Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 23 Researches
7.7
USERS' SCORE
Good
Based on 12 Reviews
8.3
Supplement Facts
Serving Size: 3 tablets
Serving Per Container: 83
Amount Per Serving
%DV
Calcium (as calcium carbonate, calcium gluconate, calcium citrate)
1,000 mg
77%
Magnesium (as magnesium oxide, magnesium gluconate, magnesium citrate)
400 mg
95%
Zinc (as zinc gluconate)
15 mg
136%
Sodium†
15 mg
<1%

Top Medical Research Studies

7
Magnesium supplements lower heart failure risk
We examined how magnesium supplements might influence heart failure and serious heart-related issues in diabetic patients.

In a study involving over 94,000 veterans, we found that those taking magnesium supplements experienced a lower risk of heart failure compared to nonusers. Specifically, 8.0% of supplement users developed heart failure, versus 9.7% of nonusers.

Furthermore, magnesium intake was linked to a reduced chance of major adverse cardiac events. However, it’s important to note that these findings need further investigation through randomized controlled trials.
Read More
9
Magnesium reduces mortality in HFpEF
We explored how magnesium supplementation might influence mortality rates in patients with heart failure and preserved ejection fraction (HFpEF). The study involved nearly 2,000 patients, with careful matching to ensure a fair comparison between those receiving magnesium and those who weren’t.

Interestingly, we found that magnesium intake was linked to a significant reduction in 28-day mortality rates. This effect was most notable in older adults, women, and patients with high blood pressure. Despite these positive findings, magnesium treatment did lead to longer hospital and ICU stays.

Overall, magnesium shows promise as a supportive treatment for HFpEF, but further investigation is necessary to better understand its benefits and implications.
Read More
8
Magnesium levels and heart disease mortality
We examined the link between serum magnesium levels and the risk of death from heart failure, coronary heart disease, and stroke in patients with chronic kidney disease who don’t require dialysis. Over a decade, we followed 1,271 patients, noting that those with higher magnesium levels experienced significantly lower mortality rates from these conditions.

This suggests that maintaining adequate magnesium levels may help improve health outcomes for individuals with advanced kidney issues and an increased risk of cardiovascular problems.
Read More

Most Useful Reviews

9
Reduced cramps
112 people found this helpful
This complex is among the best calcium preparations due to its chelated form, ensuring maximum absorption. Calcium strengthens bones, magnesium aids its distribution, and zinc supports collagen production. After using this for my parents, my father's arm cramps post-heart attack ceased, and my mother no longer suffers from leg cramps at night. Remember to take Vitamin D for better calcium absorption.
Read More
9
Cured heart pain
40 people found this helpful
Super! I have a small child, and lack of sleep was affecting my heart. Following my cardiologist's advice, I started taking Calcium, Magnesium, and Zinc. Since then, my heart pain has vanished. I highly recommend this preparation, though it can be hard to find; I'll definitely purchase it again. If my review was useful, please say “yes”.
Read More
9
Adjusted heart rate
15 people found this helpful
I drank all 250 tablets. The effects were immediate; my heart rate stabilised, and my tachycardia disappeared. This product relieves stress and anxiety, and I now take it only as needed. I'm very satisfied with this drug.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 23 Researches
7.7
  • All Researches
We explored how enhancing mitochondrial calcium uptake can influence heart disease, particularly in the context of heart hypertrophy, a condition that can lead to heart failure. The study focused on the mitochondrial calcium uniporter (MCU), a protein responsible for transporting calcium into mitochondria.

By examining heart samples from humans and mice at different stages of hypertrophy, we found that MCU levels increased during the initial adaptive phase but decreased when heart failure occurred. This tells us that the body tries to cope with added stress before ultimately struggling.

Our experiments involved manipulating MCU levels in mice through viral techniques, allowing us to observe the effects during pressure overload, simulating conditions of heart disease. We noticed that reducing MCU led to faster deterioration of heart function and increased fibrosis, indicating a poorer health status. Conversely, boosting MCU seemed to help preserve heart function and maintain tissue health even under stress.

