' 
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8
USERS' SCORE
Good
Based on 7 Reviews
8.7
Supplement Facts
Serving Size: 3 tablets
Serving Per Container: 83
Amount Per Serving
%DV
Calcium (as calcium carbonate, calcium gluconate, calcium citrate)
1,000 mg
77%
Magnesium (as magnesium oxide, magnesium gluconate, magnesium citrate)
400 mg
95%
Zinc (as zinc gluconate)
15 mg
136%
Sodium†
15 mg
<1%
Top Medical Research Studies
9
Zinc reduces migraine symptoms
Assessing the Effect of Zinc Supplementation on the Frequency of Migraine Attack, Duration, Severity, Lipid Profile and hs-CRP in Adult Women.
Direct investigation of zinc efficacy
We conducted a randomized, double-blind, placebo-controlled trial to explore how zinc gluconate affects migraine symptoms in women. Sixty participants, with an average age of 35, were given either 15 mg of zinc per day or a placebo for 12 weeks, allowing us to measure the impact on headache frequency, duration, and intensity.
The results were quite promising; zinc supplementation significantly reduced how often headaches occurred, shortened their duration, and decreased the severity of the migraines reported. Participants in the zinc group experienced notable improvements, as indicated by their responses to the headache severity scale and a disability assessment questionnaire.
Furthermore, we found that zinc also had a positive effect on certain health markers. The serum levels of low-density lipoprotein (LDL), total cholesterol, and high-sensitivity C-reactive protein (hs-CRP) decreased with zinc supplementation. However, we didn’t observe significant changes in triglycerides or high-density lipoprotein (HDL) levels after adjusting for baseline values.
In conclusion, zinc supplementation appears to hold beneficial effects on migraine severity and frequency, offering a potential alternative for those who seek relief from these debilitating headaches.
The results were quite promising; zinc supplementation significantly reduced how often headaches occurred, shortened their duration, and decreased the severity of the migraines reported. Participants in the zinc group experienced notable improvements, as indicated by their responses to the headache severity scale and a disability assessment questionnaire.
Furthermore, we found that zinc also had a positive effect on certain health markers. The serum levels of low-density lipoprotein (LDL), total cholesterol, and high-sensitivity C-reactive protein (hs-CRP) decreased with zinc supplementation. However, we didn’t observe significant changes in triglycerides or high-density lipoprotein (HDL) levels after adjusting for baseline values.
In conclusion, zinc supplementation appears to hold beneficial effects on migraine severity and frequency, offering a potential alternative for those who seek relief from these debilitating headaches.
Read More
7
Zinc may aid migraine relief
Zinc Administration Favorably Affects Prophylactic Therapy-refractory Migraine Attacks: A Case Series.
Study focuses on zinc's effects
We explored the impact of zinc on migraine headaches, particularly looking at its effectiveness for those who haven’t found relief from traditional preventive treatments. Our investigation involved four patients suffering from migraine attacks that were resistant to usual prophylactic therapies.
Each of these patients reported a notable improvement in the frequency and severity of their headaches after incorporating zinc supplements into their regimen. This suggests that zinc might serve as a beneficial alternative for those grappling with stubborn migraines.
While our findings are promising, it's crucial to recognize that further research is needed to firmly establish the efficacy of zinc replacement therapy in this context. Nevertheless, zinc administration could offer hope for individuals facing challenges with typical migraine treatment options.
Each of these patients reported a notable improvement in the frequency and severity of their headaches after incorporating zinc supplements into their regimen. This suggests that zinc might serve as a beneficial alternative for those grappling with stubborn migraines.
While our findings are promising, it's crucial to recognize that further research is needed to firmly establish the efficacy of zinc replacement therapy in this context. Nevertheless, zinc administration could offer hope for individuals facing challenges with typical migraine treatment options.
Read More
9
We explored the impact of magnesium on migraine headaches, focusing on its potential benefits based on various studies. Magnesium deficiency is quite common and can arise from different factors, such as not consuming enough through diet or losing more through bodily systems.
A wealth of research, including case reports and controlled trials, suggests that magnesium supplementation can effectively alleviate migraines, both in the short term and long term. The proposed reasons for this effectiveness range from magnesium's role in preventing spreading cortical depression to its ability to manage oxidative stress and inflammation.
This evidence leads us to consider magnesium not just as a dietary supplement but as an important player in migraine management. Understanding these links helps us contemplate magnesium’s role in prevention and treatment, promising a potential path for those who suffer from this debilitating condition.
A wealth of research, including case reports and controlled trials, suggests that magnesium supplementation can effectively alleviate migraines, both in the short term and long term. The proposed reasons for this effectiveness range from magnesium's role in preventing spreading cortical depression to its ability to manage oxidative stress and inflammation.
