementation exhibited significantly reduced levels of harmful substances, bringing them back closer to control levels.
Our findings highlight zinc's protective effects in a model of MS, suggesting that incorporating zinc into treatment plans could help alleviate some symptoms associated with this autoimmune disorder. This is promising for future treatment strategies for those affected by MS.
After eight weeks of treatment, we found that the rats with MS symptoms showed elevated markers of tissue damage and inflammation, particularly in the groups that lacked zinc. Notably, those receiving zinc supplementation exhibited significantly reduced levels of harmful substances, bringing them back closer to control levels.
Our findings highlight zinc's protective effects in a model of MS, suggesting that incorporating zinc into treatment plans could help alleviate some symptoms associated with this autoimmune disorder. This is promising for future treatment strategies for those affected by MS.
9.5
Joint pain relief
Most Useful Review
The composition of Calcium, Magnesium, and Zinc is wonderful. I have ordered this for the second time, and I've noticed the pain in my joints has disappeared.
Allergies details
SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8.4
USERS' SCORE
Good
Based on 8 Reviews
8.8
9
Zinc may relieve allergy symptoms
Alleviating effect of intranasal zinc on symptoms of allergic rhinitis.
Most Relevant Research
We investigated how intranasal zinc (Zn) treatment affects symptoms of allergic rhinitis (AR), specifically focusing on individuals suffering from Japanese cedar pollinosis (JCP), a common seasonal allergy. In our study, we monitored 57 control subjects and 44 patients from preseason through the allergy season, observing the levels of Zn in both nasal fluid and serum.
Our findings showed that after exposure to pollen, the level of zinc in the nasal lining fluid of JCP patients significantly increased, while their serum zinc levels notably decreased compared to the control group during the JCP season. To delve deeper, we used model mice that could mimic these changes and the allergy symptoms of the patients.
The results from this mouse study were promising. We observed that treating these mice with a dose of zinc, similar to what humans might use, led to a notable improvement in their allergy symptoms. Additionally, the number of mucin-secreting goblet cells, which indicate a response to allergies, significantly decreased following the zinc treatment.
Our study points towards the potential of using intranasal zinc as a way to alleviate allergy symptoms, suggesting a new approach to managing allergic rhinitis.
Our findings showed that after exposure to pollen, the level of zinc in the nasal lining fluid of JCP patients significantly increased, while their serum zinc levels notably decreased compared to the control group during the JCP season. To delve deeper, we used model mice that could mimic these changes and the allergy symptoms of the patients.
The results from this mouse study were promising. We observed that treating these mice with a dose of zinc, similar to what humans might use, led to a notable improvement in their allergy symptoms. Additionally, the number of mucin-secreting goblet cells, which indicate a response to allergies, significantly decreased following the zinc treatment.
Our study points towards the potential of using intranasal zinc as a way to alleviate allergy symptoms, suggesting a new approach to managing allergic rhinitis.
9.5
Relieves allergy symptoms
Most Useful Review
I liked it! A very good product that offers great value. My calcium intake is low due to lactose intolerance, but I started taking this product three weeks ago. It hasn’t caused any stomach issues or allergies.
Heart Disease details
SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8.3
USERS' SCORE
Good
Based on 12 Reviews
8.8
9
Zinc benefits heart health post-cisplatin
Role of zinc oxide nanoparticles supplementation on alleviate side effects of cisplatin induced cardiotoxicity in rats.
Most Relevant Research
We explored the potential benefits of zinc oxide nanoparticles (ZnONPs) in preventing heart damage caused by cisplatin, a powerful chemotherapy drug known for its efficacy but also for its side effects, particularly cardiotoxicity.
In our study, rats were divided into several groups, including control groups and those receiving different doses of ZnONPs. We specifically looked at a range of health markers such as lipid levels, antioxidant activity, and inflammation in heart tissues to see how ZnONPs could help soften the impact of cisplatin on heart health.
As we gradually increased the dosage of ZnONPs to 50 mg/kg, we observed significant improvements across the various health parameters examined. Notably, at this optimal dose, the rats' heart health markers showed a remarkable recovery, aligning closely with those in the healthy control group. This suggests that ZnONPs effectively protect heart tissue from oxidative stress and inflammation associated with cisplatin treatment.
Overall, our findings highlight the promising role of zinc oxide nanoparticles in mitigating heart damage linked to cancer treatments, paving the way for further research in this arena.
In our study, rats were divided into several groups, including control groups and those receiving different doses of ZnONPs. We specifically looked at a range of health markers such as lipid levels, antioxidant activity, and inflammation in heart tissues to see how ZnONPs could help soften the impact of cisplatin on heart health.
As we gradually increased the dosage of ZnONPs to 50 mg/kg, we observed significant improvements across the various health parameters examined. Notably, at this optimal dose, the rats' heart health markers showed a remarkable recovery, aligning closely with those in the healthy control group. This suggests that ZnONPs effectively protect heart tissue from oxidative stress and inflammation associated with cisplatin treatment.
Overall, our findings highlight the promising role of zinc oxide nanoparticles in mitigating heart damage linked to cancer treatments, paving the way for further research in this arena.
9.5
Reduced cramps
Most Useful Review
This complex is among the best calcium preparations due to its chelated form, ensuring maximum absorption. Calcium strengthens bones, magnesium aids its distribution, and zinc supports collagen production. After using this for my parents, my father's arm cramps post-heart attack ceased, and my mother no longer suffers from leg cramps at night. Remember to take Vitamin D for better calcium absorption.
Cardiovascular Disease details
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.7
USERS' SCORE
Good
Based on 2 Reviews
8.7
8
Magnesium's impact on heart health
The Role of Dietary Magnesium in Cardiovascular Disease.
Most Relevant Research
We examined the connection between dietary magnesium and cardiovascular disease, focusing on how magnesium intake or serum levels relate to heart health. Over the last couple of decades, numerous studies have shown that low magnesium levels are associated with several heart-related issues, including high blood pressure, heart attacks, and even heart failure.
Our insights reveal that even mild or moderate magnesium deficiencies can trigger physiological and metabolic changes that may heighten cardiovascular risks. When magnesium levels are insufficient, we see a rise in inflammation, oxidative stress, and issues with how fats are processed in the body, which can lead to serious heart problems.
Furthermore, we noted that many individuals often consume less magnesium than what is recommended, particularly those who do not regularly eat whole grains, legumes, or green vegetables. This widespread lack of magnesium is concerning, as it could be a significant factor influencing heart disease in the general population.
Our insights reveal that even mild or moderate magnesium deficiencies can trigger physiological and metabolic changes that may heighten cardiovascular risks. When magnesium levels are insufficient, we see a rise in inflammation, oxidative stress, and issues with how fats are processed in the body, which can lead to serious heart problems.
Furthermore, we noted that many individuals often consume less magnesium than what is recommended, particularly those who do not regularly eat whole grains, legumes, or green vegetables. This widespread lack of magnesium is concerning, as it could be a significant factor influencing heart disease in the general population.
10
Joint health improved
Most Useful Review
The best brand of Solgar. After taking these for about two weeks, I have noticed changes—my joint disease has improved. The packaging is of good quality. I would definitely recommend these.
Constipation details
SCIENTIFIC SCORE
Questionable
Based on 14 Researches
6.9
USERS' SCORE
Good
Based on 5 Reviews
8.7
4
Effectiveness of magnesium on constipation
Effect of reduced daily magnesium oxide doses on laxative effect: a single-center retrospective study.
Most Relevant Research
We explored how changing the frequency of magnesium oxide (MgO) doses influences its effectiveness in relieving constipation. In this study, we looked at 11 patients who had been regularly using MgO to manage their bowel movements and decided to reduce their daily dose frequency over two weeks.