Importantly, we found that improved mitochondrial calcium uptake triggered protective signals involving reactive oxygen species and Akt activation within the heart cells. These findings suggest that enhancing calcium uptake could offer a potential therapeutic strategy against maladaptive heart hypertrophy and contribute to a healthier heart response under stress.
Read More
9
Magnesium reduces mortality in HFpEF
We explored how magnesium supplementation might influence mortality rates in patients with heart failure and preserved ejection fraction (HFpEF). The study involved nearly 2,000 patients, with careful matching to ensure a fair comparison between those receiving magnesium and those who weren’t.

Interestingly, we found that magnesium intake was linked to a significant reduction in 28-day mortality rates. This effect was most notable in older adults, women, and patients with high blood pressure. Despite these positive findings, magnesium treatment did lead to longer hospital and ICU stays.

Overall, magnesium shows promise as a supportive treatment for HFpEF, but further investigation is necessary to better understand its benefits and implications.
Read More
We explored the fascinating relationship between heart health, atrial natriuretic peptide (ANP), and zinc (Zn) in the context of ischemia/reperfusion (I/R) injury, a condition that occurs when blood supply returns to the heart after a period of being blocked. Our research utilized a range of models, including isolated heart experiments in rats and ANP knockout mice, along with clinical investigations involving plasma samples from 216 patients suffering from ischemia-related diseases.

During our experiments, we observed that levels of ANP significantly increased during reperfusion, which, in turn, promoted zinc accumulation in the heart tissue. This uptick in zinc led to protective effects on the heart, primarily by reducing injury during the reperfusion phase. Interestingly, when we applied a zinc chelator, we found that it negated the beneficial impacts of both ANP and zinc, highlighting the crucial role zinc plays in conjunction with ANP.

Furthermore, we discovered that ANP modulates zinc levels by downregulating a specific transporter known as ZnT8 through a pathway called PI3K signaling. While the interplay between ANP and zinc is evident, the study suggests that zinc alone's effectiveness in treating heart conditions cannot be fully isolated due to these combined effects. Overall, our findings point to a complex relationship in heart protection strategies, where both ANP and zinc play essential, interlinked roles.
Read More
9
Zinc benefits heart health post-cisplatin
We explored the potential benefits of zinc oxide nanoparticles (ZnONPs) in preventing heart damage caused by cisplatin, a powerful chemotherapy drug known for its efficacy but also for its side effects, particularly cardiotoxicity.

In our study, rats were divided into several groups, including control groups and those receiving different doses of ZnONPs. We specifically looked at a range of health markers such as lipid levels, antioxidant activity, and inflammation in heart tissues to see how ZnONPs could help soften the impact of cisplatin on heart health.

As we gradually increased the dosage of ZnONPs to 50 mg/kg, we observed significant improvements across the various health parameters examined. Notably, at this optimal dose, the rats' heart health markers showed a remarkable recovery, aligning closely with those in the healthy control group. This suggests that ZnONPs effectively protect heart tissue from oxidative stress and inflammation associated with cisplatin treatment.

Overall, our findings highlight the promising role of zinc oxide nanoparticles in mitigating heart damage linked to cancer treatments, paving the way for further research in this arena.
Read More
8
Calcium scoring aids heart disease prevention
We conducted a randomized trial to see how combining coronary artery calcium (CAC) scoring with a prevention strategy could limit plaque progression in patients who have a family history of heart disease. The study involved participants aged 40 to 70 who were asymptomatic but had relatives with early-onset coronary artery disease (CAD).

For those who had a CAC score between 1 and 399, we randomized them into two groups: one followed a prevention plan informed by their CAC score, while the other received usual care. After three years, we measured the plaque volume through follow-up assessments to observe how each group fared in terms of plaque progression.

Remarkably, our findings indicated that using the CAC score alongside a primary prevention approach helped reduce harmful lipids in the blood and slowed the development of plaque compared to standard care. This suggests that the CAC score can play a vital role in informing and enhancing preventive measures for those at intermediate risk of heart disease.
Read More

