Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7
USERS' SCORE
Good
Based on 3 Reviews
8.2
Supplement Facts
Serving Size: 3 tablets
Serving Per Container: 83
Amount Per Serving
%DV
Calcium (as calcium carbonate, calcium gluconate, calcium citrate)
1,000 mg
77%
Magnesium (as magnesium oxide, magnesium gluconate, magnesium citrate)
400 mg
95%
Zinc (as zinc gluconate)
15 mg
136%
Sodium†
15 mg
<1%
Top Medical Research Studies
8
We set out to understand how magnesium sulphate influences the symptoms of irritable bowel syndrome (IBS). In a study involving 20 IBS patients, magnesium sulphate was administered orally, resulting in a quick boost in colonic motor activity. Most participants experienced this increase within just two to six minutes.
Specifically, the percentage of colonic activity rose from 16.2% to 23.7%, signaling a notable change. Those who often felt abdominal pain after eating showed even more pronounced reactions, with their activity jumping from 16.1% to 29.8%. However, it’s important to note that three of these patients still experienced their usual pain after taking magnesium, suggesting that while magnesium can enhance motility, it doesn’t eliminate the pain for everyone.
Ultimately, these findings lend support to the idea that some cases of abdominal pain related to food may stem from heightened intestinal responses to cholecystokinin, a hormone released by the intestine. So while magnesium shows promise for intriguing changes in colonic movement in IBS patients, its effectiveness in alleviating pain remains mixed.
Specifically, the percentage of colonic activity rose from 16.2% to 23.7%, signaling a notable change. Those who often felt abdominal pain after eating showed even more pronounced reactions, with their activity jumping from 16.1% to 29.8%. However, it’s important to note that three of these patients still experienced their usual pain after taking magnesium, suggesting that while magnesium can enhance motility, it doesn’t eliminate the pain for everyone.
Ultimately, these findings lend support to the idea that some cases of abdominal pain related to food may stem from heightened intestinal responses to cholecystokinin, a hormone released by the intestine. So while magnesium shows promise for intriguing changes in colonic movement in IBS patients, its effectiveness in alleviating pain remains mixed.
Read More
9
We conducted a double-blind, randomized clinical trial involving 76 patients diagnosed with diarrhea-predominant irritable bowel syndrome (IBS) to evaluate the effectiveness of a dried extract combined with calcium treatment. Participants were split into two groups: one receiving a placebo, and the other receiving a combination of 75 mg of the dried extract and 175 mg of dibasic calcium phosphate (calcium).
Throughout the treatment period, we observed significant improvements in the quality of life, temperament, and various IBS symptoms among those who received the active treatment. Even four weeks after the treatment ended, there was a slight decrease in these benefits but still indicated some level of effectiveness.
Overall, we found that the whole extract, supplemented with calcium, helped to moderate symptoms of IBS and improve patients' overall quality of life. However, it’s important to note that due to the calcium's inclusion as part of the formulation, we can't define its isolated effect on IBS conclusively.
Throughout the treatment period, we observed significant improvements in the quality of life, temperament, and various IBS symptoms among those who received the active treatment. Even four weeks after the treatment ended, there was a slight decrease in these benefits but still indicated some level of effectiveness.
Overall, we found that the whole extract, supplemented with calcium, helped to moderate symptoms of IBS and improve patients' overall quality of life. However, it’s important to note that due to the calcium's inclusion as part of the formulation, we can't define its isolated effect on IBS conclusively.
Read More
4
We explored the potential connection between dietary zinc intake and the risk of developing irritable bowel syndrome (IBS) through a large-scale analysis of participants from the UK Biobank. By assessing the dietary habits of 175,421 individuals who did not have IBS at the start of the study, we sought to understand how various levels of zinc, as well as copper and their ratio, might influence the onset of this troublesome condition.