Initially, patients were taking magnesium three times a day, but we reduced this to either two or one dose per day while keeping the total amount the same. We found that the average number of bowel movements dropped from 7.6 to 6.6 in this period. However, this change wasn't statistically significant, indicating that it may not be clinically meaningful.
Additionally, we measured stool consistency using the Bristol Stool Form Scale and noted no significant difference before and after the dosage adjustment. Our findings suggest that reducing the number of doses does not impact the laxative effect of magnesium oxide. This implies that patients can comfortably manage their magnesium intake without sacrificing effectiveness.
Initially, patients were taking magnesium three times a day, but we reduced this to either two or one dose per day while keeping the total amount the same. We found that the average number of bowel movements dropped from 7.6 to 6.6 in this period. However, this change wasn't statistically significant, indicating that it may not be clinically meaningful.
Additionally, we measured stool consistency using the Bristol Stool Form Scale and noted no significant difference before and after the dosage adjustment. Our findings suggest that reducing the number of doses does not impact the laxative effect of magnesium oxide. This implies that patients can comfortably manage their magnesium intake without sacrificing effectiveness.
9.5
Constipation relief
Most Useful Review
I consume alcohol and wanted to take zinc. Previously, when I stopped taking calcium/magnesium tablets, I became constipated. This time, I opted for one that includes zinc. It seems alcohol can deplete your zinc levels, which is crucial for immunity. Since starting this, my constipation has disappeared, likely due to the magnesium.
Headache details
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8
USERS' SCORE
Good
Based on 7 Reviews
8.7
9
Zinc reduces migraine symptoms
Assessing the Effect of Zinc Supplementation on the Frequency of Migraine Attack, Duration, Severity, Lipid Profile and hs-CRP in Adult Women.
Most Relevant Research
We conducted a randomized, double-blind, placebo-controlled trial to explore how zinc gluconate affects migraine symptoms in women. Sixty participants, with an average age of 35, were given either 15 mg of zinc per day or a placebo for 12 weeks, allowing us to measure the impact on headache frequency, duration, and intensity.
The results were quite promising; zinc supplementation significantly reduced how often headaches occurred, shortened their duration, and decreased the severity of the migraines reported. Participants in the zinc group experienced notable improvements, as indicated by their responses to the headache severity scale and a disability assessment questionnaire.
Furthermore, we found that zinc also had a positive effect on certain health markers. The serum levels of low-density lipoprotein (LDL), total cholesterol, and high-sensitivity C-reactive protein (hs-CRP) decreased with zinc supplementation. However, we didn’t observe significant changes in triglycerides or high-density lipoprotein (HDL) levels after adjusting for baseline values.
In conclusion, zinc supplementation appears to hold beneficial effects on migraine severity and frequency, offering a potential alternative for those who seek relief from these debilitating headaches.
The results were quite promising; zinc supplementation significantly reduced how often headaches occurred, shortened their duration, and decreased the severity of the migraines reported. Participants in the zinc group experienced notable improvements, as indicated by their responses to the headache severity scale and a disability assessment questionnaire.
Furthermore, we found that zinc also had a positive effect on certain health markers. The serum levels of low-density lipoprotein (LDL), total cholesterol, and high-sensitivity C-reactive protein (hs-CRP) decreased with zinc supplementation. However, we didn’t observe significant changes in triglycerides or high-density lipoprotein (HDL) levels after adjusting for baseline values.
In conclusion, zinc supplementation appears to hold beneficial effects on migraine severity and frequency, offering a potential alternative for those who seek relief from these debilitating headaches.
9.5
Headache frequency
Most Useful Review
I’ve had numerous headaches since middle school—migraines, tension, and a Thunder Clap headache a few times. After taking these three a day, my headaches are much less frequent, and my body absorbs this pill much better than others. It has truly helped!
Insomnia details
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.6
USERS' SCORE
Good
Based on 9 Reviews
8.7
9
Magnesium improves elderly insomnia
The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial.
Most Relevant Research
We conducted a double-blind, placebo-controlled clinical trial to investigate the effects of magnesium supplementation on insomnia in elderly individuals. Our study involved 46 participants who were assigned either to receive 500 mg of magnesium daily or a placebo for a duration of 8 weeks.
Throughout the study, we employed various questionnaires, including the Insomnia Severity Index (ISI), to evaluate the participants' sleep quality both before and after the treatment period. We also monitored the intake of other nutrients and performed blood tests to assess hormone levels related to sleep.
The results showed that magnesium supplementation led to significant improvements in areas such as sleep efficiency, sleep onset timing, and overall insomnia severity. We observed increases in serum levels of melatonin and changes in cortisol and renin levels, indicating a physiological response that could enhance sleep quality.
Overall, it seems that supplementing with magnesium has the potential to improve sleep for older adults struggling with insomnia. This finding could pave the way for new, accessible treatment options for those affected by sleep disorders.
Throughout the study, we employed various questionnaires, including the Insomnia Severity Index (ISI), to evaluate the participants' sleep quality both before and after the treatment period. We also monitored the intake of other nutrients and performed blood tests to assess hormone levels related to sleep.
The results showed that magnesium supplementation led to significant improvements in areas such as sleep efficiency, sleep onset timing, and overall insomnia severity. We observed increases in serum levels of melatonin and changes in cortisol and renin levels, indicating a physiological response that could enhance sleep quality.
Overall, it seems that supplementing with magnesium has the potential to improve sleep for older adults struggling with insomnia. This finding could pave the way for new, accessible treatment options for those affected by sleep disorders.
9.5
Regained sleep quality
Most Useful Review
I previously struggled with long-term insomnia and severe hair loss. My doctor recommended supplements containing magnesium and zinc, and shortly after starting them, my sleep quality improved and my hair thickened. The results are quite impressive, and I will continue taking them, recommending them to others in need!
Knee Pain details
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
6.5
USERS' SCORE
Good
Based on 20 Reviews
8.7
9
Calcium injection aids knee function
Total Knee Conversion Rates and Functional Outcome After Calcium Phosphate Injection for Bone Marrow Lesions of the Knee.
Most Relevant Research
We explored how calcium phosphate (CaP) injections impact knee pain, particularly in patients suffering from osteoarthritis-related bone marrow lesions (OA-BML). In this study, we compared two groups of patients: those who received knee arthroscopy combined with CaP injections and those who had knee arthroscopy for different knee issues.
Our observations showed that patients receiving the CaP injections experienced less frequent conversions to total knee arthroplasty (TKA) when compared to the other group. Notably, within the CaP group, we noticed a significant improvement in their knee injury and functional outcome scores before and after the procedure. However, patients who only underwent knee arthroscopy did not show the same level of improvement.
Overall, we found that adding CaP injections during knee surgery for OA-BML significantly enhanced functional outcomes over traditional surgery alone. This study underscores the potential benefits of CaP treatments in managing knee pain and improving quality of life for those suffering from knee OA.
Our observations showed that patients receiving the CaP injections experienced less frequent conversions to total knee arthroplasty (TKA) when compared to the other group. Notably, within the CaP group, we noticed a significant improvement in their knee injury and functional outcome scores before and after the procedure. However, patients who only underwent knee arthroscopy did not show the same level of improvement.
Overall, we found that adding CaP injections during knee surgery for OA-BML significantly enhanced functional outcomes over traditional surgery alone. This study underscores the potential benefits of CaP treatments in managing knee pain and improving quality of life for those suffering from knee OA.
9.5
No leg pain
Most Useful Review
I no longer feel pain in my legs.