User Reviews

USERS' SCORE
Good
Based on 12 Reviews
8.3
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Reduced cramps
112 people found this helpful
This complex is among the best calcium preparations due to its chelated form, ensuring maximum absorption. Calcium strengthens bones, magnesium aids its distribution, and zinc supports collagen production. After using this for my parents, my father's arm cramps post-heart attack ceased, and my mother no longer suffers from leg cramps at night. Remember to take Vitamin D for better calcium absorption.
Read More
9
Cured heart pain
40 people found this helpful
Super! I have a small child, and lack of sleep was affecting my heart. Following my cardiologist's advice, I started taking Calcium, Magnesium, and Zinc. Since then, my heart pain has vanished. I highly recommend this preparation, though it can be hard to find; I'll definitely purchase it again. If my review was useful, please say “yes”.
Read More
9
Adjusted heart rate
15 people found this helpful
I drank all 250 tablets. The effects were immediate; my heart rate stabilised, and my tachycardia disappeared. This product relieves stress and anxiety, and I now take it only as needed. I'm very satisfied with this drug.
Read More
9
Supported heart health
6 people found this helpful
Good decision! I take magnesium to strengthen my heart muscle due to tachycardia and extrasystole. Since starting this, I’ve had only one attack. I'm pleased with the results.
Read More
9
Improved absorption
2 people found this helpful
If you’re seeking a supplement complex, this is the best! Its special chelated form ensures maximum absorption. Calcium maintains bone strength, magnesium distributes calcium, and zinc aids collagen production. I bought it for my parents, and it significantly helped my father with his post-heart attack cramps and my mother’s night cramps. Don’t forget to take Vitamin D for enhanced absorption.
Read More

Frequently Asked Questions

9
Adjusted heart rate
15 people found this helpful
I drank all 250 tablets. The effects were immediate; my heart rate stabilised, and my tachycardia disappeared. This product relieves stress and anxiety, and I now take it only as needed. I'm very satisfied with this drug.
9
Relieved joint pain
Solgar is the best brand! After two weeks, I noticed significant changes. My joint disease improved, and the packaging is high quality. I definitely recommend purchasing it. 👍
9
Reduced cramps
112 people found this helpful
This complex is among the best calcium preparations due to its chelated form, ensuring maximum absorption. Calcium strengthens bones, magnesium aids its distribution, and zinc supports collagen production. After using this for my parents, my father's arm cramps post-heart attack ceased, and my mother no longer suffers from leg cramps at night. Remember to take Vitamin D for better calcium absorption.
9
Cured heart pain
40 people found this helpful
Super! I have a small child, and lack of sleep was affecting my heart. Following my cardiologist's advice, I started taking Calcium, Magnesium, and Zinc. Since then, my heart pain has vanished. I highly recommend this preparation, though it can be hard to find; I'll definitely purchase it again. If my review was useful, please say “yes”.
7.5
Enhanced heart muscle
6 people found this helpful
Excellent! This vitamin complex is kosher and free of gluten and preservatives. The Solgar Vitamin Complex provides essential trace elements. Calcium strengthens bones, magnesium improves heart muscle functioning and calms the nervous system, while zinc boosts immunity. After taking it for two weeks, I noticed improvements in my nails and a reduction in muscle spasms.
9
Boosted immunity
Excellent calcium, magnesium, and zinc with effective dosages. I took them for my immunity and heart health, and they did the job brilliantly. I highly recommend them!
0
Increased heart rate
3 people found this helpful
Cautiously, I noticed an increase in my heart rate after a week of taking the product. I gave it to my sister, and she began experiencing heart pain...
9
Supported heart health
6 people found this helpful
Good decision! I take magnesium to strengthen my heart muscle due to tachycardia and extrasystole. Since starting this, I’ve had only one attack. I'm pleased with the results.
7
Magnesium supplements lower heart failure risk
We examined how magnesium supplements might influence heart failure and serious heart-related issues in diabetic patients.

In a study involving over 94,000 veterans, we found that those taking magnesium supplements experienced a lower risk of heart failure compared to nonusers. Specifically, 8.0% of supplement users developed heart failure, versus 9.7% of nonusers.

Furthermore, magnesium intake was linked to a reduced chance of major adverse cardiac events. However, it’s important to note that these findings need further investigation through randomized controlled trials.
8
Magnesium levels and heart disease mortality
We examined the link between serum magnesium levels and the risk of death from heart failure, coronary heart disease, and stroke in patients with chronic kidney disease who don’t require dialysis. Over a decade, we followed 1,271 patients, noting that those with higher magnesium levels experienced significantly lower mortality rates from these conditions.

This suggests that maintaining adequate magnesium levels may help improve health outcomes for individuals with advanced kidney issues and an increased risk of cardiovascular problems.
8
Zinc supplementation improves heart health
We explored the connection between zinc supplementation and heart health, particularly in the context of obesity. Our research focused on how zinc affects cardiac remodeling, a process that can lead to serious heart issues when influenced by factors like high-fat diets. In our study, obese mice were examined after being fed a high-fat diet, allowing us to observe changes in their heart structures and inflammation levels.