Over an average follow-up period of 13.3 years, we observed that 2,240 participants were diagnosed with new-onset IBS. Notably, our findings revealed a U-shaped relationship between zinc intake and IBS incidence. For those consuming less than 10 mg of zinc per day, an increase in intake was linked to a decreased risk of IBS. Specifically, individuals taking less than 10 mg of zinc daily experienced a reduced risk with higher zinc consumption.
However, the relationship shifted for individuals who had higher intakes of copper and zinc; no significant benefits were noted when intakes reached or exceeded established thresholds. This suggests that there's a delicate balance to maintain when it comes to zinc and copper in the diet.
Importantly, subgroup analysis indicated that younger individuals, particularly those under 60, could benefit more from slight increases in zinc. Overall, our study highlights the significance of dietary management, emphasizing that reasonable zinc intake may contribute to lowering IBS risk while keeping copper and the copper/zinc ratio in a sensible range.
Over an average follow-up period of 13.3 years, we observed that 2,240 participants were diagnosed with new-onset IBS. Notably, our findings revealed a U-shaped relationship between zinc intake and IBS incidence. For those consuming less than 10 mg of zinc per day, an increase in intake was linked to a decreased risk of IBS. Specifically, individuals taking less than 10 mg of zinc daily experienced a reduced risk with higher zinc consumption.
However, the relationship shifted for individuals who had higher intakes of copper and zinc; no significant benefits were noted when intakes reached or exceeded established thresholds. This suggests that there's a delicate balance to maintain when it comes to zinc and copper in the diet.
Importantly, subgroup analysis indicated that younger individuals, particularly those under 60, could benefit more from slight increases in zinc. Overall, our study highlights the significance of dietary management, emphasizing that reasonable zinc intake may contribute to lowering IBS risk while keeping copper and the copper/zinc ratio in a sensible range.
Read More
Most Useful Reviews
6
Life-changing supplement
Excellent! The tinted glass jar is very pleasing and reflects the seriousness of the manufacturer. Previously, the woman was often irritable, sleepy, and depressed at work. However, after taking this dietary supplement, her zest for life returned, and the change in him has been remarkable. It’s difficult to find as it quickly sells out.
Read More
7.5
Effective magnesium boost
Worthy product! This great complex truly works. I purchased more due to the magnesium content, as I became a bit irritable after my illness. After just two weeks of taking it, I'm already noticing improvements. My nervous system feels steadier, and the tablet size isn't intimidating; it’s easy to take. I recommend it!
Read More
7.5
Fast results noticed
Great complex! This truly works. I bought more for the magnesium, as I had become a touch irritable post-illness. After only two weeks of use, I'm seeing results, and my nervous system hasn’t failed me. The size of the tablets is manageable and easy to swallow. I recommend this product!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7
- All Researches
9
We conducted a double-blind, randomized clinical trial involving 76 patients diagnosed with diarrhea-predominant irritable bowel syndrome (IBS) to evaluate the effectiveness of a dried extract combined with calcium treatment. Participants were split into two groups: one receiving a placebo, and the other receiving a combination of 75 mg of the dried extract and 175 mg of dibasic calcium phosphate (calcium).
Throughout the treatment period, we observed significant improvements in the quality of life, temperament, and various IBS symptoms among those who received the active treatment. Even four weeks after the treatment ended, there was a slight decrease in these benefits but still indicated some level of effectiveness.
Overall, we found that the whole extract, supplemented with calcium, helped to moderate symptoms of IBS and improve patients' overall quality of life. However, it’s important to note that due to the calcium's inclusion as part of the formulation, we can't define its isolated effect on IBS conclusively.
Throughout the treatment period, we observed significant improvements in the quality of life, temperament, and various IBS symptoms among those who received the active treatment. Even four weeks after the treatment ended, there was a slight decrease in these benefits but still indicated some level of effectiveness.