Sleep Apnea details
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Good
Based on 13 Reviews
8.7
9
Zinc protects heart function in OSA
Zinc Is Indispensable in Exercise-Induced Cardioprotection against Intermittent Hypoxia-Induced Left Ventricular Function Impairment in Rats.
Most Relevant Research
We explored how zinc affects heart function in the context of obstructive sleep apnea (OSA), specifically focusing on cases of intermittent hypoxia (IH). In a detailed study using male rats, researchers set up different groups: a control group and one that underwent 10 weeks of exercise training. Half of the rats in both groups were exposed to IH conditions to simulate the effects of sleep apnea.
The results were eye-opening. Rats that experienced IH showed notable impairment in their heart's left ventricular function, characterized by reduced ejection fraction and increased inflammation. However, when treated with zinc, these negative effects were significantly countered. Notably, those who exercised and received zinc treatment displayed improved heart function and antioxidant capabilities compared to their counterparts that did not receive zinc.
On the flip side, exercise alone did not provide the same protective benefits when zinc was absent. The findings suggest that zinc is essential not only for the heart's protection against the damaging effects of IH but also enhances the benefits of physical exercise. This research indicates the importance of zinc in potentially managing heart health in individuals suffering from sleep apnea.
The results were eye-opening. Rats that experienced IH showed notable impairment in their heart's left ventricular function, characterized by reduced ejection fraction and increased inflammation. However, when treated with zinc, these negative effects were significantly countered. Notably, those who exercised and received zinc treatment displayed improved heart function and antioxidant capabilities compared to their counterparts that did not receive zinc.
On the flip side, exercise alone did not provide the same protective benefits when zinc was absent. The findings suggest that zinc is essential not only for the heart's protection against the damaging effects of IH but also enhances the benefits of physical exercise. This research indicates the importance of zinc in potentially managing heart health in individuals suffering from sleep apnea.
9.5
Heart pain relief
Most Useful Review
Super! I have a small child and suffered from sleep deprivation, which caused my heart to ache. After visiting a cardiologist, he recommended Calcium, Magnesium, and Zinc. Since I started taking these supplements, my heart no longer hurts. I highly recommend this preparation, although it can be hard to find.
Anemia details
SCIENTIFIC SCORE
Questionable
Based on 8 Researches
6.9
USERS' SCORE
Good
Based on 2 Reviews
8.6
9
Zinc deficiency linked to anemia
Zinc Deficiency Presenting With Diverse Symptoms in a Young Patient: A Case Report.
Most Relevant Research
We explored the connection between zinc deficiency and anemia through the case of an 18-year-old woman who faced a series of health issues, including urinary tract infections and insulin dysfunction. After a thorough assessment, she was diagnosed with zinc deficiency, shedding light on how this overlooked issue can impact overall health.
What stood out to us was the rapid recovery the patient experienced after beginning oral zinc supplementation. Zinc plays a critical role in numerous bodily functions, including immune support and protein regulation. By addressing her deficiency, we observed significant improvement in her symptoms, including anemia.
The patient’s diet contained high levels of substances that were inhibiting her zinc absorption, which likely contributed to her condition. This case emphasizes the importance of recognizing zinc deficiency as a potential underlying cause for unexplained health issues, particularly anemia. Prompt diagnosis and treatment can lead to a complete turnaround in the patient's health.
By sharing this experience, we hope to raise awareness among clinicians about the vital role of zinc in managing anemia and encourage timely interventions for patients showing diverse symptoms.
What stood out to us was the rapid recovery the patient experienced after beginning oral zinc supplementation. Zinc plays a critical role in numerous bodily functions, including immune support and protein regulation. By addressing her deficiency, we observed significant improvement in her symptoms, including anemia.
The patient’s diet contained high levels of substances that were inhibiting her zinc absorption, which likely contributed to her condition. This case emphasizes the importance of recognizing zinc deficiency as a potential underlying cause for unexplained health issues, particularly anemia. Prompt diagnosis and treatment can lead to a complete turnaround in the patient's health.
By sharing this experience, we hope to raise awareness among clinicians about the vital role of zinc in managing anemia and encourage timely interventions for patients showing diverse symptoms.
9.5
Increased energy levels
Most Useful Review
I purchased this for my 13-year-old son, who is active and takes it along with iron to prevent anaemia and support his development. He feels fantastic, and his energy levels have increased significantly. I highly recommend it.
Arthritis details
SCIENTIFIC SCORE
Moderately Effective
Based on 22 Researches
8.1
USERS' SCORE
Good
Based on 4 Reviews
8.6
8
Magnesium protects against bone erosion
Serum ionized magnesium acts as an independent protective factor against bone erosion in patients with gouty arthritis: a cross-sectional study.
Most Relevant Research
We delved into the relationship between magnesium levels and gouty arthritis, a condition known for causing painful flare-ups and damaging joint function. Our research focused on measuring serum ionized magnesium levels in a group of 769 patients and assessing how these levels relate to bone erosion, a serious complication of gout.
Our findings revealed that patients experiencing bone erosion had significantly lower magnesium levels compared to those without erosion. When we categorized magnesium levels into quartiles, the data showed that those in the lowest quartile (Q1) were more likely to have bone erosion compared to patients in higher quartiles. In fact, the prevalence of erosion in the lowest magnesium group was much higher, illustrating a clear connection.
Through detailed analysis, we concluded that higher levels of serum ionized magnesium may serve as a protective factor against bone erosion in gouty arthritis. This suggests that magnesium supplementation could be a promising strategy for individuals suffering from this debilitating condition, potentially helping to slow down or prevent further joint damage.
Our findings revealed that patients experiencing bone erosion had significantly lower magnesium levels compared to those without erosion. When we categorized magnesium levels into quartiles, the data showed that those in the lowest quartile (Q1) were more likely to have bone erosion compared to patients in higher quartiles. In fact, the prevalence of erosion in the lowest magnesium group was much higher, illustrating a clear connection.
Through detailed analysis, we concluded that higher levels of serum ionized magnesium may serve as a protective factor against bone erosion in gouty arthritis. This suggests that magnesium supplementation could be a promising strategy for individuals suffering from this debilitating condition, potentially helping to slow down or prevent further joint damage.
8.3
High-quality supplement
Most Useful Review
The quality is high, and the quantity is substantial; it has helped me significantly with arthritis.
Dizziness details
SCIENTIFIC SCORE
Moderately Effective
Based on 8 Researches
8.8
USERS' SCORE
Good
Based on 4 Reviews
8.6
9
Calcium alleviates chemotherapy symptoms
Hypomagnesemia because of nedaplatin for cervical cancer: A case report.
Most Relevant Research
We observed a striking case involving a 76-year-old woman diagnosed with cervical cancer, who was treated with nedaplatin, a platinum-based chemotherapy drug. Shortly after starting her treatment, she experienced troubling symptoms, including numbness, dizziness, and a noticeable loss of appetite.
Upon investigation, we discovered low levels of calcium and magnesium in her blood, which were likely contributing to her symptoms. Thankfully, after administering intravenous calcium and magnesium, we saw a prompt improvement in both her mineral levels and her symptoms.
The case underscores the importance of monitoring electrolyte levels during chemotherapy treatments, such as nedaplatin. By focusing on these disturbances, healthcare providers can unveil potential diagnoses even when patients present with vague symptoms. Regular follow-ups during anticancer therapies could be crucial in effectively managing side effects such as dizziness.
Upon investigation, we discovered low levels of calcium and magnesium in her blood, which were likely contributing to her symptoms. Thankfully, after administering intravenous calcium and magnesium, we saw a prompt improvement in both her mineral levels and her symptoms.