Notably, we found that zinc appeared to counteract some of the harmful effects associated with obesity. For instance, when zinc was administered, it helped boost the levels of metallothionein, a protein known to protect the heart. This was significant as mice lacking this protein exhibited increased heart inflammation and structural changes when exposed to high-fat diets compared to their counterparts who received adequate zinc.

Ultimately, we concluded that zinc plays a crucial role in maintaining heart health, especially in conditions of obesity. This suggests that zinc could be a useful supplement for individuals struggling with weight-related heart problems, promoting better overall heart function and reducing inflammation.
8
Trace minerals and heart health
We analyzed the relationship between trace mineral intake, specifically zinc, and the risk of coronary artery disease (CAD) in middle-aged and older adults. The participants, totaling 895 residents from Shika town in Japan, were selected carefully to exclude those with a genetic predisposition to high cholesterol levels.

Our findings indicated interesting interactions between dyslipidaemia and various trace minerals like zinc, copper, and manganese. We observed that lower intakes of these minerals were notably associated with a higher occurrence of CAD among individuals with dyslipidaemia. For instance, zinc was highlighted as a significant factor, with a lower risk ratio for CAD when intake was sufficient.

While our study emphasizes the importance of trace minerals, especially zinc, in relation to heart disease, it also underlines the complexity of these relationships. The study suggests that addressing low mineral intake could be part of a strategy to manage heart disease in affected individuals. However, further research over a longer duration is essential to fully understand these dynamics and their potential impact on heart health.