This evidence leads us to consider magnesium not just as a dietary supplement but as an important player in migraine management. Understanding these links helps us contemplate magnesium’s role in prevention and treatment, promising a potential path for those who suffer from this debilitating condition.
Read More
Most Useful Reviews
9.5
Headache frequency
I’ve had numerous headaches since middle school—migraines, tension, and a Thunder Clap headache a few times. After taking these three a day, my headaches are much less frequent, and my body absorbs this pill much better than others. It has truly helped!
Read More
8.8
Long-lasting relief
My wife's stomach is in good shape and my ten-year-old headache has been alleviated. I will continue to use it for a long time.
Read More
9.5
Recommending warmly
Excellent firm, good composition. I take it to my mum. Sleep is improving and headaches disappear. It doesn’t cause discomfort and is well absorbed. I definitely recommend it.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8
9.5
Calcium's uncertain headache impact
Reversible Cerebral Vasoconstriction Syndrome Secondary to Escitalopram.
Study raises questions on effectiveness
We explored the connection between calcium treatment and headaches, particularly in patients with reversible cerebral vasoconstriction syndrome (RCVS). In this case, we observed a healthy young woman who had been using escitalopram for a long time. She presented with bilateral neurological deficits, and after treatment with intra-arterial calcium channel blockers, her symptoms improved significantly.
However, it’s important to note that while calcium channel blockers were administered, the study does not specifically isolate calcium’s effects on headache relief. This combination of treatments makes it challenging to understand how much calcium alone contributes to alleviating headache symptoms, if at all.
As we considered the overall findings, it became clear that while calcium channel blockers can lead to symptom improvement in RCVS, the direct impact of calcium on headaches remains uncertain. Therefore, individuals experiencing thunderclap headaches, especially those on selective serotonin reuptake inhibitors, should consider RCVS as a possible diagnosis, but we cannot definitively conclude that calcium treatment is effective for headaches based on this case alone.
However, it’s important to note that while calcium channel blockers were administered, the study does not specifically isolate calcium’s effects on headache relief. This combination of treatments makes it challenging to understand how much calcium alone contributes to alleviating headache symptoms, if at all.
As we considered the overall findings, it became clear that while calcium channel blockers can lead to symptom improvement in RCVS, the direct impact of calcium on headaches remains uncertain. Therefore, individuals experiencing thunderclap headaches, especially those on selective serotonin reuptake inhibitors, should consider RCVS as a possible diagnosis, but we cannot definitively conclude that calcium treatment is effective for headaches based on this case alone.
Read More
9
We explored the impact of magnesium on migraine headaches, focusing on its potential benefits based on various studies. Magnesium deficiency is quite common and can arise from different factors, such as not consuming enough through diet or losing more through bodily systems.
A wealth of research, including case reports and controlled trials, suggests that magnesium supplementation can effectively alleviate migraines, both in the short term and long term. The proposed reasons for this effectiveness range from magnesium's role in preventing spreading cortical depression to its ability to manage oxidative stress and inflammation.
This evidence leads us to consider magnesium not just as a dietary supplement but as an important player in migraine management. Understanding these links helps us contemplate magnesium’s role in prevention and treatment, promising a potential path for those who suffer from this debilitating condition.
A wealth of research, including case reports and controlled trials, suggests that magnesium supplementation can effectively alleviate migraines, both in the short term and long term. The proposed reasons for this effectiveness range from magnesium's role in preventing spreading cortical depression to its ability to manage oxidative stress and inflammation.
This evidence leads us to consider magnesium not just as a dietary supplement but as an important player in migraine management. Understanding these links helps us contemplate magnesium’s role in prevention and treatment, promising a potential path for those who suffer from this debilitating condition.
Read More
9
Magnesium's role in headache treatment
[Therapeutic approaches to comorbid pathology in episodic migraine and tension-type headache].
Combined treatment limits magnesium's isolation
We examined the effects of magnesium treatment on individuals suffering from episodic migraine and tension-type headache, aiming to understand its potential benefits alongside other therapeutic approaches. The study involved 104 participants, who were assessed for anxiety, depression, insomnia, and fatigue before and after receiving various treatments, including magnesium.
Our findings indicated that a significant portion of patients reported anxiety and depression, affecting their headache severity. After treatment, we noticed a marked decrease in headache intensity, along with improvements in anxiety and depressive symptoms. However, the specific impact of magnesium alone couldn’t be isolated in this study, as we looked at it alongside other medications like anxiolytics and antidepressants.
Overall, while magnesium was part of the treatment plan and showed potential benefits, we must acknowledge that its individual effectiveness cannot be clearly determined from our research. It appears to contribute to an overall improvement in managing headaches when combined with other treatments.
