' 
![]()
SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7
USERS' SCORE
Good
Based on 5 Reviews
8.6
Supplement Facts
Serving Size: 3 tablets
Serving Per Container: 83
Amount Per Serving
%DV
Calcium (as calcium carbonate, calcium gluconate, calcium citrate)
1,000 mg
77%
Magnesium (as magnesium oxide, magnesium gluconate, magnesium citrate)
400 mg
95%
Zinc (as zinc gluconate)
15 mg
136%
Sodium†
15 mg
<1%
Top Medical Research Studies
9
Magnesium implantation improves heart recovery
Magnesium implantation as a continuous hydrogen production generator for the treatment of myocardial infarction in rats.
Direct effect on MI treatment
We explored the potential of magnesium implantation as a new approach to combat heart attacks, specifically myocardial infarction (MI). Our research centered on using magnesium slices implanted under the skin of rats to generate hydrogen gas continuously. This method could ensure a greater and longer-lasting concentration of hydrogen directly reaching the heart, which is crucial for its therapeutic effects.
Through our study, we measured how effectively the magnesium produced hydrogen and evaluated its safety. The results were promising; we observed that magnesium implantation not only improved cardiac function in rats suffering from MI, but also played a role in eliminating harmful free radicals from mitochondrial dysfunction. Furthermore, it helped reduce cell death in heart muscle cells, which is a common consequence of heart attacks.
Compared to traditional hydrogen inhalation, which has limitations in delivering sufficient doses over time, magnesium implantation proved to be a superior method. Overall, our findings pave the way for innovative treatments that could enhance recovery after heart attacks by harnessing the unique properties of magnesium for hydrogen production.
Through our study, we measured how effectively the magnesium produced hydrogen and evaluated its safety. The results were promising; we observed that magnesium implantation not only improved cardiac function in rats suffering from MI, but also played a role in eliminating harmful free radicals from mitochondrial dysfunction. Furthermore, it helped reduce cell death in heart muscle cells, which is a common consequence of heart attacks.
Compared to traditional hydrogen inhalation, which has limitations in delivering sufficient doses over time, magnesium implantation proved to be a superior method. Overall, our findings pave the way for innovative treatments that could enhance recovery after heart attacks by harnessing the unique properties of magnesium for hydrogen production.
Read More
9
ZnO NPs protect heart health
In vivo cardioprotective effect of zinc oxide nanoparticles against doxorubicin-induced myocardial infarction by enhancing the antioxidant system and nitric oxide production.
Direct focus on cardioprotection
We aimed to explore how zinc oxide nanoparticles (ZnO NPs) could protect the heart from damage caused by doxorubicin, a drug that can lead to serious heart issues, including myocardial infarction (MI). Our study involved rats that were injected with doxorubicin to induce MI and then treated with ZnO NPs at two different doses.
Throughout the research, we observed significant improvements in heart health among the rats that received these nanoparticles. Specifically, their heart function showed recovery, with important biochemical markers reflecting less damage. The lower dose of ZnO NPs was especially effective, aiding the antioxidant system and boosting nitric oxide production, which is vital for heart function.
Our findings suggest that ZnO NPs could be a promising way to counteract the cardiotoxic effects of doxorubicin. This insight opens new avenues for treatment strategies aimed at patients who need chemotherapy without risking their heart health.
Throughout the research, we observed significant improvements in heart health among the rats that received these nanoparticles. Specifically, their heart function showed recovery, with important biochemical markers reflecting less damage. The lower dose of ZnO NPs was especially effective, aiding the antioxidant system and boosting nitric oxide production, which is vital for heart function.
Our findings suggest that ZnO NPs could be a promising way to counteract the cardiotoxic effects of doxorubicin. This insight opens new avenues for treatment strategies aimed at patients who need chemotherapy without risking their heart health.
Read More
8
Zinc treatment aids heart recovery
PIAS3 acts as a zinc sensor under zinc deficiency and plays an important role in myocardial ischemia/reperfusion injury.