The case underscores the importance of monitoring electrolyte levels during chemotherapy treatments, such as nedaplatin. By focusing on these disturbances, healthcare providers can unveil potential diagnoses even when patients present with vague symptoms. Regular follow-ups during anticancer therapies could be crucial in effectively managing side effects such as dizziness.
9.5
Dizziness alleviated
Most Useful Review
This combination really works. The twitching of my eyelids and panic attacks have disappeared. When I stop taking the drug, the panic attacks return, which is very unpleasant. While on this medication, everything normalises. I advise anyone with dizziness and panic attacks to try it.
Heart Attack details
SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7
USERS' SCORE
Good
Based on 5 Reviews
8.6
9
Magnesium implantation improves heart recovery
Magnesium implantation as a continuous hydrogen production generator for the treatment of myocardial infarction in rats.
Most Relevant Research
We explored the potential of magnesium implantation as a new approach to combat heart attacks, specifically myocardial infarction (MI). Our research centered on using magnesium slices implanted under the skin of rats to generate hydrogen gas continuously. This method could ensure a greater and longer-lasting concentration of hydrogen directly reaching the heart, which is crucial for its therapeutic effects.
Through our study, we measured how effectively the magnesium produced hydrogen and evaluated its safety. The results were promising; we observed that magnesium implantation not only improved cardiac function in rats suffering from MI, but also played a role in eliminating harmful free radicals from mitochondrial dysfunction. Furthermore, it helped reduce cell death in heart muscle cells, which is a common consequence of heart attacks.
Compared to traditional hydrogen inhalation, which has limitations in delivering sufficient doses over time, magnesium implantation proved to be a superior method. Overall, our findings pave the way for innovative treatments that could enhance recovery after heart attacks by harnessing the unique properties of magnesium for hydrogen production.
Through our study, we measured how effectively the magnesium produced hydrogen and evaluated its safety. The results were promising; we observed that magnesium implantation not only improved cardiac function in rats suffering from MI, but also played a role in eliminating harmful free radicals from mitochondrial dysfunction. Furthermore, it helped reduce cell death in heart muscle cells, which is a common consequence of heart attacks.
Compared to traditional hydrogen inhalation, which has limitations in delivering sufficient doses over time, magnesium implantation proved to be a superior method. Overall, our findings pave the way for innovative treatments that could enhance recovery after heart attacks by harnessing the unique properties of magnesium for hydrogen production.
9.5
Heart pain relief
Most Useful Review
Super! I have a small child, and with sleepless nights, my heart ached from fatigue. After consulting a cardiologist, I began taking Calcium, Magnesium, and Zinc, which stopped my heart from hurting. I highly recommend this preparation, though it can be hard to find; I will purchase it again.
Menopause details
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.4
USERS' SCORE
Good
Based on 2 Reviews
8.6
9
Zinc enhances vitamin D in menopause
Effectiveness of eight-week zinc supplementation on vitamin D status and leptin levels in a population of postmenopausal women: a double-blind randomized trial.
Most Relevant Research
We set out to understand how zinc supplementation could affect vitamin D status and leptin levels in postmenopausal women. The study involved 51 healthy postmenopausal women aged between 44 and 76 from Granada, Spain. They were divided into two groups: one receiving a zinc supplement of 50 mg daily for eight weeks and the other receiving a placebo.
Our findings revealed that zinc supplementation significantly improved vitamin D status in these women. Particularly, those who had reached menopause at a younger age saw a notable increase in their vitamin D levels after taking zinc.
Additionally, we discovered a connection between zinc and leptin levels, a hormone that regulates energy balance. Both dietary zinc intake and its plasma levels were found to be inversely related to serum leptin levels—meaning as zinc levels increased, leptin levels tended to decrease.
Overall, these results suggest that zinc supplementation may play a beneficial role during menopause by enhancing vitamin D levels and influencing leptin balance among postmenopausal women.
Our findings revealed that zinc supplementation significantly improved vitamin D status in these women. Particularly, those who had reached menopause at a younger age saw a notable increase in their vitamin D levels after taking zinc.
Additionally, we discovered a connection between zinc and leptin levels, a hormone that regulates energy balance. Both dietary zinc intake and its plasma levels were found to be inversely related to serum leptin levels—meaning as zinc levels increased, leptin levels tended to decrease.
Overall, these results suggest that zinc supplementation may play a beneficial role during menopause by enhancing vitamin D levels and influencing leptin balance among postmenopausal women.
9.5
Improved overall condition
Most Useful Review
After two weeks of taking this drug, I noticed considerable improvements in the condition of my nails and hair. My sleep has enhanced, and the mood swings associated with menopause have disappeared. I highly recommend this worthy drug.
Nausea details
SCIENTIFIC SCORE
Questionable
Based on 8 Researches
6.6
USERS' SCORE
Good
Based on 3 Reviews
8.6
8
Magnesium effectively reduces PONV
Effects of intra-operative magnesium sulfate infusion on orthognathic surgery: A prospective and randomized controlled trial.
Most Relevant Research
We conducted a study to discover how magnesium sulfate affects nausea during orthognathic surgery. In this research, we divided 75 adult patients into two groups: one group received magnesium sulfate, while the other received a placebo saline solution.
We discovered that those who received magnesium experienced significantly less postoperative nausea and vomiting (PONV) compared to the control group. Specifically, at two hours post-surgery, patients in the magnesium group reported less severe PONV.
Additionally, this group also had lower requirements for remifentanil, a pain reliever, indicating that magnesium not only helps with nausea but may also play a role in overall pain management during recovery. The magnesium levels in the blood after surgery were notably higher in the magnesium group, further supporting its effectiveness.
This research suggests that incorporating magnesium sulfate into treatment protocols during orthognathic surgeries can greatly enhance patient comfort by minimizing nausea and improving pain control.
We discovered that those who received magnesium experienced significantly less postoperative nausea and vomiting (PONV) compared to the control group. Specifically, at two hours post-surgery, patients in the magnesium group reported less severe PONV.
Additionally, this group also had lower requirements for remifentanil, a pain reliever, indicating that magnesium not only helps with nausea but may also play a role in overall pain management during recovery. The magnesium levels in the blood after surgery were notably higher in the magnesium group, further supporting its effectiveness.
This research suggests that incorporating magnesium sulfate into treatment protocols during orthognathic surgeries can greatly enhance patient comfort by minimizing nausea and improving pain control.
9.5
No nausea
Most Useful Review
This dietary supplement is good for improving sleep and boosting immunity, delivering impressive results. I had no nausea while taking it, and I highly recommend this combination.
Prostate Cancer details
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 2 Reviews
8.6
7
Calcium's role in prostate cancer
Amorphous calcium phosphate-coated surfaces as a model for bone microenvironment in prostate cancer.
Most Relevant Research
We investigated how calcium influences prostate cancer cells by creating an experimental setup that mimics the bone microenvironment, which is where bone metastasis commonly occurs. Our approach involved using cell culture vessels coated with amorphous calcium phosphate, a substance designed to simulate the bone matrix. This innovative method represented a significant step forward in modeling the conditions that prostate cancer cells face in the body.
During our experiments, we found that hormone-sensitive prostate epithelial cell lines thrived more effectively on these calcium-rich surfaces. This enhanced adhesion and proliferation suggested that the high-calcium environment somehow supports cancer cell survival, even making them less dependent on androgens.
Furthermore, we observed notable changes in gene expression among early adenocarcinoma cell lines cultured on these amorphous calcium surfaces. These changes appeared to align with biological factors associated with prostate cancer progression, reinforcing the notion that calcium plays a significant role in cancer development and spread.