Overall, we found that the whole extract, supplemented with calcium, helped to moderate symptoms of IBS and improve patients' overall quality of life. However, it’s important to note that due to the calcium's inclusion as part of the formulation, we can't define its isolated effect on IBS conclusively.
Read More
8
We set out to understand how magnesium sulphate influences the symptoms of irritable bowel syndrome (IBS). In a study involving 20 IBS patients, magnesium sulphate was administered orally, resulting in a quick boost in colonic motor activity. Most participants experienced this increase within just two to six minutes.
Specifically, the percentage of colonic activity rose from 16.2% to 23.7%, signaling a notable change. Those who often felt abdominal pain after eating showed even more pronounced reactions, with their activity jumping from 16.1% to 29.8%. However, it’s important to note that three of these patients still experienced their usual pain after taking magnesium, suggesting that while magnesium can enhance motility, it doesn’t eliminate the pain for everyone.
Ultimately, these findings lend support to the idea that some cases of abdominal pain related to food may stem from heightened intestinal responses to cholecystokinin, a hormone released by the intestine. So while magnesium shows promise for intriguing changes in colonic movement in IBS patients, its effectiveness in alleviating pain remains mixed.
Specifically, the percentage of colonic activity rose from 16.2% to 23.7%, signaling a notable change. Those who often felt abdominal pain after eating showed even more pronounced reactions, with their activity jumping from 16.1% to 29.8%. However, it’s important to note that three of these patients still experienced their usual pain after taking magnesium, suggesting that while magnesium can enhance motility, it doesn’t eliminate the pain for everyone.
Ultimately, these findings lend support to the idea that some cases of abdominal pain related to food may stem from heightened intestinal responses to cholecystokinin, a hormone released by the intestine. So while magnesium shows promise for intriguing changes in colonic movement in IBS patients, its effectiveness in alleviating pain remains mixed.
Read More
4
We explored the potential connection between dietary zinc intake and the risk of developing irritable bowel syndrome (IBS) through a large-scale analysis of participants from the UK Biobank. By assessing the dietary habits of 175,421 individuals who did not have IBS at the start of the study, we sought to understand how various levels of zinc, as well as copper and their ratio, might influence the onset of this troublesome condition.
Over an average follow-up period of 13.3 years, we observed that 2,240 participants were diagnosed with new-onset IBS. Notably, our findings revealed a U-shaped relationship between zinc intake and IBS incidence. For those consuming less than 10 mg of zinc per day, an increase in intake was linked to a decreased risk of IBS. Specifically, individuals taking less than 10 mg of zinc daily experienced a reduced risk with higher zinc consumption.
However, the relationship shifted for individuals who had higher intakes of copper and zinc; no significant benefits were noted when intakes reached or exceeded established thresholds. This suggests that there's a delicate balance to maintain when it comes to zinc and copper in the diet.
Importantly, subgroup analysis indicated that younger individuals, particularly those under 60, could benefit more from slight increases in zinc. Overall, our study highlights the significance of dietary management, emphasizing that reasonable zinc intake may contribute to lowering IBS risk while keeping copper and the copper/zinc ratio in a sensible range.
Over an average follow-up period of 13.3 years, we observed that 2,240 participants were diagnosed with new-onset IBS. Notably, our findings revealed a U-shaped relationship between zinc intake and IBS incidence. For those consuming less than 10 mg of zinc per day, an increase in intake was linked to a decreased risk of IBS. Specifically, individuals taking less than 10 mg of zinc daily experienced a reduced risk with higher zinc consumption.
However, the relationship shifted for individuals who had higher intakes of copper and zinc; no significant benefits were noted when intakes reached or exceeded established thresholds. This suggests that there's a delicate balance to maintain when it comes to zinc and copper in the diet.