Significant findings on zinc's role
We explored the impact of zinc on heart attack recovery, particularly focusing on how zinc deficiency affects heart cells during ischemia/reperfusion (I/R) injury. The study highlighted that when zinc levels drop, a protein known as PIAS3 is quickly degraded. This degradation helps activate another protein called STAT3, which plays a key role in encouraging the expression of zinc transporter genes. These transporters are vital in regulating zinc levels within heart cells.
The importance of the RING finger domain of PIAS3 emerged as crucial. It turns out that this domain is necessary for both degrading PIAS3 and inhibiting STAT3 activation. We found that when PIAS3 was knocked down, cardiac zinc levels increased, leading to less myocardial infarction in mice undergoing I/R. In contrast, overexpressing the regular PIAS3 protein lowered zinc levels and worsened heart damage.
Through these findings, we gained insight into a fascinating mechanism—when zinc is lacking, the body quickly eliminates this regulatory protein, thereby helping to restore balance and protect the heart from injury during the critical ischemia/reperfusion phase.
The importance of the RING finger domain of PIAS3 emerged as crucial. It turns out that this domain is necessary for both degrading PIAS3 and inhibiting STAT3 activation. We found that when PIAS3 was knocked down, cardiac zinc levels increased, leading to less myocardial infarction in mice undergoing I/R. In contrast, overexpressing the regular PIAS3 protein lowered zinc levels and worsened heart damage.
Through these findings, we gained insight into a fascinating mechanism—when zinc is lacking, the body quickly eliminates this regulatory protein, thereby helping to restore balance and protect the heart from injury during the critical ischemia/reperfusion phase.
Read More
Most Useful Reviews
9.5
Heart pain relief
Super! I have a small child, and with sleepless nights, my heart ached from fatigue. After consulting a cardiologist, I began taking Calcium, Magnesium, and Zinc, which stopped my heart from hurting. I highly recommend this preparation, though it can be hard to find; I will purchase it again.
Read More
8.8
Stopped cramping
This complex is one of the best calcium preparations due to its special chelated form. The minerals are absorbed effectively. Calcium maintains bone strength, magnesium aids calcium absorption, and zinc contributes to collagen production. I buy it for my parents; my father stopped cramping his arms after a heart attack, and my mother has no more leg cramps at night. It’s essential to take vitamin D alongside this complex for better absorption.
Read More
9.5
Tachycardia resolved
This supplement was beneficial for my heart. After consuming all 250 tablets, I noticed an immediate effect: my heart rate normalised, and my tachycardia disappeared, relieving my stress and anxiety. I now take it as needed and am very satisfied with the results.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7
9
Calcium's role in heart regeneration
Pharmacological or genetic inhibition of LTCC promotes cardiomyocyte proliferation through inhibition of calcineurin activity.
Moderate clarity on calcium's effects
We explored how calcium signaling influences heart cell proliferation, particularly after injuries like heart attacks. Our study centered on the L-Type Calcium Channel (LTCC) and how its inhibition might help heart cells regenerate. Remarkably, when we inhibited LTCC—either through pharmacological means or by enhancing the activity of an inherent inhibitor called RRAD—we observed significant boosts in heart cell activity.
This process appears connected to calcineurin activity, a key player in cell signaling. By carefully manipulating these pathways, we managed to not only provoke heart cell growth in lab settings but also improve heart function and reduce scar tissue in live animal models post-heart attack.
Through our findings, we highlight the potential for new calcium-related treatments that could significantly benefit patients with heart injury, paving the way for exciting advancements in regenerative medicine. By understanding this intricate relationship between calcium signaling and heart cell growth, we open doors for innovative therapies that could transform recovery strategies in cardiovascular care.
This process appears connected to calcineurin activity, a key player in cell signaling. By carefully manipulating these pathways, we managed to not only provoke heart cell growth in lab settings but also improve heart function and reduce scar tissue in live animal models post-heart attack.
Through our findings, we highlight the potential for new calcium-related treatments that could significantly benefit patients with heart injury, paving the way for exciting advancements in regenerative medicine. By understanding this intricate relationship between calcium signaling and heart cell growth, we open doors for innovative therapies that could transform recovery strategies in cardiovascular care.