Overall, our findings emphasize the importance of considering calcium's effects when developing preclinical models for prostate cancer. A deeper understanding of how calcium interacts with cancer cells could provide vital insights into potential treatments and management strategies for affected individuals.
During our experiments, we found that hormone-sensitive prostate epithelial cell lines thrived more effectively on these calcium-rich surfaces. This enhanced adhesion and proliferation suggested that the high-calcium environment somehow supports cancer cell survival, even making them less dependent on androgens.
Furthermore, we observed notable changes in gene expression among early adenocarcinoma cell lines cultured on these amorphous calcium surfaces. These changes appeared to align with biological factors associated with prostate cancer progression, reinforcing the notion that calcium plays a significant role in cancer development and spread.
Overall, our findings emphasize the importance of considering calcium's effects when developing preclinical models for prostate cancer. A deeper understanding of how calcium interacts with cancer cells could provide vital insights into potential treatments and management strategies for affected individuals.
8.8
Zinc benefits noted
Most Useful Review
Excellent! It contains zinc, which is beneficial for individuals suffering from prostate cancer.
Reflux details
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.5
USERS' SCORE
Good
Based on 1 Review
8.6
8
Calcium's role in reflux protection
A combination of carbonates and Opuntia ficus-indica extract protects esophageal cells against simulated acidic and non-acidic reflux in vitro.
Most Relevant Research
We examined a combination product of carbonate antacids—specifically calcium carbonate and magnesium carbonate—with an extract from Opuntia ficus-indica, commonly known as prickly pear. This study looked at how this product could potentially protect esophageal cells from damage caused by both acidic and non-acidic reflux.
Through a series of laboratory tests, we aimed to understand the effectiveness of the product in two ways: neutralizing stomach acid and protecting esophageal cells. The carbonate ingredients showed promising results in neutralizing acidity, which is a common complaint for those suffering from heartburn. However, while calcium’s role in this combination is significant, it isn't isolated; the extract from prickly pear also plays a crucial role in lowering inflammation triggered by bile acids.
Ultimately, we found that the combination product provided dual benefits, helping cells withstand both acidic conditions and irritation from bile acids. Yet, it's essential to note that we could not determine the isolated impact of calcium on reflux, as it works in tandem with other active ingredients. This insight encourages further exploration into the specific effects of calcium in reflux management.
Through a series of laboratory tests, we aimed to understand the effectiveness of the product in two ways: neutralizing stomach acid and protecting esophageal cells. The carbonate ingredients showed promising results in neutralizing acidity, which is a common complaint for those suffering from heartburn. However, while calcium’s role in this combination is significant, it isn't isolated; the extract from prickly pear also plays a crucial role in lowering inflammation triggered by bile acids.
Ultimately, we found that the combination product provided dual benefits, helping cells withstand both acidic conditions and irritation from bile acids. Yet, it's essential to note that we could not determine the isolated impact of calcium on reflux, as it works in tandem with other active ingredients. This insight encourages further exploration into the specific effects of calcium in reflux management.
9.5
Less anxious
Most Useful Review
Two a day keeps the doctor away! Following an old pharmacist's advice, I take two tablets daily—one in the morning and one in the evening. I am much less anxious, and my bowel movements are regular. I used to experience bouts of acid reflux and sour stomach, but not anymore.
Acne details
SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7.7
USERS' SCORE
Good
Based on 1 Review
8.5
8
Zinc effective for acne treatment
Serum zinc levels and efficacy of zinc treatment in acne vulgaris: A systematic review and meta-analysis.
Most Relevant Research
We explored how zinc affects acne through a systematic review and meta-analysis that looked at two main questions. First, we wanted to know if there are differences in zinc levels between people with acne and those without. Second, we examined how effective zinc treatments are for managing acne.
Our findings showed that individuals with acne had noticeably lower serum zinc levels compared to those in the control group. Furthermore, when we looked at treatments, those who received zinc showed a significant reduction in their inflammatory papule count—a common symptom of acne. Importantly, we noted that side effects from zinc supplementation were similar to those seen in other treatments, suggesting that zinc is safe to use.
Overall, acne patients appear to benefit from improved zinc levels, especially when zinc is used either on its own or alongside other acne treatments. This gives hope for those looking for effective ways to tackle acne issues!
Our findings showed that individuals with acne had noticeably lower serum zinc levels compared to those in the control group. Furthermore, when we looked at treatments, those who received zinc showed a significant reduction in their inflammatory papule count—a common symptom of acne. Importantly, we noted that side effects from zinc supplementation were similar to those seen in other treatments, suggesting that zinc is safe to use.
Overall, acne patients appear to benefit from improved zinc levels, especially when zinc is used either on its own or alongside other acne treatments. This gives hope for those looking for effective ways to tackle acne issues!
8.8
Noted improvements
Most Useful Review
I took it as a complex to treat my teenage son's acne. There is an effect; we'll see what happens, but so far, we've noticed improvements.
Chronic Fatigue Syndrome details
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.9
USERS' SCORE
Good
Based on 1 Review
8.5
7
Zinc supplementation may benefit CFS
Lower serum zinc in Chronic Fatigue Syndrome (CFS): relationships to immune dysfunctions and relevance for the oxidative stress status in CFS.
Most Relevant Research
We explored the relationship between serum zinc levels and chronic fatigue syndrome (CFS) in a study that compared patients with CFS to normal volunteers. By using an atomic absorption method, we measured serum zinc concentrations and found that those suffering from CFS had significantly lower levels of zinc compared to healthy individuals.
Interestingly, we observed a trend indicating that lower zinc levels correlated with greater CFS severity. Patients also reported a negative correlation between their zinc levels and their subjective experiences of infection. This suggests that zinc plays a role in the immune dysfunction commonly seen in CFS.
Furthermore, we noted that lower serum zinc was associated with higher levels of inflammatory markers and certain defects in the early activation of T cells. Since zinc acts as a potent antioxidant, our findings indicate that CFS is linked to increased oxidative stress in these patients. Given this, it may be beneficial for some CFS patients to consider zinc supplements as part of their treatment approach.
Interestingly, we observed a trend indicating that lower zinc levels correlated with greater CFS severity. Patients also reported a negative correlation between their zinc levels and their subjective experiences of infection. This suggests that zinc plays a role in the immune dysfunction commonly seen in CFS.
Furthermore, we noted that lower serum zinc was associated with higher levels of inflammatory markers and certain defects in the early activation of T cells. Since zinc acts as a potent antioxidant, our findings indicate that CFS is linked to increased oxidative stress in these patients. Given this, it may be beneficial for some CFS patients to consider zinc supplements as part of their treatment approach.
8.8
Alleviated muscle weakness
Most Useful Review
This product performs simple magic! For those suffering from muscle problems, weakness, and fatigue, this is an excellent choice. In Israel, 100 tablets cost NIS 70; here, you get double the amount at a highly recommended price.
Food Poisoning details
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8.8
USERS' SCORE
Good
Based on 1 Review
8.5
9.5
Zinc oxide combats foodborne pathogens
Active Packaging of Immobilized Zinc Oxide Nanoparticles Controls Campylobacter jejuni in Raw Chicken Meat.
Most Relevant Research
We set out to explore how zinc oxide nanoparticles (ZnO NPs) could help control the bacteria responsible for food poisoning in raw chicken meat. Our approach involved integrating these nanoparticles into packaging materials to see if they could effectively inactivate Campylobacter jejuni, a common and concerning pathogen in poultry.