Importantly, subgroup analysis indicated that younger individuals, particularly those under 60, could benefit more from slight increases in zinc. Overall, our study highlights the significance of dietary management, emphasizing that reasonable zinc intake may contribute to lowering IBS risk while keeping copper and the copper/zinc ratio in a sensible range.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
6
Life-changing supplement
Excellent! The tinted glass jar is very pleasing and reflects the seriousness of the manufacturer. Previously, the woman was often irritable, sleepy, and depressed at work. However, after taking this dietary supplement, her zest for life returned, and the change in him has been remarkable. It’s difficult to find as it quickly sells out.
Read More
7.5
Effective magnesium boost
Worthy product! This great complex truly works. I purchased more due to the magnesium content, as I became a bit irritable after my illness. After just two weeks of taking it, I'm already noticing improvements. My nervous system feels steadier, and the tablet size isn't intimidating; it’s easy to take. I recommend it!
Read More
7.5
Fast results noticed
Great complex! This truly works. I bought more for the magnesium, as I had become a touch irritable post-illness. After only two weeks of use, I'm seeing results, and my nervous system hasn’t failed me. The size of the tablets is manageable and easy to swallow. I recommend this product!
Read More
Frequently Asked Questions
7.5
Effective magnesium boost
Worthy product! This great complex truly works. I purchased more due to the magnesium content, as I became a bit irritable after my illness. After just two weeks of taking it, I'm already noticing improvements. My nervous system feels steadier, and the tablet size isn't intimidating; it’s easy to take. I recommend it!
7.5
Fast results noticed
Great complex! This truly works. I bought more for the magnesium, as I had become a touch irritable post-illness. After only two weeks of use, I'm seeing results, and my nervous system hasn’t failed me. The size of the tablets is manageable and easy to swallow. I recommend this product!
6
Life-changing supplement
Excellent! The tinted glass jar is very pleasing and reflects the seriousness of the manufacturer. Previously, the woman was often irritable, sleepy, and depressed at work. However, after taking this dietary supplement, her zest for life returned, and the change in him has been remarkable. It’s difficult to find as it quickly sells out.
9
We conducted a double-blind, randomized clinical trial involving 76 patients diagnosed with diarrhea-predominant irritable bowel syndrome (IBS) to evaluate the effectiveness of a dried extract combined with calcium treatment. Participants were split into two groups: one receiving a placebo, and the other receiving a combination of 75 mg of the dried extract and 175 mg of dibasic calcium phosphate (calcium).
Throughout the treatment period, we observed significant improvements in the quality of life, temperament, and various IBS symptoms among those who received the active treatment. Even four weeks after the treatment ended, there was a slight decrease in these benefits but still indicated some level of effectiveness.
Overall, we found that the whole extract, supplemented with calcium, helped to moderate symptoms of IBS and improve patients' overall quality of life. However, it’s important to note that due to the calcium's inclusion as part of the formulation, we can't define its isolated effect on IBS conclusively.
Throughout the treatment period, we observed significant improvements in the quality of life, temperament, and various IBS symptoms among those who received the active treatment. Even four weeks after the treatment ended, there was a slight decrease in these benefits but still indicated some level of effectiveness.
Overall, we found that the whole extract, supplemented with calcium, helped to moderate symptoms of IBS and improve patients' overall quality of life. However, it’s important to note that due to the calcium's inclusion as part of the formulation, we can't define its isolated effect on IBS conclusively.
8
We set out to understand how magnesium sulphate influences the symptoms of irritable bowel syndrome (IBS). In a study involving 20 IBS patients, magnesium sulphate was administered orally, resulting in a quick boost in colonic motor activity. Most participants experienced this increase within just two to six minutes.
Specifically, the percentage of colonic activity rose from 16.2% to 23.7%, signaling a notable change. Those who often felt abdominal pain after eating showed even more pronounced reactions, with their activity jumping from 16.1% to 29.8%. However, it’s important to note that three of these patients still experienced their usual pain after taking magnesium, suggesting that while magnesium can enhance motility, it doesn’t eliminate the pain for everyone.