Read More
9
Magnesium implantation improves heart recovery
Magnesium implantation as a continuous hydrogen production generator for the treatment of myocardial infarction in rats.
Direct effect on MI treatment
We explored the potential of magnesium implantation as a new approach to combat heart attacks, specifically myocardial infarction (MI). Our research centered on using magnesium slices implanted under the skin of rats to generate hydrogen gas continuously. This method could ensure a greater and longer-lasting concentration of hydrogen directly reaching the heart, which is crucial for its therapeutic effects.
Through our study, we measured how effectively the magnesium produced hydrogen and evaluated its safety. The results were promising; we observed that magnesium implantation not only improved cardiac function in rats suffering from MI, but also played a role in eliminating harmful free radicals from mitochondrial dysfunction. Furthermore, it helped reduce cell death in heart muscle cells, which is a common consequence of heart attacks.
Compared to traditional hydrogen inhalation, which has limitations in delivering sufficient doses over time, magnesium implantation proved to be a superior method. Overall, our findings pave the way for innovative treatments that could enhance recovery after heart attacks by harnessing the unique properties of magnesium for hydrogen production.
Through our study, we measured how effectively the magnesium produced hydrogen and evaluated its safety. The results were promising; we observed that magnesium implantation not only improved cardiac function in rats suffering from MI, but also played a role in eliminating harmful free radicals from mitochondrial dysfunction. Furthermore, it helped reduce cell death in heart muscle cells, which is a common consequence of heart attacks.
Compared to traditional hydrogen inhalation, which has limitations in delivering sufficient doses over time, magnesium implantation proved to be a superior method. Overall, our findings pave the way for innovative treatments that could enhance recovery after heart attacks by harnessing the unique properties of magnesium for hydrogen production.
Read More
9
Magnesium scaffolds improve heart attack outcomes
Outcomes of the two generations of bioresorbable scaffolds (Magmaris vs. Absorb) in acute coronary syndrome in routine clinical practice.
Study indicates magnesium benefits
We examined the performance of two types of bioresorbable scaffolds in patients experiencing acute coronary syndrome (ACS) - a common and serious manifestation of heart disease. Specifically, we compared the effectiveness of magnesium-based scaffolds, known as Magmaris, with the earlier polymer scaffolds called Absorb.
Our study included 193 patients using Magmaris and 160 patients using Absorb, all treated in similar clinical settings. Over the course of one year, we monitored their health outcomes, particularly focusing on serious issues like cardiac death, heart attacks, and instances of scaffold thrombosis.
Surprisingly, we found that patients with Magmaris had significantly better outcomes than those with Absorb. Specifically, the rates of primary complications and target lesion failures were notably lower with Magmaris. We noted a concerning trend with Absorb, where patients experienced a higher rate of scaffold thrombosis.
Overall, our findings suggest that magnesium-based scaffolds could provide a safer and more effective option for patients undergoing treatment for heart attacks compared to their polymer counterparts.
Our study included 193 patients using Magmaris and 160 patients using Absorb, all treated in similar clinical settings. Over the course of one year, we monitored their health outcomes, particularly focusing on serious issues like cardiac death, heart attacks, and instances of scaffold thrombosis.
Surprisingly, we found that patients with Magmaris had significantly better outcomes than those with Absorb. Specifically, the rates of primary complications and target lesion failures were notably lower with Magmaris. We noted a concerning trend with Absorb, where patients experienced a higher rate of scaffold thrombosis.
Overall, our findings suggest that magnesium-based scaffolds could provide a safer and more effective option for patients undergoing treatment for heart attacks compared to their polymer counterparts.
Read More
9
ZnO NPs protect heart health
In vivo cardioprotective effect of zinc oxide nanoparticles against doxorubicin-induced myocardial infarction by enhancing the antioxidant system and nitric oxide production.