Through our experiments, we discovered that immobilizing ZnO NPs in functional pads placed under raw chicken could dramatically reduce bacterial counts. In fact, we saw a reduction from about 4 log CFU to an undetectable level within just three days when storing chicken at 4°C. Notably, we monitored zinc levels in the chicken meat, confirming a safe release of zinc without any migration of nanoparticles onto the food. This means that we can help keep raw chicken safe and fresh without compromising its integrity or quality.
Not only did we find that these functional pads inactivated the harmful bacteria, but we also noted a related increase in lactic acid production, which plays a role in further protecting the meat. Our findings open up new avenues for using zinc in food packaging, offering a way to enhance food safety without directly adding chemicals to the food itself. Overall, this study highlights the potential for nanotechnology to play a significant role in managing foodborne pathogens like Campylobacter in poultry products.
Through our experiments, we discovered that immobilizing ZnO NPs in functional pads placed under raw chicken could dramatically reduce bacterial counts. In fact, we saw a reduction from about 4 log CFU to an undetectable level within just three days when storing chicken at 4°C. Notably, we monitored zinc levels in the chicken meat, confirming a safe release of zinc without any migration of nanoparticles onto the food. This means that we can help keep raw chicken safe and fresh without compromising its integrity or quality.
Not only did we find that these functional pads inactivated the harmful bacteria, but we also noted a related increase in lactic acid production, which plays a role in further protecting the meat. Our findings open up new avenues for using zinc in food packaging, offering a way to enhance food safety without directly adding chemicals to the food itself. Overall, this study highlights the potential for nanotechnology to play a significant role in managing foodborne pathogens like Campylobacter in poultry products.
8.3
Relieved muscle cramps
Most Useful Review
Purchasing from iHerb saved me 50%. This bottle of supplements costs twice as much at my local health food shop. Since taking CM+Z every morning, my evening leg muscle cramps have been alleviated, which helps me avoid instances of food poisoning.
Heartburn details
SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8.1
USERS' SCORE
Good
Based on 1 Review
8.5
9
Zinc's role in heartburn relief
Esophageal ulcer related to zinc deficiency following a total gastrectomy.
Most Relevant Research
We investigated how zinc affects heartburn through the case of a 76-year-old Japanese man who experienced significant discomfort after undergoing a total gastrectomy. For two weeks, he suffered from a sore throat, heartburn, and difficulty swallowing. Endoscopy revealed deep, craterlike ulcers in his esophagus, but tests for viral infections were negative.
After initial treatment, his symptoms returned, prompting further investigation. Eventually, we found that his serum zinc level was low at 38 µg/dL, which led to a diagnosis of zinc deficiency. Following oral zinc supplementation, the patient reported relief from his symptoms and a noticeable improvement in the esophageal ulcers observed during a follow-up endoscopy.
Over the five years since his treatment, the patient has continued to take zinc supplements and has not faced similar issues again. This case suggests that zinc can play a crucial role in treating heartburn issues related to ulcers, especially in those with a deficiency.
After initial treatment, his symptoms returned, prompting further investigation. Eventually, we found that his serum zinc level was low at 38 µg/dL, which led to a diagnosis of zinc deficiency. Following oral zinc supplementation, the patient reported relief from his symptoms and a noticeable improvement in the esophageal ulcers observed during a follow-up endoscopy.
Over the five years since his treatment, the patient has continued to take zinc supplements and has not faced similar issues again. This case suggests that zinc can play a crucial role in treating heartburn issues related to ulcers, especially in those with a deficiency.
8.8
Effective for heartburn
Most Useful Review
I appreciated having several vitamins in a single tablet, which assists me with heartburn. I find it beneficial to take before bed due to my heartburn issues. The tablet size is moderate.
Irritable Bowel Syndrome details
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7
USERS' SCORE
Good
Based on 3 Reviews
8.5
8
Magnesium boosts colonic activity
Effects of oral magnesium sulphate on colonic motility in patients with the irritable bowel syndrome.
Most Relevant Research
We set out to understand how magnesium sulphate influences the symptoms of irritable bowel syndrome (IBS). In a study involving 20 IBS patients, magnesium sulphate was administered orally, resulting in a quick boost in colonic motor activity. Most participants experienced this increase within just two to six minutes.
Specifically, the percentage of colonic activity rose from 16.2% to 23.7%, signaling a notable change. Those who often felt abdominal pain after eating showed even more pronounced reactions, with their activity jumping from 16.1% to 29.8%. However, it’s important to note that three of these patients still experienced their usual pain after taking magnesium, suggesting that while magnesium can enhance motility, it doesn’t eliminate the pain for everyone.
Ultimately, these findings lend support to the idea that some cases of abdominal pain related to food may stem from heightened intestinal responses to cholecystokinin, a hormone released by the intestine. So while magnesium shows promise for intriguing changes in colonic movement in IBS patients, its effectiveness in alleviating pain remains mixed.
Specifically, the percentage of colonic activity rose from 16.2% to 23.7%, signaling a notable change. Those who often felt abdominal pain after eating showed even more pronounced reactions, with their activity jumping from 16.1% to 29.8%. However, it’s important to note that three of these patients still experienced their usual pain after taking magnesium, suggesting that while magnesium can enhance motility, it doesn’t eliminate the pain for everyone.
Ultimately, these findings lend support to the idea that some cases of abdominal pain related to food may stem from heightened intestinal responses to cholecystokinin, a hormone released by the intestine. So while magnesium shows promise for intriguing changes in colonic movement in IBS patients, its effectiveness in alleviating pain remains mixed.
8
Life-changing supplement
Most Useful Review
Excellent! The tinted glass jar is very pleasing and reflects the seriousness of the manufacturer. Previously, the woman was often irritable, sleepy, and depressed at work. However, after taking this dietary supplement, her zest for life returned, and the change in him has been remarkable. It’s difficult to find as it quickly sells out.
Kidney Stones details
SCIENTIFIC SCORE
Possibly Effective
Based on 17 Researches
7.1
USERS' SCORE
Good
Based on 5 Reviews
8.5
9
Magnesium reduces kidney stone risk
Effect of magnesium oxide or citrate supplements on metabolic risk factors in kidney stone formers with idiopathic hyperoxaluria: a randomized clinical trial.
Most Relevant Research
We conducted a randomized, double-blind, placebo-controlled clinical trial to explore how magnesium treatments influence kidney stones, specifically for those with high levels of oxalate in their urine. Our study involved 90 participants with a history of calcium kidney stones, all of whom were experiencing idiopathic hyperoxaluria. They were divided into three groups receiving either magnesium oxide (MgO), magnesium citrate (MgCit), or a placebo for eight weeks, while their diets were monitored to keep nutritional intake consistent.
After the treatment period, we observed promising results. Both MgO and MgCit effectively reduced the excretion of oxalate in urine, which is a key factor in kidney stone formation. The Group taking magnesium citrate showed even more significant reductions in both oxalate levels and the calcium oxalate supersaturation index, which measures the concentration of stone-forming minerals in urine. This was notably true for participants with normal magnesium levels.
Overall, we found that magnesium supplements might play a beneficial role in decreasing critical risk factors for kidney stones, especially for those using magnesium citrate. It's encouraging to see that this may offer a practical option for those struggling with recurrent stones due to high oxalate excretion.
After the treatment period, we observed promising results. Both MgO and MgCit effectively reduced the excretion of oxalate in urine, which is a key factor in kidney stone formation. The Group taking magnesium citrate showed even more significant reductions in both oxalate levels and the calcium oxalate supersaturation index, which measures the concentration of stone-forming minerals in urine. This was notably true for participants with normal magnesium levels.
Overall, we found that magnesium supplements might play a beneficial role in decreasing critical risk factors for kidney stones, especially for those using magnesium citrate. It's encouraging to see that this may offer a practical option for those struggling with recurrent stones due to high oxalate excretion.