Ultimately, these findings lend support to the idea that some cases of abdominal pain related to food may stem from heightened intestinal responses to cholecystokinin, a hormone released by the intestine. So while magnesium shows promise for intriguing changes in colonic movement in IBS patients, its effectiveness in alleviating pain remains mixed.
Specifically, the percentage of colonic activity rose from 16.2% to 23.7%, signaling a notable change. Those who often felt abdominal pain after eating showed even more pronounced reactions, with their activity jumping from 16.1% to 29.8%. However, it’s important to note that three of these patients still experienced their usual pain after taking magnesium, suggesting that while magnesium can enhance motility, it doesn’t eliminate the pain for everyone.
Ultimately, these findings lend support to the idea that some cases of abdominal pain related to food may stem from heightened intestinal responses to cholecystokinin, a hormone released by the intestine. So while magnesium shows promise for intriguing changes in colonic movement in IBS patients, its effectiveness in alleviating pain remains mixed.
4
We explored the potential connection between dietary zinc intake and the risk of developing irritable bowel syndrome (IBS) through a large-scale analysis of participants from the UK Biobank. By assessing the dietary habits of 175,421 individuals who did not have IBS at the start of the study, we sought to understand how various levels of zinc, as well as copper and their ratio, might influence the onset of this troublesome condition.
Over an average follow-up period of 13.3 years, we observed that 2,240 participants were diagnosed with new-onset IBS. Notably, our findings revealed a U-shaped relationship between zinc intake and IBS incidence. For those consuming less than 10 mg of zinc per day, an increase in intake was linked to a decreased risk of IBS. Specifically, individuals taking less than 10 mg of zinc daily experienced a reduced risk with higher zinc consumption.
However, the relationship shifted for individuals who had higher intakes of copper and zinc; no significant benefits were noted when intakes reached or exceeded established thresholds. This suggests that there's a delicate balance to maintain when it comes to zinc and copper in the diet.
Importantly, subgroup analysis indicated that younger individuals, particularly those under 60, could benefit more from slight increases in zinc. Overall, our study highlights the significance of dietary management, emphasizing that reasonable zinc intake may contribute to lowering IBS risk while keeping copper and the copper/zinc ratio in a sensible range.
Over an average follow-up period of 13.3 years, we observed that 2,240 participants were diagnosed with new-onset IBS. Notably, our findings revealed a U-shaped relationship between zinc intake and IBS incidence. For those consuming less than 10 mg of zinc per day, an increase in intake was linked to a decreased risk of IBS. Specifically, individuals taking less than 10 mg of zinc daily experienced a reduced risk with higher zinc consumption.
However, the relationship shifted for individuals who had higher intakes of copper and zinc; no significant benefits were noted when intakes reached or exceeded established thresholds. This suggests that there's a delicate balance to maintain when it comes to zinc and copper in the diet.
Importantly, subgroup analysis indicated that younger individuals, particularly those under 60, could benefit more from slight increases in zinc. Overall, our study highlights the significance of dietary management, emphasizing that reasonable zinc intake may contribute to lowering IBS risk while keeping copper and the copper/zinc ratio in a sensible range.
References
- Heydari P, Ghanadian M, Asghari G, Azimi M, Babaeian M, et al. A double-blind randomized clinical trial of Boiss. in the patients with diarrhea-predominant irritable bowel syndrome. Res Pharm Sci. 2023;18:89. doi:10.4103/1735-5362.363599
- Harvey RF, Read AE. Effects of oral magnesium sulphate on colonic motility in patients with the irritable bowel syndrome. Gut. 1973;14:983.
- Zhuang Y, Li L, Ran Y, Zhang Y, Chen J, et al. Dietary copper, zinc, copper/zinc ratio intakes and irritable bowel syndrome risk: a large-scale prospective cohort study from UK Biobank. Am J Epidemiol. 2024. doi:10.1093/aje/kwae412