Direct focus on cardioprotection
We aimed to explore how zinc oxide nanoparticles (ZnO NPs) could protect the heart from damage caused by doxorubicin, a drug that can lead to serious heart issues, including myocardial infarction (MI). Our study involved rats that were injected with doxorubicin to induce MI and then treated with ZnO NPs at two different doses.
Throughout the research, we observed significant improvements in heart health among the rats that received these nanoparticles. Specifically, their heart function showed recovery, with important biochemical markers reflecting less damage. The lower dose of ZnO NPs was especially effective, aiding the antioxidant system and boosting nitric oxide production, which is vital for heart function.
Our findings suggest that ZnO NPs could be a promising way to counteract the cardiotoxic effects of doxorubicin. This insight opens new avenues for treatment strategies aimed at patients who need chemotherapy without risking their heart health.
Throughout the research, we observed significant improvements in heart health among the rats that received these nanoparticles. Specifically, their heart function showed recovery, with important biochemical markers reflecting less damage. The lower dose of ZnO NPs was especially effective, aiding the antioxidant system and boosting nitric oxide production, which is vital for heart function.
Our findings suggest that ZnO NPs could be a promising way to counteract the cardiotoxic effects of doxorubicin. This insight opens new avenues for treatment strategies aimed at patients who need chemotherapy without risking their heart health.
Read More
9
Zinc benefits heart attack recovery
Zn SiO Bioceramic Attenuates Cardiac Remodeling after Myocardial Infarction.
Combined effects of zinc and silicon
We investigated how zinc contributes to recovery after a heart attack, specifically focusing on its role in promoting heart health. The study centered on a new bioceramic material made from zinc and silicon oxide, which releases bioactive elements that work together to support heart cell function and reduce damage.
Our findings revealed that both zinc and silicon oxide enhance blood vessel growth and protect heart cells from harm during a heart attack. We observed that administering this material, either through injections or as a hydrogel, improved heart function and reduced scar tissue formation in a murine model of myocardial infarction.
This research marks a significant step in demonstrating the combined benefits of zinc and silicon oxide in heart protection. While zinc alone is part of the treatment, it’s essential to note that this study showcases their combined effects rather than evaluating zinc in isolation.
Our findings revealed that both zinc and silicon oxide enhance blood vessel growth and protect heart cells from harm during a heart attack. We observed that administering this material, either through injections or as a hydrogel, improved heart function and reduced scar tissue formation in a murine model of myocardial infarction.
This research marks a significant step in demonstrating the combined benefits of zinc and silicon oxide in heart protection. While zinc alone is part of the treatment, it’s essential to note that this study showcases their combined effects rather than evaluating zinc in isolation.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.6
9.5
Heart pain relief
Super! I have a small child, and with sleepless nights, my heart ached from fatigue. After consulting a cardiologist, I began taking Calcium, Magnesium, and Zinc, which stopped my heart from hurting. I highly recommend this preparation, though it can be hard to find; I will purchase it again.
Read More
9.5
Tachycardia resolved
This supplement was beneficial for my heart. After consuming all 250 tablets, I noticed an immediate effect: my heart rate normalised, and my tachycardia disappeared, relieving my stress and anxiety. I now take it as needed and am very satisfied with the results.
8.8
Stopped cramping
This complex is one of the best calcium preparations due to its special chelated form. The minerals are absorbed effectively. Calcium maintains bone strength, magnesium aids calcium absorption, and zinc contributes to collagen production. I buy it for my parents; my father stopped cramping his arms after a heart attack, and my mother has no more leg cramps at night. It’s essential to take vitamin D alongside this complex for better absorption.
Read More
8.8
Stopped cramping
If you're looking for a supplement, this is the best! It combines minerals in a chelated form for optimal absorption. Calcium preserves bone strength, magnesium ensures even distribution and absorption, and zinc helps with collagen production. I buy it for my parents—they both experienced relief from cramps after my father's heart attack.
Read More
2.5
Heartbeat increased
Caution is advised; after a week of taking it, I noticed my heart rate increased. I handed it to my sister, and her heart began to hurt as well.