9.5
Prevents kidney stones
Most Useful Review
Easy to use; chelated minerals do not cause kidney stones or diarrhoea!
Multiple Sclerosis details
SCIENTIFIC SCORE
Possibly Effective
Based on 5 Researches
7.8
USERS' SCORE
Good
Based on 1 Review
8.5
7
Zinc levels and MS correlation
Relationship between zinc-related nutritional status and the progression of multiple sclerosis.
Most Relevant Research
We conducted a study to understand how zinc may affect multiple sclerosis (MS). Our research involved 98 participants, divided into two groups: one with MS and another matched control group without the condition. We aimed to examine the levels of zinc in both plasma and red blood cells to see if there’s a connection with MS severity and outbreaks.
The findings were intriguing. We discovered that while the average plasma zinc levels were normal in MS patients, their red blood cell zinc levels were actually higher than those in the control group. Additionally, we noticed that the activity of an important enzyme called superoxide dismutase (SOD) was significantly elevated in MS patients, which correlates positively with these higher zinc levels. This suggests that while the body might be managing zinc rather well, it’s working overtime, possibly to counteract oxidative stress related to MS.
Importantly, we observed a direct correlation between erythrocyte zinc and SOD activity, which was also linked inversely to MS outbreaks—indicating that as SOD increases in activity, the frequency of outbreaks tends to decrease. These insights confirm that there could be a beneficial relationship between zinc levels and the management of MS, but more research is certainly needed to explore this further.
The findings were intriguing. We discovered that while the average plasma zinc levels were normal in MS patients, their red blood cell zinc levels were actually higher than those in the control group. Additionally, we noticed that the activity of an important enzyme called superoxide dismutase (SOD) was significantly elevated in MS patients, which correlates positively with these higher zinc levels. This suggests that while the body might be managing zinc rather well, it’s working overtime, possibly to counteract oxidative stress related to MS.
Importantly, we observed a direct correlation between erythrocyte zinc and SOD activity, which was also linked inversely to MS outbreaks—indicating that as SOD increases in activity, the frequency of outbreaks tends to decrease. These insights confirm that there could be a beneficial relationship between zinc levels and the management of MS, but more research is certainly needed to explore this further.
8.8
Notable improvement
Most Useful Review
Great product with good ingredients. I ordered it for my husband who has multiple sclerosis; he notices an improvement in the sensation in his hands and body when taking these. It's indeed a quality supplement.
Osteoporosis details
SCIENTIFIC SCORE
Possibly Effective
Based on 27 Researches
7.7
USERS' SCORE
Good
Based on 17 Reviews
8.5
9
Magnesium's role in osteoporosis therapy
Mg-ZIF nanozyme regulates the switch between osteogenic and lipogenic differentiation in BMSCs via lipid metabolism.
Most Relevant Research
We explored the effects of a special material called magnesium-based zeolitic imidazolate frameworks, or Mg-ZIF, on osteoporosis. This study aimed to find a way to tackle osteoporosis by reducing reactive oxygen species (ROS)—harmful molecules that affect our bone health.
Our findings revealed that Mg-ZIF is effective at scavenging ROS, which helps boost the bone-forming ability of bone mesenchymal stem cells (BMSCs). By promoting osteogenic differentiation, Mg-ZIF supports the formation of new bone while simultaneously discouraging the development of fat cells from BMSCs, a process known as lipogenic differentiation.
In our in vivo experiments, we confirmed that administering Mg-ZIF could successfully lower ROS levels and mitigate the effects of osteoporosis. On a deeper level, the mechanism behind this involves Mg-ZIF enhancing BMSC differentiation into bone-forming cells by upregulating specific lipid metabolic pathways.
Overall, we believe that Mg-ZIF holds promise as a therapeutic approach for osteoporosis. By addressing the oxidative stress in the bone marrow environment, it opens a new door for potential treatments targeting this common bone disease.
Our findings revealed that Mg-ZIF is effective at scavenging ROS, which helps boost the bone-forming ability of bone mesenchymal stem cells (BMSCs). By promoting osteogenic differentiation, Mg-ZIF supports the formation of new bone while simultaneously discouraging the development of fat cells from BMSCs, a process known as lipogenic differentiation.
In our in vivo experiments, we confirmed that administering Mg-ZIF could successfully lower ROS levels and mitigate the effects of osteoporosis. On a deeper level, the mechanism behind this involves Mg-ZIF enhancing BMSC differentiation into bone-forming cells by upregulating specific lipid metabolic pathways.
Overall, we believe that Mg-ZIF holds promise as a therapeutic approach for osteoporosis. By addressing the oxidative stress in the bone marrow environment, it opens a new door for potential treatments targeting this common bone disease.
9.5
Cramps alleviated
Most Useful Review
I ordered this for my husband and now our whole family enjoys it. He had concerns about leg cramps, but after more than a month on the supplement, the cramps have ceased. I also began taking calcium, magnesium, and zinc to prevent osteoporosis. The dosage is appropriate, and the large packaging lasts a long time.
Back Pain details
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.6
USERS' SCORE
Good
Based on 17 Reviews
8.4
9.5
Magnesium reduces postoperative back pain
Effect of perioperative intravenous magnesium sulfate on postoperative pain after iliac venous stenting.
Most Relevant Research
We explored the effectiveness of magnesium sulfate (MS) in relieving low back pain (LBP) for patients who underwent iliac venous stenting. This study involved 97 patients, divided into two groups: one received MS infusion during their surgery, while the other did not.
Patients who received MS experienced significantly lower pain levels at all follow-up intervals. We found that, at 24 hours after surgery, those in the magnesium group consumed much less tramadol—a common pain medication—compared to the control group. Additionally, the need for extra pain relief was lower among those who received magnesium.
Importantly, the side effects like nausea and vomiting were similar in both groups, indicating that magnesium can be a safe option for pain management after this type of surgery. Overall, the findings suggest that magnesium sulfate not only alleviates pain but also reduces reliance on opioids, making it a valuable treatment for postoperative care.
Patients who received MS experienced significantly lower pain levels at all follow-up intervals. We found that, at 24 hours after surgery, those in the magnesium group consumed much less tramadol—a common pain medication—compared to the control group. Additionally, the need for extra pain relief was lower among those who received magnesium.
Importantly, the side effects like nausea and vomiting were similar in both groups, indicating that magnesium can be a safe option for pain management after this type of surgery. Overall, the findings suggest that magnesium sulfate not only alleviates pain but also reduces reliance on opioids, making it a valuable treatment for postoperative care.
9.5
Joint and muscle relief
Most Useful Review
The composition is excellent, with noticeably better quality than others. The capsules are of manageable size, with optimal dosages of calcium, magnesium, and zinc. After a week, my joint pain, muscle cramps, and sleep issues improved significantly.
Brain Tumor details
SCIENTIFIC SCORE
Likely Very Effective
Based on 4 Researches
9
USERS' SCORE
Good
Based on 5 Reviews
8.4
9
Zinc aids in glioblastoma treatment
Ketogenic diet with oxyresveratrol and zinc inhibits glioblastoma and restores memory function and motor coordination.
Most Relevant Research
We evaluated the potential of zinc in combination with a ketogenic diet and oxyresveratrol in fighting glioblastoma, a highly aggressive brain tumor. Through a series of carefully designed experiments, we examined how these treatments affect tumor growth and overall brain function.
In our study, we induced brain tumors in Wistar rats and then applied our treatment regimen. We tracked various outcomes, including tumor size, proliferation rates, memory function, and motor coordination. By assessing glucose and ketone levels, we gained insights into the metabolic changes occurring as a result of the treatments.