Our findings indicated that a significant portion of patients reported anxiety and depression, affecting their headache severity. After treatment, we noticed a marked decrease in headache intensity, along with improvements in anxiety and depressive symptoms. However, the specific impact of magnesium alone couldn’t be isolated in this study, as we looked at it alongside other medications like anxiolytics and antidepressants.
Overall, while magnesium was part of the treatment plan and showed potential benefits, we must acknowledge that its individual effectiveness cannot be clearly determined from our research. It appears to contribute to an overall improvement in managing headaches when combined with other treatments.
Read More
9
Zinc reduces migraine symptoms
Assessing the Effect of Zinc Supplementation on the Frequency of Migraine Attack, Duration, Severity, Lipid Profile and hs-CRP in Adult Women.
Direct investigation of zinc efficacy
We conducted a randomized, double-blind, placebo-controlled trial to explore how zinc gluconate affects migraine symptoms in women. Sixty participants, with an average age of 35, were given either 15 mg of zinc per day or a placebo for 12 weeks, allowing us to measure the impact on headache frequency, duration, and intensity.
The results were quite promising; zinc supplementation significantly reduced how often headaches occurred, shortened their duration, and decreased the severity of the migraines reported. Participants in the zinc group experienced notable improvements, as indicated by their responses to the headache severity scale and a disability assessment questionnaire.
Furthermore, we found that zinc also had a positive effect on certain health markers. The serum levels of low-density lipoprotein (LDL), total cholesterol, and high-sensitivity C-reactive protein (hs-CRP) decreased with zinc supplementation. However, we didn’t observe significant changes in triglycerides or high-density lipoprotein (HDL) levels after adjusting for baseline values.
In conclusion, zinc supplementation appears to hold beneficial effects on migraine severity and frequency, offering a potential alternative for those who seek relief from these debilitating headaches.
The results were quite promising; zinc supplementation significantly reduced how often headaches occurred, shortened their duration, and decreased the severity of the migraines reported. Participants in the zinc group experienced notable improvements, as indicated by their responses to the headache severity scale and a disability assessment questionnaire.
Furthermore, we found that zinc also had a positive effect on certain health markers. The serum levels of low-density lipoprotein (LDL), total cholesterol, and high-sensitivity C-reactive protein (hs-CRP) decreased with zinc supplementation. However, we didn’t observe significant changes in triglycerides or high-density lipoprotein (HDL) levels after adjusting for baseline values.
In conclusion, zinc supplementation appears to hold beneficial effects on migraine severity and frequency, offering a potential alternative for those who seek relief from these debilitating headaches.
Read More
8
Magnesium shows potential in VM therapy
Effects of nonprescription therapies on vestibular migraine: a questionnaire-based observational study.
Combination product limits specific conclusions.
We conducted a study assessing how nonprescription therapies, particularly a combination product containing magnesium, affect symptoms of vestibular migraine (VM). Our research involved collecting data from patients diagnosed with VM who were given guidance on lifestyle changes, like hydration and nutrition, alongside the supplement.
After three months of treatment, we observed promising results. The severity and frequency of headache-related symptoms showed significant improvement based on assessments using established scales. For instance, participants reported a reduction in dizziness and headache intensity, with many noting a better quality of life.
Notably, half of the patients observed an enhancement in their symptoms, while most tolerated the supplement without any issues. These findings suggest that magnesium, when combined with other nutrients, could contribute positively to managing VM headaches.
Overall, our study offers preliminary support for magnesium's potential role in treating VM, particularly through a holistic approach that includes lifestyle modifications.
After three months of treatment, we observed promising results. The severity and frequency of headache-related symptoms showed significant improvement based on assessments using established scales. For instance, participants reported a reduction in dizziness and headache intensity, with many noting a better quality of life.
Notably, half of the patients observed an enhancement in their symptoms, while most tolerated the supplement without any issues. These findings suggest that magnesium, when combined with other nutrients, could contribute positively to managing VM headaches.
Overall, our study offers preliminary support for magnesium's potential role in treating VM, particularly through a holistic approach that includes lifestyle modifications.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.7
9.5
Recommending warmly
Excellent firm, good composition. I take it to my mum. Sleep is improving and headaches disappear. It doesn’t cause discomfort and is well absorbed. I definitely recommend it.
9.5
Energy boost
I liked the product. It had a positive effect on my nervous system. After two weeks, the headaches stopped, and I feel more energetic and calmer.
9.5
Headache frequency
I’ve had numerous headaches since middle school—migraines, tension, and a Thunder Clap headache a few times. After taking these three a day, my headaches are much less frequent, and my body absorbs this pill much better than others. It has truly helped!
8.8
Long-lasting relief
My wife's stomach is in good shape and my ten-year-old headache has been alleviated. I will continue to use it for a long time.
8.8
Effective for PMS
I use it as a hedge against my heavy period, but I find it effective because my PMS is calmer and there’s not much headache.