References

  1. Sato T, Matsumura M, Yamamoto K, Sugizaki Y, Shlofmitz E, et al. A Revised Optical Coherence Tomography-Derived Calcium Score to Predict Stent Underexpansion in Severely Calcified Lesions. JACC Cardiovasc Interv. 2025;18:622. doi:10.1016/j.jcin.2024.12.001
  2. Zaglia T, Campo A, Moro N, Di Mauro V, Borile G, et al. Enhancement of mitochondrial calcium uptake is cardioprotective against maladaptive hypertrophy by retrograde signaling uptuning Akt. Proc Natl Acad Sci U S A. 2025;122:e2402639122. doi:10.1073/pnas.2402639122
  3. Nerlekar N, Vasanthakumar SA, Whitmore K, Soh CH, Chan J, et al. Effects of Combining Coronary Calcium Score With Treatment on Plaque Progression in Familial Coronary Artery Disease: A Randomized Clinical Trial. JAMA. 2025. doi:10.1001/jama.2025.0584
  4. Cheng Y, Zullo AR, Yin Y, Shao Y, Liu S, et al. Nonprescription Magnesium Supplement Use and Risk of Heart Failure in Patients With Diabetes: A Target Trial Emulation. J Am Heart Assoc. 2025;14:e038870. doi:10.1161/JAHA.124.038870
  5. Moyano-Peregrin C, Rodelo-Haad C, Martín-Malo A, Muñoz-Castañeda JR, Ojeda R, et al. Upper normal serum magnesium is associated with a reduction in incident death from fatal heart failure, coronary heart disease and stroke in non-dialysis patients with CKD stages 4 and 5. Clin Kidney J. 2025;18:sfae390. doi:10.1093/ckj/sfae390
  6. Dong H, Lu N, Wang J, Hu P. Serum magnesium, not calcium, is inversely associated with abnormal HbA1c concentrations in adults with coronary artery disease. Asia Pac J Clin Nutr. 2025;34:104. doi:10.6133/apjcn.202502_34(1).0010
  7. Song L, Ying J, Li M, Ying L, Zhao C. Propensity score matched cohort study on magnesium supplementation and mortality in critically ill patients with HFpEF. Sci Rep. 2025;15:1944. doi:10.1038/s41598-025-85931-1
  8. Sun L, Du J. Magnesium status, serum vitamin D concentration and mortality among congestive heart failure patients: a cohort study from NHANES 2007-2018. Magnes Res. 2024;37:61. doi:10.1684/mrh.2024.0528
  9. Song Q, Song L, Liu H, Tan H, Yang B, et al. Association of magnesium intake with predicted atherosclerotic lesions and cardiovascular risk in young adults based on PDAY score: a cross-sectional study. BMC Public Health. 2024;24:3232. doi:10.1186/s12889-024-20785-2
  10. Behers BJ, Behers BM, Stephenson-Moe CA, Vargas IA, Meng Z, et al. Magnesium and Potassium Supplementation for Systolic Blood Pressure Reduction in the General Normotensive Population: A Systematic Review and Subgroup Meta-Analysis for Optimal Dosage and Treatment Length. Nutrients. 2024;16. doi:10.3390/nu16213617
  11. Jiang Y, Luo B, Chen Y, Lu W, Peng Y, et al. Serum calcium-magnesium ratio at admission predicts adverse outcomes in patients with acute coronary syndrome. PLoS One. 2024;19:e0313352. doi:10.1371/journal.pone.0313352
  12. Wyss C, Gündling PW, Kostev K. Real world effectiveness of Hawthorn special extract WS 1442 in a retrospective cohort study from Germany. Sci Rep. 2024;14:22986. doi:10.1038/s41598-024-74325-4
  13. Seguchi M, Aytekin A, Xhepa E, Haude M, Wlodarczak A, et al. Vascular response following implantation of the third-generation drug-eluting resorbable coronary magnesium scaffold: an intravascular imaging analysis of the BIOMAG-I first-in-human study. EuroIntervention. 2024;20:e1173. doi:10.4244/EIJ-D-24-00055
  14. Zhang J, Chen Z, Rao L, He Y. Coronary bioresorbable metallic stents: Advancements and future perspectives. J Cardiol. 2025;85:69. doi:10.1016/j.jjcc.2024.08.003
  15. Copp KL, Steffen LM, Yi SY, Lutsey PL, Rebholz CM, et al. Magnesium-rich diet score is inversely associated with incident cardiovascular disease: the Atherosclerosis Risk in Communities (ARIC) study. Eur J Prev Cardiol. 2025;32:386. doi:10.1093/eurjpc/zwae251
  16. Zhuang J, Zhang Q, Wang H, Su PH, Chen PY. Association between short-term changes in serum magnesium and in-hospital mortality following acute myocardial infarction: a cohort study based on the MIMIC database. Magnes Res. 2024;37:45. doi:10.1684/mrh.2024.0517
  17. Fruh V, Babalola T, Sears C, Wellenius GA, Webster TF, et al. Dietary Minerals and Incident Cardiovascular Outcomes among Never-Smokers in a Danish Case-Cohort Study. Int J Environ Res Public Health. 2024;21. doi:10.3390/ijerph21070932
  18. Tao J, Wang J, Peng H, Yuan Y, Lai H, et al. Association between serum phosphate, magnesium, calcium and aortic valve sclerosis: a propensity score-matched case-control study. Acta Cardiol. 2024;79:522. doi:10.1080/00015385.2024.2379682
  19. Zhang J, Sun D, Guo Y, Tong J, Liu Q, et al. Targeted delivery of black phosphorus nanosheets by ROS responsive complex hydrogel based on angiogenesis and antioxidant promotes myocardial infarction repair. J Nanobiotechnology. 2024;22:433. doi:10.1186/s12951-024-02685-0
  20. Ma YT, Laga T, Zhong CN, Zhuang BQ, Quan HL, et al. ANP Increases Zn Accumulation During Reperfusion in Ex Vivo and In Vivo Hearts. Curr Med Sci. 2025;45:35. doi:10.1007/s11596-025-00019-1
  21. Al-Lbban AM. Role of zinc oxide nanoparticles supplementation on alleviate side effects of cisplatin induced cardiotoxicity in rats. Braz J Biol. 2025;84:e287764. doi:10.1590/1519-6984.287764
  22. Zhang H, Zhou W, Wang X, Men H, Wang J, et al. Exacerbation by knocking-out metallothionein gene of obesity-induced cardiac remodeling is associated with the activation of CARD9 signaling. Int J Biol Sci. 2025;21:1032. doi:10.7150/ijbs.105513
  23. Kimura K, Suzuki F, Tsujiguchi H, Hara A, Miyagi S, et al. Relationship between coronary artery disease with dyslipidaemia and trace mineral intake: a cross-sectional analysis of the Shika study. J Nutr Sci. 2024;13:e45. doi:10.1017/jns.2024.26
image