The findings suggested that zinc played a supportive role alongside the ketogenic diet and oxyresveratrol in reducing tumor growth. Moreover, these treatments appeared to enhance memory and motor coordination, indicating a multi-faceted benefit. Overall, this progression offered valuable information about the role of diet and supplementary compounds in battling aggressive brain tumors like glioblastoma.
In our study, we induced brain tumors in Wistar rats and then applied our treatment regimen. We tracked various outcomes, including tumor size, proliferation rates, memory function, and motor coordination. By assessing glucose and ketone levels, we gained insights into the metabolic changes occurring as a result of the treatments.
The findings suggested that zinc played a supportive role alongside the ketogenic diet and oxyresveratrol in reducing tumor growth. Moreover, these treatments appeared to enhance memory and motor coordination, indicating a multi-faceted benefit. Overall, this progression offered valuable information about the role of diet and supplementary compounds in battling aggressive brain tumors like glioblastoma.
9.5
Supports brain health
Most Useful Review
I truly admire this manufacturer! Magnesium is very helpful for the brain and maintaining calm, particularly crucial in epilepsy. Zinc enhances skin condition, and calcium is vital, especially considering the quality of milk these days. The product quality is exceptional!
Chest Pain details
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.6
USERS' SCORE
Good
Based on 3 Reviews
8.4
9
Zinc treatment for angina pectoris
High-dose zinc to terminate angina pectoris: a review and hypothesis for action by ICAM inhibition.
Most Relevant Research
We delved into an intriguing question: Can high doses of zinc help relieve chest pain caused by angina pectoris? Our research reviewed studies that highlight how zinc may play a role in managing this condition. Angina pectoris often results from arteriosclerosis, where the arteries become narrowed due to cholesterol buildup and other factors.
We discovered that patients with severe atherosclerosis showed promising improvements when treated with high-dose zinc. Specifically, a treatment regimen involved raising serum zinc levels significantly, resulting in symptom relief for many individuals. In one notable case, 12 out of 16 patients experienced measurable benefits, including one patient who also suffered from Raynaud's disease.
Furthermore, our analysis noted that long-term exposure to zinc in the environment correlated with reduced incidence of angina and ischemic events during exercise. Zinc appears to possess antioxidant properties, which may protect against the oxidation of LDL cholesterol, a key player in artery damage. By blocking certain inflammatory factors and promoting better circulation, zinc might enhance heart function and alleviate chest pain.
Based on these findings, we propose that zinc treatment should be considered a fundamental option in both prevention and therapy for atherosclerosis-related chest pain. This could lead to a renewed focus on restoring a healthier cardiac function among those affected by these conditions.
We discovered that patients with severe atherosclerosis showed promising improvements when treated with high-dose zinc. Specifically, a treatment regimen involved raising serum zinc levels significantly, resulting in symptom relief for many individuals. In one notable case, 12 out of 16 patients experienced measurable benefits, including one patient who also suffered from Raynaud's disease.
Furthermore, our analysis noted that long-term exposure to zinc in the environment correlated with reduced incidence of angina and ischemic events during exercise. Zinc appears to possess antioxidant properties, which may protect against the oxidation of LDL cholesterol, a key player in artery damage. By blocking certain inflammatory factors and promoting better circulation, zinc might enhance heart function and alleviate chest pain.
Based on these findings, we propose that zinc treatment should be considered a fundamental option in both prevention and therapy for atherosclerosis-related chest pain. This could lead to a renewed focus on restoring a healthier cardiac function among those affected by these conditions.
8.3
Relief from pain
Most Useful Review
I feel relieved from back pain! After taking this, I am very comfortable.
Migraine details
SCIENTIFIC SCORE
Possibly Effective
Based on 23 Researches
7.4
USERS' SCORE
Good
Based on 6 Reviews
8.4
9
We explored how magnesium supplementation can help alleviate migraines, a condition that affects countless individuals and can be incredibly disabling. Research has shown a strong link between magnesium deficiency and various factors that contribute to migraines, such as neurological changes and inflammation.
Studies, including randomized controlled trials, indicate that magnesium can reduce the frequency and severity of migraine attacks, both in the short term and as a preventative measure. This effectiveness is thought to stem from magnesium's ability to influence nerve function and reduce stress responses in the body.
We've examined the accumulating evidence from case studies and clinical trials, and it clearly points to magnesium being a valuable option for those suffering from migraines. By addressing magnesium deficiency, we may offer a new avenue for relief and improved management of this challenging condition.
Studies, including randomized controlled trials, indicate that magnesium can reduce the frequency and severity of migraine attacks, both in the short term and as a preventative measure. This effectiveness is thought to stem from magnesium's ability to influence nerve function and reduce stress responses in the body.
We've examined the accumulating evidence from case studies and clinical trials, and it clearly points to magnesium being a valuable option for those suffering from migraines. By addressing magnesium deficiency, we may offer a new avenue for relief and improved management of this challenging condition.
9.5
Significantly reduced headaches
Most Useful Review
I've suffered from many types of headaches, including migraines and tension headaches, since middle school. After taking these supplements (3 a day), my headaches have become much less frequent. My body seems to absorb this formulation far better than others, leading to a notable improvement!
Diarrhea details
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.8
USERS' SCORE
Medium or Average
Based on 3 Reviews
6.7
9.5
Magnesium shows potential for diarrhea
Mg2+ supplementation treats secretory diarrhea in mice by activating calcium-sensing receptor in intestinal epithelial cells.
Most Relevant Research
We explored the impact of magnesium on secretory diarrhea, particularly in the context of cholera, a significant global health issue. The focus was on understanding how magnesium, often overlooked, could serve as an effective treatment option. In our study, we found that increasing levels of magnesium can significantly inhibit chloride secretion in intestinal cells, which is crucial during episodes of diarrhea.
We observed that magnesium, at concentrations typically seen in stool, reduced this secretory process by a remarkable 65%. This effect primarily occurs through a specific receptor in the intestinal cells known as the calcium-sensing receptor (CaSR). Interestingly, we noted that magnesium also counteracted Cl- secretion triggered by cholera toxin and other enterotoxins by about 50%.
Using mouse models, we saw that administering magnesium effectively decreased fluid loss associated with cholera by 40%. In a model mimicking the intestinal environment during cholera, adding magnesium not only curbed fluid secretion but also reversed it, promoting absorption instead. Given that patients suffering from cholera often have negligible magnesium levels in their stool, our findings suggest that oral magnesium supplementation could be a simple but effective therapeutic strategy for managing cholera and potentially other forms of secretory diarrhea.
We observed that magnesium, at concentrations typically seen in stool, reduced this secretory process by a remarkable 65%. This effect primarily occurs through a specific receptor in the intestinal cells known as the calcium-sensing receptor (CaSR). Interestingly, we noted that magnesium also counteracted Cl- secretion triggered by cholera toxin and other enterotoxins by about 50%.
Using mouse models, we saw that administering magnesium effectively decreased fluid loss associated with cholera by 40%. In a model mimicking the intestinal environment during cholera, adding magnesium not only curbed fluid secretion but also reversed it, promoting absorption instead. Given that patients suffering from cholera often have negligible magnesium levels in their stool, our findings suggest that oral magnesium supplementation could be a simple but effective therapeutic strategy for managing cholera and potentially other forms of secretory diarrhea.
6
Beware of diarrhea
Most Useful Review
Solgar consistently delivers quality. Ensure you check for required ingredients. Although the tablet size is somewhat large, caution is advised when taking magnesium for the first time due to potential diarrhoea. The packaging is adequately cushioned for protection.
